Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 1.27 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 3.08 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 5.27 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of VEGF-stimulated VEGFR-2 autophosphorylation in intact cells. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 8.79 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of recombinant FGFR-2 tyrosine kinase using exogenous substrate. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of recombinant VEGFR-2 tyrosine kinase using exogenous substrate. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 33.9 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 54.2 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 419 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 4 (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of recombinant PDGFR tyrosine kinase using exogenous substrate. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM50089038![]() (CGP 71683 | CGP-71683A | CHEMBL17645 | N-{[(1r,4r)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 3.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM50354083![]() (CHEMBL1836102 | N-{[(1r,4r)-4-{[(4-aminoquinazolin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM178091![]() (5-chloro-N-{[(1r,4r)-4-{[(4-aminoquinazolin-2-yl)a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 5.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of recombinant EGFR tyrosine kinase using exogenous substrate. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM178092![]() ({[7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM25115![]() (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PanOptica, Inc. US Patent | Assay Description Inhibition of recombinant IR tyrosine kinase using exogenous substrate. | US Patent US9446026 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM178093![]() ([7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-ben...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aquaporin-1 (Homo sapiens (Human)) | BDBM178094![]() ({[7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research Institute | Assay Description Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P... | Chem Biol Drug Des 87: 794-805 (2016) Article DOI: 10.1111/cbdd.12713 BindingDB Entry DOI: 10.7270/Q2GQ6WHZ | |||||||||||
More data for this Ligand-Target Pair |