Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246595 (Camptothecin (CPT)) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246595 (Camptothecin (CPT)) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246594 (Bi-lawsone analog, 3d) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246593 (Bi-lawsone analog, 3c) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246591 (Bi-lawsone analog, 3a) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246592 (Bi-lawsone analog, 3b) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50555459 (CHEMBL4800560) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human topoisomerase 2 assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA incubated for 30 min... | Citation and Details Article DOI: 10.1021/acs.jmedchem.7b01797 BindingDB Entry DOI: 10.7270/Q2BZ69QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50555458 (CHEMBL4753823) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human topoisomerase 2 assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA incubated for 30 min... | Citation and Details Article DOI: 10.1021/acs.jmedchem.7b01797 BindingDB Entry DOI: 10.7270/Q2BZ69QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246592 (Bi-lawsone analog, 3b) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.75E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246591 (Bi-lawsone analog, 3a) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246594 (Bi-lawsone analog, 3d) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I/type IB small subunit (Leishmania donovani) | BDBM246593 (Bi-lawsone analog, 3c) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.40E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Karunya University | Assay Description In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation... | J Enzyme Inhib Med Chem 29: 185-9 (2014) Article DOI: 10.3109/14756366.2013.765413 BindingDB Entry DOI: 10.7270/Q2CJ8CDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Leishmania donovani) | BDBM50239186 (1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.30E+5 | n/a | n/a | n/a | n/a | n/a |
India Institute of Chemical Biology Curated by ChEMBL | Assay Description Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L mutant after 24 hrs by equilibrium dia... | Antimicrob Agents Chemother 53: 2589-98 (2009) Article DOI: 10.1128/AAC.01648-08 BindingDB Entry DOI: 10.7270/Q2542RDS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase type IB small subunit (Leishmania donovani) | BDBM50239186 (1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a |
India Institute of Chemical Biology Curated by ChEMBL | Assay Description Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant after 24 hrs by equilibrium dia... | Antimicrob Agents Chemother 53: 2589-98 (2009) Article DOI: 10.1128/AAC.01648-08 BindingDB Entry DOI: 10.7270/Q2542RDS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Leishmania donovani) | BDBM50239186 (1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 7.60E+5 | n/a | n/a | n/a | n/a | n/a |
India Institute of Chemical Biology Curated by ChEMBL | Assay Description Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant after 24 hrs by equilibr... | Antimicrob Agents Chemother 53: 2589-98 (2009) Article DOI: 10.1128/AAC.01648-08 BindingDB Entry DOI: 10.7270/Q2542RDS | |||||||||||
More data for this Ligand-Target Pair |