Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM310268

Substrate/Competitor

n/a

Meas. Tech.

[35S]GTPgammaS Binding

EC50

29.0±n/a nM

Citation

Chen, X; Cheng, AC; Connors, RV; Debenedetto, MV; Dransfield, PJ; Fu, Z; Harvey, JS; Heath, JA; Houze, J; Judd, TC; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor US Patent US10150760 Publication Date 12/11/2018

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM310268

n/a

Name

BDBM310268

Synonyms:

US10150760, Example 64.0 | US10150760, Example 65.0

Type

Small organic molecule

Emp. Form.

C23H29ClN6O6S

Mol. Mass.

553.031

SMILES

CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.81,-3.92,;3.48,-3.15,;3.48,-1.61,;2.14,-.84,;2.14,.7,;.81,-1.61,;.04,-2.94,;1.58,-2.94,;-.52,-.84,;-1.86,-1.61,;-2.33,-3.07,;-3.87,-3.07,;-4.35,-1.61,;-5.84,-1.21,;-6.24,.28,;-7.72,.68,;-8.81,-.41,;-8.41,-1.9,;-6.93,-2.3,;-3.1,-.7,;-3.1,.84,;-4.44,1.61,;-5.77,.84,;-7.1,1.61,;-4.44,3.15,;-3.1,3.92,;-1.77,3.15,;-1.77,1.61,;-.44,.84,;.9,1.61,;4.81,-.84,;6.14,-1.61,;7.48,-.84,;7.48,.7,;8.81,1.47,;6.14,1.47,;4.81,.7,)|

Structure