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Compile Data Set for Download or QSAR

Found 88 hits with Last Name = 'nakama' and Initial = 'c'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a 0.130n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301204
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCSCC2)oc1C
Show InChI InChI=1S/C22H27N5OS2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-29-10-8-27)11-19(26-21)14-30-22-25-16(2)17(3)28-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.160n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a 0.200n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301203
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCSCC2)oc1C
Show InChI InChI=1S/C21H24FN5OS2/c1-14-15(2)28-21(24-14)30-13-17-10-18(27-6-8-29-9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 0.270n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301209
PNG
(6-((4,5-dimethylthiazol-2-ylthio)methyl)-N-((6-met...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C22H27N5OS2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-28-10-8-27)11-19(26-21)14-29-22-25-16(2)17(3)30-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.270n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301207
PNG
(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-N-((6-...)
Show SMILES CCc1oc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C23H29N5O2S/c1-4-21-17(3)26-23(30-21)31-15-19-12-20(28-8-10-29-11-9-28)13-22(27-19)24-14-18-7-5-6-16(2)25-18/h5-7,12-13H,4,8-11,14-15H2,1-3H3,(H,24,27)
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n/an/a 0.390n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301208
PNG
(CHEMBL566040 | N-((6-methylpyridin-2-yl)methyl)-4-...)
Show SMILES Cc1cccc(CNc2cc(cc(CSc3nc4CCCCc4o3)n2)N2CCOCC2)n1
Show InChI InChI=1S/C24H29N5O2S/c1-17-5-4-6-18(26-17)15-25-23-14-20(29-9-11-30-12-10-29)13-19(27-23)16-32-24-28-21-7-2-3-8-22(21)31-24/h4-6,13-14H,2-3,7-12,15-16H2,1H3,(H,25,27)
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n/an/a 0.460n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301210
PNG
(6-((5-(fluoromethyl)-4-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)sc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(27-21)14-30-22-26-16(2)20(12-23)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,27)
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n/an/a 0.560n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301202
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C22H27N5O2S/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-28-10-8-27)11-19(26-21)14-30-22-25-16(2)17(3)29-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.690n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50296002
PNG
(CHEMBL564536 | isopropyl 3-chloro-5-(1-(6-(2-(5-et...)
Show SMILES CCc1sc(CCc2cc(cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C29H38ClN5O3S/c1-6-26-20(5)32-28(39-26)8-7-23-16-25(35-9-11-37-12-10-35)17-27(33-23)31-19(4)21-13-22(30)15-24(14-21)34-29(36)38-18(2)3/h13-19H,6-12H2,1-5H3,(H,31,33)(H,34,36)
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n/an/a 1.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301197
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(24-14)30-13-17-10-18(27-6-8-28-9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 1.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301206
PNG
(CHEMBL566889 | [6-(4,5-Dimethyl-oxazol-2-ylsulfany...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCS(=O)(=O)CC2)oc1C
Show InChI InChI=1S/C22H27N5O3S2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-32(28,29)10-8-27)11-19(26-21)14-31-22-25-16(2)17(3)30-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 1.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301200
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(flu...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(CF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C22H26FN5O2S/c1-15-16(2)30-22(25-15)31-14-19-10-20(28-6-8-29-9-7-28)11-21(27-19)24-13-18-5-3-4-17(12-23)26-18/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,27)
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n/an/a 1.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301198
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(met...)
Show SMILES COCc1cccc(CNc2cc(cc(CSc3nc(C)c(C)o3)n2)N2CCOCC2)n1
Show InChI InChI=1S/C23H29N5O3S/c1-16-17(2)31-23(25-16)32-15-20-11-21(28-7-9-30-10-8-28)12-22(27-20)24-13-18-5-4-6-19(26-18)14-29-3/h4-6,11-12H,7-10,13-15H2,1-3H3,(H,24,27)
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n/an/a 4.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301196
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((2-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3ccnc(F)c3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-10-18(27-5-7-28-8-6-27)11-20(26-17)24-12-16-3-4-23-19(22)9-16/h3-4,9-11H,5-8,12-13H2,1-2H3,(H,24,26)
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n/an/a 5.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301195
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((2-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccnc3F)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-10-18(27-6-8-28-9-7-27)11-19(26-17)24-12-16-4-3-5-23-20(16)22/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,24,26)
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n/an/a 7.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301205
PNG
(CHEMBL566441 | [6-(4,5-Dimethyl-oxazol-2-ylsulfany...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCS(=O)(=O)CC2)oc1C
Show InChI InChI=1S/C21H24FN5O3S2/c1-14-15(2)30-21(24-14)31-13-17-10-18(27-6-8-32(28,29)9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 8n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301199
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-((2-...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(COCCF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C24H30FN5O3S/c1-17-18(2)33-24(27-17)34-16-21-12-22(30-7-10-31-11-8-30)13-23(29-21)26-14-19-4-3-5-20(28-19)15-32-9-6-25/h3-5,12-13H,6-11,14-16H2,1-2H3,(H,26,29)
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n/an/a 10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301201
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(2-f...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(OCCF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C23H28FN5O3S/c1-16-17(2)32-23(26-16)33-15-19-12-20(29-7-10-30-11-8-29)13-21(27-19)25-14-18-4-3-5-22(28-18)31-9-6-24/h3-5,12-13H,6-11,14-15H2,1-2H3,(H,25,27)
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n/an/a 19n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50301194
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3ccc(F)nc3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-9-18(27-5-7-28-8-6-27)10-20(26-17)24-12-16-3-4-19(22)23-11-16/h3-4,9-11H,5-8,12-13H2,1-2H3,(H,24,26)
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n/an/a 21n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296002
PNG
(CHEMBL564536 | isopropyl 3-chloro-5-(1-(6-(2-(5-et...)
Show SMILES CCc1sc(CCc2cc(cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C29H38ClN5O3S/c1-6-26-20(5)32-28(39-26)8-7-23-16-25(35-9-11-37-12-10-35)17-27(33-23)31-19(4)21-13-22(30)15-24(14-21)34-29(36)38-18(2)3/h13-19H,6-12H2,1-5H3,(H,31,33)(H,34,36)
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n/an/a 36n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295987
PNG
(CHEMBL564513 | N-ethyl-6-(2-(5-ethyl-4-methyloxazo...)
Show SMILES CCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C19H28N4O2/c1-4-17-14(3)21-19(25-17)7-6-15-12-16(13-18(22-15)20-5-2)23-8-10-24-11-9-23/h12-13H,4-11H2,1-3H3,(H,20,22)
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n/an/a 400n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295989
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C20H30N4O2/c1-4-8-21-19-14-17(24-9-11-25-12-10-24)13-16(23-19)6-7-20-22-15(3)18(5-2)26-20/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 480n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295990
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-isoprop...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)C)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O2/c1-5-18-15(4)22-20(26-18)7-6-16-12-17(24-8-10-25-11-9-24)13-19(23-16)21-14(2)3/h12-14H,5-11H2,1-4H3,(H,21,23)
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n/an/a 540n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295988
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-methyl-...)
Show SMILES CCc1oc(CCc2cc(cc(NC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H26N4O2/c1-4-16-13(2)20-18(24-16)6-5-14-11-15(12-17(19-3)21-14)22-7-9-23-10-8-22/h11-12H,4-10H2,1-3H3,(H,19,21)
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n/an/a 830n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295991
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-(2-meth...)
Show SMILES CCc1oc(CCc2cc(cc(NCCOC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O3/c1-4-18-15(2)22-20(27-18)6-5-16-13-17(24-8-11-26-12-9-24)14-19(23-16)21-7-10-25-3/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 900n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295994
PNG
(CHEMBL562831 | ethyl 2-(6-(2-(5-ethyl-4-methyloxaz...)
Show SMILES CCOC(=O)CNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C21H30N4O4/c1-4-18-15(3)23-20(29-18)7-6-16-12-17(25-8-10-27-11-9-25)13-19(24-16)22-14-21(26)28-5-2/h12-13H,4-11,14H2,1-3H3,(H,22,24)
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n/an/a 910n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295996
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCc1oc(CCc2cc(cc(NCC(F)(F)F)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25F3N4O2/c1-3-16-13(2)24-18(28-16)5-4-14-10-15(26-6-8-27-9-7-26)11-17(25-14)23-12-19(20,21)22/h10-11H,3-9,12H2,1-2H3,(H,23,25)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295993
PNG
(3-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H27N5O2/c1-3-18-15(2)23-20(27-18)6-5-16-13-17(25-9-11-26-12-10-25)14-19(24-16)22-8-4-7-21/h13-14H,3-6,8-12H2,1-2H3,(H,22,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295996
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCc1oc(CCc2cc(cc(NCC(F)(F)F)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25F3N4O2/c1-3-16-13(2)24-18(28-16)5-4-14-10-15(26-6-8-27-9-7-26)11-17(25-14)23-12-19(20,21)22/h10-11H,3-9,12H2,1-2H3,(H,23,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295992
PNG
(2-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25N5O2/c1-3-17-14(2)22-19(26-17)5-4-15-12-16(24-8-10-25-11-9-24)13-18(23-15)21-7-6-20/h12-13H,3-5,7-11H2,1-2H3,(H,21,23)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295995
PNG
(CHEMBL559987 | N-(6-(2-(5-ethyl-4-methyloxazol-2-y...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)=O)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H26N4O3/c1-4-17-13(2)20-19(26-17)6-5-15-11-16(23-7-9-25-10-8-23)12-18(22-15)21-14(3)24/h11-12H,4-10H2,1-3H3,(H,21,22,24)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295997
PNG
(2-(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-4-m...)
Show SMILES CCc1oc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H23N5O2S/c1-3-16-13(2)21-18(25-16)26-12-14-10-15(23-6-8-24-9-7-23)11-17(22-14)20-5-4-19/h10-11H,3,5-9,12H2,1-2H3,(H,20,22)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295989
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C20H30N4O2/c1-4-8-21-19-14-17(24-9-11-25-12-10-24)13-16(23-19)6-7-20-22-15(3)18(5-2)26-20/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))		BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY5 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))		BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))		BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY5 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296001
PNG
(2-(6-((4,5-dimethylthiazol-2-ylthio)methyl)-4-morp...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C17H21N5OS2/c1-12-13(2)25-17(20-12)24-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296000
PNG
(2-(4-morpholino-6-((1,4,5-trimethyl-1H-imidazol-2-...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)n(C)c1C
Show InChI InChI=1S/C18H24N6OS/c1-13-14(2)23(3)18(21-13)26-12-15-10-16(24-6-8-25-9-7-24)11-17(22-15)20-5-4-19/h10-11H,5-9,12H2,1-3H3,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295998
PNG
(2-(6-((4,5-dimethyloxazol-2-ylthio)methyl)-4-morph...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C17H21N5O2S/c1-12-13(2)24-17(20-12)25-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))		BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor

Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295991
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-(2-meth...)
Show SMILES CCc1oc(CCc2cc(cc(NCCOC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O3/c1-4-18-15(2)22-20(27-18)6-5-16-13-17(24-8-11-26-12-9-24)14-19(23-16)21-7-10-25-3/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295994
PNG
(CHEMBL562831 | ethyl 2-(6-(2-(5-ethyl-4-methyloxaz...)
Show SMILES CCOC(=O)CNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C21H30N4O4/c1-4-18-15(3)23-20(29-18)7-6-16-12-17(25-8-10-27-11-9-25)13-19(24-16)22-14-21(26)28-5-2/h12-13H,4-11,14H2,1-3H3,(H,22,24)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50296001
PNG
(2-(6-((4,5-dimethylthiazol-2-ylthio)methyl)-4-morp...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C17H21N5OS2/c1-12-13(2)25-17(20-12)24-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295987
PNG
(CHEMBL564513 | N-ethyl-6-(2-(5-ethyl-4-methyloxazo...)
Show SMILES CCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C19H28N4O2/c1-4-17-14(3)21-19(25-17)7-6-15-12-16(13-18(22-15)20-5-2)23-8-10-24-11-9-23/h12-13H,4-11H2,1-3H3,(H,20,22)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295992
PNG
(2-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25N5O2/c1-3-17-14(2)22-19(26-17)5-4-15-12-16(24-8-10-25-11-9-24)13-18(23-15)21-7-6-20/h12-13H,3-5,7-11H2,1-2H3,(H,21,23)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295997
PNG
(2-(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-4-m...)
Show SMILES CCc1oc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H23N5O2S/c1-3-16-13(2)21-18(25-16)26-12-14-10-15(23-6-8-24-9-7-23)11-17(22-14)20-5-4-19/h10-11H,3,5-9,12H2,1-2H3,(H,20,22)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295993
PNG
(3-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H27N5O2/c1-3-18-15(2)23-20(27-18)6-5-16-13-17(25-9-11-26-12-10-25)14-19(24-16)22-8-4-7-21/h13-14H,3-6,8-12H2,1-2H3,(H,22,24)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
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