Compile Data Set for Download or QSAR

Found 80 hits with Last Name = 'ooboki' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395359 (US10308636, Example 44-6) Show SMILES OC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)c1Cl Show InChI InChI=1S/C22H20ClF3N4O3/c23-19-15(21(31)32)2-1-3-16(19)33-12-13-6-8-30(9-7-13)18-5-4-14(10-27-18)20-28-11-17(29-20)22(24,25)26/h1-5,10-11,13H,6-9,12H2,(H,28,29)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395327 (US10308636, Example 4-15) Show SMILES CCC(CC)(COc1cnc(cn1)-c1ccc(nc1)-c1ncc([nH]1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H25N5O3/c1-3-25(4-2,24(31)32)16-33-22-15-27-20(13-28-22)18-10-11-19(26-12-18)23-29-14-21(30-23)17-8-6-5-7-9-17/h5-15H,3-4,16H2,1-2H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395378 (US10308636, Example 110) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(n[nH]1)-c1ccc(OC)cc1 Show InChI InChI=1S/C26H26N4O4/c1-26(2,25(31)33-4)16-34-22-14-11-20(15-27-22)17-5-7-18(8-6-17)23-28-24(30-29-23)19-9-12-21(32-3)13-10-19/h5-15H,16H2,1-4H3,(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395380 (US10308636, Example 75) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2ccc(cc2)C#N)n(COCC[Si](C)(C)C)n1 Show InChI InChI=1S/C32H37N5O5Si/c1-32(2,30(38)39-3)21-41-28-16-13-26(20-34-28)24-9-11-25(12-10-24)29-35-31(42-27-14-7-23(19-33)8-15-27)37(36-29)22-40-17-18-43(4,5)6/h7-16,20H,17-18,21-22H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395381 (US10308636, Example 74) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(OCC(F)(F)C(F)(F)F)n(COCC[Si](C)(C)C)n1 Show InChI InChI=1S/C28H35F5N4O5Si/c1-26(2,24(38)39-3)16-41-22-12-11-21(15-34-22)19-7-9-20(10-8-19)23-35-25(42-17-27(29,30)28(31,32)33)37(36-23)18-40-13-14-43(4,5)6/h7-12,15H,13-14,16-18H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395364 (US10308636, Example 46-5) Show SMILES Fc1ccccc1OC[C@H]1CC[C@@H](CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F |r,wU:12.16,wD:9.9,(-7.12,-1.57,;-7.12,-3.11,;-8.5,-3.85,;-8.45,-5.42,;-7.12,-6.19,;-5.79,-5.42,;-5.79,-3.88,;-4.45,-3.11,;-3.12,-3.88,;-1.78,-3.11,;-.45,-3.88,;.88,-3.11,;.88,-1.57,;-.45,-.8,;-1.78,-1.57,;2.22,-.8,;2.22,.74,;3.55,1.51,;4.88,.74,;4.88,-.8,;3.55,-1.57,;6.22,1.51,;6.22,3.05,;7.7,3.56,;8.59,2.28,;7.68,1.03,;8.17,5.03,;8.65,6.49,;9.64,4.55,;6.71,5.5,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395361 (US10308636, Example 45-1) Show SMILES CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C Show InChI InChI=1S/C32H42F3N3O4Si/c1-6-41-31(39)27-8-7-9-28(23(27)2)42-21-24-14-16-37(17-15-24)26-12-10-25(11-13-26)30-36-29(32(33,34)35)20-38(30)22-40-18-19-43(3,4)5/h7-13,20,24H,6,14-19,21-22H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395325 (US10308636, Example 4-1) Show SMILES Cc1cc(OCC(C)(C)C(=O)OC(C)(C)C)ncc1-c1cnc(-c2ncc([nH]2)-c2ccccc2)c(F)c1 Show InChI InChI=1S/C29H31FN4O3/c1-18-12-24(36-17-29(5,6)27(35)37-28(2,3)4)31-15-21(18)20-13-22(30)25(32-14-20)26-33-16-23(34-26)19-10-8-7-9-11-19/h7-16H,17H2,1-6H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395383 (US10308636, Example 78) Show SMILES NC(=O)c1ccc(Br)cc1F Show InChI InChI=1S/C7H5BrFNO/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H2,10,11)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395345 (US10308636, Example 32-2) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1nc(c[nH]1)C#N Show InChI InChI=1S/C21H20N4O3/c1-13-8-18(28-12-21(2,3)20(26)27)23-11-17(13)14-4-6-15(7-5-14)19-24-10-16(9-22)25-19/h4-8,10-11H,12H2,1-3H3,(H,24,25)(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395386 (US10308636, Example 83) Show SMILES C[Si](C)(C)CCOCn1nc(nc1Oc1ccc(F)cc1)-c1ccc(Br)cc1F Show InChI InChI=1S/C20H22BrF2N3O2Si/c1-29(2,3)11-10-27-13-26-20(28-16-7-5-15(22)6-8-16)24-19(25-26)17-9-4-14(21)12-18(17)23/h4-9,12H,10-11,13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395326 (US10308636, Example 4-3) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)-c1ccccc1 Show InChI InChI=1S/C25H23N5O3/c1-16-10-21(33-15-25(24(31)32)8-5-9-25)26-13-19(16)18-11-27-22(28-12-18)23-29-14-20(30-23)17-6-3-2-4-7-17/h2-4,6-7,10-14H,5,8-9,15H2,1H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395313 (US10308636, Example 1-34) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1cccs1)C(O)=O Show InChI InChI=1S/C23H21N3O3S/c1-23(2,22(27)28)14-29-17-8-5-15(6-9-17)18-10-7-16(12-24-18)21-25-13-19(26-21)20-4-3-11-30-20/h3-13H,14H2,1-2H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395379 (US10308636, Example 72) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2cccnc2)n(COCC[Si](C)(C)C)n1 Show InChI InChI=1S/C30H37N5O5Si/c1-30(2,28(36)37-3)20-39-26-14-13-24(18-32-26)22-9-11-23(12-10-22)27-33-29(40-25-8-7-15-31-19-25)35(34-27)21-38-16-17-41(4,5)6/h7-15,18-19H,16-17,20-21H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395324 (US10308636, Example 3-7) Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)-c2ccccc2OC(F)(F)F)c(F)c1 Show InChI InChI=1S/C26H20F4N4O4/c1-14-8-21(37-13-25(6-7-25)24(35)36)31-11-17(14)15-9-18(27)22(32-10-15)23-33-12-19(34-23)16-4-2-3-5-20(16)38-26(28,29)30/h2-5,8-12H,6-7,13H2,1H3,(H,33,34)(H,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395320 (US10308636, Example 2-7) Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(cc1)-c1ncc([nH]1)-c1ccccc1)C([O-])=O Show InChI InChI=1S/C25H23N3O3/c1-25(2,24(29)30)16-31-22-13-12-20(14-26-22)17-8-10-19(11-9-17)23-27-15-21(28-23)18-6-4-3-5-7-18/h3-15H,16H2,1-2H3,(H,27,28)(H,29,30)/p-1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395372 (US10308636, Example 59) Show SMILES Brc1ccc(cc1)-c1nnc([nH]1)-c1ccccc1 Show InChI InChI=1S/C14H10BrN3/c15-12-8-6-11(7-9-12)14-16-13(17-18-14)10-4-2-1-3-5-10/h1-9H,(H,16,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395347 (US10308636, Example 35-1) Show SMILES FC(F)(F)c1cnc([nH]1)-c1ccc(nc1)N1CCN(CC1)C(=O)Cc1ccccc1Cl Show InChI InChI=1S/C21H19ClF3N5O/c22-16-4-2-1-3-14(16)11-19(31)30-9-7-29(8-10-30)18-6-5-15(12-26-18)20-27-13-17(28-20)21(23,24)25/h1-6,12-13H,7-11H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395321 (US10308636, Example 2-8) Show SMILES COc1ccc(cc1)-c1cnc([nH]1)-c1ccc(cc1)-c1ccc(OCC(C)(C)C([O-])=O)nc1 Show InChI InChI=1S/C26H25N3O4/c1-26(2,25(30)31)16-33-23-13-10-20(14-27-23)17-4-6-19(7-5-17)24-28-15-22(29-24)18-8-11-21(32-3)12-9-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)/p-1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395337 (US10308636, Example 17) Show SMILES COC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(cn1)-c1ncc(n1COCC[Si](C)(C)C)C(F)(F)F |r,wU:8.11,wD:5.4,(-13.86,-15.18,;-12.68,-16.17,;-11.35,-15.4,;-11.35,-13.86,;-10.02,-16.17,;-8.68,-15.4,;-7.35,-16.17,;-6.01,-15.4,;-6.01,-13.86,;-7.35,-13.09,;-8.68,-13.86,;-4.68,-13.09,;-4.68,-11.55,;-3.35,-10.78,;-2.01,-11.55,;-2.01,-13.09,;-3.35,-13.86,;-.68,-10.78,;-.68,-9.24,;.65,-8.47,;1.99,-9.24,;1.99,-10.78,;.65,-11.55,;3.32,-8.47,;3.32,-6.93,;4.79,-6.46,;5.81,-7.7,;4.79,-8.95,;5.56,-10.28,;7.1,-10.28,;7.87,-8.95,;9.41,-8.95,;10.18,-10.28,;10.95,-11.62,;8.84,-11.05,;11.51,-9.51,;7.35,-7.69,;8.89,-7.69,;7.34,-6.15,;8.59,-8.6,)| Show InChI InChI=1S/C30H38F3N3O3Si/c1-38-28(37)17-21-5-7-22(8-6-21)23-9-11-24(12-10-23)26-14-13-25(18-34-26)29-35-19-27(30(31,32)33)36(29)20-39-15-16-40(2,3)4/h9-14,18-19,21-22H,5-8,15-17,20H2,1-4H3/t21-,22-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395336 (US10308636, Example 14) Show SMILES COc1ccc(cc1)-c1cn(COCC[Si](C)(C)C)c(n1)-c1ccc(cc1Cl)-c1cnc(OCC(C)(C)C)cc1C Show InChI InChI=1S/C33H42ClN3O3Si/c1-23-17-31(40-21-33(2,3)4)35-19-28(23)25-11-14-27(29(34)18-25)32-36-30(24-9-12-26(38-5)13-10-24)20-37(32)22-39-15-16-41(6,7)8/h9-14,17-20H,15-16,21-22H2,1-8H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395328 (US10308636, Example 5-2) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C25H22F3N5O3/c1-14-8-20(36-13-24(2,3)23(34)35)29-11-17(14)15-9-30-21(31-10-15)22-32-12-19(33-22)16-6-4-5-7-18(16)25(26,27)28/h4-12H,13H2,1-3H3,(H,32,33)(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395388 (US10308636, Example 23-1) Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(cc1)-c1ccc(cn1)-c1nc(C)c(n1)C(F)(F)F)C(O)=O |r,wU:6.9,3.2,wD:3.35,(-14.81,-2.24,;-14.04,-3.58,;-12.5,-3.58,;-11.73,-4.91,;-11.73,-6.45,;-10.4,-7.22,;-9.07,-6.45,;-9.07,-4.91,;-10.4,-4.14,;-7.73,-7.22,;-6.4,-6.45,;-6.4,-4.91,;-5.06,-4.14,;-3.73,-4.91,;-3.73,-6.45,;-5.06,-7.22,;-2.4,-4.14,;-2.4,-2.6,;-1.06,-1.83,;.27,-2.6,;.27,-4.14,;-1.06,-4.91,;1.6,-1.83,;3.13,-2.35,;4.01,-1.06,;5.55,-1.02,;3.07,.19,;1.6,-.29,;3.53,1.66,;2.48,2.79,;5.03,1.99,;4.57,.52,;-13.22,-5.31,;-13.62,-6.8,;-14.31,-4.22,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395318 (US10308636, Example 1-63) Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1ccc(nc1)-c1ncc([nH]1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C26H21F3N4O4/c1-15-10-22(36-14-25(8-9-25)24(34)35)31-12-18(15)16-6-7-19(30-11-16)23-32-13-20(33-23)17-4-2-3-5-21(17)37-26(27,28)29/h2-7,10-13H,8-9,14H2,1H3,(H,32,33)(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395384 (US10308636, Example 80) Show SMILES [#6]-[#16]\[#6](-[#16]-[#6])=[#7]/[#6](=O)-c1ccc(Cl)nc1 Show InChI InChI=1S/C9H9ClN2OS2/c1-14-9(15-2)12-8(13)6-3-4-7(10)11-5-6/h3-5H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395322 (US10308636, Example 2-11) Show SMILES COc1ccc(cc1)-c1cnc([nH]1)-c1ccc(cc1)-c1cnc(OCC(C)(C)C([O-])=O)cc1C Show InChI InChI=1S/C27H27N3O4/c1-17-13-24(34-16-27(2,3)26(31)32)28-14-22(17)18-5-7-20(8-6-18)25-29-15-23(30-25)19-9-11-21(33-4)12-10-19/h5-15H,16H2,1-4H3,(H,29,30)(H,31,32)/p-1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395375 (US10308636, Example 67) Show SMILES CCOC(=O)[C@@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cc1)-c1nc(OCC)n(COCC[Si](C)(C)C)n1 |r,wU:5.4,8.11,(-4.28,-19,;-4.28,-20.54,;-5.61,-21.31,;-5.61,-22.85,;-6.95,-23.62,;-4.28,-23.62,;-4.28,-25.16,;-2.95,-25.93,;-1.61,-25.16,;-1.61,-23.62,;-2.95,-22.85,;-.28,-25.93,;1.06,-25.16,;1.06,-23.62,;2.39,-22.85,;3.72,-23.62,;3.72,-25.16,;2.39,-25.93,;5.06,-22.85,;6.39,-23.62,;7.72,-22.85,;7.72,-21.31,;6.39,-20.54,;5.06,-21.31,;9.06,-20.54,;9.06,-19,;10.52,-18.52,;10.92,-17.03,;12.41,-16.63,;12.81,-15.15,;11.43,-19.77,;12.91,-20.16,;13.31,-21.65,;12.22,-22.74,;10.74,-22.34,;9.65,-23.43,;10.05,-24.92,;9.25,-21.94,;8.16,-23.03,;10.52,-21.01,)| Show InChI InChI=1S/C30H42N4O5Si/c1-6-37-29(35)24-12-15-26(16-13-24)39-27-17-14-25(20-31-27)22-8-10-23(11-9-22)28-32-30(38-7-2)34(33-28)21-36-18-19-40(3,4)5/h8-11,14,17,20,24,26H,6-7,12-13,15-16,18-19,21H2,1-5H3/t24-,26+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395316 (US10308636, Example 1-44) Show SMILES Cc1cc(ccc1-c1ncc([nH]1)-c1ccccc1)-c1ccc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C26H25N3O3/c1-17-13-19(20-10-12-23(27-14-20)32-16-26(2,3)25(30)31)9-11-21(17)24-28-15-22(29-24)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395348 (US10308636, Example 37-3) Show SMILES Cc1[nH]c(nc1C#N)-c1ccc(nc1)N1CCN(CC1)c1ccc(C)cc1 Show InChI InChI=1S/C21H22N6/c1-15-3-6-18(7-4-15)26-9-11-27(12-10-26)20-8-5-17(14-23-20)21-24-16(2)19(13-22)25-21/h3-8,14H,9-12H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395363 (US10308636, Example 46-4) Show SMILES Cc1ccc(OC[C@H]2CC[C@@H](CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)cc1 |r,wU:10.13,wD:7.6,(-9.79,-6.19,;-8.45,-5.42,;-8.5,-3.85,;-7.12,-3.11,;-5.79,-3.88,;-4.45,-3.11,;-3.12,-3.88,;-1.78,-3.11,;-.45,-3.88,;.88,-3.11,;.88,-1.57,;-.45,-.8,;-1.78,-1.57,;2.22,-.8,;2.22,.74,;3.55,1.51,;4.88,.74,;4.88,-.8,;3.55,-1.57,;6.22,1.51,;6.22,3.05,;7.7,3.56,;8.59,2.28,;7.68,1.03,;8.17,5.03,;8.65,6.49,;9.64,4.55,;6.71,5.5,;-5.79,-5.42,;-7.12,-6.19,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395385 (US10308636, Example 82) Show SMILES C[Si](C)(C)CCOCn1nc(nc1OCC(F)(F)F)-c1ccc(Br)cc1F Show InChI InChI=1S/C16H20BrF4N3O2Si/c1-27(2,3)7-6-25-10-24-15(26-9-16(19,20)21)22-14(23-24)12-5-4-11(17)8-13(12)18/h4-5,8H,6-7,9-10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395335 (US10308636, Example 12) Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(Cl)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C26H24ClN3O3/c1-26(2,25(31)32-3)16-33-20-12-9-17(10-13-20)21-14-11-19(15-28-21)24-29-22(23(27)30-24)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395376 (US10308636, Example 108) Show SMILES NNC(=O)C1(CC1)C(F)(F)F Show InChI InChI=1S/C5H7F3N2O/c6-5(7,8)4(1-2-4)3(11)10-9/h1-2,9H2,(H,10,11)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395374 (US10308636, Example 61) Show SMILES Nc1nnc(o1)-c1ccc(Br)cc1 Show InChI InChI=1S/C8H6BrN3O/c9-6-3-1-5(2-4-6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395323 (US10308636, Example 2-16) Show SMILES COc1nc([nH]c1-c1ccccc1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C([O-])=O)cc1 Show InChI InChI=1S/C26H25N3O4/c1-26(2,25(30)31)16-33-20-12-9-17(10-13-20)21-14-11-19(15-27-21)23-28-22(24(29-23)32-3)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)/p-1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395331 (US10308636, Example 8) Show SMILES COC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)-c1ccccc1 |r,wU:8.11,wD:5.4,(-12.85,3.15,;-11.67,2.16,;-10.33,2.93,;-10.33,4.47,;-9,2.16,;-7.67,2.93,;-6.33,2.16,;-5,2.93,;-5,4.47,;-6.33,5.24,;-7.67,4.47,;-3.66,5.24,;-2.33,4.47,;-1,5.24,;-1,6.78,;-2.33,7.55,;-3.66,6.78,;.34,7.55,;.34,9.09,;1.67,9.86,;3,9.09,;3,7.55,;1.67,6.78,;4.34,9.86,;4.34,11.4,;5.8,11.88,;6.71,10.63,;5.8,9.39,;6.2,7.9,;5.11,6.81,;5.51,5.33,;4.42,4.24,;4.82,2.75,;3.73,1.66,;5.22,1.26,;6.64,2.75,;6.57,13.21,;8.11,13.21,;8.88,14.55,;8.11,15.88,;6.57,15.88,;5.8,14.55,)| Show InChI InChI=1S/C35H43N3O3Si/c1-40-34(39)22-26-10-12-27(13-11-26)28-14-16-30(17-15-28)32-19-18-31(23-36-32)35-37-33(29-8-6-5-7-9-29)24-38(35)25-41-20-21-42(2,3)4/h5-9,14-19,23-24,26-27H,10-13,20-22,25H2,1-4H3/t26-,27-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395333 (US10308636, Example 10) Show SMILES COc1ccc(COc2ccc(cc2)-c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C36H39N3O5Si/c1-41-31-15-10-28(11-16-31)24-43-32-17-12-29(13-18-32)33-19-14-30(22-37-33)35-38-34(23-39(35)26-42-20-21-45(2,3)4)36(40)44-25-27-8-6-5-7-9-27/h5-19,22-23H,20-21,24-26H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395344 (US10308636, Example 31-2) Show SMILES CCOCc1nc([nH]c1Cl)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1 Show InChI InChI=1S/C22H24ClN3O4/c1-4-29-12-18-19(23)26-20(25-18)15-7-10-17(24-11-15)14-5-8-16(9-6-14)30-13-22(2,3)21(27)28/h5-11H,4,12-13H2,1-3H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395387 (US10308636, Example 104) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)B1OC(C)(C)C(C)(C)O1 Show InChI InChI=1S/C17H26BNO5/c1-15(2,14(20)21-7)11-22-13-9-8-12(10-19-13)18-23-16(3,4)17(5,6)24-18/h8-10H,11H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395309 (US10308636, Example 1-3) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1cccc(F)c1)C(O)=O Show InChI InChI=1S/C25H22FN3O3/c1-25(2,24(30)31)15-32-20-9-6-16(7-10-20)21-11-8-18(13-27-21)23-28-14-22(29-23)17-4-3-5-19(26)12-17/h3-14H,15H2,1-2H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395338 (US10308636, Example 21-2) Show SMILES OC(=O)C[C@H]1CCC[C@@H](C1)Oc1ccc(cc1)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395332 (US10308636, Example 9) Show SMILES CC1(C)OB(OC1(C)C)c1ccc(nc1)-c1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C24H26BNO3/c1-23(2)24(3,4)29-25(28-23)20-12-15-22(26-16-20)19-10-13-21(14-11-19)27-17-18-8-6-5-7-9-18/h5-16H,17H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395308 (US10308636, Example 1-1) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H23N3O3/c1-25(2,24(29)30)16-31-20-11-8-18(9-12-20)21-13-10-19(14-26-21)23-27-15-22(28-23)17-6-4-3-5-7-17/h3-15H,16H2,1-2H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395370 (US10308636, Example 55) Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(Br)cn1)C(=O)OC(C)(C)C |r,wU:3.18,wD:6.9,3.2,(1.49,-2.47,;1.49,-4.01,;0,-4.41,;.4,-5.9,;1.73,-5.13,;3.07,-5.9,;3.07,-7.44,;1.73,-8.21,;.4,-7.44,;4.4,-8.21,;5.73,-7.44,;5.73,-5.9,;7.07,-5.13,;8.4,-5.9,;9.74,-5.13,;8.4,-7.44,;7.07,-8.21,;-1.09,-5.5,;-2.18,-6.59,;-1.86,-4.17,;-3.34,-3.77,;-4.43,-4.86,;-2.57,-2.43,;-3.74,-2.28,)| Show InChI InChI=1S/C18H26BrNO4/c1-17(2,3)24-16(21)18(12-22-4)9-7-14(8-10-18)23-15-6-5-13(19)11-20-15/h5-6,11,14H,7-10,12H2,1-4H3/t14-,18-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395366 (US10308636, Example 48) Show SMILES CCOC(=O)Cc1ccc(cc1)C1CCC(CC1)c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)C(F)(F)F |w:9.12,(-7.25,-10.87,;-8.24,-9.69,;-9.69,-10.22,;-9.69,-11.76,;-11.03,-12.53,;-8.36,-12.53,;-8.36,-14.07,;-9.69,-14.84,;-9.69,-16.38,;-8.36,-17.15,;-7.02,-16.38,;-7.02,-14.84,;-8.36,-18.69,;-7.02,-19.46,;-7.02,-21,;-8.36,-21.77,;-9.69,-21,;-9.69,-19.46,;-8.36,-23.31,;-9.69,-24.08,;-9.69,-25.62,;-8.36,-26.39,;-7.02,-25.62,;-7.02,-24.08,;-8.36,-27.93,;-7.11,-28.84,;-7.59,-30.3,;-9.13,-30.3,;-9.6,-28.84,;-11.07,-28.36,;-11.39,-26.85,;-12.85,-26.38,;-14,-27.41,;-13.68,-28.92,;-13.36,-30.42,;-15.18,-29.24,;-12.17,-28.6,;-6.68,-31.55,;-5.78,-32.79,;-5.44,-30.64,;-7.93,-32.45,)| Show InChI InChI=1S/C31H40F3N3O3Si/c1-5-40-29(38)18-22-6-8-23(9-7-22)24-10-12-25(13-11-24)27-15-14-26(19-35-27)30-36-28(31(32,33)34)20-37(30)21-39-16-17-41(2,3)4/h6-9,14-15,19-20,24-25H,5,10-13,16-18,21H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395355 (US10308636, Example 43-1) Show SMILES Cc1cccc(OCC2CCN(CC2)c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1 Show InChI InChI=1S/C28H37F3N4O2Si/c1-21-6-5-7-24(16-21)37-19-22-10-12-34(13-11-22)26-9-8-23(17-32-26)27-33-25(28(29,30)31)18-35(27)20-36-14-15-38(2,3)4/h5-9,16-18,22H,10-15,19-20H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395346 (US10308636, Example 34) Show SMILES C[Si](C)(C)CCOCn1cc(nc1-c1ccc(nc1)-c1ccc(OCc2ccccc2)cc1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C35H37N3O4Si/c1-43(2,3)21-20-40-26-38-23-33(35(39)42-25-28-12-8-5-9-13-28)37-34(38)30-16-19-32(36-22-30)29-14-17-31(18-15-29)41-24-27-10-6-4-7-11-27/h4-19,22-23H,20-21,24-26H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395365 (US10308636, Example 47-1) Show SMILES Cc1ccnc(OC[C@H]2CC[C@@H](CC2)c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1 |r,wU:8.7,wD:11.14,(10.75,-5.86,;9.22,-6.02,;8.59,-7.43,;7.06,-7.59,;6.15,-6.34,;6.78,-4.94,;5.87,-3.69,;6.5,-2.29,;5.59,-1.04,;4.06,-1.2,;3.16,.05,;3.78,1.45,;5.32,1.61,;6.22,.37,;2.88,2.7,;3.51,4.11,;2.6,5.35,;1.07,5.19,;.44,3.78,;1.35,2.54,;.16,6.44,;.64,7.9,;-.61,8.81,;-1.85,7.9,;-1.38,6.44,;-2.28,5.19,;-3.81,5.35,;-4.72,4.11,;-6.25,4.27,;-7.15,3.02,;-8.06,1.77,;-8.4,3.93,;-5.91,2.12,;-.61,10.35,;-.61,11.89,;-2.15,10.35,;.93,10.35,;8.31,-4.78,)| Show InChI InChI=1S/C28H37F3N4O2Si/c1-20-11-12-32-26(15-20)37-18-21-5-7-22(8-6-21)24-10-9-23(16-33-24)27-34-25(28(29,30)31)17-35(27)19-36-13-14-38(2,3)4/h9-12,15-17,21-22H,5-8,13-14,18-19H2,1-4H3/t21-,22-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395362 (US10308636, Example 46-1) Show SMILES CCOC(=O)C1CCC(CC1)c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)C(F)(F)F |(3.93,-12.04,;4.36,-13.52,;5.89,-13.63,;6.52,-12.22,;8.05,-12.06,;5.61,-10.98,;6.24,-9.57,;5.33,-8.33,;3.8,-8.49,;3.18,-9.89,;4.08,-11.14,;2.9,-7.24,;3.52,-5.83,;2.62,-4.59,;1.09,-4.75,;.46,-6.16,;1.37,-7.4,;.18,-3.5,;.66,-2.04,;-.59,-1.13,;-1.83,-2.04,;-1.36,-3.5,;-2.26,-4.75,;-3.79,-4.59,;-4.7,-5.83,;-6.23,-5.67,;-6.86,-4.27,;-7.48,-2.86,;-5.45,-3.64,;-8.26,-4.89,;-.59,.41,;-.59,1.95,;-2.13,.41,;.95,.41,)| Show InChI InChI=1S/C24H34F3N3O3Si/c1-5-33-23(31)18-8-6-17(7-9-18)20-11-10-19(14-28-20)22-29-21(24(25,26)27)15-30(22)16-32-12-13-34(2,3)4/h10-11,14-15,17-18H,5-9,12-13,16H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395329 (US10308636, Example 6) Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)-c1cccc(c1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C40H45N3O6Si/c1-40(2,39(45)46-3)27-49-34-18-15-30(16-19-34)35-20-17-33(24-41-35)37-42-36(25-43(37)28-47-21-22-50(4,5)6)31-13-10-14-32(23-31)38(44)48-26-29-11-8-7-9-12-29/h7-20,23-25H,21-22,26-28H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair

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