Compile Data Set for Download or QSAR

Found 307 hits with Last Name = 'bifulco' and Initial = 'n'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM158154 (US10081622, Compound 11 | US10370379, Entrectinib ...) Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1 Show InChI InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM158154 (US10081622, Compound 11 | US10370379, Entrectinib ...) Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1 Show InChI InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B1G
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM513991 (US11059827, Compound TSR-011) Show SMILES CC(C)NC(=O)C1CCC(CC1)n1c(NC(=O)c2ccc(F)cc2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12 |(-.59,-12.16,;-1.62,-11.02,;-3.12,-11.34,;-1.14,-9.55,;-2.17,-8.41,;-3.68,-8.73,;-1.7,-6.94,;-2.73,-5.8,;-2.25,-4.33,;-.74,-4.01,;.29,-5.16,;-.19,-6.62,;-.27,-2.55,;-1.17,-1.3,;-2.71,-1.3,;-3.48,.03,;-5.02,.03,;-2.71,1.36,;-3.48,2.7,;-2.71,4.03,;-1.17,4.03,;-.4,5.37,;-.4,2.7,;-1.17,1.36,;-.27,-.06,;1.2,-.53,;2.53,.24,;3.86,-.53,;3.86,-2.07,;5.2,-2.84,;6.53,-2.07,;6.53,-.53,;7.87,.24,;9.2,-.53,;9.2,-2.07,;7.87,-2.84,;10.53,.24,;11.87,1.01,;11.3,-1.1,;9.76,1.57,;2.53,-2.84,;1.2,-2.07,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B1G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES CC(C)NC(=O)[C@H]1CC[C@H](CC1)n1c(NC(=O)c2ccc(F)cc2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12 |r,wU:9.12,6.5,(21.34,-25.87,;19.83,-25.56,;19.35,-24.09,;18.81,-26.7,;17.3,-26.39,;16.27,-27.53,;16.82,-24.92,;15.31,-24.6,;14.83,-23.15,;15.87,-22,;17.37,-22.31,;17.85,-23.77,;15.38,-20.54,;16.29,-19.28,;17.83,-19.27,;18.59,-17.94,;17.81,-16.61,;20.13,-17.93,;20.9,-19.25,;22.44,-19.25,;23.2,-17.91,;24.74,-17.9,;22.42,-16.57,;20.88,-16.59,;15.37,-18.03,;13.9,-18.52,;12.56,-17.76,;11.23,-18.53,;11.23,-20.07,;9.9,-20.84,;8.56,-20.07,;8.56,-18.53,;7.24,-17.76,;5.9,-18.52,;5.9,-20.06,;7.23,-20.84,;4.56,-17.74,;3.79,-16.41,;5.33,-16.4,;3.23,-18.51,;12.56,-20.84,;13.9,-20.07,)| Show InChI InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)/t24-,27+	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50306682 ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...) Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B1G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50306682 ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...) Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103860 (US9695165, 43) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1cccc(NC(=O)C=C)c1 |(4,8.08,;4,6.54,;2.67,5.78,;1.33,6.54,;,5.78,;-1.33,6.54,;-2.67,5.78,;,4.23,;-1.33,3.47,;1.33,3.47,;2.67,4.23,;4,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;4,-2.69,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.8,-.68,;-3.7,-1.93,;-2.8,-3.17,;-1.33,-2.69,;,1.15,;-1.33,1.93,;2.67,-5,;4,-5.78,;4,-7.31,;2.67,-8.08,;1.33,-7.31,;,-8.08,;-1.33,-7.31,;-1.33,-5.77,;-2.67,-8.08,;-4,-7.31,;1.33,-5.78,)| Show InChI InChI=1S/C30H27Cl2N3O4/c1-4-26(36)34-19-9-7-8-17(12-19)22-14-23-18(16-33-22)13-21(30(37)35(23)20-10-5-6-11-20)27-28(31)24(38-2)15-25(39-3)29(27)32/h4,7-9,12-16,20H,1,5-6,10-11H2,2-3H3,(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103862 (US9695165, 45) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCCN(C(=O)C=C)c2c1 |(5.33,.77,;4,,;2.67,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;,2.31,;1.33,3.08,;1.33,4.62,;,5.39,;-1.33,4.62,;,6.93,;-1.33,7.7,;-2.67,6.93,;1.33,7.7,;2.67,6.93,;4,7.7,;4,9.24,;2.67,5.39,;4,4.62,;2.67,2.31,;4,3.08,;,-3.85,;1.33,-4.62,;1.33,-6.16,;,-6.93,;,-8.47,;-1.33,-9.24,;-2.67,-8.47,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-6.93,;-5.33,-8.47,;-1.33,-6.16,;-1.33,-4.62,)| Show InChI InChI=1S/C30H27Cl2N3O4/c1-5-26(36)35-11-7-8-17-9-10-18(13-22(17)35)21-14-23-19(16-33-21)12-20(30(37)34(23)6-2)27-28(31)24(38-3)15-25(39-4)29(27)32/h5,9-10,12-16H,1,6-8,11H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103864 (US9695165, 47) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(5.33,.77,;4,,;2.67,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;,2.31,;1.33,3.08,;1.33,4.62,;,5.39,;-1.33,4.62,;,6.93,;-1.33,7.7,;-2.67,6.93,;1.33,7.7,;2.67,6.93,;4,7.7,;4,9.24,;2.67,5.39,;4,4.62,;2.67,2.31,;4,3.08,;,-3.85,;1.33,-4.62,;1.33,-6.16,;,-6.93,;,-8.47,;-1.33,-9.24,;-2.67,-8.47,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-6.93,;-5.33,-8.47,;-1.33,-6.16,;-1.33,-4.62,)| Show InChI InChI=1S/C29H25Cl2N3O5/c1-5-25(35)34-9-10-39-22-8-7-16(12-21(22)34)19-13-20-17(15-32-19)11-18(29(36)33(20)6-2)26-27(30)23(37-3)14-24(38-4)28(26)31/h5,7-8,11-15H,1,6,9-10H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103867 (US9695165, 50) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc2OCCN(C(=O)C=C)c2c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C28H26Cl2N4O5/c1-5-24(35)33-9-10-39-21-8-7-16(11-20(21)33)18-12-19-17(14-31-18)15-34(28(36)32(19)6-2)27-25(29)22(37-3)13-23(38-4)26(27)30/h5,7-8,11-14H,1,6,9-10,15H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103869 (US9695165, 52) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1 |(5.33,1.44,;4,.67,;2.67,1.44,;1.33,.67,;1.33,-.87,;,-1.64,;-1.33,-.87,;-1.33,.67,;,1.44,;,2.98,;1.33,3.75,;1.33,5.29,;,6.06,;-1.33,5.29,;,7.6,;-1.33,8.37,;-2.67,7.6,;1.33,8.37,;2.67,7.6,;4,8.37,;4,9.91,;2.67,6.06,;4,5.29,;2.67,2.98,;4,3.75,;,-3.18,;1.33,-3.95,;1.33,-5.49,;,-6.26,;,-7.8,;-1.33,-8.57,;-2.1,-9.91,;-.56,-9.91,;-2.67,-7.8,;-2.67,-6.26,;-4,-5.49,;-4,-3.95,;-5.33,-6.26,;-5.33,-7.8,;-1.33,-5.49,;-1.33,-3.95,)| Show InChI InChI=1S/C31H29Cl2N3O5/c1-7-26(37)36-16-31(3,4)41-23-10-9-17(12-22(23)36)20-13-21-18(15-34-20)11-19(30(38)35(21)8-2)27-28(32)24(39-5)14-25(40-6)29(27)33/h7,9-15H,1,8,16H2,2-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103870 (US9695165, 53) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc2N(C(C)COc2cc1F)C(=O)C=C |(3.33,.77,;2,,;.67,.77,;-.67,,;-.67,-1.54,;-2,-2.31,;-3.33,-1.54,;-3.33,,;-2,.77,;-2,2.31,;-.67,3.08,;-.67,4.62,;-2,5.39,;-3.33,4.62,;-2,6.93,;-3.33,7.7,;-4.67,6.93,;-.67,7.7,;.67,6.93,;2,7.7,;2,9.24,;.67,5.39,;2,4.62,;.67,2.31,;2,3.08,;-2,-3.85,;-.67,-4.62,;-.67,-6.16,;.67,-6.93,;.67,-8.47,;2,-9.24,;-.67,-9.24,;-2,-8.47,;-2,-6.93,;-3.33,-6.16,;-3.33,-4.62,;-4.67,-3.85,;2,-6.16,;2,-4.62,;3.33,-6.93,;4.67,-6.16,)| Show InChI InChI=1S/C30H26Cl2FN3O5/c1-6-26(37)36-15(3)14-41-23-10-19(33)17(9-22(23)36)20-11-21-16(13-34-20)8-18(30(38)35(21)7-2)27-28(31)24(39-4)12-25(40-5)29(27)32/h6,8-13,15H,1,7,14H2,2-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103873 (US9695165, 56) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(3.85,9.24,;3.85,7.7,;2.52,6.93,;1.18,7.7,;-.15,6.93,;-1.48,7.7,;-2.82,6.93,;-.15,5.39,;-1.48,4.62,;1.18,4.62,;2.52,5.39,;3.85,4.62,;1.18,3.08,;2.52,2.31,;2.52,.77,;3.85,,;3.85,-1.54,;2.52,-2.31,;1.18,-1.54,;1.18,,;-.15,.77,;-1.48,,;-2.95,.48,;-3.85,-.77,;-2.95,-2.02,;-1.48,-1.54,;-.15,2.31,;-1.48,3.08,;2.52,-3.85,;3.85,-4.62,;3.85,-6.16,;2.52,-6.93,;2.52,-8.47,;1.18,-9.24,;-.15,-8.47,;-.15,-6.93,;-1.48,-6.16,;-1.48,-4.62,;-2.82,-6.93,;-2.82,-8.47,;1.18,-6.16,;1.18,-4.62,)| Show InChI InChI=1S/C31H28Cl2N4O5/c1-4-26(38)36-11-12-42-23-10-9-17(13-22(23)36)19-14-21-20(16-34-19)35-30(31(39)37(21)18-7-5-6-8-18)27-28(32)24(40-2)15-25(41-3)29(27)33/h4,9-10,13-16,18H,1,5-8,11-12H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410184 (5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-yl)pyrrol...) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cncc(F)c1 |r| Show InChI InChI=1S/C16H12F2N6/c17-12-3-10(6-20-8-12)14-4-13(18)9-23(14)15-1-2-24-16(22-15)11(5-19)7-21-24/h1-3,6-8,13-14H,4,9H2/t13-,14+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410185 (US10370379, Compound 2 | US11059827, Compound 2) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H12F3N5/c18-11-1-2-14(20)13(5-11)15-6-12(19)9-24(15)16-3-4-25-17(23-16)10(7-21)8-22-25/h1-5,8,12,15H,6,9H2/t12-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410187 (6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...) Show SMILES F[C@H]1C[C@@H](N(C1)c1nc2c(cnn2cc1F)C#N)c1cncc(F)c1 |r| Show InChI InChI=1S/C16H11F3N6/c17-11-1-9(4-21-6-11)14-2-12(18)7-24(14)16-13(19)8-25-15(23-16)10(3-20)5-22-25/h1,4-6,8,12,14H,2,7H2/t12-,14+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410189 (5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrr...) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(c1)C#N |r| Show InChI InChI=1S/C18H12F2N6/c19-14-4-11(7-21)3-12(5-14)16-6-15(20)10-25(16)17-1-2-26-18(24-17)13(8-22)9-23-26/h1-5,9,15-16H,6,10H2/t15-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410190 (5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3...) Show SMILES COc1ncc(F)cc1[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C17H14F2N6O/c1-26-17-13(4-11(18)8-21-17)14-5-12(19)9-24(14)15-2-3-25-16(23-15)10(6-20)7-22-25/h2-4,7-8,12,14H,5,9H2,1H3/t12-,14+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410192 (US10370379, Compound 9 | US11059827, Compound 9) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(Cl)c1 |r| Show InChI InChI=1S/C17H12ClF2N5/c18-12-3-10(4-13(19)5-12)15-6-14(20)9-24(15)16-1-2-25-17(23-16)11(7-21)8-22-25/h1-5,8,14-15H,6,9H2/t14-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410193 (US10370379, Compound 10 | US11059827, Compound 10) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cnc1Cl |r| Show InChI InChI=1S/C16H11ClF2N6/c17-15-12(3-10(18)7-21-15)13-4-11(19)8-24(13)14-1-2-25-16(23-14)9(5-20)6-22-25/h1-3,6-7,11,13H,4,8H2/t11-,13+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410194 (US10370379, Compound 11 | US11059827, Compound 11) Show SMILES NC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C18H14F2N6O/c19-13-4-10(3-11(5-13)17(22)27)15-6-14(20)9-25(15)16-1-2-26-18(24-16)12(7-21)8-23-26/h1-5,8,14-15H,6,9H2,(H2,22,27)/t14-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410195 (US10370379, Compound 12 | US11059827, Compound 12) Show SMILES F[C@H]1C[C@@H](N(C1)c1nc2c(cnn2cc1F)C#N)c1cc(F)cc(c1)C#N |r| Show InChI InChI=1S/C18H11F3N6/c19-13-2-10(5-22)1-11(3-13)16-4-14(20)8-26(16)18-15(21)9-27-17(25-18)12(6-23)7-24-27/h1-3,7,9,14,16H,4,8H2/t14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410196 (US10370379, Compound 13 | US11059827, Compound 13) Show SMILES COc1c(F)cc(F)cc1[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C18H14F3N5O/c1-27-17-13(4-11(19)5-14(17)21)15-6-12(20)9-25(15)16-2-3-26-18(24-16)10(7-22)8-23-26/h2-5,8,12,15H,6,9H2,1H3/t12-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410198 (US10370379, Compound 15) Show SMILES NC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1nc2c(cnn2cc1F)C#N |r| Show InChI InChI=1S/C18H13F3N6O/c19-12-2-9(1-10(3-12)16(23)28)15-4-13(20)7-26(15)18-14(21)8-27-17(25-18)11(5-22)6-24-27/h1-3,6,8,13,15H,4,7H2,(H2,23,28)/t13-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410199 (US10370379, Compound 16 | US11059827, Compound 16) Show SMILES NS(=O)(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C17H14F2N6O2S/c18-12-3-10(4-14(5-12)28(21,26)27)15-6-13(19)9-24(15)16-1-2-25-17(23-16)11(7-20)8-22-25/h1-5,8,13,15H,6,9H2,(H2,21,26,27)/t13-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410200 (US10370379, Compound 17 | US11059827, Compound 17) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)ccc1OC(F)(F)F |r| Show InChI InChI=1S/C18H12F5N5O/c19-11-1-2-15(29-18(21,22)23)13(5-11)14-6-12(20)9-27(14)16-3-4-28-17(26-16)10(7-24)8-25-28/h1-5,8,12,14H,6,9H2/t12-,14+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410202 (US10370379, Compound 19 | US11059827, Compound 19) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(c1)C(=O)NCC1CC1 |r| Show InChI InChI=1S/C22H20F2N6O/c23-17-6-14(5-15(7-17)22(31)26-10-13-1-2-13)19-8-18(24)12-29(19)20-3-4-30-21(28-20)16(9-25)11-27-30/h3-7,11,13,18-19H,1-2,8,10,12H2,(H,26,31)/t18-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102160 (US9695165, 9) Show SMILES CCn1c2cc(ncc2cc(-c2cc(ccc2Cl)C(=O)NOC)c1=O)-c1ccccc1NC(=O)C=C Show InChI InChI=1S/C27H23ClN4O4/c1-4-25(33)30-22-9-7-6-8-18(22)23-14-24-17(15-29-23)13-20(27(35)32(24)5-2)19-12-16(10-11-21(19)28)26(34)31-36-3/h4,6-15H,1,5H2,2-3H3,(H,30,33)(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102167 (US9695165, 10) Show SMILES COc1cc(OC)c(F)c(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H25F2N3O4/c1-6-26(34)32-17-7-8-22(29)21(10-17)23-13-24-16(14-31-23)9-20(28(35)33(24)15(2)3)19-11-18(36-4)12-25(37-5)27(19)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102180 (US9695165, 12) Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102180 (US9695165, 12) Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102207 (US9695165, 17) Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;3.33,-.77,;4.67,1.54,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102207 (US9695165, 17) Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;3.33,-.77,;4.67,1.54,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102213 (US9695165, 18) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C Show InChI InChI=1S/C27H20Cl2FN3O3/c1-4-23(34)33-8-7-14-10-18(30)17(11-20(14)33)27-31-13-16-9-15(5-6-19(16)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102217 (US9695165, 19) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1NC(=O)C=C |(-6,-.38,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-.67,4.23,;.67,3.47,;-.67,5.78,;.67,6.54,;2,5.78,;-2,6.54,;-3.33,5.78,;-4.67,6.54,;-4.67,8.08,;-3.33,4.23,;-4.67,3.47,;-3.33,1.15,;-4.67,1.93,;-.67,-5,;-2,-5.78,;-2,-7.31,;-.67,-8.08,;.67,-7.31,;.67,-5.78,;2,-5,;3.33,-5.77,;3.33,-7.31,;4.67,-5,;6,-5.77,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-18-10-8-7-9-16(18)19-12-20-15(14-30-19)11-17(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102218 (US9695165, 20) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1 |(6,-.39,;4.67,-1.16,;3.33,-.39,;2,-1.16,;2,-2.7,;.67,-3.47,;-.67,-2.7,;-.67,-1.16,;.67,-.39,;.67,1.15,;2,1.92,;2,3.46,;.67,4.23,;-.67,3.46,;.67,5.77,;-.67,6.54,;-2,5.77,;2,6.54,;3.33,5.77,;4.67,6.55,;4.67,8.09,;3.33,4.23,;4.67,3.47,;3.33,1.15,;4.67,1.92,;.67,-5.01,;2,-5.78,;2,-7.32,;.67,-8.09,;-.67,-7.32,;-2,-8.09,;-3.33,-7.32,;-3.33,-5.78,;-4.67,-8.09,;-6,-7.32,;-.67,-5.78,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102218 (US9695165, 20) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1 |(6,-.39,;4.67,-1.16,;3.33,-.39,;2,-1.16,;2,-2.7,;.67,-3.47,;-.67,-2.7,;-.67,-1.16,;.67,-.39,;.67,1.15,;2,1.92,;2,3.46,;.67,4.23,;-.67,3.46,;.67,5.77,;-.67,6.54,;-2,5.77,;2,6.54,;3.33,5.77,;4.67,6.55,;4.67,8.09,;3.33,4.23,;4.67,3.47,;3.33,1.15,;4.67,1.92,;.67,-5.01,;2,-5.78,;2,-7.32,;.67,-8.09,;-.67,-7.32,;-2,-8.09,;-3.33,-7.32,;-3.33,-5.78,;-4.67,-8.09,;-6,-7.32,;-.67,-5.78,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102219 (US9695165, 21) Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102219 (US9695165, 21) Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102229 (US9695165, 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C26H20Cl2FN3O4/c1-5-22(33)31-14-6-7-17(29)15(9-14)18-10-19-13(12-30-18)8-16(26(34)32(19)2)23-24(27)20(35-3)11-21(36-4)25(23)28/h5-12H,1H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102277 (US9695165, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103607 (US9695165, 28) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1F)C(=O)C=C Show InChI InChI=1S/C27H20Cl2FN3O4/c1-4-23(34)33-7-8-37-20-11-17(30)16(10-19(20)33)27-31-13-15-9-14(5-6-18(15)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103847 (US9695165, 30 | US9695165, 31) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103847 (US9695165, 30 | US9695165, 31) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103849 (US9695165, 32) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cc(NC(=O)C=C)ccc1F)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H23Cl2FN4O4/c1-5-22(34)31-15-7-8-17(29)16(9-15)18-10-19-14(12-30-18)13-33(26(35)32(19)6-2)25-23(27)20(36-3)11-21(37-4)24(25)28/h5,7-12H,1,6,13H2,2-4H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103852 (US9695165, 35) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCN(C(=O)C=C)c2c1 |(5.19,.45,;3.86,-.32,;2.53,.45,;1.19,-.32,;1.19,-1.86,;-.14,-2.63,;-1.47,-1.86,;-1.47,-.32,;-.14,.45,;-.14,1.99,;1.19,2.76,;1.19,4.3,;-.14,5.07,;-1.47,4.3,;-.14,6.61,;-1.47,7.38,;-2.81,6.61,;1.19,7.38,;2.53,6.61,;3.86,7.38,;3.86,8.92,;2.53,5.07,;3.86,4.3,;2.53,1.99,;3.86,2.76,;-.14,-4.17,;1.19,-4.94,;1.19,-6.48,;-.14,-7.25,;-.46,-8.76,;-1.99,-8.92,;-2.62,-7.51,;-4.11,-7.11,;-5.19,-8.2,;-4.5,-5.63,;-3.42,-4.54,;-1.47,-6.48,;-1.47,-4.94,)| Show InChI InChI=1S/C28H24Cl2N4O4/c1-5-22(35)34-10-9-15-7-8-16(12-19(15)34)26-31-14-17-11-18(28(36)33(6-2)27(17)32-26)23-24(29)20(37-3)13-21(38-4)25(23)30/h5,7-8,11-14H,1,6,9-10H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103854 (US9695165, 37) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(-3.33,9.24,;-3.33,7.7,;-2,6.93,;-.67,7.7,;.67,6.93,;2,7.7,;3.33,6.93,;.67,5.39,;2,4.62,;-.67,4.62,;-2,5.39,;-3.33,4.62,;-.67,3.08,;-2,2.31,;-2,.77,;-3.33,,;-3.33,-1.54,;-2,-2.31,;-.67,-1.54,;-.67,,;.67,.77,;2,,;.67,2.31,;2,3.08,;-2,-3.85,;-3.33,-4.62,;-3.33,-6.16,;-2,-6.93,;-2,-8.47,;-.67,-9.24,;.67,-8.47,;.67,-6.93,;2,-6.16,;2,-4.62,;3.33,-6.93,;3.33,-8.47,;-.67,-6.16,;-.67,-4.62,)| Show InChI InChI=1S/C28H23Cl2N3O5/c1-5-24(34)33-8-9-38-21-7-6-15(11-20(21)33)18-12-19-16(14-31-18)10-17(28(35)32(19)2)25-26(29)22(36-3)13-23(37-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103857 (US9695165, 40) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;4.67,1.54,;3.33,-.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24Cl2FN3O4/c1-6-24(35)33-16-7-8-19(31)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(29)22(37-4)12-23(38-5)27(25)30/h6-14H,1H2,2-5H3,(H,33,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair

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