| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase I |
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| Ligand | BDBM50239186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_730544 (CHEMBL1697631) |
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| Kd | 530000±n/a nM |
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| Citation |  Roy, A; BoseDasgupta, S; Ganguly, A; Jaisankar, P; Majumder, HK Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane. Antimicrob Agents Chemother53:2589-98 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase I |
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| Name: | DNA topoisomerase I |
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| Synonyms: | DNA topoisomerase IB large subunit |
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| Type: | Protein |
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| Mol. Mass.: | 73610.41 |
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| Organism: | Leishmania donovani |
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| Description: | E9BRC0 |
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| Residue: | 635 |
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| Sequence: | MKVENSKMGVKREQSHSNEDEEINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEY
EPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPI
RRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQVANFR
VEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHKWAAVQHDHTVTWLA
MWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKLKDKVDDIRASYMEDFKSNDLHVAQ
RAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQND
VAVLPEVYALLQRFTRRKSPGTDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDR
WFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSKNFKLQMMQLTTKSEYTRKTIE
LLEKAEVTAKKKSVEEAAKEFLEEQDRMQREWLESYGTEEQKKEFEEIVAKRAAPRVRSE
KKKSTSGAKKAESASGKKRAAKKKKSAKKGGKVLSKKAASKSSKKAPKKLKEEDEDDVPL
VSVAAKTKKTAGVKRQRANKVVSDDDDVPLAALRV
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| BDBM50239186 |
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| n/a |
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| Name | BDBM50239186 |
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| Synonyms: | 1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmethane | 3,3-Diindolylmethane | Arundine | CHEBI:50182 | Diindolylmethane |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N2 |
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| Mol. Mass. | 246.3065 |
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| SMILES | C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |
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| Structure | 
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