Compile Data Set for Download or QSAR

Found 144 hits with Last Name = 'casey' and Initial = 'pj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14713 (GGTI-DU40 | N-[(1S)-1-carbamoyl-2-phenylethyl]-4-{...) Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccccc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C30H31Cl2N5O3S/c1-41-16-13-23-28(21-9-5-14-34-19-21)36-37(22-11-12-24(31)25(32)18-22)30(23)40-15-6-10-27(38)35-26(29(33)39)17-20-7-3-2-4-8-20/h2-5,7-9,11-12,14,18-19,26H,6,10,13,15-17H2,1H3,(H2,33,39)(H,35,38)/t26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	8.24	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...				J Biol Chem 281: 12445-50 (2006) Article DOI: 10.1074/jbc.M600168200 BindingDB Entry DOI: 10.7270/Q2PC30N8
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327720 (1-octyl-3-(pyrrolidin-1-ylmethyl)-5-m-tolyl-1H-ind...) Show SMILES CCCCCCCCn1cc(CN2CCCC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C28H38N2/c1-3-4-5-6-7-8-18-30-22-26(21-29-16-9-10-17-29)27-20-25(14-15-28(27)30)24-13-11-12-23(2)19-24/h11-15,19-20,22H,3-10,16-18,21H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327731 (CHEMBL1257625 | N-ethyl-N-((1-octyl-5-p-tolyl-1H-i...) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccc(C)cc1 Show InChI InChI=1S/C28H40N2/c1-5-8-9-10-11-12-19-30-22-26(21-29(6-2)7-3)27-20-25(17-18-28(27)30)24-15-13-23(4)14-16-24/h13-18,20,22H,5-12,19,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327730 (CHEMBL1257624 | N-ethyl-N-((1-octyl-5-o-tolyl-1H-i...) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccccc1C Show InChI InChI=1S/C28H40N2/c1-5-8-9-10-11-14-19-30-22-25(21-29(6-2)7-3)27-20-24(17-18-28(27)30)26-16-13-12-15-23(26)4/h12-13,15-18,20,22H,5-11,14,19,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327721 (1-octyl-3-(piperidin-1-ylmethyl)-5-m-tolyl-1H-indo...) Show SMILES CCCCCCCCn1cc(CN2CCCCC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C29H40N2/c1-3-4-5-6-7-11-19-31-23-27(22-30-17-9-8-10-18-30)28-21-26(15-16-29(28)31)25-14-12-13-24(2)20-25/h12-16,20-21,23H,3-11,17-19,22H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327716 (CHEMBL1258659 | N-ethyl-N-((1-octyl-5-m-tolyl-1H-i...) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C28H40N2/c1-5-8-9-10-11-12-18-30-22-26(21-29(6-2)7-3)27-20-25(16-17-28(27)30)24-15-13-14-23(4)19-24/h13-17,19-20,22H,5-12,18,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327714 ((1-octyl-5-m-tolyl-1H-indol-3-yl)methanamine | CHE...) Show SMILES CCCCCCCCn1cc(CN)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C24H32N2/c1-3-4-5-6-7-8-14-26-18-22(17-25)23-16-21(12-13-24(23)26)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17,25H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327740 (CHEMBL1258097 | N,N-diethyl-2-(5-(3-methoxyphenyl)...) Show SMILES CCCCCCCCn1cc(CC(=O)N(CC)CC)c2cc(ccc12)-c1cccc(OC)c1 Show InChI InChI=1S/C29H40N2O2/c1-5-8-9-10-11-12-18-31-22-25(21-29(32)30(6-2)7-3)27-20-24(16-17-28(27)31)23-14-13-15-26(19-23)33-4/h13-17,19-20,22H,5-12,18,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327718 (CHEMBL1258775 | N-((1-octyl-5-m-tolyl-1H-indol-3-y...) Show SMILES CCCCCCCCn1cc(CN(CCC)CCC)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C30H44N2/c1-5-8-9-10-11-12-20-32-24-28(23-31(18-6-2)19-7-3)29-22-27(16-17-30(29)32)26-15-13-14-25(4)21-26/h13-17,21-22,24H,5-12,18-20,23H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433080 (CHEMBL2376504) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cnc(N)nc1 Show InChI InChI=1S/C25H37N5/c1-4-7-8-9-10-11-14-30-19-22(18-29(5-2)6-3)23-15-20(12-13-24(23)30)21-16-27-25(26)28-17-21/h12-13,15-17,19H,4-11,14,18H2,1-3H3,(H2,26,27,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327722 (3-((4-methylpiperazin-1-yl)methyl)-1-octyl-5-m-tol...) Show SMILES CCCCCCCCn1cc(CN2CCN(C)CC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C29H41N3/c1-4-5-6-7-8-9-15-32-23-27(22-31-18-16-30(3)17-19-31)28-21-26(13-14-29(28)32)25-12-10-11-24(2)20-25/h10-14,20-21,23H,4-9,15-19,22H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327719 (CHEMBL1258776 | N-methyl-N-((1-octyl-5-m-tolyl-1H-...) Show SMILES CCCCCCCCn1cc(CN(C)C(C)C)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C28H40N2/c1-6-7-8-9-10-11-17-30-21-26(20-29(5)22(2)3)27-19-25(15-16-28(27)30)24-14-12-13-23(4)18-24/h12-16,18-19,21-22H,6-11,17,20H2,1-5H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433083 (CHEMBL2376433) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccncc1F Show InChI InChI=1S/C26H36FN3/c1-4-7-8-9-10-11-16-30-20-22(19-29(5-2)6-3)24-17-21(12-13-26(24)30)23-14-15-28-18-25(23)27/h12-15,17-18,20H,4-11,16,19H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327707 (2-(1-(3,7-dimethylocta-2,6-dienyl)-5-m-tolyl-1H-in...) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-n1cc(-[#6]-[#6](-[#7])=O)c2cc(ccc12)-c1cccc(-[#6])c1 Show InChI InChI=1S/C27H32N2O/c1-19(2)7-5-8-20(3)13-14-29-18-24(17-27(28)30)25-16-23(11-12-26(25)29)22-10-6-9-21(4)15-22/h6-7,9-13,15-16,18H,5,8,14,17H2,1-4H3,(H2,28,30)/b20-13+	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327697 (2-(1-octyl-5-o-tolyl-1H-indol-3-yl)acetamide | CHE...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1ccccc1C Show InChI InChI=1S/C25H32N2O/c1-3-4-5-6-7-10-15-27-18-21(17-25(26)28)23-16-20(13-14-24(23)27)22-12-9-8-11-19(22)2/h8-9,11-14,16,18H,3-7,10,15,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327698 (2-(1-octyl-5-p-tolyl-1H-indol-3-yl)acetamide | CHE...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1ccc(C)cc1 Show InChI InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-15-27-18-22(17-25(26)28)23-16-21(13-14-24(23)27)20-11-9-19(2)10-12-20/h9-14,16,18H,3-8,15,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327741 (2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)-N,N-d...) Show SMILES CCCCCCCCn1cc(CC(=O)N(CC)CC)c2cc(ccc12)-c1cccc(OCC)c1 Show InChI InChI=1S/C30H42N2O2/c1-5-9-10-11-12-13-19-32-23-26(22-30(33)31(6-2)7-3)28-21-25(17-18-29(28)32)24-15-14-16-27(20-24)34-8-4/h14-18,20-21,23H,5-13,19,22H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327725 (3-(1-octyl-5-m-tolyl-1H-indol-3-yl)propanamide | C...) Show SMILES CCCCCCCCn1cc(CCC(N)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C26H34N2O/c1-3-4-5-6-7-8-16-28-19-23(13-15-26(27)29)24-18-22(12-14-25(24)28)21-11-9-10-20(2)17-21/h9-12,14,17-19H,3-8,13,15-16H2,1-2H3,(H2,27,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327729 (CHEMBL1257507 | N-((1-octyl-5-m-tolyl-1H-indol-3-y...) Show SMILES CCCCCCCCn1cc(CNS(C)(=O)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C25H34N2O2S/c1-4-5-6-7-8-9-15-27-19-23(18-26-30(3,28)29)24-17-22(13-14-25(24)27)21-12-10-11-20(2)16-21/h10-14,16-17,19,26H,4-9,15,18H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327711 (2-(1-octyl-5-m-tolyl-1H-indol-3-yl)-1-(pyrrolidin-...) Show SMILES CCCCCCCCn1cc(CC(=O)N2CCCC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C29H38N2O/c1-3-4-5-6-7-8-18-31-22-26(21-29(32)30-16-9-10-17-30)27-20-25(14-15-28(27)31)24-13-11-12-23(2)19-24/h11-15,19-20,22H,3-10,16-18,21H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327715 (CHEMBL1258548 | N,N-dimethyl-1-(1-octyl-5-m-tolyl-...) Show SMILES CCCCCCCCn1cc(CN(C)C)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C26H36N2/c1-5-6-7-8-9-10-16-28-20-24(19-27(3)4)25-18-23(14-15-26(25)28)22-13-11-12-21(2)17-22/h11-15,17-18,20H,5-10,16,19H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327700 (2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)acetam...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(OCC)c1 Show InChI InChI=1S/C26H34N2O2/c1-3-5-6-7-8-9-15-28-19-22(18-26(27)29)24-17-21(13-14-25(24)28)20-11-10-12-23(16-20)30-4-2/h10-14,16-17,19H,3-9,15,18H2,1-2H3,(H2,27,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327710 (CHEMBL1258326 | N,N-diethyl-2-(1-octyl-5-m-tolyl-1...) Show SMILES CCCCCCCCn1cc(CC(=O)N(CC)CC)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C29H40N2O/c1-5-8-9-10-11-12-18-31-22-26(21-29(32)30(6-2)7-3)27-20-25(16-17-28(27)31)24-15-13-14-23(4)19-24/h13-17,19-20,22H,5-12,18,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327696 (2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | CHE...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-14-27-18-22(17-25(26)28)23-16-21(12-13-24(23)27)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327709 (CHEMBL1258210 | N,N-dimethyl-2-(1-octyl-5-m-tolyl-...) Show SMILES CCCCCCCCn1cc(CC(=O)N(C)C)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C27H36N2O/c1-5-6-7-8-9-10-16-29-20-24(19-27(30)28(3)4)25-18-23(14-15-26(25)29)22-13-11-12-21(2)17-22/h11-15,17-18,20H,5-10,16,19H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433082 (CHEMBL2376434) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cncnc1 Show InChI InChI=1S/C25H36N4/c1-4-7-8-9-10-11-14-29-19-23(18-28(5-2)6-3)24-15-21(12-13-25(24)29)22-16-26-20-27-17-22/h12-13,15-17,19-20H,4-11,14,18H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433089 (CHEMBL2376427) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cccc(F)c1 Show InChI InChI=1S/C27H37FN2/c1-4-7-8-9-10-11-17-30-21-24(20-29(5-2)6-3)26-19-23(15-16-27(26)30)22-13-12-14-25(28)18-22/h12-16,18-19,21H,4-11,17,20H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433084 (CHEMBL2376432) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccc(nc1)N(C)C Show InChI InChI=1S/C28H42N4/c1-6-9-10-11-12-13-18-32-22-25(21-31(7-2)8-3)26-19-23(14-16-27(26)32)24-15-17-28(29-20-24)30(4)5/h14-17,19-20,22H,6-13,18,21H2,1-5H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327717 (CHEMBL1258660 | N-isopropyl-N-((1-octyl-5-m-tolyl-...) Show SMILES CCCCCCCCn1cc(CN(C(C)C)C(C)C)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C30H44N2/c1-7-8-9-10-11-12-18-31-21-28(22-32(23(2)3)24(4)5)29-20-27(16-17-30(29)31)26-15-13-14-25(6)19-26/h13-17,19-21,23-24H,7-12,18,22H2,1-6H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327713 (1-(4-methylpiperazin-1-yl)-2-(1-octyl-5-m-tolyl-1H...) Show SMILES CCCCCCCCn1cc(CC(=O)N2CCN(C)CC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C30H41N3O/c1-4-5-6-7-8-9-15-33-23-27(22-30(34)32-18-16-31(3)17-19-32)28-21-26(13-14-29(28)33)25-12-10-11-24(2)20-25/h10-14,20-21,23H,4-9,15-19,22H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433087 (CHEMBL2376429) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccc(cc1)S(=O)(=O)NC Show InChI InChI=1S/C28H41N3O2S/c1-5-8-9-10-11-12-19-31-22-25(21-30(6-2)7-3)27-20-24(15-18-28(27)31)23-13-16-26(17-14-23)34(32,33)29-4/h13-18,20,22,29H,5-12,19,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433088 (CHEMBL2376428) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C28H40N2O2S/c1-5-8-9-10-11-12-19-30-22-25(21-29(6-2)7-3)27-20-24(15-18-28(27)30)23-13-16-26(17-14-23)33(4,31)32/h13-18,20,22H,5-12,19,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433085 (CHEMBL2376431) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cccnc1 Show InChI InChI=1S/C26H37N3/c1-4-7-8-9-10-11-17-29-21-24(20-28(5-2)6-3)25-18-22(14-15-26(25)29)23-13-12-16-27-19-23/h12-16,18-19,21H,4-11,17,20H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327712 (2-(1-octyl-5-m-tolyl-1H-indol-3-yl)-1-(piperidin-1...) Show SMILES CCCCCCCCn1cc(CC(=O)N2CCCCC2)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C30H40N2O/c1-3-4-5-6-7-9-19-32-23-27(22-30(33)31-17-10-8-11-18-31)28-21-26(15-16-29(28)32)25-14-12-13-24(2)20-25/h12-16,20-21,23H,3-11,17-19,22H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327701 (2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide | CHEM...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1ccccc1 Show InChI InChI=1S/C24H30N2O/c1-2-3-4-5-6-10-15-26-18-21(17-24(25)27)22-16-20(13-14-23(22)26)19-11-8-7-9-12-19/h7-9,11-14,16,18H,2-6,10,15,17H2,1H3,(H2,25,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327728 (CHEMBL1257506 | N-((1-octyl-5-m-tolyl-1H-indol-3-y...) Show SMILES CCCCCCCCn1cc(CNC(C)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C26H34N2O/c1-4-5-6-7-8-9-15-28-19-24(18-27-21(3)29)25-17-23(13-14-26(25)28)22-12-10-11-20(2)16-22/h10-14,16-17,19H,4-9,15,18H2,1-3H3,(H,27,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327699 (2-(5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl)aceta...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(OC)c1 Show InChI InChI=1S/C25H32N2O2/c1-3-4-5-6-7-8-14-27-18-21(17-25(26)28)23-16-20(12-13-24(23)27)19-10-9-11-22(15-19)29-2/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327696 (2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | CHE...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-14-27-18-22(17-25(26)28)23-16-21(12-13-24(23)27)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327735 (4-((1-(3-methylbut-2-enyl)-5-m-tolyl-1H-indol-3-yl...) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1cc(-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)c2cc(ccc12)-c1cccc(-[#6])c1 Show InChI InChI=1S/C25H30N2O/c1-19(2)9-10-27-18-23(17-26-11-13-28-14-12-26)24-16-22(7-8-25(24)27)21-6-4-5-20(3)15-21/h4-9,15-16,18H,10-14,17H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14713 (GGTI-DU40 | N-[(1S)-1-carbamoyl-2-phenylethyl]-4-{...) Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccccc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C30H31Cl2N5O3S/c1-41-16-13-23-28(21-9-5-14-34-19-21)36-37(22-11-12-24(31)25(32)18-22)30(23)40-15-6-10-27(38)35-26(29(33)39)17-20-7-3-2-4-8-20/h2-5,7-9,11-12,14,18-19,26H,6,10,13,15-17H2,1H3,(H2,33,39)(H,35,38)/t26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...				J Biol Chem 281: 12445-50 (2006) Article DOI: 10.1074/jbc.M600168200 BindingDB Entry DOI: 10.7270/Q2PC30N8
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327696 (2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | CHE...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-14-27-18-22(17-25(26)28)23-16-21(12-13-24(23)27)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of ICMT expressed in Sf9 cells				Bioorg Med Chem Lett 17: 1025-32 (2007) Article DOI: 10.1016/j.bmcl.2006.11.030 BindingDB Entry DOI: 10.7270/Q2X34ZP3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327734 (1-(3-methylbut-2-enyl)-3-(piperidin-1-ylmethyl)-5-...) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1cc(-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)c2cc(ccc12)-c1cccc(-[#6])c1 Show InChI InChI=1S/C26H32N2/c1-20(2)12-15-28-19-24(18-27-13-5-4-6-14-27)25-17-23(10-11-26(25)28)22-9-7-8-21(3)16-22/h7-12,16-17,19H,4-6,13-15,18H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327716 (CHEMBL1258659 | N-ethyl-N-((1-octyl-5-m-tolyl-1H-i...) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cccc(C)c1 Show InChI InChI=1S/C28H40N2/c1-5-8-9-10-11-12-18-30-22-26(21-29(6-2)7-3)27-20-25(16-17-28(27)30)24-15-13-14-23(4)19-24/h13-17,19-20,22H,5-12,18,21H2,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327700 (2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)acetam...) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(OCC)c1 Show InChI InChI=1S/C26H34N2O2/c1-3-5-6-7-8-9-15-28-19-22(18-26(27)29)24-17-21(13-14-25(24)28)20-11-10-12-23(16-20)30-4-2/h10-14,16-17,19H,3-9,15,18H2,1-2H3,(H2,27,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of ICMT expressed in Sf9 cells				Bioorg Med Chem Lett 17: 1025-32 (2007) Article DOI: 10.1016/j.bmcl.2006.11.030 BindingDB Entry DOI: 10.7270/Q2X34ZP3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433078 (CHEMBL2376506) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2ccc(F)cc12 Show InChI InChI=1S/C21H33FN2/c1-4-7-8-9-10-11-14-24-17-18(16-23(5-2)6-3)20-13-12-19(22)15-21(20)24/h12-13,15,17H,4-11,14,16H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433081 (CHEMBL2376435) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1cnc(nc1)C#N Show InChI InChI=1S/C26H35N5/c1-4-7-8-9-10-11-14-31-20-23(19-30(5-2)6-3)24-15-21(12-13-25(24)31)22-17-28-26(16-27)29-18-22/h12-13,15,17-18,20H,4-11,14,19H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433077 (CHEMBL2376507) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cccc(F)c12 Show InChI InChI=1S/C21H33FN2/c1-4-7-8-9-10-11-15-24-17-18(16-23(5-2)6-3)19-13-12-14-20(22)21(19)24/h12-14,17H,4-11,15-16H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50411513 (CHEMBL394211) Show SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(F)c1 Show InChI InChI=1S/C24H29FN2O/c1-2-3-4-5-6-7-13-27-17-20(16-24(26)28)22-15-19(11-12-23(22)27)18-9-8-10-21(25)14-18/h8-12,14-15,17H,2-7,13,16H2,1H3,(H2,26,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of ICMT expressed in Sf9 cells				Bioorg Med Chem Lett 17: 1025-32 (2007) Article DOI: 10.1016/j.bmcl.2006.11.030 BindingDB Entry DOI: 10.7270/Q2X34ZP3
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50327733 (CHEMBL1257748 | N-ethyl-N-((1-(3-methylbut-2-enyl)...) Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-c1cn(-[#6]\[#6]=[#6](\[#6])-[#6])c2ccc(cc12)-c1cccc(-[#6])c1 Show InChI InChI=1S/C25H32N2/c1-6-26(7-2)17-23-18-27(14-13-19(3)4)25-12-11-22(16-24(23)25)21-10-8-9-20(5)15-21/h8-13,15-16,18H,6-7,14,17H2,1-5H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting				J Med Chem 53: 6838-50 (2010) Article DOI: 10.1021/jm1002843 BindingDB Entry DOI: 10.7270/Q2VT1SB1
					More data for this Ligand-Target Pair
Protein-S-isoprenylcysteine O-methyltransferase (Homo sapiens (Human))	BDBM50433091 (CHEMBL2376425) Show SMILES CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H37N3/c1-4-7-8-9-10-11-18-31-22-26(21-30(5-2)6-3)27-19-25(16-17-28(27)31)24-14-12-23(20-29)13-15-24/h12-17,19,22H,4-11,18,21H2,1-3H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...				Eur J Med Chem 63: 378-86 (2013) Article DOI: 10.1016/j.ejmech.2013.02.007 BindingDB Entry DOI: 10.7270/Q25140M3
					More data for this Ligand-Target Pair

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