Found 174 hits with Last Name = 'lofgren' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312922
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312754
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(4-7-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-2-5-14(6-3-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312750
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-4-1-11(2-5-14)7-15(23)10-24-18-28-27-17(29-18)12-3-6-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312744
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(c2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(5-6-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-3-2-4-14(7-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352823
(CHEMBL1823663)Show SMILES CN1CC(C1)[C@@H](NC(=O)c1ccc2cnccc2c1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H19Cl2N3O/c1-26-11-17(12-26)20(14-4-5-18(22)19(23)9-14)25-21(27)15-2-3-16-10-24-7-6-13(16)8-15/h2-10,17,20H,11-12H2,1H3,(H,25,27)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352815
(CHEMBL1823655)Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312934
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)oc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4O2S/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312931
((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-4-1-12(2-5-15)7-16(24)10-25-19-26-11-18(29-19)13-3-6-17-14(8-13)9-27-28-17/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312755
((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2)s1 |r| Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(4-7-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-2-5-14(20)6-3-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312922
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312942
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312757
((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(F)c(F)c2)s1 |r| Show InChI InChI=1S/C19H18F2N6S/c1-10-14-8-12(3-5-17(14)25-24-10)18-26-27-19(28-18)23-9-13(22)6-11-2-4-15(20)16(21)7-11/h2-5,7-8,13H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312936
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES Cn1c2cc(ccc2[nH]c1=O)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H20F3N5OS/c1-29-17-9-13(4-7-16(17)28-20(29)30)18-11-27-19(31-18)26-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H,26,27)(H,28,30)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312942
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312924
((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312754
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(4-7-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-2-5-14(6-3-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312765
((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(Cl)c2)s1 |r| Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312756
((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2Cl)s1 |r| Show InChI InChI=1S/C19H18Cl2N6S/c1-10-15-7-12(3-5-17(15)25-24-10)18-26-27-19(28-18)23-9-14(22)6-11-2-4-13(20)8-16(11)21/h2-5,7-8,14H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312765
((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(Cl)c2)s1 |r| Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312757
((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(F)c(F)c2)s1 |r| Show InChI InChI=1S/C19H18F2N6S/c1-10-14-8-12(3-5-17(14)25-24-10)18-26-27-19(28-18)23-9-13(22)6-11-2-4-15(20)16(21)7-11/h2-5,7-8,13H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352824
(CHEMBL1823630)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352813
(CHEMBL1823653)Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCCNC1 Show InChI InChI=1S/C22H21Cl2N3O/c23-19-6-5-15(11-20(19)24)21(18-2-1-8-25-13-18)27-22(28)16-3-4-17-12-26-9-7-14(17)10-16/h3-7,9-12,18,21,25H,1-2,8,13H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352839
(CHEMBL1823651)Show SMILES Fc1cc2cc(ccc2cn1)C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C22H20Cl2FN3O/c23-18-4-3-14(10-19(18)24)21(13-5-7-26-8-6-13)28-22(29)15-1-2-16-12-27-20(25)11-17(16)9-15/h1-4,9-13,21,26H,5-8H2,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312749
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C18H17ClN6S/c19-14-4-1-11(2-5-14)7-15(20)10-21-18-25-24-17(26-18)12-3-6-16-13(8-12)9-22-23-16/h1-6,8-9,15H,7,10,20H2,(H,21,25)(H,22,23)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312750
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-4-1-11(2-5-14)7-15(23)10-24-18-28-27-17(29-18)12-3-6-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312747
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-3-1-2-11(6-14)7-15(23)10-24-18-28-27-17(29-18)12-4-5-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312935
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)sc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4OS2/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(29-18)12-3-6-15-16(8-12)30-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352814
(CHEMBL1823654)Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNC1 Show InChI InChI=1S/C21H19Cl2N3O/c22-18-4-3-14(10-19(18)23)20(17-6-8-25-12-17)26-21(27)15-1-2-16-11-24-7-5-13(16)9-15/h1-5,7,9-11,17,20,25H,6,8,12H2,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312943
((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cncnc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-5-1-13(2-6-16)7-17(25)10-27-20-28-11-19(30-20)14-3-4-15-9-26-12-29-18(15)8-14/h1-6,8-9,11-12,17H,7,10,25H2,(H,27,28)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312744
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(c2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(5-6-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-3-2-4-14(7-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312764
((S)-3-(3-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(F)c2)s1 |r| Show InChI InChI=1S/C19H19FN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352844
(CHEMBL1823649)Show SMILES COc1cc2cnccc2cc1C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H23Cl2N3O2/c1-30-21-12-17-13-27-9-6-15(17)10-18(21)23(29)28-22(14-4-7-26-8-5-14)16-2-3-19(24)20(25)11-16/h2-3,6,9-14,22,26H,4-5,7-8H2,1H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312751
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C18H16Cl2N6S/c19-13-3-1-10(15(20)7-13)6-14(21)9-22-18-26-25-17(27-18)11-2-4-16-12(5-11)8-23-24-16/h1-5,7-8,14H,6,9,21H2,(H,22,26)(H,23,24)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312925
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352837
(CHEMBL1823643)Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21Cl2N3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352835
(CHEMBL1823641)Show SMILES Fc1cc(ccc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21ClFN3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312749
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C18H17ClN6S/c19-14-4-1-11(2-5-14)7-15(20)10-21-18-25-24-17(26-18)12-3-6-16-13(8-12)9-22-23-16/h1-6,8-9,15H,7,10,20H2,(H,21,25)(H,22,23)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312762
((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2Cl)s1 |r| Show InChI InChI=1S/C19H19ClN6S/c1-11-15-9-13(6-7-17(15)24-23-11)18-25-26-19(27-18)22-10-14(21)8-12-4-2-3-5-16(12)20/h2-7,9,14H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312932
((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H18F3N7S/c20-19(21,22)13-4-1-11(2-5-13)7-14(23)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29(24)28-27-15/h1-6,8,10,14H,7,9,23-24H2,(H,25,26)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312762
((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2Cl)s1 |r| Show InChI InChI=1S/C19H19ClN6S/c1-11-15-9-13(6-7-17(15)24-23-11)18-25-26-19(27-18)22-10-14(21)8-12-4-2-3-5-16(12)20/h2-7,9,14H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352833
(CHEMBL1823639)Show SMILES Clc1cccc(c1)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H22ClN3O/c23-20-3-1-2-17(13-20)21(15-6-9-24-10-7-15)26-22(27)18-4-5-19-14-25-11-8-16(19)12-18/h1-5,8,11-15,21,24H,6-7,9-10H2,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 |
Bioorg Med Chem Lett 21: 5191-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.056
BindingDB Entry DOI: 10.7270/Q21G0MNQ |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312756
((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2Cl)s1 |r| Show InChI InChI=1S/C19H18Cl2N6S/c1-10-15-7-12(3-5-17(15)25-24-10)18-26-27-19(28-18)23-9-14(22)6-11-2-4-13(20)8-16(11)21/h2-5,7-8,14H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312759
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2)s1 |r| Show InChI InChI=1S/C19H20N6S/c1-12-16-10-14(7-8-17(16)23-22-12)18-24-25-19(26-18)21-11-15(20)9-13-5-3-2-4-6-13/h2-8,10,15H,9,11,20H2,1H3,(H,21,25)(H,22,23)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1652-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC |
More data for this
Ligand-Target Pair | |
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