Found 74 hits with Last Name = 'sakuraba' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297070
(CHEMBL560474 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-2-3-16)27-21-11-9-19(13-28(14)21)26-23(29)20-10-6-17(12-25-20)15-4-7-18(24)8-5-15/h4-13,16H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297062
(4-(5-chloropyridin-2-yl)-N-(2-cyclopropyl-3-methyl...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cn3)cn12)C1CC1 Show InChI InChI=1S/C23H19ClN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)20-10-8-18(24)12-25-20/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297073
(CHEMBL564106 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-21(15-2-3-15)27-20-9-8-17(12-28(13)20)26-22(29)19-11-24-18(10-25-19)14-4-6-16(23)7-5-14/h4-12,15H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30177
(2-aminobenzimidazole-based compound, 25)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cc2[nH]1 Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-17-9-8-16(10-18(17)28-22)26-21(30)20-12-24-19(11-25-20)14-4-6-15(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30172
(2-aminobenzimidazole-based compound, 20)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C24H22F3N5O/c1-14(2)32(3)23-30-20-11-9-18(12-21(20)31-23)29-22(33)16-6-4-15(5-7-16)19-10-8-17(13-28-19)24(25,26)27/h4-14H,1-3H3,(H,29,33)(H,30,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297061
(CHEMBL551934 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccccn3)cn12)C1CC1 Show InChI InChI=1S/C23H20N4O/c1-15-22(17-7-8-17)26-21-12-11-19(14-27(15)21)25-23(28)18-9-5-16(6-10-18)20-4-2-3-13-24-20/h2-6,9-14,17H,7-8H2,1H3,(H,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297059
(CHEMBL561134 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C24H19F3N4O/c1-14-22(16-4-5-16)30-21-11-9-19(13-31(14)21)29-23(32)17-6-2-15(3-7-17)20-10-8-18(12-28-20)24(25,26)27/h2-3,6-13,16H,4-5H2,1H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297067
(CHEMBL565105 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(nc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C24H19F3N4O/c1-14-22(16-4-5-16)30-21-11-9-19(13-31(14)21)29-23(32)17-6-2-15(3-7-17)18-8-10-20(28-12-18)24(25,26)27/h2-3,6-13,16H,4-5H2,1H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297071
(CHEMBL562136 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-2-3-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-10-20(25-12-17)15-4-7-18(24)8-5-15/h4-13,16H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30164
(2-aminobenzimidazole-based compound, 12)Show SMILES CN(C1CCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C23H25F3N4O/c1-30(18-4-2-3-5-18)22-28-19-12-11-17(14-20(19)29-22)27-21(31)13-8-15-6-9-16(10-7-15)23(24,25)26/h6-7,9-12,14,18H,2-5,8,13H2,1H3,(H,27,31)(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | 22 | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297068
(CHEMBL551470 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)nc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)18-8-10-20(24)25-12-18/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297042
(CHEMBL557731 | N-(2-methylimidazo[1,2-a]pyridin-6-...)Show SMILES Cc1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C22H16F3N3O/c1-14-12-28-13-19(10-11-20(28)26-14)27-21(29)17-4-2-15(3-5-17)16-6-8-18(9-7-16)22(23,24)25/h2-13H,1H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297064
(CHEMBL563728 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(C)cn3)cn12)C1CC1 Show InChI InChI=1S/C24H22N4O/c1-15-3-11-21(25-13-15)17-4-8-19(9-5-17)24(29)26-20-10-12-22-27-23(18-6-7-18)16(2)28(22)14-20/h3-5,8-14,18H,6-7H2,1-2H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297052
(CHEMBL563725 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C25H20F3N3O/c1-15-23(18-4-5-18)30-22-13-12-21(14-31(15)22)29-24(32)19-6-2-16(3-7-19)17-8-10-20(11-9-17)25(26,27)28/h2-3,6-14,18H,4-5H2,1H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297063
(CHEMBL559680 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)cn3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)20-10-8-18(24)12-25-20/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297041
(CHEMBL557664 | N-(2-isopropylimidazo[1,2-a]pyridin...)Show SMILES CC(C)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C24H20F3N3O/c1-15(2)21-14-30-13-20(11-12-22(30)29-21)28-23(31)18-5-3-16(4-6-18)17-7-9-19(10-8-17)24(25,26)27/h3-15H,1-2H3,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30174
(2-aminobenzimidazole-based compound, 22)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cc2[nH]1 Show InChI InChI=1S/C23H22FN5O/c1-14(2)29(3)23-27-20-11-9-18(12-21(20)28-23)26-22(30)16-6-10-19(25-13-16)15-4-7-17(24)8-5-15/h4-14H,1-3H3,(H,26,30)(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297044
(CHEMBL557730 | N-(2-cyclopropylimidazo[1,2-a]pyrid...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2nc(cn2c1)C1CC1 Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)19-9-7-16(8-10-19)15-1-5-18(6-2-15)23(31)28-20-11-12-22-29-21(17-3-4-17)14-30(22)13-20/h1-2,5-14,17H,3-4H2,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30156
(2-aminobenzimidazole-based compound, 8)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C21H23F3N4O/c1-13(2)28(3)20-26-17-10-9-16(12-18(17)27-20)25-19(29)11-6-14-4-7-15(8-5-14)21(22,23)24/h4-5,7-10,12-13H,6,11H2,1-3H3,(H,25,29)(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | 21 | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297065
(CHEMBL563096 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES COc1ccc(nc1)-c1ccc(cc1)C(=O)Nc1ccc2nc(C3CC3)c(C)n2c1 Show InChI InChI=1S/C24H22N4O2/c1-15-23(17-5-6-17)27-22-12-9-19(14-28(15)22)26-24(29)18-7-3-16(4-8-18)21-11-10-20(30-2)13-25-21/h3-4,7-14,17H,5-6H2,1-2H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30165
(2-aminobenzimidazole-based compound, 13)Show SMILES CN(C1CCCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C24H27F3N4O/c1-31(19-5-3-2-4-6-19)23-29-20-13-12-18(15-21(20)30-23)28-22(32)14-9-16-7-10-17(11-8-16)24(25,26)27/h7-8,10-13,15,19H,2-6,9,14H2,1H3,(H,28,32)(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | 27 | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297072
(CHEMBL558826 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ncc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-20(15-2-3-15)27-19-9-8-18(12-28(13)19)26-22(29)21-24-10-16(11-25-21)14-4-6-17(23)7-5-14/h4-12,15H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297045
(CHEMBL549512 | N-(2-tert-butylimidazo[1,2-a]pyridi...)Show SMILES CC(C)(C)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C25H22F3N3O/c1-24(2,3)21-15-31-14-20(12-13-22(31)30-21)29-23(32)18-6-4-16(5-7-18)17-8-10-19(11-9-17)25(26,27)28/h4-15H,1-3H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297058
(CHEMBL556432 | N-(2-cyclopropylimidazo[1,2-a]pyrid...)Show SMILES FC(F)(F)c1ccc(nc1)-c1ccc(cc1)C(=O)Nc1ccc2nc(cn2c1)C1CC1 Show InChI InChI=1S/C23H17F3N4O/c24-23(25,26)17-7-9-19(27-11-17)14-3-5-16(6-4-14)22(31)28-18-8-10-21-29-20(15-1-2-15)13-30(21)12-18/h3-13,15H,1-2H2,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30173
(2-aminobenzimidazole-based compound, 21)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccccc3)cc2[nH]1 Show InChI InChI=1S/C23H23N5O/c1-15(2)28(3)23-26-20-12-10-18(13-21(20)27-23)25-22(29)17-9-11-19(24-14-17)16-7-5-4-6-8-16/h4-15H,1-3H3,(H,25,29)(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297043
(CHEMBL554287 | N-(2-propylimidazo[1,2-a]pyridin-6-...)Show SMILES CCCc1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C24H20F3N3O/c1-2-3-20-14-30-15-21(12-13-22(30)28-20)29-23(31)18-6-4-16(5-7-18)17-8-10-19(11-9-17)24(25,26)27/h4-15H,2-3H2,1H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297055
(CHEMBL562074 | N-(2-cyclopropyl-3-(hydroxymethyl)i...)Show SMILES OCc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C25H20F3N3O2/c26-25(27,28)19-9-7-16(8-10-19)15-1-5-18(6-2-15)24(33)29-20-11-12-22-30-23(17-3-4-17)21(14-32)31(22)13-20/h1-2,5-13,17,32H,3-4,14H2,(H,29,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30161
(2-aminobenzimidazole-based compound, 9)Show SMILES CN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C19H19F3N4O/c1-26(2)18-24-15-9-8-14(11-16(15)25-18)23-17(27)10-5-12-3-6-13(7-4-12)19(20,21)22/h3-4,6-9,11H,5,10H2,1-2H3,(H,23,27)(H,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30176
(2-aminobenzimidazole-based compound, 24)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ncc(cn3)-c3ccc(F)cc3)cc2[nH]1 Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-18-9-8-17(10-19(18)28-22)26-21(30)20-24-11-15(12-25-20)14-4-6-16(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297049
(CHEMBL560334 | N-(2-(2-hydroxypropan-2-yl)imidazo[...)Show SMILES CC(C)(O)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C24H20F3N3O2/c1-23(2,32)20-14-30-13-19(11-12-21(30)29-20)28-22(31)17-5-3-15(4-6-17)16-7-9-18(10-8-16)24(25,26)27/h3-14,32H,1-2H3,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30162
(2-aminobenzimidazole-based compound, 10)Show SMILES CCN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C20H21F3N4O/c1-3-27(2)19-25-16-10-9-15(12-17(16)26-19)24-18(28)11-6-13-4-7-14(8-5-13)20(21,22)23/h4-5,7-10,12H,3,6,11H2,1-2H3,(H,24,28)(H,25,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297068
(CHEMBL551470 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)nc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)18-8-10-20(24)25-12-18/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30168
(2-aminobenzimidazole-based compound, 16)Show SMILES CN(C1CCN(C)CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C24H28F3N5O/c1-31-13-11-19(12-14-31)32(2)23-29-20-9-8-18(15-21(20)30-23)28-22(33)10-5-16-3-6-17(7-4-16)24(25,26)27/h3-4,6-9,15,19H,5,10-14H2,1-2H3,(H,28,33)(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30163
(2-aminobenzimidazole-based compound, 11)Show SMILES CN(C1CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C21H21F3N4O/c1-28(16-8-9-16)20-26-17-10-7-15(12-18(17)27-20)25-19(29)11-4-13-2-5-14(6-3-13)21(22,23)24/h2-3,5-7,10,12,16H,4,8-9,11H2,1H3,(H,25,29)(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297061
(CHEMBL551934 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccccn3)cn12)C1CC1 Show InChI InChI=1S/C23H20N4O/c1-15-22(17-7-8-17)26-21-12-11-19(14-27(15)21)25-23(28)18-9-5-16(6-10-18)20-4-2-3-13-24-20/h2-6,9-14,17H,7-8H2,1H3,(H,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297053
(CHEMBL551332 | N-(2-cyclopropyl-3-ethylimidazo[1,2...)Show SMILES CCc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C26H22F3N3O/c1-2-22-24(18-5-6-18)31-23-14-13-21(15-32(22)23)30-25(33)19-7-3-16(4-8-19)17-9-11-20(12-10-17)26(27,28)29/h3-4,7-15,18H,2,5-6H2,1H3,(H,30,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30166
(2-aminobenzimidazole-based compound, 14)Show SMILES CN(C1CCOC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C22H23F3N4O2/c1-29(17-10-11-31-13-17)21-27-18-8-7-16(12-19(18)28-21)26-20(30)9-4-14-2-5-15(6-3-14)22(23,24)25/h2-3,5-8,12,17H,4,9-11,13H2,1H3,(H,26,30)(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297072
(CHEMBL558826 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ncc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-20(15-2-3-15)27-19-9-8-18(12-28(13)19)26-22(29)21-24-10-16(11-25-21)14-4-6-17(23)7-5-14/h4-12,15H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297048
(CHEMBL556296 | N-(2-(1-hydroxyethyl)imidazo[1,2-a]...)Show SMILES CC(O)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C23H18F3N3O2/c1-14(30)20-13-29-12-19(10-11-21(29)28-20)27-22(31)17-4-2-15(3-5-17)16-6-8-18(9-7-16)23(24,25)26/h2-14,30H,1H3,(H,27,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30167
(2-aminobenzimidazole-based compound, 15)Show SMILES CN(C1CCN(C1)C(C)=O)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C24H26F3N5O2/c1-15(33)32-12-11-19(14-32)31(2)23-29-20-9-8-18(13-21(20)30-23)28-22(34)10-5-16-3-6-17(7-4-16)24(25,26)27/h3-4,6-9,13,19H,5,10-12,14H2,1-2H3,(H,28,34)(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297051
(CHEMBL551408 | N-(2-((N-methylacetamido)methyl)imi...)Show SMILES CN(Cc1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1)C(C)=O Show InChI InChI=1S/C25H21F3N4O2/c1-16(33)31(2)13-22-15-32-14-21(11-12-23(32)29-22)30-24(34)19-5-3-17(4-6-19)18-7-9-20(10-8-18)25(26,27)28/h3-12,14-15H,13H2,1-2H3,(H,30,34) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30171
(2-aminobenzimidazole-based compound, 19)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cn3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C20H22F3N5O/c1-12(2)28(3)19-26-16-8-6-15(10-17(16)27-19)25-18(29)9-7-14-5-4-13(11-24-14)20(21,22)23/h4-6,8,10-12H,7,9H2,1-3H3,(H,25,29)(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297076
(CHEMBL559801 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cn3)-c3ccc(F)nc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-21(14-2-3-14)27-20-9-6-17(12-28(13)20)26-22(29)18-7-4-15(10-24-18)16-5-8-19(23)25-11-16/h4-12,14H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297066
(CHEMBL563836 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)S(C)(=O)=O)cn12)C1CC1 Show InChI InChI=1S/C24H22N4O3S/c1-15-23(17-5-6-17)27-22-12-9-19(14-28(15)22)26-24(29)18-7-3-16(4-8-18)21-11-10-20(13-25-21)32(2,30)31/h3-4,7-14,17H,5-6H2,1-2H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297070
(CHEMBL560474 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-2-3-16)27-21-11-9-19(13-28(14)21)26-23(29)20-10-6-17(12-25-20)15-4-7-18(24)8-5-15/h4-13,16H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297075
(CHEMBL558326 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)nc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-21(14-2-3-14)27-20-9-6-17(12-28(13)20)26-22(29)16-4-7-18(24-11-16)15-5-8-19(23)25-10-15/h4-12,14H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297073
(CHEMBL564106 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-21(15-2-3-15)27-20-9-8-17(12-28(13)20)26-22(29)19-11-24-18(10-25-19)14-4-6-16(23)7-5-14/h4-12,15H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297050
(CHEMBL563984 | N-(2-((dimethylamino)methyl)imidazo...)Show SMILES CN(C)Cc1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C24H21F3N4O/c1-30(2)13-21-15-31-14-20(11-12-22(31)28-21)29-23(32)18-5-3-16(4-6-18)17-7-9-19(10-8-17)24(25,26)27/h3-12,14-15H,13H2,1-2H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297064
(CHEMBL563728 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(C)cn3)cn12)C1CC1 Show InChI InChI=1S/C24H22N4O/c1-15-3-11-21(25-13-15)17-4-8-19(9-5-17)24(29)26-20-10-12-22-27-23(18-6-7-18)16(2)28(22)14-20/h3-5,8-14,18H,6-7H2,1-2H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297063
(CHEMBL559680 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)cn3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)20-10-8-18(24)12-25-20/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCH1 receptor expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Search and Browse
