Found 422 hits Enz. Inhib. hit(s) with Target = 'Protein-S-isoprenylcysteine O-methyltransferase' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50183409
(CHEMBL3822531)Show SMILES [#6]-1-[#6]\[#6](-[#6]-[#6]-[#8]-1)=[#6](\c1cccs1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H18OS/c1-2-5-17-14-18(8-7-15(17)4-1)20(19-6-3-13-22-19)16-9-11-21-12-10-16/h1-8,13-14H,9-12H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes using increasing AFC substr... |
Medchemcomm 7: 1016-1021 (2016)
BindingDB Entry DOI: 10.7270/Q2C82C8P |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Rattus norvegicus) | BDBM50034278
(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyls...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-c1ccccc1-[#6](-[#8])=O Show InChI InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biological Research
Curated by ChEMBL
| Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems |
J Med Chem 38: 1267-72 (1995)
BindingDB Entry DOI: 10.7270/Q2N015KK |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50183409
(CHEMBL3822531)Show SMILES [#6]-1-[#6]\[#6](-[#6]-[#6]-[#8]-1)=[#6](\c1cccs1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H18OS/c1-2-5-17-14-18(8-7-15(17)4-1)20(19-6-3-13-22-19)16-9-11-21-12-10-16/h1-8,13-14H,9-12H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes with increasing [14C]-S... |
Medchemcomm 7: 1016-1021 (2016)
BindingDB Entry DOI: 10.7270/Q2C82C8P |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Saccharomyces cerevisiae) | BDBM50174225
(((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylsul...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6](-[#8-])=O Show InChI InChI=1S/C17H28O2S/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-20-13-17(18)19/h7,9,11H,5-6,8,10,12-13H2,1-4H3,(H,18,19)/p-1/b15-9+,16-11+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferase |
Bioorg Med Chem Lett 15: 5080-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.075
BindingDB Entry DOI: 10.7270/Q2028SBB |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Rattus norvegicus) | BDBM50034280
(2-Chloro-5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-c1ccc(Cl)c(c1)-[#6](-[#8])=O Show InChI InChI=1S/C22H30ClNO2/c1-16(2)7-5-8-17(3)9-6-10-18(4)13-14-24-19-11-12-21(23)20(15-19)22(25)26/h7,9,11-13,15,24H,5-6,8,10,14H2,1-4H3,(H,25,26)/b17-9+,18-13+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biological Research
Curated by ChEMBL
| Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems |
J Med Chem 38: 1267-72 (1995)
BindingDB Entry DOI: 10.7270/Q2N015KK |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Rattus norvegicus) | BDBM50034277
(CHEMBL23289 | Thioacetic acid S-((2E,6E)-3,7,11-tr...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6](-[#6])=O Show InChI InChI=1S/C17H28OS/c1-14(2)8-6-9-15(3)10-7-11-16(4)12-13-19-17(5)18/h8,10,12H,6-7,9,11,13H2,1-5H3/b15-10+,16-12+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
| PubMed
| 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biological Research
Curated by ChEMBL
| Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems |
J Med Chem 38: 1267-72 (1995)
BindingDB Entry DOI: 10.7270/Q2N015KK |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Saccharomyces cerevisiae) | BDBM50174226
(2-acetamido-3-[(2E,6E,10E)-3,7,11,15-tetramethylhe...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]S(=O)[#6]-[#6](-[#7]-[#6](-[#6])=O)-[#6](-[#8-])=O Show InChI InChI=1S/C25H41NO4S/c1-19(2)10-7-11-20(3)12-8-13-21(4)14-9-15-22(5)16-17-31(30)18-24(25(28)29)26-23(6)27/h10,12,14,16,24H,7-9,11,13,15,17-18H2,1-6H3,(H,26,27)(H,28,29)/p-1/b20-12+,21-14+,22-16+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferase |
Bioorg Med Chem Lett 15: 5080-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.075
BindingDB Entry DOI: 10.7270/Q2028SBB |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Rattus norvegicus) | BDBM50034276
(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyl-...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-c1ncccc1-[#6](-[#8])=O Show InChI InChI=1S/C21H29NO2S/c1-16(2)8-5-9-17(3)10-6-11-18(4)13-15-25-20-19(21(23)24)12-7-14-22-20/h7-8,10,12-14H,5-6,9,11,15H2,1-4H3,(H,23,24)/b17-10+,18-13+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biological Research
Curated by ChEMBL
| Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems |
J Med Chem 38: 1267-72 (1995)
BindingDB Entry DOI: 10.7270/Q2N015KK |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Saccharomyces cerevisiae) | BDBM50174224
((R)-2-Acetylamino-3-[(2Z,6E)-7,11-dimethyl-3-(3-me...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]\[#6]=[#6](/[#6])-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]-[#6](-[#6])=O)-[#6](-[#8-])=O Show InChI InChI=1S/C24H39NO3S/c1-18(2)9-7-10-20(5)11-8-12-22(14-13-19(3)4)15-16-29-17-23(24(27)28)25-21(6)26/h9,11,13,15,23H,7-8,10,12,14,16-17H2,1-6H3,(H,25,26)(H,27,28)/p-1/b20-11+,22-15-/t23-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| 1.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferase |
Bioorg Med Chem Lett 15: 5080-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.075
BindingDB Entry DOI: 10.7270/Q2028SBB |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Rattus norvegicus) | BDBM50034279
(5-Amino-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-c1ccc(-[#7])cc1-[#6](-[#8])=O Show InChI InChI=1S/C22H31NO2S/c1-16(2)7-5-8-17(3)9-6-10-18(4)13-14-26-21-12-11-19(23)15-20(21)22(24)25/h7,9,11-13,15H,5-6,8,10,14,23H2,1-4H3,(H,24,25)/b17-9+,18-13+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biological Research
Curated by ChEMBL
| Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems |
J Med Chem 38: 1267-72 (1995)
BindingDB Entry DOI: 10.7270/Q2N015KK |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502491
(CHEMBL4443354 | US11834430, Compound 41)Show SMILES C[C@H](COc1cccc(c1)-n1ccnc1C1CC1)Oc1ccc(cc1F)C#N |r| Show InChI InChI=1S/C22H20FN3O2/c1-15(28-21-8-5-16(13-24)11-20(21)23)14-27-19-4-2-3-18(12-19)26-10-9-25-22(26)17-6-7-17/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502491
(CHEMBL4443354 | US11834430, Compound 41)Show SMILES C[C@H](COc1cccc(c1)-n1ccnc1C1CC1)Oc1ccc(cc1F)C#N |r| Show InChI InChI=1S/C22H20FN3O2/c1-15(28-21-8-5-16(13-24)11-20(21)23)14-27-19-4-2-3-18(12-19)26-10-9-25-22(26)17-6-7-17/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502493
(CHEMBL4558383 | US11834430, Compound 81)Show SMILES COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-n1ccnc1C1CC1)C#N |r| Show InChI InChI=1S/C23H23N3O3/c1-16(29-21-9-6-17(14-24)12-22(21)27-2)15-28-20-5-3-4-19(13-20)26-11-10-25-23(26)18-7-8-18/h3-6,9-13,16,18H,7-8,15H2,1-2H3/t16-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502489
(CHEMBL4583704 | US11834430, Compound 72)Show SMILES COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-n1ccnc1C)C#N |r| Show InChI InChI=1S/C21H21N3O3/c1-15(27-20-8-7-17(13-22)11-21(20)25-3)14-26-19-6-4-5-18(12-19)24-10-9-23-16(24)2/h4-12,15H,14H2,1-3H3/t15-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637711
(3-methoxy-4-((1-(3- (2-methyl-1H- imidazol-1- yl)p...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502494
(CHEMBL4446351 | US11834430, Compound 9)Show InChI InChI=1S/C21H18ClN3O2/c22-19-12-15(14-23)4-7-20(19)27-11-10-26-18-3-1-2-17(13-18)25-9-8-24-21(25)16-5-6-16/h1-4,7-9,12-13,16H,5-6,10-11H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502494
(CHEMBL4446351 | US11834430, Compound 9)Show InChI InChI=1S/C21H18ClN3O2/c22-19-12-15(14-23)4-7-20(19)27-11-10-26-18-3-1-2-17(13-18)25-9-8-24-21(25)16-5-6-16/h1-4,7-9,12-13,16H,5-6,10-11H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637738
((S)-3-chloro-4-((1- (3-(2-methyl-1H- imidazol-1- y...)Show SMILES C[C@@H](COc1cccc(c1)-n1ccnc1C)Oc1ccc(cc1Cl)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502488
(CHEMBL4449942 | US11834430, Compound 62)Show InChI InChI=1S/C21H19N3O2/c22-15-16-4-8-19(9-5-16)25-12-13-26-20-3-1-2-18(14-20)24-11-10-23-21(24)17-6-7-17/h1-5,8-11,14,17H,6-7,12-13H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502488
(CHEMBL4449942 | US11834430, Compound 62)Show InChI InChI=1S/C21H19N3O2/c22-15-16-4-8-19(9-5-16)25-12-13-26-20-3-1-2-18(14-20)24-11-10-23-21(24)17-6-7-17/h1-5,8-11,14,17H,6-7,12-13H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502492
(CHEMBL4446048 | US11834430, Compound 8)Show InChI InChI=1S/C20H19N3O3/c1-15-22-8-9-23(15)17-4-3-5-18(13-17)25-10-11-26-19-7-6-16(14-21)12-20(19)24-2/h3-9,12-13H,10-11H2,1-2H3 | KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502486
(CHEMBL4468997 | US11834430, Compound 5)Show InChI InChI=1S/C19H16ClN3O2/c1-14-22-7-8-23(14)16-3-2-4-17(12-16)24-9-10-25-19-6-5-15(13-21)11-18(19)20/h2-8,11-12H,9-10H2,1H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502492
(CHEMBL4446048 | US11834430, Compound 8)Show InChI InChI=1S/C20H19N3O3/c1-15-22-8-9-23(15)17-4-3-5-18(13-17)25-10-11-26-19-7-6-16(14-21)12-20(19)24-2/h3-9,12-13H,10-11H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637731
((S)-4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)ph...)Show SMILES C[C@@H](COc1cccc(c1)-n1ccnc1C1CC1)Oc1ccc(cc1C)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637758
(4-(2-((2-(2- cyclopropyl-1H- imidazol-1- yl)pyridi...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637735
(3-fluoro-4-(2-((2-(2- methyl-1H- imidazol-1- yl)py...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637730
((R)-3-methoxy-4- ((1-(3-(1-methyl- 1H-pyrazol-5- y...)Show SMILES COc1cc(ccc1O[C@H](C)COc1cccc(c1)-c1ccnn1C)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502489
(CHEMBL4583704 | US11834430, Compound 72)Show SMILES COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-n1ccnc1C)C#N |r| Show InChI InChI=1S/C21H21N3O3/c1-15(27-20-8-7-17(13-22)11-21(20)25-3)14-26-19-6-4-5-18(12-19)24-10-9-23-16(24)2/h4-12,15H,14H2,1-3H3/t15-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502490
(CHEMBL4464629 | US11834430, Compound 47)Show SMILES C[C@@H](COc1cccc(c1)-c1ccnn1C)Oc1ccc(cc1F)C#N |r| Show InChI InChI=1S/C20H18FN3O2/c1-14(26-20-7-6-15(12-22)10-18(20)21)13-25-17-5-3-4-16(11-17)19-8-9-23-24(19)2/h3-11,14H,13H2,1-2H3/t14-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637759
((R)-3-methoxy-4- ((1-(3-(2-methyl- 1H-imidazol-1- ...)Show SMILES COc1cc(ccc1O[C@H](C)COc1cccc(c1)-n1ccnc1C)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637719
(3-fluoro-4-((1-(3-(1- methyl-1H-pyrazol- 5- yl)phe...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637742
((S)-3-methoxy-4- ((1-(3-(1-methyl- 1H-pyrazol-5- y...)Show SMILES COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-c1ccnn1C)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637743
(4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)phenox...)Show SMILES CC(COc1cccc(c1)-n1ccnc1C1CC1)Oc1ccc(cc1C)C#N | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502487
(CHEMBL4473893 | US11834430, Compound 15)Show InChI InChI=1S/C20H19N3O3/c1-23-18(8-9-22-23)16-4-3-5-17(13-16)25-10-11-26-19-7-6-15(14-21)12-20(19)24-2/h3-9,12-13H,10-11H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502493
(CHEMBL4558383 | US11834430, Compound 81)Show SMILES COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-n1ccnc1C1CC1)C#N |r| Show InChI InChI=1S/C23H23N3O3/c1-16(29-21-9-6-17(14-24)12-22(21)27-2)15-28-20-5-3-4-19(13-20)26-11-10-25-23(26)18-7-8-18/h3-6,9-13,16,18H,7-8,15H2,1-2H3/t16-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50348075
(CHEMBL1800705)Show SMILES COc1cccc(NCCC2(CC(C)(C)OC(C)(C)C2)c2ccccc2)c1 Show InChI InChI=1S/C24H33NO2/c1-22(2)17-24(18-23(3,4)27-22,19-10-7-6-8-11-19)14-15-25-20-12-9-13-21(16-20)26-5/h6-13,16,25H,14-15,17-18H2,1-5H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Myrexis, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su... |
J Med Chem 54: 5031-47 (2011)
Article DOI: 10.1021/jm200249a
BindingDB Entry DOI: 10.7270/Q2XW4K49 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637728
((R)-3-fluoro-4-((1- (3-(1-methyl-1H- pyrazol-5- yl...)Show SMILES C[C@H](COc1cccc(c1)-c1ccnn1C)Oc1ccc(cc1F)C#N |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637706
(3-chloro-4-(2-((2-(2- methyl-1H- imidazol-1- yl)py...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502487
(CHEMBL4473893 | US11834430, Compound 15)Show InChI InChI=1S/C20H19N3O3/c1-23-18(8-9-22-23)16-4-3-5-17(13-16)25-10-11-26-19-7-6-15(14-21)12-20(19)24-2/h3-9,12-13H,10-11H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637713
(3-methoxy-4-((1-(3- (1-methyl-1H- pyrazol-5- yl)ph...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637750
((R)-4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)ph...)Show SMILES C[C@H](COc1cccc(c1)N1C=CNC1C1CC1)Oc1ccc(cc1C)C#N |r,c:12| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637715
((S)-3-chloro-4-(2- (3-(2-methyl-1H- imidazol-1- yl...)Show SMILES C[C@@H](COc1ccc(cc1Cl)C#N)Oc1cccc(c1)-n1ccnc1C |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637712
(3-methyl-4-((1-(3- (1-methyl-1H- pyrazol-5- yl)phe...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM50502495
(CHEMBL4445788 | US11834430, Compound 40)Show SMILES C[C@@H](COc1cccc(c1)-c1ccnn1C)Oc1ccc(cc1C)C#N |r| Show InChI InChI=1S/C21H21N3O2/c1-15-11-17(13-22)7-8-21(15)26-16(2)14-25-19-6-4-5-18(12-19)20-9-10-23-24(20)3/h4-12,16H,14H2,1-3H3/t16-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 10: 1024-1025 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00269
BindingDB Entry DOI: 10.7270/Q2FN19F4 |
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637710
(4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)phenox...)Show SMILES CC(COc1cccc(c1)-n1ccnc1C1CC1)Oc1ccc(cc1F)C#N | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637776
(4-(2-(3-fluoro-5-(1- methyl-1H-pyrazol- 5- yl)phen...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637786
(4-(2-(4-bromo-2- fluorophenoxy) ethoxy)-2-(2-methy...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637782
(3-chloro-4-(2-((2-(1- methyl-1H-pyrazol- 5-yl)pyri...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637688
(3-fluoro-4-(2-(3-(2- methyl-1H- imidazol-1- yl)phe...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein-S-isoprenylcysteine O-methyltransferase
(Homo sapiens (Human)) | BDBM637800
(3-chloro-4-(2-(3-(1- cyclopropyl-1H- pyrazol-5- yl...) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
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