Compile Data Set for Download or QSAR

Found 526 hits with Last Name = 'lowe' and Initial = 'r'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50054245 (5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...) Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410281 (CHEMBL2094063) Show SMILES CCCC[C@H](N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H30ClFN4O/c1-5-7-8-21(17-9-12-19(26)13-10-17)30(15-6-2)24-27-23(29(3)28-24)20-14-11-18(25)16-22(20)31-4/h9-14,16,21H,5-8,15H2,1-4H3/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162472 ((S)-[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,...) Show SMILES CCCCC(N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H31ClN4O/c1-5-7-13-21(18-11-9-8-10-12-18)29(16-6-2)24-26-23(28(3)27-24)20-15-14-19(25)17-22(20)30-4/h8-12,14-15,17,21H,5-7,13,16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410280 (CHEMBL2094043) Show SMILES CCCN([C@@H](CC)c1ccc(cc1)C(F)(F)F)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 |r| Show InChI InChI=1S/C23H26ClF3N4O/c1-5-13-31(19(6-2)15-7-9-16(10-8-15)23(25,26)27)22-28-21(30(3)29-22)18-12-11-17(24)14-20(18)32-4/h7-12,14,19H,5-6,13H2,1-4H3/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410278 (CHEMBL2093962) Show SMILES CCCC[C@H](N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 |r| Show InChI InChI=1S/C25H34N4O/c1-6-8-14-23(20-12-10-9-11-13-20)29(17-7-2)25-26-24(28(4)27-25)22-16-15-21(30-5)18-19(22)3/h9-13,15-16,18,23H,6-8,14,17H2,1-5H3/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162458 ((S)-[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,...) Show SMILES CCCC(N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C23H29ClN4O/c1-5-10-20(17-11-8-7-9-12-17)28(15-6-2)23-25-22(27(3)26-23)19-14-13-18(24)16-21(19)29-4/h7-9,11-14,16,20H,5-6,10,15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162472 ((S)-[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,...) Show SMILES CCCCC(N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H31ClN4O/c1-5-7-13-21(18-11-9-8-10-12-18)29(16-6-2)24-26-23(28(3)27-24)20-15-14-19(25)17-22(20)30-4/h8-12,14-15,17,21H,5-7,13,16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162452 (CHEMBL426419 | [5-(4-Methoxy-2-methyl-phenyl)-1-me...) Show SMILES CCCCC(N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 Show InChI InChI=1S/C25H34N4O/c1-6-8-14-23(20-12-10-9-11-13-20)29(17-7-2)25-26-24(28(4)27-25)22-16-15-21(30-5)18-19(22)3/h9-13,15-16,18,23H,6-8,14,17H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162462 (CHEMBL362453 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCCCC(N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccc(F)cc1 Show InChI InChI=1S/C24H30ClFN4O/c1-5-7-8-21(17-9-12-19(26)13-10-17)30(15-6-2)24-27-23(29(3)28-24)20-14-11-18(25)16-22(20)31-4/h9-14,16,21H,5-8,15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410279 (CHEMBL2094044) Show SMILES CCC[C@H](N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 |r| Show InChI InChI=1S/C24H32N4O/c1-6-11-22(19-12-9-8-10-13-19)28(16-7-2)24-25-23(27(4)26-24)21-15-14-20(29-5)17-18(21)3/h8-10,12-15,17,22H,6-7,11,16H2,1-5H3/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50107083 (CHEMBL110609 | [5-(2,4-Dichloro-phenyl)-1-methyl-1...) Show SMILES CCCN(C(C1CC1)C1CC1)c1nc(-c2ccc(Cl)cc2Cl)n(C)n1 Show InChI InChI=1S/C19H24Cl2N4/c1-3-10-25(17(12-4-5-12)13-6-7-13)19-22-18(24(2)23-19)15-9-8-14(20)11-16(15)21/h8-9,11-13,17H,3-7,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162470 (CHEMBL178117 | [5-(4-Methoxy-2-methyl-phenyl)-1-me...) Show SMILES CCCN(C(CC)c1ccc(cc1)C(F)(F)F)c1nc(-c2ccc(OC)cc2C)n(C)n1 Show InChI InChI=1S/C24H29F3N4O/c1-6-14-31(21(7-2)17-8-10-18(11-9-17)24(25,26)27)23-28-22(30(4)29-23)20-13-12-19(32-5)15-16(20)3/h8-13,15,21H,6-7,14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162476 (CHEMBL178735 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCCN(C(CC)c1ccc(cc1)C(F)(F)F)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 Show InChI InChI=1S/C23H26ClF3N4O/c1-5-13-31(19(6-2)15-7-9-16(10-8-15)23(25,26)27)22-28-21(30(3)29-22)18-12-11-17(24)14-20(18)32-4/h7-12,14,19H,5-6,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162458 ((S)-[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,...) Show SMILES CCCC(N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C23H29ClN4O/c1-5-10-20(17-11-8-7-9-12-17)28(15-6-2)23-25-22(27(3)26-23)19-14-13-18(24)16-21(19)29-4/h7-9,11-14,16,20H,5-6,10,15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162470 (CHEMBL178117 | [5-(4-Methoxy-2-methyl-phenyl)-1-me...) Show SMILES CCCN(C(CC)c1ccc(cc1)C(F)(F)F)c1nc(-c2ccc(OC)cc2C)n(C)n1 Show InChI InChI=1S/C24H29F3N4O/c1-6-14-31(21(7-2)17-8-10-18(11-9-17)24(25,26)27)23-28-22(30(4)29-23)20-13-12-19(32-5)15-16(20)3/h8-13,15,21H,6-7,14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162454 ((S)-[5-(2-Chloro-4,5-dimethoxy-phenyl)-1-methyl-1H...) Show SMILES CCCC(N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H31ClN4O2/c1-6-11-20(17-12-9-8-10-13-17)29(14-7-2)24-26-23(28(3)27-24)18-15-21(30-4)22(31-5)16-19(18)25/h8-10,12-13,15-16,20H,6-7,11,14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380515 (CHEMBL2019024) Show SMILES Cc1ccc2nc(SCc3ccccn3)[nH]c2c1 Show InChI InChI=1S/C14H13N3S/c1-10-5-6-12-13(8-10)17-14(16-12)18-9-11-4-2-3-7-15-11/h2-8H,9H2,1H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162457 (CHEMBL179647 | [5-(2,4-Dimethoxy-phenyl)-1-methyl-...) Show SMILES CCCC(N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H32N4O2/c1-6-11-21(18-12-9-8-10-13-18)28(16-7-2)24-25-23(27(3)26-24)20-15-14-19(29-4)17-22(20)30-5/h8-10,12-15,17,21H,6-7,11,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162474 (CHEMBL179540 | [5-(2,4-Dimethoxy-phenyl)-1-methyl-...) Show SMILES CCCCC(N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1)c1ccc(F)cc1 Show InChI InChI=1S/C25H33FN4O2/c1-6-8-9-22(18-10-12-19(26)13-11-18)30(16-7-2)25-27-24(29(3)28-25)21-15-14-20(31-4)17-23(21)32-5/h10-15,17,22H,6-9,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162465 (CHEMBL433940 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCCN(C(CC)c1ccccc1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 Show InChI InChI=1S/C22H27ClN4O/c1-5-14-27(19(6-2)16-10-8-7-9-11-16)22-24-21(26(3)25-22)18-13-12-17(23)15-20(18)28-4/h7-13,15,19H,5-6,14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50107069 (CHEMBL107786 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCCN(C(C1CC1)C1CC1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 Show InChI InChI=1S/C20H27ClN4O/c1-4-11-25(18(13-5-6-13)14-7-8-14)20-22-19(24(2)23-20)16-10-9-15(21)12-17(16)26-3/h9-10,12-14,18H,4-8,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380507 (CHEMBL2018921) Show SMILES COc1ccc2nc(SCc3ccc(I)cc3)[nH]c2c1 Show InChI InChI=1S/C15H13IN2OS/c1-19-12-6-7-13-14(8-12)18-15(17-13)20-9-10-2-4-11(16)5-3-10/h2-8H,9H2,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380531 (CHEMBL2018917) Show SMILES COc1ccc2nc(SCc3ccc(cc3)C(C)C)[nH]c2c1 Show InChI InChI=1S/C18H20N2OS/c1-12(2)14-6-4-13(5-7-14)11-22-18-19-16-9-8-15(21-3)10-17(16)20-18/h4-10,12H,11H2,1-3H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162459 (CHEMBL362847 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCCCC(CC)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 Show InChI InChI=1S/C20H31ClN4O/c1-6-9-10-16(8-3)25(13-7-2)20-22-19(24(4)23-20)17-12-11-15(21)14-18(17)26-5/h11-12,14,16H,6-10,13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410282 (CHEMBL2093960) Show SMILES CCCC[C@@H](N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H30ClFN4O/c1-5-7-8-21(17-9-12-19(26)13-10-17)30(15-6-2)24-27-23(29(3)28-24)20-14-11-18(25)16-22(20)31-4/h9-14,16,21H,5-8,15H2,1-4H3/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380510 (CHEMBL2018925) Show SMILES COc1ccc2nc(SCc3cccc(Oc4ccccc4)c3)[nH]c2c1 Show InChI InChI=1S/C21H18N2O2S/c1-24-17-10-11-19-20(13-17)23-21(22-19)26-14-15-6-5-9-18(12-15)25-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380514 (CHEMBL296580) Show SMILES C(Sc1nc2ccccc2[nH]1)c1ccccn1 Show InChI InChI=1S/C13H11N3S/c1-2-7-12-11(6-1)15-13(16-12)17-9-10-5-3-4-8-14-10/h1-8H,9H2,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380534 (CHEMBL2018908) Show SMILES CCCCCCCSc1nc2ccc(OC)cc2[nH]1 Show InChI InChI=1S/C15H22N2OS/c1-3-4-5-6-7-10-19-15-16-13-9-8-12(18-2)11-14(13)17-15/h8-9,11H,3-7,10H2,1-2H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410277 (CHEMBL2093961) Show SMILES CCC[C@@H](N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 |r| Show InChI InChI=1S/C24H32N4O/c1-6-11-22(19-12-9-8-10-13-19)28(16-7-2)24-25-23(27(4)26-24)21-15-14-20(29-5)17-18(21)3/h8-10,12-15,17,22H,6-7,11,16H2,1-5H3/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50275736 (6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...) Show SMILES COc1ccc2nc(SCc3ccc4ccccc4c3)[nH]c2c1 Show InChI InChI=1S/C19H16N2OS/c1-22-16-8-9-17-18(11-16)21-19(20-17)23-12-13-6-7-14-4-2-3-5-15(14)10-13/h2-11H,12H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380523 (CHEMBL2018909) Show SMILES COc1ccc2nc(SCC(C)C)[nH]c2c1 Show InChI InChI=1S/C12H16N2OS/c1-8(2)7-16-12-13-10-5-4-9(15-3)6-11(10)14-12/h4-6,8H,7H2,1-3H3,(H,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380521 (CHEMBL2018904) Show SMILES CCCCCSc1nc2ccc(OC)cc2[nH]1 Show InChI InChI=1S/C13H18N2OS/c1-3-4-5-8-17-13-14-11-7-6-10(16-2)9-12(11)15-13/h6-7,9H,3-5,8H2,1-2H3,(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162463 (CHEMBL175902 | [5-(4-Methoxy-2-methyl-phenyl)-1-me...) Show SMILES CCCC(N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H32N4O/c1-6-11-22(19-12-9-8-10-13-19)28(16-7-2)24-25-23(27(4)26-24)21-15-14-20(29-5)17-18(21)3/h8-10,12-15,17,22H,6-7,11,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380508 (CHEMBL2018923) Show SMILES COc1ccc2nc(SCc3cccc(c3)-c3ccccc3)[nH]c2c1 Show InChI InChI=1S/C21H18N2OS/c1-24-18-10-11-19-20(13-18)23-21(22-19)25-14-15-6-5-9-17(12-15)16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380522 (CHEMBL2018907) Show SMILES CCCCCCSc1nc2ccc(OC)cc2[nH]1 Show InChI InChI=1S/C14H20N2OS/c1-3-4-5-6-9-18-14-15-12-8-7-11(17-2)10-13(12)16-14/h7-8,10H,3-6,9H2,1-2H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380506 (CHEMBL2018920) Show SMILES COc1ccc2nc(SCc3ccc(Br)cc3)[nH]c2c1 Show InChI InChI=1S/C15H13BrN2OS/c1-19-12-6-7-13-14(8-12)18-15(17-13)20-9-10-2-4-11(16)5-3-10/h2-8H,9H2,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50275735 (2-(3,5-dimethoxybenzylthio)-6-methoxy-1H-benzo[d]i...) Show SMILES COc1ccc2nc(SCc3cc(OC)cc(OC)c3)[nH]c2c1 Show InChI InChI=1S/C17H18N2O3S/c1-20-12-4-5-15-16(9-12)19-17(18-15)23-10-11-6-13(21-2)8-14(7-11)22-3/h4-9H,10H2,1-3H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50385164 (CHEMBL2035944) Show SMILES Clc1ccc(CNC(=O)[C@H]2CN(CC3CC3)C[C@H]2C(=O)NC2CCN(Cc3ccccc3)C2)c(Cl)c1 |r| Show InChI InChI=1S/C28H34Cl2N4O2/c29-22-9-8-21(26(30)12-22)13-31-27(35)24-17-34(15-20-6-7-20)18-25(24)28(36)32-23-10-11-33(16-23)14-19-4-2-1-3-5-19/h1-5,8-9,12,20,23-25H,6-7,10-11,13-18H2,(H,31,35)(H,32,36)/t23?,24-,25+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [125I]NDPMSH from human MC4 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting				Bioorg Med Chem 20: 3565-74 (2012) Article DOI: 10.1016/j.bmc.2012.04.001 BindingDB Entry DOI: 10.7270/Q24M95K5
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50107084 (CHEMBL106972 | [5-(2,4-Dichloro-phenyl)-1-ethyl-1H...) Show SMILES CCCN(C(C1CC1)C1CC1)c1nc(-c2ccc(Cl)cc2Cl)n(CC)n1 Show InChI InChI=1S/C20H26Cl2N4/c1-3-11-25(18(13-5-6-13)14-7-8-14)20-23-19(26(4-2)24-20)16-10-9-15(21)12-17(16)22/h9-10,12-14,18H,3-8,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162454 ((S)-[5-(2-Chloro-4,5-dimethoxy-phenyl)-1-methyl-1H...) Show SMILES CCCC(N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H31ClN4O2/c1-6-11-20(17-12-9-8-10-13-17)29(14-7-2)24-26-23(28(3)27-24)18-15-21(30-4)22(31-5)16-19(18)25/h8-10,12-13,15-16,20H,6-7,11,14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	84	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380505 (CHEMBL2018919) Show SMILES COc1ccc2nc(SCc3ccc(Cl)cc3)[nH]c2c1 Show InChI InChI=1S/C15H13ClN2OS/c1-19-12-6-7-13-14(8-12)18-15(17-13)20-9-10-2-4-11(16)5-3-10/h2-8H,9H2,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162457 (CHEMBL179647 | [5-(2,4-Dimethoxy-phenyl)-1-methyl-...) Show SMILES CCCC(N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C24H32N4O2/c1-6-11-21(18-12-9-8-10-13-18)28(16-7-2)24-25-23(27(3)26-24)20-15-14-19(29-4)17-22(20)30-5/h8-10,12-15,17,21H,6-7,11,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380530 (CHEMBL2018916) Show SMILES COc1ccc2nc(SCc3ccc(C)cc3)[nH]c2c1 Show InChI InChI=1S/C16H16N2OS/c1-11-3-5-12(6-4-11)10-20-16-17-14-8-7-13(19-2)9-15(14)18-16/h3-9H,10H2,1-2H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380526 (CHEMBL2018912) Show SMILES COc1ccc2nc(SCC3CCCCC3)[nH]c2c1 Show InChI InChI=1S/C15H20N2OS/c1-18-12-7-8-13-14(9-12)17-15(16-13)19-10-11-5-3-2-4-6-11/h7-9,11H,2-6,10H2,1H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162451 (CHEMBL178346 | [5-(4-Chloro-2-methoxy-phenyl)-1-me...) Show SMILES CCC(N(CC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccccc1 Show InChI InChI=1S/C21H25ClN4O/c1-5-18(15-10-8-7-9-11-15)26(6-2)21-23-20(25(3)24-21)17-13-12-16(22)14-19(17)27-4/h7-14,18H,5-6H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50385162 (CHEMBL2035942) Show SMILES Clc1ccc(CCNC(=O)[C@H]2CN(CC3CC3)C[C@H]2C(=O)NC2CCN(Cc3ccccc3)C2)c(Cl)c1 |r| Show InChI InChI=1S/C29H36Cl2N4O2/c30-23-9-8-22(27(31)14-23)10-12-32-28(36)25-18-35(16-21-6-7-21)19-26(25)29(37)33-24-11-13-34(17-24)15-20-4-2-1-3-5-20/h1-5,8-9,14,21,24-26H,6-7,10-13,15-19H2,(H,32,36)(H,33,37)/t24?,25-,26+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [125I]NDPMSH from human MC4 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting				Bioorg Med Chem 20: 3565-74 (2012) Article DOI: 10.1016/j.bmc.2012.04.001 BindingDB Entry DOI: 10.7270/Q24M95K5
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380532 (CHEMBL2018918) Show SMILES COc1ccc2nc(SCc3ccc(cc3)C(C)(C)C)[nH]c2c1 Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)14-7-5-13(6-8-14)12-23-18-20-16-10-9-15(22-4)11-17(16)21-18/h5-11H,12H2,1-4H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50162469 (CHEMBL178667 | N-[5-(4-Chloro-2-methoxy-phenyl)-1-...) Show SMILES CCCCC(CC)N(OCCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 Show InChI InChI=1S/C20H31ClN4O2/c1-6-9-10-16(8-3)25(27-13-7-2)20-22-19(24(4)23-20)17-12-11-15(21)14-18(17)26-5/h11-12,14,16H,6-10,13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50380511 (CHEMBL2018926) Show SMILES COc1ccc2nc(SCc3ccc(OCc4ccccc4)cc3)[nH]c2c1 Show InChI InChI=1S/C22H20N2O2S/c1-25-19-11-12-20-21(13-19)24-22(23-20)27-15-17-7-9-18(10-8-17)26-14-16-5-3-2-4-6-16/h2-13H,14-15H2,1H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 mins				J Med Chem 55: 1205-14 (2012) Article DOI: 10.1021/jm201346g BindingDB Entry DOI: 10.7270/Q2QV3NHG
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410276 (CHEMBL2094064) Show SMILES CCCC[C@@H](N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1)c1ccccc1 |r| Show InChI InChI=1S/C25H34N4O/c1-6-8-14-23(20-12-10-9-11-13-20)29(17-7-2)25-26-24(28(4)27-25)22-16-15-21(30-5)18-19(22)3/h9-13,15-16,18,23H,6-8,14,17H2,1-5H3/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair

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