Found 1988 hits with Last Name = 'harvey' and Initial = 'js' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM310222
((2S,3R)-N-(4-((1r,2R,6S)-2,6-dimethoxycyclohexyl)-...)Show SMILES CO[C@@H]1CCC[C@H](OC)[C@H]1n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CCCO1 |r| Show InChI InChI=1S/C23H36N6O5S/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h12-13,15-20H,6-11H2,1-5H3,(H,27,28)/t15-,16-,17-,18+,19?,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310224
(US10150760, Example 4.0 | US10150760, Example 5.0)Show SMILES CO[C@@H]1CCC[C@H](OC)[C@H]1n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCOC1 |r| Show InChI InChI=1S/C23H36N6O5S/c1-14-11-24-21(25-12-14)15(2)16(3)35(30,31)28-23-27-26-22(17-9-10-34-13-17)29(23)20-18(32-4)7-6-8-19(20)33-5/h11-12,15-20H,6-10,13H2,1-5H3,(H,27,28)/t15-,16-,17+,18-,19+,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 890 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310224
(US10150760, Example 4.0 | US10150760, Example 5.0)Show SMILES CO[C@@H]1CCC[C@H](OC)[C@H]1n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCOC1 |r| Show InChI InChI=1S/C23H36N6O5S/c1-14-11-24-21(25-12-14)15(2)16(3)35(30,31)28-23-27-26-22(17-9-10-34-13-17)29(23)20-18(32-4)7-6-8-19(20)33-5/h11-12,15-20H,6-10,13H2,1-5H3,(H,27,28)/t15-,16-,17+,18-,19+,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >4.20E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310226
(US10150760, Example 6.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1[C@@H]1CCOC1 |r,wU:29.31,wD:16.17,(.66,-12.82,;-.67,-13.59,;-2,-12.82,;-2,-11.28,;-3.34,-10.51,;-4.67,-11.28,;-4.67,-12.82,;-6,-13.59,;-7.34,-12.82,;-3.34,-13.59,;-3.34,-15.13,;-2.09,-16.03,;-.76,-15.26,;.58,-16.03,;-.76,-16.8,;1.91,-16.8,;1.91,-15.26,;1.91,-13.72,;3.24,-16.03,;4.58,-15.26,;5.91,-16.03,;7.25,-15.26,;7.25,-13.72,;8.58,-12.95,;5.91,-12.95,;4.58,-13.72,;-2.57,-17.5,;-4.11,-17.5,;-4.58,-16.03,;-6.12,-16.03,;-7.03,-14.79,;-8.49,-15.26,;-8.49,-16.8,;-7.03,-17.28,)| Show InChI InChI=1S/C21H25FN6O5S/c1-13(9-18-23-10-15(22)11-24-18)34(29,30)27-21-26-25-20(14-7-8-33-12-14)28(21)19-16(31-2)5-4-6-17(19)32-3/h4-6,10-11,13-14H,7-9,12H2,1-3H3,(H,26,27)/t13-,14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310227
((R)-2-(4-chlorophenyl)-N-(4-(2,6-dimethoxyphenyl)-...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1[C@@H]1CCOC1 |r,wD:28.30,(-7.01,-3.89,;-5.68,-4.66,;-4.34,-3.89,;-4.34,-2.35,;-3.01,-1.58,;-1.67,-2.35,;-1.67,-3.89,;-.34,-4.66,;.99,-3.89,;-3.01,-4.66,;-3.01,-6.2,;-1.76,-7.11,;-.3,-6.63,;1.04,-7.4,;1.81,-8.74,;.27,-8.74,;2.37,-6.63,;3.7,-7.4,;5.04,-6.63,;6.37,-7.4,;7.7,-6.63,;7.7,-5.09,;9.04,-4.32,;6.37,-4.32,;5.04,-5.09,;-2.24,-8.57,;-3.78,-8.57,;-4.25,-7.11,;-5.72,-6.63,;-6.96,-7.54,;-8.21,-6.63,;-7.73,-5.17,;-6.19,-5.17,)| Show InChI InChI=1S/C22H25ClN4O5S/c1-30-18-4-3-5-19(31-2)20(18)27-21(16-10-12-32-14-16)24-25-22(27)26-33(28,29)13-11-15-6-8-17(23)9-7-15/h3-9,16H,10-14H2,1-2H3,(H,25,26)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310228
(US10150760, Example 15.0 | US10150760, Example 16....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)| Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 470 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310228
(US10150760, Example 15.0 | US10150760, Example 16....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)| Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 380 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310228
(US10150760, Example 15.0 | US10150760, Example 16....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)| Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310231
(US10150760, Example 18.0)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:2.2,1.0,wD:12.11,(3.2,-3.53,;3.2,-1.99,;1.87,-1.22,;1.87,.32,;.53,-1.99,;1.87,-2.76,;-.8,-2.76,;-.8,-1.22,;-2.13,-1.99,;-2.61,-3.46,;-4.15,-3.46,;-4.63,-1.99,;-6.17,-1.99,;-7.07,-3.24,;-8.54,-2.76,;-8.54,-1.22,;-7.07,-.75,;-3.38,-1.09,;-3.38,.45,;-4.71,1.22,;-6.05,.45,;-4.71,2.76,;-3.38,3.53,;-2.05,2.76,;-2.05,1.22,;-.71,.45,;4.53,-1.22,;5.87,-1.99,;7.2,-1.22,;7.2,.32,;8.54,1.09,;5.87,1.09,;4.53,.32,)| Show InChI InChI=1S/C21H24F2N6O3S/c1-12-10-24-19(25-11-12)13(2)14(3)33(30,31)28-21-27-26-20(17-8-5-9-32-17)29(21)18-15(22)6-4-7-16(18)23/h4,6-7,10-11,13-14,17H,5,8-9H2,1-3H3,(H,27,28)/t13-,14-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310232
(US10150760, Example 19.0)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:12.11,2.2,1.0,(3.2,-3.53,;3.2,-1.99,;1.87,-1.22,;1.87,.32,;.53,-1.99,;1.87,-2.76,;-.8,-2.76,;-.8,-1.22,;-2.13,-1.99,;-2.61,-3.46,;-4.15,-3.46,;-4.63,-1.99,;-6.17,-1.99,;-7.07,-3.24,;-8.54,-2.76,;-8.54,-1.22,;-7.07,-.75,;-3.38,-1.09,;-3.38,.45,;-4.71,1.22,;-6.05,.45,;-4.71,2.76,;-3.38,3.53,;-2.05,2.76,;-2.05,1.22,;-.71,.45,;4.53,-1.22,;5.87,-1.99,;7.2,-1.22,;7.2,.32,;8.54,1.09,;5.87,1.09,;4.53,.32,)| Show InChI InChI=1S/C21H24F2N6O3S/c1-12-10-24-19(25-11-12)13(2)14(3)33(30,31)28-21-27-26-20(17-8-5-9-32-17)29(21)18-15(22)6-4-7-16(18)23/h4,6-7,10-11,13-14,17H,5,8-9H2,1-3H3,(H,27,28)/t13-,14-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310233
(US10150760, Example 20.0 | US10150760, Example 21....)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:12.11,2.2,1.0,(3.2,1.09,;3.2,2.63,;1.87,3.4,;1.87,4.94,;.53,2.63,;1.87,1.86,;-.8,1.86,;-.8,3.4,;-2.13,2.63,;-2.61,1.16,;-4.15,1.16,;-4.63,2.63,;-6.17,2.63,;-7.07,1.38,;-8.54,1.86,;-8.54,3.4,;-7.07,3.87,;-3.38,3.53,;-3.38,5.07,;-4.71,5.84,;-6.05,5.07,;-4.71,7.38,;-3.38,8.15,;-2.05,7.38,;-2.05,5.84,;-.71,5.07,;4.53,3.4,;5.87,2.63,;7.2,3.4,;7.2,4.94,;8.54,5.71,;5.87,5.71,;4.53,4.94,)| Show InChI InChI=1S/C21H24F2N6O3S/c1-12-9-24-19(25-10-12)13(2)14(3)33(30,31)28-21-27-26-20(15-7-8-32-11-15)29(21)18-16(22)5-4-6-17(18)23/h4-6,9-10,13-15H,7-8,11H2,1-3H3,(H,27,28)/t13-,14-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310233
(US10150760, Example 20.0 | US10150760, Example 21....)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:12.11,2.2,1.0,(3.2,1.09,;3.2,2.63,;1.87,3.4,;1.87,4.94,;.53,2.63,;1.87,1.86,;-.8,1.86,;-.8,3.4,;-2.13,2.63,;-2.61,1.16,;-4.15,1.16,;-4.63,2.63,;-6.17,2.63,;-7.07,1.38,;-8.54,1.86,;-8.54,3.4,;-7.07,3.87,;-3.38,3.53,;-3.38,5.07,;-4.71,5.84,;-6.05,5.07,;-4.71,7.38,;-3.38,8.15,;-2.05,7.38,;-2.05,5.84,;-.71,5.07,;4.53,3.4,;5.87,2.63,;7.2,3.4,;7.2,4.94,;8.54,5.71,;5.87,5.71,;4.53,4.94,)| Show InChI InChI=1S/C21H24F2N6O3S/c1-12-9-24-19(25-10-12)13(2)14(3)33(30,31)28-21-27-26-20(15-7-8-32-11-15)29(21)18-16(22)5-4-6-17(18)23/h4-6,9-10,13-15H,7-8,11H2,1-3H3,(H,27,28)/t13-,14-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310235
(US10150760, Example 22.0 | US10150760, Example 23....)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCOC2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:2.2,1.0,wD:12.11,(3.56,1.09,;3.56,2.63,;2.22,3.4,;2.22,4.94,;.89,2.63,;2.22,1.86,;-.45,1.86,;-.45,3.4,;-1.78,2.63,;-2.25,1.16,;-3.79,1.16,;-4.27,2.63,;-5.81,2.63,;-6.58,1.29,;-8.12,1.29,;-8.89,2.63,;-8.12,3.96,;-6.58,3.96,;-3.02,3.53,;-3.02,5.07,;-4.36,5.84,;-5.69,5.07,;-4.36,7.38,;-3.02,8.15,;-1.69,7.38,;-1.69,5.84,;-.36,5.07,;4.89,3.4,;6.22,2.63,;7.56,3.4,;7.56,4.94,;8.89,5.71,;6.22,5.71,;4.89,4.94,)| Show InChI InChI=1S/C22H26F2N6O3S/c1-13-10-25-20(26-11-13)14(2)15(3)34(31,32)29-22-28-27-21(16-6-5-9-33-12-16)30(22)19-17(23)7-4-8-18(19)24/h4,7-8,10-11,14-16H,5-6,9,12H2,1-3H3,(H,28,29)/t14-,15-,16+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310235
(US10150760, Example 22.0 | US10150760, Example 23....)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCOC2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |r,wU:2.2,1.0,wD:12.11,(3.56,1.09,;3.56,2.63,;2.22,3.4,;2.22,4.94,;.89,2.63,;2.22,1.86,;-.45,1.86,;-.45,3.4,;-1.78,2.63,;-2.25,1.16,;-3.79,1.16,;-4.27,2.63,;-5.81,2.63,;-6.58,1.29,;-8.12,1.29,;-8.89,2.63,;-8.12,3.96,;-6.58,3.96,;-3.02,3.53,;-3.02,5.07,;-4.36,5.84,;-5.69,5.07,;-4.36,7.38,;-3.02,8.15,;-1.69,7.38,;-1.69,5.84,;-.36,5.07,;4.89,3.4,;6.22,2.63,;7.56,3.4,;7.56,4.94,;8.89,5.71,;6.22,5.71,;4.89,4.94,)| Show InChI InChI=1S/C22H26F2N6O3S/c1-13-10-25-20(26-11-13)14(2)15(3)34(31,32)29-22-28-27-21(16-6-5-9-33-12-16)30(22)19-17(23)7-4-8-18(19)24/h4,7-8,10-11,14-16H,5-6,9,12H2,1-3H3,(H,28,29)/t14-,15-,16+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310237
((2S,3R)-3-(5-cyano-2-pyrimidinyl)-N-(4-(2,6-dimeth...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCCO1 |r,wU:16.17,18.19,30.32,(-9.4,16.25,;-8.07,15.48,;-6.74,16.25,;-6.74,17.79,;-5.4,18.56,;-4.07,17.79,;-4.07,16.25,;-2.74,15.48,;-1.4,16.25,;-5.4,15.48,;-5.4,13.94,;-4.16,13.03,;-2.82,13.8,;-1.49,13.03,;-.16,12.26,;-2.82,12.26,;-.16,13.8,;-.16,15.34,;1.18,13.03,;1.18,11.49,;2.51,13.8,;3.84,13.03,;5.18,13.8,;5.18,15.34,;6.51,16.11,;3.84,16.11,;2.51,15.34,;-4.63,11.57,;-6.17,11.57,;-6.65,13.03,;-8.14,13.43,;-8.61,14.89,;-10.15,14.89,;-10.63,13.43,;-9.38,12.52,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-11-15(23)12-25-20)14(2)35(30,31)28-22-27-26-21(18-9-6-10-34-18)29(22)19-16(32-3)7-5-8-17(19)33-4/h5,7-8,11-14,18H,6,9-10H2,1-4H3,(H,27,28)/t13-,14-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310238
(US10150760, Example 25.0)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1-c1c(F)cncc1F)c1ncc(C)cn1 |r,wU:2.2,1.0,wD:12.11,(3.2,-3.53,;3.2,-1.99,;1.87,-1.22,;1.87,.32,;.53,-1.99,;1.87,-2.76,;-.8,-2.76,;-.8,-1.22,;-2.13,-1.99,;-2.61,-3.46,;-4.15,-3.46,;-4.63,-1.99,;-6.17,-1.99,;-7.07,-3.24,;-8.54,-2.76,;-8.54,-1.22,;-7.07,-.75,;-3.38,-1.09,;-3.38,.45,;-4.71,1.22,;-6.05,.45,;-4.71,2.76,;-3.38,3.53,;-2.05,2.76,;-2.05,1.22,;-.71,.45,;4.53,-1.22,;5.87,-1.99,;7.2,-1.22,;7.2,.32,;8.54,1.09,;5.87,1.09,;4.53,.32,)| Show InChI InChI=1S/C20H23F2N7O3S/c1-11-7-24-18(25-8-11)12(2)13(3)33(30,31)28-20-27-26-19(16-5-4-6-32-16)29(20)17-14(21)9-23-10-15(17)22/h7-10,12-13,16H,4-6H2,1-3H3,(H,27,28)/t12-,13-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310239
(US10150760, Example 26.0)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(F)cncc1F)c1ncc(C)cn1 |r,wU:12.11,2.2,1.0,(3.2,-3.53,;3.2,-1.99,;1.87,-1.22,;1.87,.32,;.53,-1.99,;1.87,-2.76,;-.8,-2.76,;-.8,-1.22,;-2.13,-1.99,;-2.61,-3.46,;-4.15,-3.46,;-4.63,-1.99,;-6.17,-1.99,;-7.07,-3.24,;-8.54,-2.76,;-8.54,-1.22,;-7.07,-.75,;-3.38,-1.09,;-3.38,.45,;-4.71,1.22,;-6.05,.45,;-4.71,2.76,;-3.38,3.53,;-2.05,2.76,;-2.05,1.22,;-.71,.45,;4.53,-1.22,;5.87,-1.99,;7.2,-1.22,;7.2,.32,;8.54,1.09,;5.87,1.09,;4.53,.32,)| Show InChI InChI=1S/C20H23F2N7O3S/c1-11-7-24-18(25-8-11)12(2)13(3)33(30,31)28-20-27-26-19(16-5-4-6-32-16)29(20)17-14(21)9-23-10-15(17)22/h7-10,12-13,16H,4-6H2,1-3H3,(H,27,28)/t12-,13-,16+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 870 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310240
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(4,6-dimet...)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1COC1 |r,wU:16.17,18.19,(-7.74,1.54,;-6.41,.77,;-5.07,1.54,;-5.07,3.08,;-3.74,3.85,;-2.4,3.08,;-2.4,1.54,;-1.07,.77,;.26,1.54,;-3.74,.77,;-3.74,-.77,;-2.49,-1.67,;-1.16,-.9,;.18,-1.67,;-.59,-3.01,;.95,-3.01,;1.66,-1.28,;2.06,.21,;2.75,-2.36,;2.35,-3.85,;4.24,-1.97,;5.33,-3.05,;6.82,-2.66,;7.21,-1.17,;8.7,-.77,;6.13,-.08,;4.64,-.48,;-2.97,-3.14,;-4.51,-3.14,;-4.98,-1.67,;-6.52,-1.67,;-7.61,-.58,;-8.7,-1.67,;-7.61,-2.76,)| Show InChI InChI=1S/C19H23ClN8O5S/c1-10(15-21-5-13(20)6-22-15)11(2)34(29,30)27-19-26-25-16(12-7-33-8-12)28(19)14-17(31-3)23-9-24-18(14)32-4/h5-6,9-12H,7-8H2,1-4H3,(H,26,27)/t10-,11-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 730 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310241
(US10150760, Example 36.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1COC1 |r,wU:16.17,18.19,(-7.74,1.54,;-6.41,.77,;-5.07,1.54,;-5.07,3.08,;-3.74,3.85,;-2.4,3.08,;-2.4,1.54,;-1.07,.77,;.26,1.54,;-3.74,.77,;-3.74,-.77,;-2.49,-1.67,;-1.16,-.9,;.18,-1.67,;-.59,-3.01,;.95,-3.01,;1.66,-1.28,;2.06,.21,;2.75,-2.36,;2.35,-3.85,;4.24,-1.97,;5.33,-3.05,;6.82,-2.66,;7.21,-1.17,;8.7,-.77,;6.13,-.08,;4.64,-.48,;-2.97,-3.14,;-4.51,-3.14,;-4.98,-1.67,;-6.52,-1.67,;-7.61,-.58,;-8.7,-1.67,;-7.61,-2.76,)| Show InChI InChI=1S/C21H25ClN6O5S/c1-12(19-23-8-15(22)9-24-19)13(2)34(29,30)27-21-26-25-20(14-10-33-11-14)28(21)18-16(31-3)6-5-7-17(18)32-4/h5-9,12-14H,10-11H2,1-4H3,(H,26,27)/t12-,13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310242
(US10150760, Example 37.0)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1[C@@H]1CCOC1 |r,wU:30.32,16.17,18.19,(-7.64,1.54,;-6.31,.77,;-4.98,1.54,;-4.98,3.08,;-3.64,3.85,;-2.31,3.08,;-2.31,1.54,;-.97,.77,;.36,1.54,;-3.64,.77,;-3.64,-.77,;-2.4,-1.67,;-1.06,-.9,;.27,-1.67,;-.5,-3.01,;1.04,-3.01,;1.76,-1.28,;2.16,.21,;2.85,-2.36,;2.45,-3.85,;4.34,-1.97,;4.73,-.48,;6.22,-.08,;7.31,-1.17,;8.8,-.77,;6.91,-2.66,;5.42,-3.05,;-2.87,-3.14,;-4.41,-3.14,;-4.89,-1.67,;-6.43,-1.67,;-7.33,-.43,;-8.8,-.9,;-8.8,-2.44,;-7.33,-2.92,)| Show InChI InChI=1S/C21H26ClN7O5S/c1-12(16-6-5-15(22)9-23-16)13(2)35(30,31)28-21-27-26-18(14-7-8-34-10-14)29(21)17-19(32-3)24-11-25-20(17)33-4/h5-6,9,11-14H,7-8,10H2,1-4H3,(H,27,28)/t12-,13-,14+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310243
(US10150760, Example 38.0)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.64,1.54,;-6.31,.77,;-4.98,1.54,;-4.98,3.08,;-3.64,3.85,;-2.31,3.08,;-2.31,1.54,;-.97,.77,;.36,1.54,;-3.64,.77,;-3.64,-.77,;-2.4,-1.67,;-1.06,-.9,;.27,-1.67,;-.5,-3.01,;1.04,-3.01,;1.76,-1.28,;2.16,.21,;2.85,-2.36,;2.45,-3.85,;4.34,-1.97,;4.73,-.48,;6.22,-.08,;7.31,-1.17,;8.8,-.77,;6.91,-2.66,;5.42,-3.05,;-2.87,-3.14,;-4.41,-3.14,;-4.89,-1.67,;-6.43,-1.67,;-7.33,-.43,;-8.8,-.9,;-8.8,-2.44,;-7.33,-2.92,)| Show InChI InChI=1S/C21H26ClN7O5S/c1-12(16-6-5-15(22)9-23-16)13(2)35(30,31)28-21-27-26-18(14-7-8-34-10-14)29(21)17-19(32-3)24-11-25-20(17)33-4/h5-6,9,11-14H,7-8,10H2,1-4H3,(H,27,28)/t12-,13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310244
(US10150760, Example 39.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1COCCO1 |r,wU:30.32,16.17,18.19,(-7.29,1.54,;-5.95,.77,;-4.62,1.54,;-4.62,3.08,;-3.29,3.85,;-1.95,3.08,;-1.95,1.54,;-.62,.77,;.71,1.54,;-3.29,.77,;-3.29,-.77,;-2.04,-1.67,;-.71,-.9,;.63,-1.67,;-.14,-3.01,;1.4,-3.01,;2.11,-1.28,;2.51,.21,;3.2,-2.36,;2.8,-3.85,;4.69,-1.97,;5.78,-3.05,;7.27,-2.66,;7.67,-1.17,;9.15,-.77,;6.58,-.08,;5.09,-.48,;-2.52,-3.14,;-4.06,-3.14,;-4.53,-1.67,;-6.07,-1.67,;-6.84,-.34,;-8.38,-.34,;-9.15,-1.67,;-8.38,-3.01,;-6.84,-3.01,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(20-24-10-15(23)11-25-20)14(2)36(30,31)28-22-27-26-21(18-12-34-8-9-35-18)29(22)19-16(32-3)6-5-7-17(19)33-4/h5-7,10-11,13-14,18H,8-9,12H2,1-4H3,(H,27,28)/t13-,14-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310245
(US10150760, Example 40.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=N)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1COCCO1 |r,wU:30.32,16.17,18.19,(-7.29,1.54,;-5.95,.77,;-4.62,1.54,;-4.62,3.08,;-3.29,3.85,;-1.95,3.08,;-1.95,1.54,;-.62,.77,;.71,1.54,;-3.29,.77,;-3.29,-.77,;-2.04,-1.67,;-.71,-.9,;.63,-1.67,;-.14,-3.01,;1.4,-3.01,;2.11,-1.28,;2.51,.21,;3.2,-2.36,;2.8,-3.85,;4.69,-1.97,;5.78,-3.05,;7.27,-2.66,;7.67,-1.17,;9.15,-.77,;6.58,-.08,;5.09,-.48,;-2.52,-3.14,;-4.06,-3.14,;-4.53,-1.67,;-6.07,-1.67,;-6.84,-.34,;-8.38,-.34,;-9.15,-1.67,;-8.38,-3.01,;-6.84,-3.01,)| Show InChI InChI=1S/C22H28ClN7O5S/c1-13(20-25-10-15(23)11-26-20)14(2)36(24,31)29-22-28-27-21(18-12-34-8-9-35-18)30(22)19-16(32-3)6-5-7-17(19)33-4/h5-7,10-11,13-14,18H,8-9,12H2,1-4H3,(H2,24,28,29,31)/t13-,14-,18-,36?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310246
(US10150760, Example 41.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCN(C1)C(=O)OC(C)(C)C |r,wU:30.32,16.17,18.19,(-5.07,2.47,;-3.73,1.7,;-2.4,2.47,;-2.4,4.01,;-1.07,4.78,;.27,4.01,;.27,2.47,;1.6,1.7,;2.94,2.47,;-1.07,1.7,;-1.07,.16,;.18,-.74,;1.51,.03,;2.85,-.74,;2.08,-2.08,;3.62,-2.08,;4.34,-.35,;4.73,1.14,;5.42,-1.43,;5.03,-2.92,;6.91,-1.04,;8,-2.12,;9.49,-1.73,;9.89,-.24,;11.37,.16,;8.8,.85,;7.31,.45,;-.3,-2.21,;-1.84,-2.21,;-2.31,-.74,;-3.85,-.74,;-4.76,.5,;-6.22,.03,;-6.22,-1.51,;-4.76,-1.99,;-7.31,-2.6,;-6.91,-4.09,;-8.8,-2.2,;-9.89,-3.29,;-11.37,-2.89,;-9.49,-4.78,;-10.98,-4.38,)| Show InChI InChI=1S/C27H36ClN7O6S/c1-16(23-29-13-19(28)14-30-23)17(2)42(37,38)33-25-32-31-24(18-11-12-34(15-18)26(36)41-27(3,4)5)35(25)22-20(39-6)9-8-10-21(22)40-7/h8-10,13-14,16-18H,11-12,15H2,1-7H3,(H,32,33)/t16-,17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 820 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310247
(US10150760, Example 42.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCN(C1)C(=O)OC(C)(C)C |r,wU:16.17,18.19,wD:30.32,(-5.07,2.47,;-3.73,1.7,;-2.4,2.47,;-2.4,4.01,;-1.07,4.78,;.27,4.01,;.27,2.47,;1.6,1.7,;2.94,2.47,;-1.07,1.7,;-1.07,.16,;.18,-.74,;1.51,.03,;2.85,-.74,;2.08,-2.08,;3.62,-2.08,;4.34,-.35,;4.73,1.14,;5.42,-1.43,;5.03,-2.92,;6.91,-1.04,;8,-2.12,;9.49,-1.73,;9.89,-.24,;11.37,.16,;8.8,.85,;7.31,.45,;-.3,-2.21,;-1.84,-2.21,;-2.31,-.74,;-3.85,-.74,;-4.76,.5,;-6.22,.03,;-6.22,-1.51,;-4.76,-1.99,;-7.31,-2.6,;-6.91,-4.09,;-8.8,-2.2,;-9.89,-3.29,;-11.37,-2.89,;-9.49,-4.78,;-10.98,-4.38,)| Show InChI InChI=1S/C27H36ClN7O6S/c1-16(23-29-13-19(28)14-30-23)17(2)42(37,38)33-25-32-31-24(18-11-12-34(15-18)26(36)41-27(3,4)5)35(25)22-20(39-6)9-8-10-21(22)40-7/h8-10,13-14,16-18H,11-12,15H2,1-7H3,(H,32,33)/t16-,17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310248
(2-(2-cyano-4-fluorophenyl)-N-(4-(2,6-dimethoxyphen...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cc2C#N)nnc1[C@H]1CCC(=O)N1 |r,wU:30.32,(-6.71,1.18,;-5.38,.41,;-4.05,1.18,;-4.05,2.72,;-2.71,3.49,;-1.38,2.72,;-1.38,1.18,;-.05,.41,;1.29,1.18,;-2.71,.41,;-2.71,-1.13,;-1.47,-2.03,;-.13,-1.26,;1.2,-2.03,;.43,-3.36,;1.97,-3.36,;2.53,-1.26,;3.87,-2.03,;5.2,-1.26,;6.54,-2.03,;7.87,-1.26,;7.87,.28,;9.2,1.05,;6.54,1.05,;5.1,.29,;3.76,1.04,;2.42,1.79,;-1.94,-3.49,;-3.48,-3.49,;-3.96,-2.03,;-5.5,-2.03,;-6.4,-3.28,;-7.87,-2.8,;-7.87,-1.26,;-9.2,-.49,;-6.4,-.78,)| Show InChI InChI=1S/C23H23FN6O5S/c1-34-18-4-3-5-19(35-2)21(18)30-22(17-8-9-20(31)26-17)27-28-23(30)29-36(32,33)11-10-14-6-7-16(24)12-15(14)13-25/h3-7,12,17H,8-11H2,1-2H3,(H,26,31)(H,28,29)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.19E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310249
(2-(2-cyano-4-fluorophenyl)-N-(4-(2,6-dimethoxyphen...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cc2C#N)nnc1[C@@H]1CCC(=O)N1 |r,wD:30.32,(-6.71,1.18,;-5.38,.41,;-4.05,1.18,;-4.05,2.72,;-2.71,3.49,;-1.38,2.72,;-1.38,1.18,;-.05,.41,;1.29,1.18,;-2.71,.41,;-2.71,-1.13,;-1.47,-2.03,;-.13,-1.26,;1.2,-2.03,;.43,-3.36,;1.97,-3.36,;2.53,-1.26,;3.87,-2.03,;5.2,-1.26,;6.54,-2.03,;7.87,-1.26,;7.87,.28,;9.2,1.05,;6.54,1.05,;5.1,.29,;3.76,1.04,;2.42,1.79,;-1.94,-3.49,;-3.48,-3.49,;-3.96,-2.03,;-5.5,-2.03,;-6.4,-3.28,;-7.87,-2.8,;-7.87,-1.26,;-9.2,-.49,;-6.4,-.78,)| Show InChI InChI=1S/C23H23FN6O5S/c1-34-18-4-3-5-19(35-2)21(18)30-22(17-8-9-20(31)26-17)27-28-23(30)29-36(32,33)11-10-14-6-7-16(24)12-15(14)13-25/h3-7,12,17H,8-11H2,1-2H3,(H,26,31)(H,28,29)/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310250
(Preparation (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCNC2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:13.12,3.3,2.1,(4.3,1.33,;2.96,2.1,;2.96,3.64,;1.63,4.41,;1.63,5.95,;.3,3.64,;-.47,2.3,;1.07,2.3,;-1.04,4.41,;-2.37,3.64,;-2.85,2.17,;-4.39,2.17,;-4.86,3.64,;-6.35,4.04,;-6.83,5.5,;-8.37,5.5,;-8.84,4.04,;-7.6,3.13,;-3.62,4.54,;-3.62,6.08,;-4.95,6.85,;-6.28,6.08,;-7.62,6.85,;-4.95,8.39,;-3.62,9.16,;-2.28,8.39,;-2.28,6.85,;-.95,6.08,;.39,6.85,;4.3,4.41,;5.63,3.64,;6.97,4.41,;6.97,5.95,;8.3,6.72,;5.63,6.72,;4.3,5.95,)| Show InChI InChI=1S/C23H31N7O5S/c1-14-11-25-21(26-12-14)20(35-5)15(2)36(31,32)29-23-28-27-22(16-9-10-24-13-16)30(23)19-17(33-3)7-6-8-18(19)34-4/h6-8,11-12,15-16,20,24H,9-10,13H2,1-5H3,(H,28,29)/t15-,16+,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 510 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310251
(US10150760, Example 47.0 | US10150760, Example 53....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-11-15(23)12-25-20)14(2)35(30,31)28-22-27-26-21(18-9-6-10-34-18)29(22)19-16(32-3)7-5-8-17(19)33-4/h5,7-8,11-14,18H,6,9-10H2,1-4H3,(H,27,28)/t13-,14-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310252
(US10150760, Example 48.0 | US10150760, Example 49....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C23H30N6O5S/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h6,8-9,12-13,15-16,19H,7,10-11H2,1-5H3,(H,27,28)/t15-,16-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310252
(US10150760, Example 48.0 | US10150760, Example 49....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C23H30N6O5S/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h6,8-9,12-13,15-16,19H,7,10-11H2,1-5H3,(H,27,28)/t15-,16-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310252
(US10150760, Example 48.0 | US10150760, Example 49....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C23H30N6O5S/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h6,8-9,12-13,15-16,19H,7,10-11H2,1-5H3,(H,27,28)/t15-,16-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310255
(US10150760, Example 51.0 | US10150760, Example 52....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,.84,;-7.42,1.61,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-11-14(23)12-25-20)36(30,31)28-22-27-26-21(17-9-6-10-35-17)29(22)18-15(32-2)7-5-8-16(18)33-3/h5,7-8,11-13,17,19H,6,9-10H2,1-4H3,(H,27,28)/t13-,17+,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310255
(US10150760, Example 51.0 | US10150760, Example 52....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,.84,;-7.42,1.61,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-11-14(23)12-25-20)36(30,31)28-22-27-26-21(17-9-6-10-35-17)29(22)18-15(32-2)7-5-8-16(18)33-3/h5,7-8,11-13,17,19H,6,9-10H2,1-4H3,(H,27,28)/t13-,17+,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310251
(US10150760, Example 47.0 | US10150760, Example 53....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-11-15(23)12-25-20)14(2)35(30,31)28-22-27-26-21(18-9-6-10-34-18)29(22)19-16(32-3)7-5-8-17(19)33-4/h5,7-8,11-14,18H,6,9-10H2,1-4H3,(H,27,28)/t13-,14-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310258
(US10150760, Example 54.0 | US10150760, Example 55....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C23H30N6O5S/c1-14-11-24-21(25-12-14)15(2)16(3)35(30,31)28-23-27-26-22(17-9-10-34-13-17)29(23)20-18(32-4)7-6-8-19(20)33-5/h6-8,11-12,15-17H,9-10,13H2,1-5H3,(H,27,28)/t15-,16-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310258
(US10150760, Example 54.0 | US10150760, Example 55....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C23H30N6O5S/c1-14-11-24-21(25-12-14)15(2)16(3)35(30,31)28-23-27-26-22(17-9-10-34-13-17)29(23)20-18(32-4)7-6-8-19(20)33-5/h6-8,11-12,15-17H,9-10,13H2,1-5H3,(H,27,28)/t15-,16-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 66 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310260
(US10150760, Example 56.0 | US10150760, Example 57....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,.84,;-7.42,1.61,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-10-15(23)11-25-20)36(30,31)28-22-27-26-21(14-8-9-35-12-14)29(22)18-16(32-2)6-5-7-17(18)33-3/h5-7,10-11,13-14,19H,8-9,12H2,1-4H3,(H,27,28)/t13-,14-,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310260
(US10150760, Example 56.0 | US10150760, Example 57....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,.84,;-7.42,1.61,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-10-15(23)11-25-20)36(30,31)28-22-27-26-21(14-8-9-35-12-14)29(22)18-16(32-2)6-5-7-17(18)33-3/h5-7,10-11,13-14,19H,8-9,12H2,1-4H3,(H,27,28)/t13-,14-,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310262
(US10150760, Example 58.0 | US10150760, Example 59....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C24H32N6O5S/c1-15-12-25-22(26-13-15)16(2)17(3)36(31,32)29-24-28-27-23(18-8-7-11-35-14-18)30(24)21-19(33-4)9-6-10-20(21)34-5/h6,9-10,12-13,16-18H,7-8,11,14H2,1-5H3,(H,28,29)/t16-,17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310262
(US10150760, Example 58.0 | US10150760, Example 59....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C24H32N6O5S/c1-15-12-25-22(26-13-15)16(2)17(3)36(31,32)29-24-28-27-23(18-8-7-11-35-14-18)30(24)21-19(33-4)9-6-10-20(21)34-5/h6,9-10,12-13,16-18H,7-8,11,14H2,1-5H3,(H,28,29)/t16-,17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310264
(US10150760, Example 60.0 | US10150760, Example 61....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-10-16(23)11-25-20)14(2)35(30,31)28-22-27-26-21(15-8-9-34-12-15)29(22)19-17(32-3)6-5-7-18(19)33-4/h5-7,10-11,13-15H,8-9,12H2,1-4H3,(H,27,28)/t13-,14-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310264
(US10150760, Example 60.0 | US10150760, Example 61....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.42,1.22,;-6.09,.45,;-4.76,1.22,;-4.76,2.76,;-3.42,3.53,;-2.09,2.76,;-2.09,1.22,;-.75,.45,;.58,1.22,;-3.42,.45,;-3.42,-1.09,;-2.18,-1.99,;-.84,-1.22,;.49,-1.99,;-.28,-3.33,;1.26,-3.33,;1.82,-1.22,;1.82,.32,;3.16,-1.99,;3.16,-3.53,;4.49,-1.22,;5.83,-1.99,;7.16,-1.22,;7.16,.32,;8.49,1.09,;5.83,1.09,;4.49,.32,;-2.65,-3.46,;-4.19,-3.46,;-4.67,-1.99,;-6,-1.22,;-6.48,.24,;-8.02,.24,;-8.49,-1.22,;-7.25,-2.13,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-10-16(23)11-25-20)14(2)35(30,31)28-22-27-26-21(15-8-9-34-12-15)29(22)19-17(32-3)6-5-7-18(19)33-4/h5-7,10-11,13-15H,8-9,12H2,1-4H3,(H,27,28)/t13-,14-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310266
(US10150760, Example 62.0 | US10150760, Example 63....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C23H29ClN6O5S/c1-14(21-25-11-17(24)12-26-21)15(2)36(31,32)29-23-28-27-22(16-7-6-10-35-13-16)30(23)20-18(33-3)8-5-9-19(20)34-4/h5,8-9,11-12,14-16H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310266
(US10150760, Example 62.0 | US10150760, Example 63....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C23H29ClN6O5S/c1-14(21-25-11-17(24)12-26-21)15(2)36(31,32)29-23-28-27-22(16-7-6-10-35-13-16)30(23)20-18(33-3)8-5-9-19(20)34-4/h5,8-9,11-12,14-16H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310268
(US10150760, Example 64.0 | US10150760, Example 65....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.81,-3.92,;3.48,-3.15,;3.48,-1.61,;2.14,-.84,;2.14,.7,;.81,-1.61,;.04,-2.94,;1.58,-2.94,;-.52,-.84,;-1.86,-1.61,;-2.33,-3.07,;-3.87,-3.07,;-4.35,-1.61,;-5.84,-1.21,;-6.24,.28,;-7.72,.68,;-8.81,-.41,;-8.41,-1.9,;-6.93,-2.3,;-3.1,-.7,;-3.1,.84,;-4.44,1.61,;-5.77,.84,;-7.1,1.61,;-4.44,3.15,;-3.1,3.92,;-1.77,3.15,;-1.77,1.61,;-.44,.84,;.9,1.61,;4.81,-.84,;6.14,-1.61,;7.48,-.84,;7.48,.7,;8.81,1.47,;6.14,1.47,;4.81,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-14(20(35-4)21-25-11-16(24)12-26-21)37(31,32)29-23-28-27-22(15-7-6-10-36-13-15)30(23)19-17(33-2)8-5-9-18(19)34-3/h5,8-9,11-12,14-15,20H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310268
(US10150760, Example 64.0 | US10150760, Example 65....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.81,-3.92,;3.48,-3.15,;3.48,-1.61,;2.14,-.84,;2.14,.7,;.81,-1.61,;.04,-2.94,;1.58,-2.94,;-.52,-.84,;-1.86,-1.61,;-2.33,-3.07,;-3.87,-3.07,;-4.35,-1.61,;-5.84,-1.21,;-6.24,.28,;-7.72,.68,;-8.81,-.41,;-8.41,-1.9,;-6.93,-2.3,;-3.1,-.7,;-3.1,.84,;-4.44,1.61,;-5.77,.84,;-7.1,1.61,;-4.44,3.15,;-3.1,3.92,;-1.77,3.15,;-1.77,1.61,;-.44,.84,;.9,1.61,;4.81,-.84,;6.14,-1.61,;7.48,-.84,;7.48,.7,;8.81,1.47,;6.14,1.47,;4.81,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-14(20(35-4)21-25-11-16(24)12-26-21)37(31,32)29-23-28-27-22(15-7-6-10-36-13-15)30(23)19-17(33-2)8-5-9-18(19)34-3/h5,8-9,11-12,14-15,20H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310270
(US10150760, Example 66.0 | US10150760, Example 67....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:33.35,18.19,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;4.49,-4.69,;5.83,-2.38,;4.49,-.07,;4.49,1.47,;5.83,2.24,;7.16,1.47,;8.49,2.24,;7.16,-.07,;5.83,-.84,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-23(18-14-26-16(3)13-27-18)17(4)38(32,33)30-25-29-28-24(21-11-8-12-36-21)31(25)22-19(34-5)9-7-10-20(22)35-6/h7,9-10,13-15,17,21,23H,8,11-12H2,1-6H3,(H,29,30)/t17-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310270
(US10150760, Example 66.0 | US10150760, Example 67....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:33.35,18.19,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;4.49,-4.69,;5.83,-2.38,;4.49,-.07,;4.49,1.47,;5.83,2.24,;7.16,1.47,;8.49,2.24,;7.16,-.07,;5.83,-.84,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-23(18-14-26-16(3)13-27-18)17(4)38(32,33)30-25-29-28-24(21-11-8-12-36-21)31(25)22-19(34-5)9-7-10-20(22)35-6/h7,9-10,13-15,17,21,23H,8,11-12H2,1-6H3,(H,29,30)/t17-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310272
(US10150760, Example 68.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1OCC[C@H]1C |r,wU:16.17,18.19,wD:30.32,34.38,(-7.5,1.65,;-6.16,.88,;-4.76,1.29,;-4.76,2.83,;-3.42,3.6,;-2.09,2.83,;-2.09,1.29,;-.75,.52,;.58,1.29,;-3.42,.52,;-3.42,-1.02,;-2.18,-1.92,;-.84,-1.15,;.49,-1.92,;-.28,-3.26,;1.26,-3.26,;1.82,-1.16,;1.82,.39,;3.16,-1.93,;3.16,-3.46,;4.49,-1.15,;5.83,-1.92,;7.16,-1.15,;7.16,.39,;8.49,1.16,;5.83,1.16,;4.49,.39,;-2.65,-3.39,;-4.19,-3.39,;-4.67,-1.92,;-6,-1.15,;-6.48,.31,;-8.02,.31,;-8.49,-1.15,;-7.25,-2.06,;-7.25,-3.6,)| Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-10-35-20(13)22-27-28-23(30(22)19-17(33-4)7-6-8-18(19)34-5)29-36(31,32)15(3)14(2)21-25-11-16(24)12-26-21/h6-8,11-15,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,15+,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
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