Found 115 hits with Last Name = 'adair' and Initial = 'oo' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Escherichia coli) | BDBM50029766
![PNG](/data/jpeg/tenK5002/BindingDB_50029766.png) (2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1cnc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C19H24N6O3/c1-10-11(8-22-18-15(10)17(20)23-19(21)24-18)9-25(2)12-6-13(26-3)16(28-5)14(7-12)27-4/h6-8H,9H2,1-5H3,(H4,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253581
![PNG](/data/jpeg/tenK5025/BindingDB_50253581.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamin...)Show InChI InChI=1S/C19H23N5O2/c1-4-24(11-12-9-14(25-2)6-8-17(12)26-3)13-5-7-16-15(10-13)18(20)23-19(21)22-16/h5-10H,4,11H2,1-3H3,(H4,20,21,22,23) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253578
![PNG](/data/jpeg/tenK5025/BindingDB_50253578.png) (2,4-Diamino-6-[N-(benzyl)-N-ethylamino]quinazoline...)Show InChI InChI=1S/C17H19N5/c1-2-22(11-12-6-4-3-5-7-12)13-8-9-15-14(10-13)16(18)21-17(19)20-15/h3-10H,2,11H2,1H3,(H4,18,19,20,21) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18224
![PNG](/data/jpeg/tenK1/BindingDB_18224.png) (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from rat liver. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50029772
![PNG](/data/jpeg/tenK5002/BindingDB_50029772.png) (5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)Show InChI InChI=1S/C18H22N6O3/c1-9-10(8-22-17-14(9)16(19)23-18(20)24-17)7-21-11-5-12(25-2)15(27-4)13(6-11)26-3/h5-6,8,21H,7H2,1-4H3,(H4,19,20,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from rat liver. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253580
![PNG](/data/jpeg/tenK5025/BindingDB_50253580.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-ethylamino]quin...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-14-7-8-15-5-3-4-6-16(15)11-14)17-9-10-19-18(12-17)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253579
![PNG](/data/jpeg/tenK5025/BindingDB_50253579.png) (2,4-Diamino-6-[N-(alpha-naphthyl)-N-ethylamino]qui...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-15-8-5-7-14-6-3-4-9-17(14)15)16-10-11-19-18(12-16)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253579
![PNG](/data/jpeg/tenK5025/BindingDB_50253579.png) (2,4-Diamino-6-[N-(alpha-naphthyl)-N-ethylamino]qui...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-15-8-5-7-14-6-3-4-9-17(14)15)16-10-11-19-18(12-16)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18268
![PNG](/data/jpeg/tenK1/BindingDB_18268.png) (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from rat liver. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18268
![PNG](/data/jpeg/tenK1/BindingDB_18268.png) (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253612
![PNG](/data/jpeg/tenK5025/BindingDB_50253612.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylami...)Show InChI InChI=1S/C20H25N5O2/c1-4-9-25(12-13-10-15(26-2)6-8-18(13)27-3)14-5-7-17-16(11-14)19(21)24-20(22)23-17/h5-8,10-11H,4,9,12H2,1-3H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253578
![PNG](/data/jpeg/tenK5025/BindingDB_50253578.png) (2,4-Diamino-6-[N-(benzyl)-N-ethylamino]quinazoline...)Show InChI InChI=1S/C17H19N5/c1-2-22(11-12-6-4-3-5-7-12)13-8-9-15-14(10-13)16(18)21-17(19)20-15/h3-10H,2,11H2,1H3,(H4,18,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253581
![PNG](/data/jpeg/tenK5025/BindingDB_50253581.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamin...)Show InChI InChI=1S/C19H23N5O2/c1-4-24(11-12-9-14(25-2)6-8-17(12)26-3)13-5-7-16-15(10-13)18(20)23-19(21)22-16/h5-10H,4,11H2,1-3H3,(H4,20,21,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253578
![PNG](/data/jpeg/tenK5025/BindingDB_50253578.png) (2,4-Diamino-6-[N-(benzyl)-N-ethylamino]quinazoline...)Show InChI InChI=1S/C17H19N5/c1-2-22(11-12-6-4-3-5-7-12)13-8-9-15-14(10-13)16(18)21-17(19)20-15/h3-10H,2,11H2,1H3,(H4,18,19,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18224
![PNG](/data/jpeg/tenK1/BindingDB_18224.png) (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253581
![PNG](/data/jpeg/tenK5025/BindingDB_50253581.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamin...)Show InChI InChI=1S/C19H23N5O2/c1-4-24(11-12-9-14(25-2)6-8-17(12)26-3)13-5-7-16-15(10-13)18(20)23-19(21)22-16/h5-10H,4,11H2,1-3H3,(H4,20,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253612
![PNG](/data/jpeg/tenK5025/BindingDB_50253612.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylami...)Show InChI InChI=1S/C20H25N5O2/c1-4-9-25(12-13-10-15(26-2)6-8-18(13)27-3)14-5-7-17-16(11-14)19(21)24-20(22)23-17/h5-8,10-11H,4,9,12H2,1-3H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50051913
![PNG](/data/jpeg/tenK5005/BindingDB_50051913.png) (CHEMBL32113 | N*6*-(2,5-Dimethoxy-benzyl)-N*6*-met...)Show InChI InChI=1S/C17H20N6O2/c1-23(9-10-6-12(24-2)4-5-14(10)25-3)11-7-13-15(18)21-17(19)22-16(13)20-8-11/h4-8H,9H2,1-3H3,(H4,18,19,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50051913
![PNG](/data/jpeg/tenK5005/BindingDB_50051913.png) (CHEMBL32113 | N*6*-(2,5-Dimethoxy-benzyl)-N*6*-met...)Show InChI InChI=1S/C17H20N6O2/c1-23(9-10-6-12(24-2)4-5-14(10)25-3)11-7-13-15(18)21-17(19)22-16(13)20-8-11/h4-8H,9H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253579
![PNG](/data/jpeg/tenK5025/BindingDB_50253579.png) (2,4-Diamino-6-[N-(alpha-naphthyl)-N-ethylamino]qui...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-15-8-5-7-14-6-3-4-9-17(14)15)16-10-11-19-18(12-16)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253611
![PNG](/data/jpeg/tenK5025/BindingDB_50253611.png) (2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)Show SMILES CCN(Cc1cc(Cl)cc(Cl)c1Cl)c1ccc2nc(N)nc(N)c2c1 Show InChI InChI=1S/C17H16Cl3N5/c1-2-25(8-9-5-10(18)6-13(19)15(9)20)11-3-4-14-12(7-11)16(21)24-17(22)23-14/h3-7H,2,8H2,1H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253580
![PNG](/data/jpeg/tenK5025/BindingDB_50253580.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-ethylamino]quin...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-14-7-8-15-5-3-4-6-16(15)11-14)17-9-10-19-18(12-17)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253614
![PNG](/data/jpeg/tenK5025/BindingDB_50253614.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-cycloprop...)Show InChI InChI=1S/C21H27N5O2/c1-4-5-10-26(13-14-11-16(27-2)7-9-19(14)28-3)15-6-8-18-17(12-15)20(22)25-21(23)24-18/h6-9,11-12H,4-5,10,13H2,1-3H3,(H4,22,23,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50029772
![PNG](/data/jpeg/tenK5002/BindingDB_50029772.png) (5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)Show InChI InChI=1S/C18H22N6O3/c1-9-10(8-22-17-14(9)16(19)23-18(20)24-17)7-21-11-5-12(25-2)15(27-4)13(6-11)26-3/h5-6,8,21H,7H2,1-4H3,(H4,19,20,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50029766
![PNG](/data/jpeg/tenK5002/BindingDB_50029766.png) (2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1cnc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C19H24N6O3/c1-10-11(8-22-18-15(10)17(20)23-19(21)24-18)9-25(2)12-6-13(26-3)16(28-5)14(7-12)27-4/h6-8H,9H2,1-5H3,(H4,20,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from rat liver. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253579
![PNG](/data/jpeg/tenK5025/BindingDB_50253579.png) (2,4-Diamino-6-[N-(alpha-naphthyl)-N-ethylamino]qui...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-15-8-5-7-14-6-3-4-9-17(14)15)16-10-11-19-18(12-16)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50056235
![PNG](/data/jpeg/tenK5005/BindingDB_50056235.png) (6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1cnc2nc(N)nc(N)c2c1 Show InChI InChI=1S/C18H22N6O3/c1-24(11-6-13(25-2)15(27-4)14(7-11)26-3)9-10-5-12-16(19)22-18(20)23-17(12)21-8-10/h5-8H,9H2,1-4H3,(H4,19,20,21,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253612
![PNG](/data/jpeg/tenK5025/BindingDB_50253612.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylami...)Show InChI InChI=1S/C20H25N5O2/c1-4-9-25(12-13-10-15(26-2)6-8-18(13)27-3)14-5-7-17-16(11-14)19(21)24-20(22)23-17/h5-8,10-11H,4,9,12H2,1-3H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253614
![PNG](/data/jpeg/tenK5025/BindingDB_50253614.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-cycloprop...)Show InChI InChI=1S/C21H27N5O2/c1-4-5-10-26(13-14-11-16(27-2)7-9-19(14)28-3)15-6-8-18-17(12-15)20(22)25-21(23)24-18/h6-9,11-12H,4-5,10,13H2,1-3H3,(H4,22,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253581
![PNG](/data/jpeg/tenK5025/BindingDB_50253581.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamin...)Show InChI InChI=1S/C19H23N5O2/c1-4-24(11-12-9-14(25-2)6-8-17(12)26-3)13-5-7-16-15(10-13)18(20)23-19(21)22-16/h5-10H,4,11H2,1-3H3,(H4,20,21,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM18268
![PNG](/data/jpeg/tenK1/BindingDB_18268.png) (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18268
![PNG](/data/jpeg/tenK1/BindingDB_18268.png) (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM18224
![PNG](/data/jpeg/tenK1/BindingDB_18224.png) (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from toxoplasma gondii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253580
![PNG](/data/jpeg/tenK5025/BindingDB_50253580.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-ethylamino]quin...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-14-7-8-15-5-3-4-6-16(15)11-14)17-9-10-19-18(12-17)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253613
![PNG](/data/jpeg/tenK5025/BindingDB_50253613.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-propylamino]qui...)Show InChI InChI=1S/C22H23N5/c1-2-11-27(14-15-7-8-16-5-3-4-6-17(16)12-15)18-9-10-20-19(13-18)21(23)26-22(24)25-20/h3-10,12-13H,2,11,14H2,1H3,(H4,23,24,25,26) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50029766
![PNG](/data/jpeg/tenK5002/BindingDB_50029766.png) (2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1cnc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C19H24N6O3/c1-10-11(8-22-18-15(10)17(20)23-19(21)24-18)9-25(2)12-6-13(26-3)16(28-5)14(7-12)27-4/h6-8H,9H2,1-5H3,(H4,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of dihydrofolate reductase from pneumocystis carinii. |
J Med Chem 46: 5074-82 (2003)
Article DOI: 10.1021/jm030312n BindingDB Entry DOI: 10.7270/Q2J38RZ9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253611
![PNG](/data/jpeg/tenK5025/BindingDB_50253611.png) (2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)Show SMILES CCN(Cc1cc(Cl)cc(Cl)c1Cl)c1ccc2nc(N)nc(N)c2c1 Show InChI InChI=1S/C17H16Cl3N5/c1-2-25(8-9-5-10(18)6-13(19)15(9)20)11-3-4-14-12(7-11)16(21)24-17(22)23-14/h3-7H,2,8H2,1H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253580
![PNG](/data/jpeg/tenK5025/BindingDB_50253580.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-ethylamino]quin...)Show InChI InChI=1S/C21H21N5/c1-2-26(13-14-7-8-15-5-3-4-6-16(15)11-14)17-9-10-19-18(12-17)20(22)25-21(23)24-19/h3-12H,2,13H2,1H3,(H4,22,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253615
![PNG](/data/jpeg/tenK5025/BindingDB_50253615.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-cyclopropyl met...)Show InChI InChI=1S/C23H25N5/c1-2-3-12-28(15-16-8-9-17-6-4-5-7-18(17)13-16)19-10-11-21-20(14-19)22(24)27-23(25)26-21/h4-11,13-14H,2-3,12,15H2,1H3,(H4,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50253614
![PNG](/data/jpeg/tenK5025/BindingDB_50253614.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-cycloprop...)Show InChI InChI=1S/C21H27N5O2/c1-4-5-10-26(13-14-11-16(27-2)7-9-19(14)28-3)15-6-8-18-17(12-15)20(22)25-21(23)24-18/h6-9,11-12H,4-5,10,13H2,1-3H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium avium dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253613
![PNG](/data/jpeg/tenK5025/BindingDB_50253613.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-propylamino]qui...)Show InChI InChI=1S/C22H23N5/c1-2-11-27(14-15-7-8-16-5-3-4-6-17(16)12-15)18-9-10-20-19(13-18)21(23)26-22(24)25-20/h3-10,12-13H,2,11,14H2,1H3,(H4,23,24,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50253611
![PNG](/data/jpeg/tenK5025/BindingDB_50253611.png) (2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)Show SMILES CCN(Cc1cc(Cl)cc(Cl)c1Cl)c1ccc2nc(N)nc(N)c2c1 Show InChI InChI=1S/C17H16Cl3N5/c1-2-25(8-9-5-10(18)6-13(19)15(9)20)11-3-4-14-12(7-11)16(21)24-17(22)23-14/h3-7H,2,8H2,1H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253613
![PNG](/data/jpeg/tenK5025/BindingDB_50253613.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-propylamino]qui...)Show InChI InChI=1S/C22H23N5/c1-2-11-27(14-15-7-8-16-5-3-4-6-17(16)12-15)18-9-10-20-19(13-18)21(23)26-22(24)25-20/h3-10,12-13H,2,11,14H2,1H3,(H4,23,24,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253611
![PNG](/data/jpeg/tenK5025/BindingDB_50253611.png) (2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)Show SMILES CCN(Cc1cc(Cl)cc(Cl)c1Cl)c1ccc2nc(N)nc(N)c2c1 Show InChI InChI=1S/C17H16Cl3N5/c1-2-25(8-9-5-10(18)6-13(19)15(9)20)11-3-4-14-12(7-11)16(21)24-17(22)23-14/h3-7H,2,8H2,1H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253578
![PNG](/data/jpeg/tenK5025/BindingDB_50253578.png) (2,4-Diamino-6-[N-(benzyl)-N-ethylamino]quinazoline...)Show InChI InChI=1S/C17H19N5/c1-2-22(11-12-6-4-3-5-7-12)13-8-9-15-14(10-13)16(18)21-17(19)20-15/h3-10H,2,11H2,1H3,(H4,18,19,20,21) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50253615
![PNG](/data/jpeg/tenK5025/BindingDB_50253615.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-cyclopropyl met...)Show InChI InChI=1S/C23H25N5/c1-2-3-12-28(15-16-8-9-17-6-4-5-7-18(17)13-16)19-10-11-21-20(14-19)22(24)27-23(25)26-21/h4-11,13-14H,2-3,12,15H2,1H3,(H4,24,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253614
![PNG](/data/jpeg/tenK5025/BindingDB_50253614.png) (2,4-Diamino-6-[N-(2,5-dimethoxybenzyl)-N-cycloprop...)Show InChI InChI=1S/C21H27N5O2/c1-4-5-10-26(13-14-11-16(27-2)7-9-19(14)28-3)15-6-8-18-17(12-15)20(22)25-21(23)24-18/h6-9,11-12H,4-5,10,13H2,1-3H3,(H4,22,23,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50066490
![PNG](/data/jpeg/tenK5006/BindingDB_50066490.png) (2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLA...)Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-8-13(24-2)5-7-16(11)25-3)12-4-6-15-14(9-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of rat liver dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50253613
![PNG](/data/jpeg/tenK5025/BindingDB_50253613.png) (2,4-Diamino-6-[N-(beta-naphthyl)-N-propylamino]qui...)Show InChI InChI=1S/C22H23N5/c1-2-11-27(14-15-7-8-16-5-3-4-6-17(16)12-15)18-9-10-20-19(13-18)21(23)26-22(24)25-20/h3-10,12-13H,2,11,14H2,1H3,(H4,23,24,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Pneumocystis carinii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50066490
![PNG](/data/jpeg/tenK5006/BindingDB_50066490.png) (2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLA...)Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-8-13(24-2)5-7-16(11)25-3)12-4-6-15-14(9-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii dihydrofolate reductase |
J Med Chem 51: 6195-200 (2008)
Article DOI: 10.1021/jm800694g BindingDB Entry DOI: 10.7270/Q2BP03PT |
More data for this Ligand-Target Pair | |