Found 4 hits with Last Name = 'nedrow-byers' and Initial = 'jr' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutamate carboxypeptidase 2
(Homo sapiens (Human)) | BDBM50358646
(CHEMBL1921899)Show SMILES OC(=O)CC[C@H](NP(O)(=O)OC[C@H](NC(=O)CC[C@H](NC(=O)CCCCCNC(=O)c1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(O)=O)C(O)=O |r,wD:18.18,12.12,5.5,(26.08,-15.33,;26.07,-13.79,;27.4,-13.02,;24.72,-13.04,;23.39,-13.81,;22.06,-13.06,;20.73,-13.83,;19.39,-13.07,;19.38,-14.61,;18.06,-13.85,;19.38,-11.53,;18.04,-10.77,;18.03,-9.23,;16.69,-8.47,;15.36,-9.24,;15.38,-10.78,;14.02,-8.49,;12.7,-9.26,;11.36,-8.51,;10.03,-9.28,;8.69,-8.52,;8.68,-6.98,;7.36,-9.3,;6.02,-8.54,;4.69,-9.32,;3.36,-8.56,;2.03,-9.34,;.68,-8.58,;-.64,-9.35,;-1.98,-8.6,;-.63,-10.89,;-1.96,-11.68,;-1.95,-13.22,;-.62,-13.97,;.71,-13.2,;.71,-11.66,;2.04,-12.42,;3.39,-13.18,;2.04,-10.88,;-.61,-15.51,;-1.93,-16.3,;-3.27,-15.53,;-4.6,-16.3,;-4.6,-17.85,;-5.93,-18.61,;-3.27,-18.62,;-1.92,-17.84,;-.59,-18.61,;.74,-17.83,;2.07,-18.58,;3.4,-17.81,;4.74,-18.57,;3.39,-16.27,;2.05,-15.51,;.74,-16.28,;11.34,-6.96,;12.68,-6.18,;10.01,-6.2,;19.36,-8.45,;20.7,-9.21,;19.35,-6.91,;22.05,-11.52,;23.38,-10.73,;20.7,-10.75,)| Show InChI InChI=1S/C40H43N4O19P/c45-21-6-9-24-30(17-21)63-31-18-22(46)7-10-25(31)35(24)23-8-5-20(16-26(23)37(52)53)36(51)41-15-3-1-2-4-32(47)42-27(38(54)55)11-13-33(48)43-29(40(58)59)19-62-64(60,61)44-28(39(56)57)12-14-34(49)50/h5-10,16-18,27-29,45H,1-4,11-15,19H2,(H,41,51)(H,42,47)(H,43,48)(H,49,50)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H2,44,60,61)/t27-,28-,29-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University
Curated by ChEMBL
| Assay Description
Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysis |
Bioorg Med Chem Lett 21: 7013-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.115
BindingDB Entry DOI: 10.7270/Q2PG1S5S |
More data for this
Ligand-Target Pair | |
Glutamate carboxypeptidase 2
(Homo sapiens (Human)) | BDBM50358645
(CHEMBL1921898)Show SMILES OC(=O)CC[C@H](NP(O)(=O)OC[C@H](NC(=O)CC[C@H](NC(=O)c1ccc(c(c1)C([O-])=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(O)=O)C(O)=O |r,wU:18.18,wD:12.12,5.5,(11.85,-15.93,;11.85,-14.39,;13.19,-13.62,;10.52,-13.62,;9.19,-14.39,;7.85,-13.62,;6.52,-14.39,;5.19,-13.63,;5.17,-15.16,;3.86,-14.4,;5.19,-12.09,;3.86,-11.32,;3.86,-9.78,;2.52,-9.01,;1.19,-9.78,;1.19,-11.32,;-.14,-9.02,;-1.48,-9.79,;-2.81,-9.02,;-2.81,-7.48,;-4.14,-6.71,;-5.47,-7.48,;-4.14,-5.17,;-5.48,-4.4,;-5.48,-2.87,;-4.14,-2.09,;-2.82,-2.86,;-2.81,-4.39,;-1.48,-2.09,;-.15,-2.85,;-2.58,-.99,;-4.14,-.56,;-5.48,.21,;-6.81,-.55,;-8.14,.22,;-8.14,1.76,;-9.47,2.53,;-6.81,2.53,;-5.48,1.77,;-4.14,2.55,;-2.79,1.77,;-1.46,2.54,;-.13,1.77,;1.2,2.54,;-.12,.22,;-1.46,-.56,;-2.8,.22,;-4.14,-9.79,;-5.47,-9.02,;-4.14,-11.33,;5.18,-9.01,;6.52,-9.78,;5.18,-7.47,;7.85,-12.09,;9.18,-11.31,;6.52,-11.31,)| Show InChI InChI=1S/C34H32N3O18P/c38-16-2-5-19-25(12-16)55-26-13-17(39)3-6-20(26)29(19)18-4-1-15(11-21(18)31(44)45)30(43)36-22(32(46)47)7-9-27(40)35-24(34(50)51)14-54-56(52,53)37-23(33(48)49)8-10-28(41)42/h1-6,11-13,22-24,38H,7-10,14H2,(H,35,40)(H,36,43)(H,41,42)(H,44,45)(H,46,47)(H,48,49)(H,50,51)(H2,37,52,53)/p-1/t22-,23-,24-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University
Curated by ChEMBL
| Assay Description
Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysis |
Bioorg Med Chem Lett 21: 7013-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.115
BindingDB Entry DOI: 10.7270/Q2PG1S5S |
More data for this
Ligand-Target Pair | |
Glutamate carboxypeptidase 2
(Homo sapiens (Human)) | BDBM50358647
(CHEMBL1921900)Show SMILES OC(=O)CC[C@H](NP(O)(=O)OC[C@H](NC(=O)CC[C@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(O)=O)C(O)=O |r,wD:18.18,12.12,5.5,(58.79,-21.53,;58.78,-20,;60.12,-19.23,;57.45,-19.23,;56.12,-20,;54.79,-19.23,;53.46,-20,;52.12,-19.23,;53.21,-18.14,;50.79,-20,;52.12,-17.69,;50.79,-16.92,;50.79,-15.39,;49.45,-14.61,;48.13,-15.38,;48.13,-16.92,;46.79,-14.61,;45.47,-15.38,;44.13,-14.61,;42.8,-15.38,;41.47,-14.61,;41.47,-13.08,;40.14,-15.38,;38.8,-14.61,;37.48,-15.38,;36.14,-14.62,;34.81,-15.39,;33.48,-14.62,;32.15,-15.39,;30.81,-14.62,;29.48,-15.39,;28.15,-14.62,;26.82,-15.39,;25.49,-14.62,;24.15,-15.39,;22.82,-14.62,;21.49,-15.39,;20.16,-14.62,;18.82,-15.39,;17.5,-14.62,;16.16,-15.39,;14.83,-14.63,;13.5,-15.39,;12.17,-14.63,;10.83,-15.4,;9.51,-14.63,;8.17,-15.4,;6.84,-14.63,;5.51,-15.4,;4.18,-14.63,;2.84,-15.4,;4.18,-13.09,;2.84,-12.32,;2.84,-10.78,;4.18,-10.02,;5.51,-10.78,;5.51,-12.31,;6.84,-10.01,;8.17,-10.77,;5.73,-8.91,;4.18,-8.47,;2.86,-7.71,;1.53,-8.48,;.19,-7.71,;.2,-6.17,;-1.14,-5.41,;1.52,-5.4,;2.85,-6.16,;4.19,-5.39,;5.53,-6.17,;6.85,-5.4,;8.19,-6.18,;9.52,-5.42,;8.18,-7.72,;6.84,-8.48,;5.52,-7.71,;44.13,-13.07,;45.47,-12.31,;42.8,-12.3,;52.12,-14.62,;53.46,-15.38,;52.12,-13.07,;54.79,-17.68,;56.12,-16.91,;53.45,-16.91,)| Show InChI InChI=1S/C53H69N4O27P/c58-34-2-5-37-43(30-34)84-44-31-35(59)3-6-38(44)48(37)36-4-1-33(29-39(36)50(65)66)49(64)54-12-14-76-16-18-78-20-22-80-24-26-82-28-27-81-25-23-79-21-19-77-17-15-75-13-11-46(61)55-40(51(67)68)7-9-45(60)56-42(53(71)72)32-83-85(73,74)57-41(52(69)70)8-10-47(62)63/h1-6,29-31,40-42,58H,7-28,32H2,(H,54,64)(H,55,61)(H,56,60)(H,62,63)(H,65,66)(H,67,68)(H,69,70)(H,71,72)(H2,57,73,74)/t40-,41-,42-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.93 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University
Curated by ChEMBL
| Assay Description
Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysis |
Bioorg Med Chem Lett 21: 7013-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.115
BindingDB Entry DOI: 10.7270/Q2PG1S5S |
More data for this
Ligand-Target Pair | |
Glutamate carboxypeptidase 2
(Homo sapiens (Human)) | BDBM50358644
(CHEMBL1921897)Show SMILES N[C@@H](CCC(=O)N[C@@H](COP(O)(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C13H22N3O12P/c14-6(11(20)21)1-3-9(17)15-8(13(24)25)5-28-29(26,27)16-7(12(22)23)2-4-10(18)19/h6-8H,1-5,14H2,(H,15,17)(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H2,16,26,27)/t6-,7-,8-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University
Curated by ChEMBL
| Assay Description
Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysis |
Bioorg Med Chem Lett 21: 7013-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.115
BindingDB Entry DOI: 10.7270/Q2PG1S5S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
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