Compile Data Set for Download or QSAR

Found 1223 hits with Last Name = 'deon' and Initial = 'dh'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364891 (US9862730, Example 349) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(Cl)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H22ClN3O5S/c1-33-21-11-24(36-16-18-6-4-8-20(10-18)35-15-17-5-3-7-19(29)9-17)22-13-26(37-25(22)12-21)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364941 (US9862730, Example 399) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4csc(C)n4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C26H22N4O5S2/c1-15-27-17(14-36-15)13-33-18-6-4-5-16(7-18)12-34-22-8-19(31-2)9-23-20(22)10-24(35-23)21-11-30-25(28-21)37-26(29-30)32-3/h4-11,14H,12-13H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364858 (US9862730, Example 314) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(F)c4F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H21F2N3O5S/c1-34-19-10-23(20-12-25(38-24(20)11-19)22-13-33-27(31-22)39-28(32-33)35-2)37-14-16-5-3-7-18(9-16)36-15-17-6-4-8-21(29)26(17)30/h3-13H,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364931 (US9862730, Example 389) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)c(OC)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C30H27N3O7S/c1-34-21-12-25(22-14-27(40-26(22)13-21)23-15-33-29(31-23)41-30(32-33)37-4)39-17-18-6-5-7-20(10-18)38-16-19-8-9-24(35-2)28(11-19)36-3/h5-15H,16-17H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364892 (US9862730, Example 350) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(OCc4ccccc4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H22FN3O5S/c1-33-20-11-24(36-16-18-8-19(29)10-21(9-18)35-15-17-6-4-3-5-7-17)22-13-26(37-25(22)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364945 (US9862730, Example 403) Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2nc(oc2c1)-c1cn2nc(SC)sc2n1 Show InChI InChI=1S/C27H22N4O4S2/c1-32-20-12-22(34-16-18-9-6-10-19(11-18)33-15-17-7-4-3-5-8-17)24-23(13-20)35-25(29-24)21-14-31-26(28-21)37-27(30-31)36-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364882 ((R)-6-(4-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)...) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3COC(C)(C)O3)cc(OC)cc2o1 |r| Show InChI InChI=1S/C20H21N3O6S/c1-20(2)27-10-12(29-20)9-26-15-5-11(24-3)6-16-13(15)7-17(28-16)14-8-23-18(21-14)30-19(22-23)25-4/h5-8,12H,9-10H2,1-4H3/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176047 (US10047103, 80 | US9688695, 80) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(Cl)nc3)cc(OC)cc2o1 Show InChI InChI=1S/C23H16ClN5O4S2/c1-30-14-5-17(32-10-13-11-34-21(26-13)12-3-4-20(24)25-8-12)15-7-19(33-18(15)6-14)16-9-29-22(27-16)35-23(28-29)31-2/h3-9,11H,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176041 (US10047103, 74 | US9688695, 74) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(C)nc3)cc(OC)cc2o1 Show InChI InChI=1S/C24H19N5O4S2/c1-13-4-5-14(9-25-13)22-26-15(12-34-22)11-32-19-6-16(30-2)7-20-17(19)8-21(33-20)18-10-29-23(27-18)35-24(28-29)31-3/h4-10,12H,11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364887 (US9862730, Example 345) Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(SC)sc2n1 Show InChI InChI=1S/C28H23N3O4S2/c1-32-21-12-24(34-17-19-9-6-10-20(11-19)33-16-18-7-4-3-5-8-18)22-14-26(35-25(22)13-21)23-15-31-27(29-23)37-28(30-31)36-2/h3-15H,16-17H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364615 (US9862730, Example 73) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cc(OC)cc2o1 Show InChI InChI=1S/C15H13N3O4S/c1-19-8-4-11(20-2)9-6-13(22-12(9)5-8)10-7-18-14(16-10)23-15(17-18)21-3/h4-7H,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176255 (US10047103, 288 | US9688695, 288) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)CC#N)cc(OC)cc2o1 Show InChI InChI=1S/C28H22N6O5S2/c1-33(9-8-29)26(35)17-6-4-16(5-7-17)25-30-18(15-40-25)14-38-22-10-19(36-2)11-23-20(22)12-24(39-23)21-13-34-27(31-21)41-28(32-34)37-3/h4-7,10-13,15H,9,14H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364957 (6-(4-((3-(Benzyloxy)benzyl)oxy)-6-(difluoromethoxy...) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC(F)F)cc2o1 Show InChI InChI=1S/C28H21F2N3O5S/c1-34-28-32-33-14-22(31-27(33)39-28)25-13-21-23(11-20(37-26(29)30)12-24(21)38-25)36-16-18-8-5-9-19(10-18)35-15-17-6-3-2-4-7-17/h2-14,26H,15-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.09	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364922 (US9862730, Example 380) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(OC)c(OC)c(OC)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C31H29N3O8S/c1-35-21-12-24(22-14-26(42-25(22)13-21)23-15-34-30(32-23)43-31(33-34)39-5)41-16-18-7-6-8-20(9-18)40-17-19-10-27(36-2)29(38-4)28(11-19)37-3/h6-15H,16-17H2,1-5H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.11	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364949 (US9862730, Example 407) Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F |r| Show InChI InChI=1S/C29H24FN3O4S/c1-18(30)28-32-33-15-24(31-29(33)38-28)27-14-23-25(12-22(34-2)13-26(23)37-27)36-17-20-9-6-10-21(11-20)35-16-19-7-4-3-5-8-19/h3-15,18H,16-17H2,1-2H3/t18-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.12	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364886 (US9862730, Example 344) Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(Br)sc2n1 Show InChI InChI=1S/C27H20BrN3O4S/c1-32-20-11-23(34-16-18-8-5-9-19(10-18)33-15-17-6-3-2-4-7-17)21-13-25(35-24(21)12-20)22-14-31-27(29-22)36-26(28)30-31/h2-14H,15-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.12	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176015 (US10047103, 48 | US9688695, 48) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)-c3ccc(cc3)C(=O)N(C)CC#N)cc(OC)cc2o1 Show InChI InChI=1S/C29H24N6O5S2/c1-16-22(31-26(41-16)17-5-7-18(8-6-17)27(36)34(2)10-9-30)15-39-23-11-19(37-3)12-24-20(23)13-25(40-24)21-14-35-28(32-21)42-29(33-35)38-4/h5-8,11-14H,10,15H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364772 (US9862730, Example 229) Show SMILES COc1cc(OC)c2cc(oc2c1)-c1cn2nc(SC)sc2n1 Show InChI InChI=1S/C15H13N3O3S2/c1-19-8-4-11(20-2)9-6-13(21-12(9)5-8)10-7-18-14(16-10)23-15(17-18)22-3/h4-7H,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.22	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364853 (US9862730, Example 309) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4OC)c3)cc(OC)cc2o1 Show InChI InChI=1S/C29H25N3O6S/c1-33-21-12-25(22-14-27(38-26(22)13-21)23-15-32-28(30-23)39-29(31-32)35-3)37-16-18-7-6-9-20(11-18)36-17-19-8-4-5-10-24(19)34-2/h4-15H,16-17H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.22	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364613 (US9862730, Example 71) Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1 Show InChI InChI=1S/C14H11N3O3S/c1-18-9-4-3-8-5-12(20-11(8)6-9)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.22	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364904 (US9862730, Example 362) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4Cl)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H22ClN3O5S/c1-33-20-11-24(36-15-17-6-5-8-19(10-17)35-16-18-7-3-4-9-22(18)29)21-13-26(37-25(21)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364943 (US9862730, Example 401) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(Cl)cc(OC)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C29H24ClN3O6S/c1-34-21-9-18(7-19(30)10-21)16-37-20-6-4-5-17(8-20)15-38-25-11-22(35-2)12-26-23(25)13-27(39-26)24-14-33-28(31-24)40-29(32-33)36-3/h4-14H,15-16H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364903 (US9862730, Example 361) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)c(OC)c4Cl)c3)cc(OC)cc2o1 Show InChI InChI=1S/C30H26ClN3O7S/c1-35-20-11-24(21-13-26(41-25(21)12-20)22-14-34-29(32-22)42-30(33-34)38-4)40-15-17-6-5-7-19(10-17)39-16-18-8-9-23(36-2)28(37-3)27(18)31/h5-14H,15-16H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.35	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364934 (US9862730, Example 392) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)cc4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C29H25N3O6S/c1-33-20-9-7-18(8-10-20)16-36-21-6-4-5-19(11-21)17-37-25-12-22(34-2)13-26-23(25)14-27(38-26)24-15-32-28(30-24)39-29(31-32)35-3/h4-15H,16-17H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.44	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364867 (US9862730, Example 323) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(Cl)cc4F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H21ClFN3O5S/c1-34-20-10-24(21-12-26(38-25(21)11-20)23-13-33-27(31-23)39-28(32-33)35-2)37-14-16-4-3-5-19(8-16)36-15-17-6-7-18(29)9-22(17)30/h3-13H,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.48	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364932 (US9862730, Example 390) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(OC)cc(OC)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C30H27N3O7S/c1-34-21-9-19(10-22(11-21)35-2)17-38-20-7-5-6-18(8-20)16-39-26-12-23(36-3)13-27-24(26)14-28(40-27)25-15-33-29(31-25)41-30(32-33)37-4/h5-15H,16-17H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176048 (US10047103, 81 | US9688695, 81) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)S(C)(=O)=O)cc(OC)cc2o1 Show InChI InChI=1S/C25H20N4O6S3/c1-32-16-8-20(34-12-15-13-36-23(26-15)14-4-6-17(7-5-14)38(3,30)31)18-10-22(35-21(18)9-16)19-11-29-24(27-19)37-25(28-29)33-2/h4-11,13H,12H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM175995 (US10047103, 75 | US9605024, Example 28 | US9688695...) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1 Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364869 (US9862730, Example 325) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(F)c(F)c4F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H20F3N3O5S/c1-35-18-9-22(19-11-24(39-23(19)10-18)21-12-34-27(32-21)40-28(33-34)36-2)38-13-15-4-3-5-17(8-15)37-14-16-6-7-20(29)26(31)25(16)30/h3-12H,13-14H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.64	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364897 (US9862730, Example 355) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OC(=O)c4ccccc4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H21N3O6S/c1-33-20-12-23(35-16-17-7-6-10-19(11-17)36-26(32)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-31-27(29-22)38-28(30-31)34-2/h3-15H,16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.65	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364898 (US9862730, Example 356) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C29H21F4N3O5S/c1-37-21-10-24(22-12-26(41-25(22)11-21)23-13-36-27(34-23)42-28(35-36)38-2)40-14-16-4-3-5-20(8-16)39-15-17-6-18(29(31,32)33)9-19(30)7-17/h3-13H,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.66	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364924 (US9862730, Example 382) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(C)cc(C)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C30H27N3O5S/c1-18-8-19(2)10-21(9-18)17-36-22-7-5-6-20(11-22)16-37-26-12-23(34-3)13-27-24(26)14-28(38-27)25-15-33-29(31-25)39-30(32-33)35-4/h5-15H,16-17H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.67	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364888 (US9862730, Example 346) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(F)cc4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H22FN3O5S/c1-33-21-11-24(36-16-18-4-3-5-20(10-18)35-15-17-6-8-19(29)9-7-17)22-13-26(37-25(22)12-21)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.68	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364928 (US9862730, Example 386) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(C)c4)c3)cc(OC)cc2o1 Show InChI InChI=1S/C29H25N3O5S/c1-18-6-4-7-19(10-18)16-35-21-9-5-8-20(11-21)17-36-25-12-22(33-2)13-26-23(25)14-27(37-26)24-15-32-28(30-24)38-29(31-32)34-3/h4-15H,16-17H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.77	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364954 (6-(4-((3-(Benzyloxy)benzyl)oxy)benzofuran-2-yl)-2-...) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cccc2o1 Show InChI InChI=1S/C27H21N3O4S/c1-31-27-29-30-15-22(28-26(30)35-27)25-14-21-23(11-6-12-24(21)34-25)33-17-19-9-5-10-20(13-19)32-16-18-7-3-2-4-8-18/h2-15H,16-17H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.82	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176040 (US10047103, 73 | US9688695, 73) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(F)nc3)cc(OC)cc2o1 Show InChI InChI=1S/C23H16FN5O4S2/c1-30-14-5-17(32-10-13-11-34-21(26-13)12-3-4-20(24)25-8-12)15-7-19(33-18(15)6-14)16-9-29-22(27-16)35-23(28-29)31-2/h3-9,11H,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176044 (US10047103, 77 | US9688695, 77) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)-c3cccc(CO)c3)cc(OC)cc2o1 Show InChI InChI=1S/C26H22N4O5S2/c1-14-20(27-24(36-14)16-6-4-5-15(7-16)12-31)13-34-21-8-17(32-2)9-22-18(21)10-23(35-22)19-11-30-25(28-19)37-26(29-30)33-3/h4-11,31H,12-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176093 (US10047103, 126 | US9688695, 126 | US9688695, 127) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CCC4(CC3)OCCO4)cc(OC)cc2o1 Show InChI InChI=1S/C26H26N4O7S2/c1-32-16-9-19(17-11-21(37-20(17)10-16)18-12-30-23(28-18)39-24(29-30)33-2)34-13-15-14-38-22(27-15)25(31)3-5-26(6-4-25)35-7-8-36-26/h9-12,14,31H,3-8,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176268 (US10047103, 301 | US9688695, 301) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N3CCCC3)cc(OC)cc2o1 Show InChI InChI=1S/C29H25N5O5S2/c1-36-20-11-23(21-13-25(39-24(21)12-20)22-14-34-28(31-22)41-29(32-34)37-2)38-15-19-16-40-26(30-19)17-5-7-18(8-6-17)27(35)33-9-3-4-10-33/h5-8,11-14,16H,3-4,9-10,15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364968 (US9862730, Example 427) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(F)cc2o1 Show InChI InChI=1S/C27H20FN3O4S/c1-32-27-30-31-14-22(29-26(31)36-27)25-13-21-23(11-19(28)12-24(21)35-25)34-16-18-8-5-9-20(10-18)33-15-17-6-3-2-4-7-17/h2-14H,15-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.91	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364862 (US9862730, Example 318) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H22FN3O5S/c1-33-20-11-24(36-15-17-6-5-8-19(10-17)35-16-18-7-3-4-9-22(18)29)21-13-26(37-25(21)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.92	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176272 (US10047103, 305 | US9688695, 305) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1 Show InChI InChI=1S/C27H20F3N5O5S2/c1-37-17-7-20(18-9-22(40-21(18)8-17)19-10-35-25(33-19)42-26(34-35)38-2)39-11-16-12-41-24(32-16)15-5-3-14(4-6-15)23(36)31-13-27(28,29)30/h3-10,12H,11,13H2,1-2H3,(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176278 (US10047103, 311 | US9688695, 311) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)CCC#N)cc(OC)cc2o1 Show InChI InChI=1S/C29H24N6O5S2/c1-34(10-4-9-30)27(36)18-7-5-17(6-8-18)26-31-19(16-41-26)15-39-23-11-20(37-2)12-24-21(23)13-25(40-24)22-14-35-28(32-22)42-29(33-35)38-3/h5-8,11-14,16H,4,10,15H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176011 (US10047103, 44 | US9688695, 44) Show SMILES CCc1sc(nc1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1)-c1ccc(cc1)C(=O)N(C)C Show InChI InChI=1S/C29H27N5O5S2/c1-6-25-21(30-26(40-25)16-7-9-17(10-8-16)27(35)33(2)3)15-38-22-11-18(36-4)12-23-19(22)13-24(39-23)20-14-34-28(31-20)41-29(32-34)37-5/h7-14H,6,15H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364747 (6-(4-Ethoxy, 6-methoxybenzofuran-2-yl)-2-(methylth...) Show SMILES CCOc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1 Show InChI InChI=1S/C16H15N3O4S/c1-4-22-12-5-9(20-2)6-13-10(12)7-14(23-13)11-8-19-15(17-11)24-16(18-19)21-3/h5-8H,4H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.01	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364896 (US9862730, Example 354) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(Br)cc4F)c3)cc(OC)cc2o1 Show InChI InChI=1S/C28H21BrFN3O5S/c1-34-20-10-24(21-12-26(38-25(21)11-20)23-13-33-27(31-23)39-28(32-33)35-2)37-14-16-4-3-5-19(8-16)36-15-17-6-7-18(29)9-22(17)30/h3-13H,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.06	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176003 (US10047103, 36 | US9688695, 36) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1 Show InChI InChI=1S/C27H23N5O5S2/c1-31(2)25(33)16-7-5-15(6-8-16)24-28-17(14-38-24)13-36-21-9-18(34-3)10-22-19(21)11-23(37-22)20-12-32-26(29-20)39-27(30-32)35-4/h5-12,14H,13H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176006 (US10047103, 39 | US9688695, 39) Show SMILES COCCN(C)C(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1 Show InChI InChI=1S/C29H27N5O6S2/c1-33(9-10-36-2)27(35)18-7-5-17(6-8-18)26-30-19(16-41-26)15-39-23-11-20(37-3)12-24-21(23)13-25(40-24)22-14-34-28(31-22)42-29(32-34)38-4/h5-8,11-14,16H,9-10,15H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364857 (US9862730, Example 313) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(cc4)C(C)C)c3)cc(OC)cc2o1 Show InChI InChI=1S/C31H29N3O5S/c1-19(2)22-10-8-20(9-11-22)17-37-23-7-5-6-21(12-23)18-38-27-13-24(35-3)14-28-25(27)15-29(39-28)26-16-34-30(32-26)40-31(33-34)36-4/h5-16,19H,17-18H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.11	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM364856 (US9862730, Example 312) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(C)cc4C)c3)cc(OC)cc2o1 Show InChI InChI=1S/C30H27N3O5S/c1-18-8-9-21(19(2)10-18)17-36-22-7-5-6-20(11-22)16-37-26-12-23(34-3)13-27-24(26)14-28(38-27)25-15-33-29(31-25)39-30(32-33)35-4/h5-15H,16-17H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.13	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Houston					Assay Description The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...				J Med Chem 48: 6661-70 (2005) BindingDB Entry DOI: 10.7270/Q2X92DKF
					More data for this Ligand-Target Pair

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