Compile Data Set for Download or QSAR

Found 458 hits with Last Name = 'long' and Initial = 'mf'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212892 (US9278960, 2-39 | US9663506, Example 2-39) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O Show InChI InChI=1S/C22H18FN3O4/c1-30-13-3-5-14(17(23)9-13)16-10-19(22(24)29)25-18-8-12(2-4-15(16)18)11-26-20(27)6-7-21(26)28/h2-5,8-10H,6-7,11H2,1H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503469 (CHEMBL4575990) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(CCc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C21H15F4N5O/c22-14-4-2-13(3-5-14)17-11-16(20(26)31)28-19-10-15(29-30(17)19)6-1-12-7-8-27-18(9-12)21(23,24)25/h2-5,7-11H,1,6H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503469 (CHEMBL4575990) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(CCc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C21H15F4N5O/c22-14-4-2-13(3-5-14)17-11-16(20(26)31)28-19-10-15(29-30(17)19)6-1-12-7-8-27-18(9-12)21(23,24)25/h2-5,7-11H,1,6H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503465 (CHEMBL4550009) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2F)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H12F5N5O2/c21-10-1-2-13(14(22)5-10)16-8-15(19(26)31)28-18-6-11(29-30(16)18)9-32-12-3-4-27-17(7-12)20(23,24)25/h1-8H,9H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503465 (CHEMBL4550009) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2F)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H12F5N5O2/c21-10-1-2-13(14(22)5-10)16-8-15(19(26)31)28-18-6-11(29-30(16)18)9-32-12-3-4-27-17(7-12)20(23,24)25/h1-8H,9H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213122 (US9278960, 8-29 | US9636337, 8-29) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-19-20(11-23(24(26)30)29-22(19)9-15)18-8-6-17(31-2)10-21(18)25/h5-13H,3-4H2,1-2H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503466 (CHEMBL4569114) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(c3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-3-14(15(22)7-12)17-9-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-4-5-27-18(8-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503466 (CHEMBL4569114) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(c3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-3-14(15(22)7-12)17-9-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-4-5-27-18(8-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278653 (CHEMBL4163186 | US10399948, Compound 20) Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O Show InChI InChI=1S/C19H15F2NO3/c20-17-7-6-14(12-18(17)21)22-9-8-16(13-19(22)23)25-11-10-24-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278653 (CHEMBL4163186 | US10399948, Compound 20) Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O Show InChI InChI=1S/C19H15F2NO3/c20-17-7-6-14(12-18(17)21)22-9-8-16(13-19(22)23)25-11-10-24-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50503463 (CHEMBL4441595) Show SMILES C[C@H]1CN(Cc2ccc3n(cc(C(N)=O)c(=O)c3c2)-c2ccc(F)cc2)C[C@@H](C)O1 |r| Show InChI InChI=1S/C23H24FN3O3/c1-14-10-26(11-15(2)30-14)12-16-3-8-21-19(9-16)22(28)20(23(25)29)13-27(21)18-6-4-17(24)5-7-18/h3-9,13-15H,10-12H2,1-2H3,(H2,25,29)/t14-,15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503467 (CHEMBL4533083) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(Br)c3)cc2n1 Show InChI InChI=1S/C19H13BrFN5O2/c20-17-8-14(5-6-23-17)28-10-13-7-18-24-15(19(22)27)9-16(26(18)25-13)11-1-3-12(21)4-2-11/h1-9H,10H2,(H2,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503467 (CHEMBL4533083) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(Br)c3)cc2n1 Show InChI InChI=1S/C19H13BrFN5O2/c20-17-8-14(5-6-23-17)28-10-13-7-18-24-15(19(22)27)9-16(26(18)25-13)11-1-3-12(21)4-2-11/h1-9H,10H2,(H2,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278662 (CHEMBL4172540) Show SMILES C[C@@H](COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1 |r| Show InChI InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278662 (CHEMBL4172540) Show SMILES C[C@@H](COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1 |r| Show InChI InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278634 (CHEMBL4173490 | US10399948, Compound 23) Show SMILES Fc1cc(cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O)C#N Show InChI InChI=1S/C20H15FN2O3/c21-16-10-15(14-22)11-17(12-16)23-7-6-19(13-20(23)24)26-9-8-25-18-4-2-1-3-5-18/h1-7,10-13H,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278634 (CHEMBL4173490 | US10399948, Compound 23) Show SMILES Fc1cc(cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O)C#N Show InChI InChI=1S/C20H15FN2O3/c21-16-10-15(14-22)11-17(12-16)23-7-6-19(13-20(23)24)26-9-8-25-18-4-2-1-3-5-18/h1-7,10-13H,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503464 (CHEMBL4550517) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(C)c3)nn12)C(N)=O Show InChI InChI=1S/C21H18FN5O3/c1-12-7-15(5-6-24-12)30-11-13-8-20-25-18(21(23)28)10-19(27(20)26-13)16-4-3-14(29-2)9-17(16)22/h3-10H,11H2,1-2H3,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503464 (CHEMBL4550517) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(C)c3)nn12)C(N)=O Show InChI InChI=1S/C21H18FN5O3/c1-12-7-15(5-6-24-12)30-11-13-8-20-25-18(21(23)28)10-19(27(20)26-13)16-4-3-14(29-2)9-17(16)22/h3-10H,11H2,1-2H3,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278642 (CHEMBL4164285 | US10399948, Compound 17) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)nc1=O Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-11-10-17(20-18(21)22)24-13-12-23-16-4-2-1-3-5-16/h1-11H,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278642 (CHEMBL4164285 | US10399948, Compound 17) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)nc1=O Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-11-10-17(20-18(21)22)24-13-12-23-16-4-2-1-3-5-16/h1-11H,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278631 (CHEMBL4162785 | US10399948, Compound 22) Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N Show InChI InChI=1S/C20H16N2O3/c21-15-16-5-4-6-17(13-16)22-10-9-19(14-20(22)23)25-12-11-24-18-7-2-1-3-8-18/h1-10,13-14H,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	339	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278631 (CHEMBL4162785 | US10399948, Compound 22) Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N Show InChI InChI=1S/C20H16N2O3/c21-15-16-5-4-6-17(13-16)22-10-9-19(14-20(22)23)25-12-11-24-18-7-2-1-3-8-18/h1-10,13-14H,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503490 (CHEMBL4549344) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccc(nc3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-4-14(15(22)7-12)17-8-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-3-5-18(27-9-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503490 (CHEMBL4549344) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccc(nc3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-4-14(15(22)7-12)17-8-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-3-5-18(27-9-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278655 (CHEMBL4171435 | US10399948, Compound 31) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2)cc1=O Show InChI InChI=1S/C19H15F2NO3/c20-14-4-6-16(7-5-14)22-9-8-18(13-19(22)23)25-11-10-24-17-3-1-2-15(21)12-17/h1-9,12-13H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278655 (CHEMBL4171435 | US10399948, Compound 31) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2)cc1=O Show InChI InChI=1S/C19H15F2NO3/c20-14-4-6-16(7-5-14)22-9-8-18(13-19(22)23)25-11-10-24-17-3-1-2-15(21)12-17/h1-9,12-13H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278643 (CHEMBL4171110 | US10399948, Compound 19) Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)cc1=O Show InChI InChI=1S/C19H16FNO3/c20-15-5-4-6-16(13-15)21-10-9-18(14-19(21)22)24-12-11-23-17-7-2-1-3-8-17/h1-10,13-14H,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	389	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278643 (CHEMBL4171110 | US10399948, Compound 19) Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)cc1=O Show InChI InChI=1S/C19H16FNO3/c20-15-5-4-6-16(13-15)21-10-9-18(14-19(21)22)24-12-11-23-17-7-2-1-3-8-17/h1-10,13-14H,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503480 (CHEMBL4516001) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H17FN4O3S/c1-11-24-8-13(9-25-11)29-10-14-6-18-20(30-14)16(7-19(26-18)21(23)27)15-4-3-12(28-2)5-17(15)22/h3-9H,10H2,1-2H3,(H2,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503480 (CHEMBL4516001) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H17FN4O3S/c1-11-24-8-13(9-25-11)29-10-14-6-18-20(30-14)16(7-19(26-18)21(23)27)15-4-3-12(28-2)5-17(15)22/h3-9H,10H2,1-2H3,(H2,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278640 (CHEMBL4160819 | US10399948, Compound 54) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2Cl)cc1=O Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-8-21-18(16)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50278640 (CHEMBL4160819 | US10399948, Compound 54) Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2Cl)cc1=O Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-8-21-18(16)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...				ACS Med Chem Lett 8: 925-930 (2017) Article DOI: 10.1021/acsmedchemlett.7b00249 BindingDB Entry DOI: 10.7270/Q2ZP48NJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503462 (CHEMBL4527834) Show SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1 |r| Show InChI InChI=1S/C21H22FN3O2S/c1-12-9-25(10-13(2)27-12)11-16-7-18-20(28-16)17(8-19(24-18)21(23)26)14-3-5-15(22)6-4-14/h3-8,12-13H,9-11H2,1-2H3,(H2,23,26)/t12-,13+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503462 (CHEMBL4527834) Show SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1 |r| Show InChI InChI=1S/C21H22FN3O2S/c1-12-9-25(10-13(2)27-12)11-16-7-18-20(28-16)17(8-19(24-18)21(23)26)14-3-5-15(22)6-4-14/h3-8,12-13H,9-11H2,1-2H3,(H2,23,26)/t12-,13+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503479 (CHEMBL4557272) Show SMILES Cc1ncc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)cn1 Show InChI InChI=1S/C20H15FN4O2S/c1-11-23-8-14(9-24-11)27-10-15-6-17-19(28-15)16(7-18(25-17)20(22)26)12-2-4-13(21)5-3-12/h2-9H,10H2,1H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503479 (CHEMBL4557272) Show SMILES Cc1ncc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)cn1 Show InChI InChI=1S/C20H15FN4O2S/c1-11-23-8-14(9-24-11)27-10-15-6-17-19(28-15)16(7-18(25-17)20(22)26)12-2-4-13(21)5-3-12/h2-9H,10H2,1H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503473 (CHEMBL4541942) Show SMILES Cc1ccc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)cn1 Show InChI InChI=1S/C21H16FN3O2S/c1-12-2-7-15(10-24-12)27-11-16-8-18-20(28-16)17(9-19(25-18)21(23)26)13-3-5-14(22)6-4-13/h2-10H,11H2,1H3,(H2,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503478 (CHEMBL4563286) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2sc(COc3cncnc3)cc2n1 Show InChI InChI=1S/C19H13FN4O2S/c20-12-3-1-11(2-4-12)15-6-17(19(21)25)24-16-5-14(27-18(15)16)9-26-13-7-22-10-23-8-13/h1-8,10H,9H2,(H2,21,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503473 (CHEMBL4541942) Show SMILES Cc1ccc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)cn1 Show InChI InChI=1S/C21H16FN3O2S/c1-12-2-7-15(10-24-12)27-11-16-8-18-20(28-16)17(9-19(25-18)21(23)26)13-3-5-14(22)6-4-13/h2-10H,11H2,1H3,(H2,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503478 (CHEMBL4563286) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2sc(COc3cncnc3)cc2n1 Show InChI InChI=1S/C19H13FN4O2S/c20-12-3-1-11(2-4-12)15-6-17(19(21)25)24-16-5-14(27-18(15)16)9-26-13-7-22-10-23-8-13/h1-8,10H,9H2,(H2,21,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503477 (CHEMBL4579281) Show SMILES Cc1ccc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)c(C)n1 Show InChI InChI=1S/C22H18FN3O2S/c1-12-3-8-20(13(2)25-12)28-11-16-9-18-21(29-16)17(10-19(26-18)22(24)27)14-4-6-15(23)7-5-14/h3-10H,11H2,1-2H3,(H2,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	741	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503477 (CHEMBL4579281) Show SMILES Cc1ccc(OCc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)c(C)n1 Show InChI InChI=1S/C22H18FN3O2S/c1-12-3-8-20(13(2)25-12)28-11-16-9-18-21(29-16)17(10-19(26-18)22(24)27)14-4-6-15(23)7-5-14/h3-10H,11H2,1-2H3,(H2,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	741	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503476 (CHEMBL4578758) Show SMILES Cc1ncccc1OCc1cc2nc(cc(-c3ccc(F)cc3)c2s1)C(N)=O Show InChI InChI=1S/C21H16FN3O2S/c1-12-19(3-2-8-24-12)27-11-15-9-17-20(28-15)16(10-18(25-17)21(23)26)13-4-6-14(22)7-5-13/h2-10H,11H2,1H3,(H2,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503476 (CHEMBL4578758) Show SMILES Cc1ncccc1OCc1cc2nc(cc(-c3ccc(F)cc3)c2s1)C(N)=O Show InChI InChI=1S/C21H16FN3O2S/c1-12-19(3-2-8-24-12)27-11-15-9-17-20(28-15)16(10-18(25-17)21(23)26)13-4-6-14(22)7-5-13/h2-10H,11H2,1H3,(H2,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair

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