Compile Data Set for Download or QSAR

Found 67 hits with Last Name = 'salo' and Initial = 'hs'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50326778 ((S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-ethane...) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N4O5S/c1-9(18-11(3)21)14(22)20-13(7-5-6-8-17-12(4)26)15(23)19-10(2)16(24)25/h9-10,13H,5-8H2,1-4H3,(H,17,26)(H,18,21)(H,19,23)(H,20,22)(H,24,25)/t9-,10-,13-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50439469 (CHEMBL2417696) Show SMILES CC(=S)NCCCC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1)C(=O)NCC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H36N4O6S/c1-20(40)30-15-9-8-14-24(27(36)31-17-26(35)22-12-6-3-7-13-22)32-28(37)25-16-23(34)18-33(25)29(38)39-19-21-10-4-2-5-11-21/h2-7,10-13,23-25,34H,8-9,14-19H2,1H3,(H,30,40)(H,31,36)(H,32,37)/t23-,24+,25+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT1 using KI177 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50257239 (CHEMBL447677 | His-Lys-Lys(epsilon-thioAc)-Leu-Met) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(O)=O |r| Show InChI InChI=1S/C31H55N9O6S2/c1-19(2)15-26(30(44)39-25(31(45)46)11-14-48-4)40-29(43)24(10-6-8-13-35-20(3)47)38-28(42)23(9-5-7-12-32)37-27(41)22(33)16-21-17-34-18-36-21/h17-19,22-26H,5-16,32-33H2,1-4H3,(H,34,36)(H,35,47)(H,37,41)(H,38,42)(H,39,44)(H,40,43)(H,45,46)/t22-,23-,24-,25-,26-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355041 (CHEMBL1835301) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H]1CCCN1C(C)=O)C(O)=O |r| Show InChI InChI=1S/C18H30N4O5S/c1-11(18(26)27)20-16(24)14(7-4-5-9-19-12(2)28)21-17(25)15-8-6-10-22(15)13(3)23/h11,14-15H,4-10H2,1-3H3,(H,19,28)(H,20,24)(H,21,25)(H,26,27)/t11-,14-,15-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355038 (CHEMBL1835296) Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O |r| Show InChI InChI=1S/C17H31N5O4S/c1-10(15(24)18-5)21-17(26)14(8-6-7-9-19-13(4)27)22-16(25)11(2)20-12(3)23/h10-11,14H,6-9H2,1-5H3,(H,18,24)(H,19,27)(H,20,23)(H,21,26)(H,22,25)/t10-,11-,14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50257287 (CHEMBL492309 | Lys-Lys(epsilon-thioAc)-Leu) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H](N)CCCCN)C(O)=O |r| Show InChI InChI=1S/C20H39N5O4S/c1-13(2)12-17(20(28)29)25-19(27)16(9-5-7-11-23-14(3)30)24-18(26)15(22)8-4-6-10-21/h13,15-17H,4-12,21-22H2,1-3H3,(H,23,30)(H,24,26)(H,25,27)(H,28,29)/t15-,16-,17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355040 (CHEMBL1835298) Show SMILES C[C@H](N)C(=O)N[C@@H](CCCCNC(C)=S)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C14H26N4O4S/c1-8(15)12(19)18-11(6-4-5-7-16-10(3)23)13(20)17-9(2)14(21)22/h8-9,11H,4-7,15H2,1-3H3,(H,16,23)(H,17,20)(H,18,19)(H,21,22)/t8-,9-,11-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355043 (CHEMBL1835302) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(O)=O |r| Show InChI InChI=1S/C19H34N4O6S/c1-11(22-18(28)29-19(4,5)6)15(24)23-14(9-7-8-10-20-13(3)30)16(25)21-12(2)17(26)27/h11-12,14H,7-10H2,1-6H3,(H,20,30)(H,21,25)(H,22,28)(H,23,24)(H,26,27)/t11-,12-,14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50439468 (CHEMBL2417682) Show SMILES COc1ccc(cc1)C(=O)CNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C25H31N3O5S/c1-18(34)26-15-7-6-10-22(28-25(31)33-17-19-8-4-3-5-9-19)24(30)27-16-23(29)20-11-13-21(32-2)14-12-20/h3-5,8-9,11-14,22H,6-7,10,15-17H2,1-2H3,(H,26,34)(H,27,30)(H,28,31)/t22-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT1 using KI177 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355048 (CHEMBL1835308) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H]1CCCN(C1)C(=O)OC(C)(C)C)C(O)=O |r| Show InChI InChI=1S/C22H38N4O6S/c1-14(20(29)30)24-19(28)17(10-6-7-11-23-15(2)33)25-18(27)16-9-8-12-26(13-16)21(31)32-22(3,4)5/h14,16-17H,6-13H2,1-5H3,(H,23,33)(H,24,28)(H,25,27)(H,29,30)/t14-,16+,17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355046 (CHEMBL1835305) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)CCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C20H29N3O4S/c1-14(20(26)27)22-19(25)17(10-6-7-13-21-15(2)28)23-18(24)12-11-16-8-4-3-5-9-16/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,21,28)(H,22,25)(H,23,24)(H,26,27)/t14-,17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355039 (CHEMBL1835297) Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O |r| Show InChI InChI=1S/C17H30N4O5S/c1-10(19-12(3)22)15(23)21-14(8-6-7-9-18-13(4)27)16(24)20-11(2)17(25)26-5/h10-11,14H,6-9H2,1-5H3,(H,18,27)(H,19,22)(H,20,24)(H,21,23)/t10-,11-,14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355049 (CHEMBL1835307) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)CCc1ccccc1O)C(O)=O |r| Show InChI InChI=1S/C20H29N3O5S/c1-13(20(27)28)22-19(26)16(8-5-6-12-21-14(2)29)23-18(25)11-10-15-7-3-4-9-17(15)24/h3-4,7,9,13,16,24H,5-6,8,10-12H2,1-2H3,(H,21,29)(H,22,26)(H,23,25)(H,27,28)/t13-,16-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355045 (CHEMBL1835304) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C19H27N3O5S/c1-13(18(24)25)21-17(23)16(10-6-7-11-20-14(2)28)22-19(26)27-12-15-8-4-3-5-9-15/h3-5,8-9,13,16H,6-7,10-12H2,1-2H3,(H,20,28)(H,21,23)(H,22,26)(H,24,25)/t13-,16-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355047 (CHEMBL1835306) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)CCc1ccccc1F)C(O)=O |r| Show InChI InChI=1S/C20H28FN3O4S/c1-13(20(27)28)23-19(26)17(9-5-6-12-22-14(2)29)24-18(25)11-10-15-7-3-4-8-16(15)21/h3-4,7-8,13,17H,5-6,9-12H2,1-2H3,(H,22,29)(H,23,26)(H,24,25)(H,27,28)/t13-,17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355053 (CHEMBL1835312) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)c1ccccc1 |r| Show InChI InChI=1S/C24H29N3O4S/c1-18(32)25-15-9-8-14-21(27-24(30)31-17-19-10-4-2-5-11-19)23(29)26-16-22(28)20-12-6-3-7-13-20/h2-7,10-13,21H,8-9,14-17H2,1H3,(H,25,32)(H,26,29)(H,27,30)/t21-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50439469 (CHEMBL2417696) Show SMILES CC(=S)NCCCC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1)C(=O)NCC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H36N4O6S/c1-20(40)30-15-9-8-14-24(27(36)31-17-26(35)22-12-6-3-7-13-22)32-28(37)25-16-23(34)18-33(25)29(38)39-19-21-10-4-2-5-11-21/h2-7,10-13,23-25,34H,8-9,14-19H2,1H3,(H,30,40)(H,31,36)(H,32,37)/t23-,24+,25+/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT2 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355054 (CHEMBL1835299) Show SMILES C[C@H](NC(=O)[C@@H](N)CCCCNC(C)=S)C(O)=O |r| Show InChI InChI=1S/C11H21N3O3S/c1-7(11(16)17)14-10(15)9(12)5-3-4-6-13-8(2)18/h7,9H,3-6,12H2,1-2H3,(H,13,18)(H,14,15)(H,16,17)/t7-,9-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 at 200 uM after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50439468 (CHEMBL2417682) Show SMILES COc1ccc(cc1)C(=O)CNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C25H31N3O5S/c1-18(34)26-15-7-6-10-22(28-25(31)33-17-19-8-4-3-5-9-19)24(30)27-16-23(29)20-11-13-21(32-2)14-12-20/h3-5,8-9,11-14,22H,6-7,10,15-17H2,1-2H3,(H,26,34)(H,27,30)(H,28,31)/t22-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT2 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355038 (CHEMBL1835296) Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O |r| Show InChI InChI=1S/C17H31N5O4S/c1-10(15(24)18-5)21-17(26)14(8-6-7-9-19-13(4)27)22-16(25)11(2)20-12(3)23/h10-11,14H,6-9H2,1-5H3,(H,18,24)(H,19,27)(H,20,23)(H,21,26)(H,22,25)/t10-,11-,14-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM50439469 (CHEMBL2417696) Show SMILES CC(=S)NCCCC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1)C(=O)NCC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H36N4O6S/c1-20(40)30-15-9-8-14-24(27(36)31-17-26(35)22-12-6-3-7-13-22)32-28(37)25-16-23(34)18-33(25)29(38)39-19-21-10-4-2-5-11-21/h2-7,10-13,23-25,34H,8-9,14-19H2,1H3,(H,30,40)(H,31,36)(H,32,37)/t23-,24+,25+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged SIRT3 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355053 (CHEMBL1835312) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)c1ccccc1 |r| Show InChI InChI=1S/C24H29N3O4S/c1-18(32)25-15-9-8-14-21(27-24(30)31-17-19-10-4-2-5-11-19)23(29)26-16-22(28)20-12-6-3-7-13-20/h2-7,10-13,21H,8-9,14-17H2,1H3,(H,25,32)(H,26,29)(H,27,30)/t21-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355052 (CHEMBL1835311) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1O |r| Show InChI InChI=1S/C22H27N3O4S/c1-16(30)23-14-8-7-12-19(21(27)24-18-11-5-6-13-20(18)26)25-22(28)29-15-17-9-3-2-4-10-17/h2-6,9-11,13,19,26H,7-8,12,14-15H2,1H3,(H,23,30)(H,24,27)(H,25,28)/t19-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50439467 (CHEMBL2417685) Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc3ccccc3)c2c1 |r| Show InChI InChI=1S/C27H34N4O4S/c1-19(36)28-14-7-6-10-25(31-27(33)35-18-20-8-4-3-5-9-20)26(32)29-15-13-21-17-30-24-12-11-22(34-2)16-23(21)24/h3-5,8-9,11-12,16-17,25,30H,6-7,10,13-15,18H2,1-2H3,(H,28,36)(H,29,32)(H,31,33)/t25-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT1 using KI177 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50257239 (CHEMBL447677 | His-Lys-Lys(epsilon-thioAc)-Leu-Met) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(O)=O |r| Show InChI InChI=1S/C31H55N9O6S2/c1-19(2)15-26(30(44)39-25(31(45)46)11-14-48-4)40-29(43)24(10-6-8-13-35-20(3)47)38-28(42)23(9-5-7-12-32)37-27(41)22(33)16-21-17-34-18-36-21/h17-19,22-26H,5-16,32-33H2,1-4H3,(H,34,36)(H,35,47)(H,37,41)(H,38,42)(H,39,44)(H,40,43)(H,45,46)/t22-,23-,24-,25-,26-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355043 (CHEMBL1835302) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(O)=O |r| Show InChI InChI=1S/C19H34N4O6S/c1-11(22-18(28)29-19(4,5)6)15(24)23-14(9-7-8-10-20-13(3)30)16(25)21-12(2)17(26)27/h11-12,14H,7-10H2,1-6H3,(H,20,30)(H,21,25)(H,22,28)(H,23,24)(H,26,27)/t11-,12-,14-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355052 (CHEMBL1835311) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1O |r| Show InChI InChI=1S/C22H27N3O4S/c1-16(30)23-14-8-7-12-19(21(27)24-18-11-5-6-13-20(18)26)25-22(28)29-15-17-9-3-2-4-10-17/h2-6,9-11,13,19,26H,7-8,12,14-15H2,1H3,(H,23,30)(H,24,27)(H,25,28)/t19-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355051 (CHEMBL1835310) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1F |r| Show InChI InChI=1S/C22H26FN3O3S/c1-16(30)24-14-8-7-13-20(21(27)25-19-12-6-5-11-18(19)23)26-22(28)29-15-17-9-3-2-4-10-17/h2-6,9-12,20H,7-8,13-15H2,1H3,(H,24,30)(H,25,27)(H,26,28)/t20-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM50439468 (CHEMBL2417682) Show SMILES COc1ccc(cc1)C(=O)CNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C25H31N3O5S/c1-18(34)26-15-7-6-10-22(28-25(31)33-17-19-8-4-3-5-9-19)24(30)27-16-23(29)20-11-13-21(32-2)14-12-20/h3-5,8-9,11-14,22H,6-7,10,15-17H2,1-2H3,(H,26,34)(H,27,30)(H,28,31)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged SIRT3 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50326778 ((S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-ethane...) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N4O5S/c1-9(18-11(3)21)14(22)20-13(7-5-6-8-17-12(4)26)15(23)19-10(2)16(24)25/h9-10,13H,5-8H2,1-4H3,(H,17,26)(H,18,21)(H,19,23)(H,20,22)(H,24,25)/t9-,10-,13-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50300464 ((S)-benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)...) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r| Show InChI InChI=1S/C22H27N3O3S/c1-17(29)23-15-9-8-14-20(21(26)24-19-12-6-3-7-13-19)25-22(27)28-16-18-10-4-2-5-11-18/h2-7,10-13,20H,8-9,14-16H2,1H3,(H,23,29)(H,24,26)(H,25,27)/t20-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355048 (CHEMBL1835308) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H]1CCCN(C1)C(=O)OC(C)(C)C)C(O)=O |r| Show InChI InChI=1S/C22H38N4O6S/c1-14(20(29)30)24-19(28)17(10-6-7-11-23-15(2)33)25-18(27)16-9-8-12-26(13-16)21(31)32-22(3,4)5/h14,16-17H,6-13H2,1-5H3,(H,23,33)(H,24,28)(H,25,27)(H,29,30)/t14-,16+,17-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355039 (CHEMBL1835297) Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](C)NC(C)=O |r| Show InChI InChI=1S/C17H30N4O5S/c1-10(19-12(3)22)15(23)21-14(8-6-7-9-18-13(4)27)16(24)20-11(2)17(25)26-5/h10-11,14H,6-9H2,1-5H3,(H,18,27)(H,19,22)(H,20,24)(H,21,23)/t10-,11-,14-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50300464 ((S)-benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)...) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r| Show InChI InChI=1S/C22H27N3O3S/c1-17(29)23-15-9-8-14-20(21(26)24-19-12-6-3-7-13-19)25-22(27)28-16-18-10-4-2-5-11-18/h2-7,10-13,20H,8-9,14-16H2,1H3,(H,23,29)(H,24,26)(H,25,27)/t20-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355051 (CHEMBL1835310) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1F |r| Show InChI InChI=1S/C22H26FN3O3S/c1-16(30)24-14-8-7-13-20(21(27)25-19-12-6-5-11-18(19)23)26-22(28)29-15-17-9-3-2-4-10-17/h2-6,9-12,20H,7-8,13-15H2,1H3,(H,24,30)(H,25,27)(H,26,28)/t20-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355045 (CHEMBL1835304) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C19H27N3O5S/c1-13(18(24)25)21-17(23)16(10-6-7-11-20-14(2)28)22-19(26)27-12-15-8-4-3-5-9-15/h3-5,8-9,13,16H,6-7,10-12H2,1-2H3,(H,20,28)(H,21,23)(H,22,26)(H,24,25)/t13-,16-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355044 (CHEMBL1835303) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](N)Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C20H30N4O4S/c1-13(20(27)28)23-19(26)17(10-6-7-11-22-14(2)29)24-18(25)16(21)12-15-8-4-3-5-9-15/h3-5,8-9,13,16-17H,6-7,10-12,21H2,1-2H3,(H,22,29)(H,23,26)(H,24,25)(H,27,28)/t13-,16+,17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355044 (CHEMBL1835303) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](N)Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C20H30N4O4S/c1-13(20(27)28)23-19(26)17(10-6-7-11-22-14(2)29)24-18(25)16(21)12-15-8-4-3-5-9-15/h3-5,8-9,13,16-17H,6-7,10-12,21H2,1-2H3,(H,22,29)(H,23,26)(H,24,25)(H,27,28)/t13-,16+,17-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 at 200 uM after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355050 (CHEMBL1835309) Show SMILES CC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCCCC1 |r| Show InChI InChI=1S/C22H33N3O3S/c1-17(29)23-15-9-8-14-20(21(26)24-19-12-6-3-7-13-19)25-22(27)28-16-18-10-4-2-5-11-18/h2,4-5,10-11,19-20H,3,6-9,12-16H2,1H3,(H,23,29)(H,24,26)(H,25,27)/t20-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50439467 (CHEMBL2417685) Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc3ccccc3)c2c1 |r| Show InChI InChI=1S/C27H34N4O4S/c1-19(36)28-14-7-6-10-25(31-27(33)35-18-20-8-4-3-5-9-20)26(32)29-15-13-21-17-30-24-12-11-22(34-2)16-23(21)24/h3-5,8-9,11-12,16-17,25,30H,6-7,10,13-15,18H2,1-2H3,(H,28,36)(H,29,32)(H,31,33)/t25-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT2 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355047 (CHEMBL1835306) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)CCc1ccccc1F)C(O)=O |r| Show InChI InChI=1S/C20H28FN3O4S/c1-13(20(27)28)23-19(26)17(9-5-6-12-22-14(2)29)24-18(25)11-10-15-7-3-4-8-16(15)21/h3-4,7-8,13,17H,5-6,9-12H2,1-2H3,(H,22,29)(H,23,26)(H,24,25)(H,27,28)/t13-,17-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM50439467 (CHEMBL2417685) Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc3ccccc3)c2c1 |r| Show InChI InChI=1S/C27H34N4O4S/c1-19(36)28-14-7-6-10-25(31-27(33)35-18-20-8-4-3-5-9-20)26(32)29-15-13-21-17-30-24-12-11-22(34-2)16-23(21)24/h3-5,8-9,11-12,16-17,25,30H,6-7,10,13-15,18H2,1-2H3,(H,28,36)(H,29,32)(H,31,33)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged SIRT3 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...				J Med Chem 56: 6681-95 (2013) Article DOI: 10.1021/jm400438k BindingDB Entry DOI: 10.7270/Q2H41SVR
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355041 (CHEMBL1835301) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H]1CCCN1C(C)=O)C(O)=O |r| Show InChI InChI=1S/C18H30N4O5S/c1-11(18(26)27)20-16(24)14(7-4-5-9-19-12(2)28)21-17(25)15-8-6-10-22(15)13(3)23/h11,14-15H,4-10H2,1-3H3,(H,19,28)(H,20,24)(H,21,25)(H,26,27)/t11-,14-,15-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355040 (CHEMBL1835298) Show SMILES C[C@H](N)C(=O)N[C@@H](CCCCNC(C)=S)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C14H26N4O4S/c1-8(15)12(19)18-11(6-4-5-7-16-10(3)23)13(20)17-9(2)14(21)22/h8-9,11H,4-7,15H2,1-3H3,(H,16,23)(H,17,20)(H,18,19)(H,21,22)/t8-,9-,11-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50156760 ((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...) Show SMILES CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 Show InChI InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of SIRT2				J Med Chem 49: 7907-11 (2006) Article DOI: 10.1021/jm060566j BindingDB Entry DOI: 10.7270/Q2G73FHM
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50241186 ((S)-N-(1-(2-(1H-indol-3-yl)ethylamino)-1-oxopropan...) Show SMILES C[C@H](NC(=O)\C=C\c1ccc(O)cc1)C(=O)NCCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C22H23N3O3/c1-15(25-21(27)11-8-16-6-9-18(26)10-7-16)22(28)23-13-12-17-14-24-20-5-3-2-4-19(17)20/h2-11,14-15,24,26H,12-13H2,1H3,(H,23,28)(H,25,27)/b11-8+/t15-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 (unknown origin) by Fluor de Lys fluorescence assay				Bioorg Med Chem 16: 8054-62 (2008) Article DOI: 10.1016/j.bmc.2008.07.059 BindingDB Entry DOI: 10.7270/Q2TB16QS
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50241185 ((E)-N-(1-(2-(1H-indol-3-yl)ethylamino)-2-methyl-1-...) Show SMILES CC(C)(NC(=O)\C=C\c1ccc(O)cc1)C(=O)NCCc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H25N3O3/c1-23(2,26-21(28)12-9-16-7-10-18(27)11-8-16)22(29)24-14-13-17-15-25-20-6-4-3-5-19(17)20/h3-12,15,25,27H,13-14H2,1-2H3,(H,24,29)(H,26,28)/b12-9+	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 (unknown origin) by Fluor de Lys fluorescence assay				Bioorg Med Chem 16: 8054-62 (2008) Article DOI: 10.1016/j.bmc.2008.07.059 BindingDB Entry DOI: 10.7270/Q2TB16QS
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50199445 ((E)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-(3-(4-(4...) Show SMILES Fc1ccc(COc2ccc(\C=C\C(=O)NC3(CCNCC3)C(=O)NCCc3c[nH]c4ccc(F)cc34)cc2)cc1 Show InChI InChI=1S/C32H32F2N4O3/c33-25-6-1-23(2-7-25)21-41-27-9-3-22(4-10-27)5-12-30(39)38-32(14-17-35-18-15-32)31(40)36-16-13-24-20-37-29-11-8-26(34)19-28(24)29/h1-12,19-20,35,37H,13-18,21H2,(H,36,40)(H,38,39)/b12-5+	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 (unknown origin) by Fluor de Lys fluorescence assay				Bioorg Med Chem 16: 8054-62 (2008) Article DOI: 10.1016/j.bmc.2008.07.059 BindingDB Entry DOI: 10.7270/Q2TB16QS
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50355042 (CHEMBL1835300) Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=S)NC(C)=O |r| Show InChI InChI=1S/C14H25N3O4S/c1-9(14(20)21-4)16-13(19)12(17-10(2)18)7-5-6-8-15-11(3)22/h9,12H,5-8H2,1-4H3,(H,15,22)(H,16,19)(H,17,18)/t9-,12-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50355049 (CHEMBL1835307) Show SMILES C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)CCc1ccccc1O)C(O)=O |r| Show InChI InChI=1S/C20H29N3O5S/c1-13(20(27)28)22-19(26)16(8-5-6-12-21-14(2)29)23-18(25)11-10-15-7-3-4-9-17(15)24/h3-4,7,9,13,16,24H,5-6,8,10-12H2,1-2H3,(H,21,29)(H,22,26)(H,23,25)(H,27,28)/t13-,16-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assay				J Med Chem 54: 6456-68 (2011) Article DOI: 10.1021/jm200590k BindingDB Entry DOI: 10.7270/Q2HT2PQ0
					More data for this Ligand-Target Pair

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