Found 10 hits with Last Name = 'romine' and Initial = 'jl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507127
(US11046675, Example 1006)Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c3CN(CC(O)=O)CCc3c2Cl)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507051
(US11046675, Example 1001)Show SMILES Cc1c(COc2cc3CCN(CC(O)=O)Cc3c(OCc3cncc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507128
(US11046675, Example 1007)Show SMILES COC(=O)c1cncc(COc2cc(OCc3cccc(c3C)-c3cccc(OCCCN4CC[C@@H](O)C4)c3C)c(Cl)c3CCN(CC(O)=O)Cc23)c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507124
(US11046675, Example 1003)Show SMILES Cc1c(COc2cc(O)c3CN(CC(O)=O)CCc3c2)cccc1-c1ccc2OCCOc2c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 775 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507123
(US11046675, Example 1002)Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)cc3CCN(CC(O)=O)Cc23)cccc1-c1ccc2OCCOc2c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 775 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507125
(US11046675, Example 1004)Show SMILES Cc1c(COc2ccc3C[C@@H](NCc3c2)C(O)=O)cccc1-c1ccc2OCCOc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50496099
(CHEMBL3121151)Show SMILES CCN(CC)[C@@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)OC)c1ccccc1 |r| Show InChI InChI=1S/C43H50N8O4/c1-5-49(6-2)38(33-12-8-7-9-13-33)42(53)51-25-11-15-37(51)40-45-27-35(48-40)32-22-18-30(19-23-32)29-16-20-31(21-17-29)34-26-44-39(47-34)36-14-10-24-50(36)41(52)28(3)46-43(54)55-4/h7-9,12-13,16-23,26-28,36-38H,5-6,10-11,14-15,24-25H2,1-4H3,(H,44,47)(H,45,48)(H,46,54)/t28-,36-,37-,38+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by whole cell patch clamp assay |
J Med Chem 57: 2013-32 (2014)
Article DOI: 10.1021/jm401836p
BindingDB Entry DOI: 10.7270/Q28918V3 |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507129
(US11046675, Example 1008)Show SMILES COC(=O)CN1CCc2c(Cl)c(OCc3cccc(c3C)-c3cccc(OCCCN4CC[C@@H](O)C4)c3C)cc(OCc3cncc(c3)C(=O)OC)c2C1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM507126
(US11046675, Example 1005)Show SMILES Cc1c(COc2ccc3C[C@H](NCc3c2)C(O)=O)cccc1-c1ccc2OCCOc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2377CVC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50387084
(BMS-790052 | DACLATASVIR)Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r| Show InChI InChI=1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by whole cell patch clamp assay |
J Med Chem 57: 2013-32 (2014)
Article DOI: 10.1021/jm401836p
BindingDB Entry DOI: 10.7270/Q28918V3 |
More data for this
Ligand-Target Pair | |
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