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Compile Data Set for Download or QSAR

Found 105 hits with Last Name = 'fang' and Initial = 'sb'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Flt4 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 1.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 2.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551663
PNG
(CHEMBL4779315)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551665
PNG
(CHEMBL4740664)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)[C@@H](OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC |r|
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n/an/a 2.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551664
PNG
(CHEMBL4761612)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)[C@H](OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC |r|
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n/an/a 2.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564969
PNG
(CHEMBL4799113)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 2.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551667
PNG
(CHEMBL4752320)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4F)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Ron (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564965
PNG
(CHEMBL4790582)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 3.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Ron (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564967
PNG
(CHEMBL4778488)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50564969
PNG
(CHEMBL4799113)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 4.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-Kit (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 4.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of VEGFR 2 (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50551663
PNG
(CHEMBL4779315)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 4.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-Kit (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551666
PNG
(CHEMBL4799621)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4cccc(F)c4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 4.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FLT-4 (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of VEGFR2 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564963
PNG
(CHEMBL4790980)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 5.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 5.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FLT-3 (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564936
PNG
(CHEMBL4790688)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 5.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 5.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGFR alpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 5.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FLT3 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50551663
PNG
(CHEMBL4779315)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 6.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FLT3 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 6.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-Kit (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564968
PNG
(CHEMBL4783511)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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TBA

Assay Description
Inhibition of c-Kit (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564964
PNG
(CHEMBL4789479)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50564969
PNG
(CHEMBL4799113)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)cc1
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n/an/a 7.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FLT-3 (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551668
PNG
(CHEMBL4763363)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(Cl)cc4)C(C)(C)C)cc3F)c2cc1OC
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551669
PNG
(CHEMBL4795132)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4cccc(Cl)c4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564966
PNG
(CHEMBL4783902)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551670
PNG
(CHEMBL4795991)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4Cl)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 8.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564962
PNG
(CHEMBL4795003)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551658
PNG
(CHEMBL4777622)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 8.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564934
PNG
(CHEMBL4795288)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564950
PNG
(CHEMBL4799667)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccc(F)cc1
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n/an/a 9.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551684
PNG
(CHEMBL4800700)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(NC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC
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n/an/a 9.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551678
PNG
(CHEMBL4797876)
Show SMILES CCCCN(C(C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)C(C)(C)C)C(=O)c1ccc(F)cc1
PDB
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564937
PNG
(CHEMBL4784312)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1cccc(F)c1
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n/an/a 11n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 11n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGFR beta (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564932
PNG
(CHEMBL4800305)
Show SMILES CCCCOc1cc2nccc(Oc3ccc(N\C(CCOC)=N\S(=O)(=O)Cc4ccc(Cl)cc4)cc3F)c2cc1OC
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n/an/a 12n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551659
PNG
(CHEMBL4778577)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(C)cc4)C(C)(C)C)cc3F)c2cc1OC
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564938
PNG
(CHEMBL4784321)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccccc1F
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TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564951
PNG
(CHEMBL4799951)
Show SMILES COCC\C(Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)=N/S(=O)(=O)Cc1ccccc1
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564948
PNG
(CHEMBL4789523)
Show SMILES COc1cc2nccc(Oc3ccc(N\C(C)=N\S(=O)(=O)Cc4ccc(F)cc4)cc3F)c2cc1OC
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50564970
PNG
(CHEMBL4778663)
Show SMILES CCCCOc1cc2nccc(Oc3ccc(N\C(CCOC)=N\S(=O)(=O)Cc4ccc(Cl)c(Cl)c4)cc3F)c2cc1OC
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr)4:1 as substrate in presence of ATP measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112470
BindingDB Entry DOI: 10.7270/Q2QN6BJ8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551671
PNG
(CHEMBL4748906)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(Br)cc4)C(C)(C)C)cc3F)c2cc1OC
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551679
PNG
(CHEMBL4740513)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(N(C(=O)c4ccc(F)cc4)C(C)(C)C)C(C)(C)C)cc3F)c2cc1OC
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50551662
PNG
(CHEMBL4748864)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(cc4)C(C)(C)C)C(C)(C)C)cc3F)c2cc1OC
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate measured after 30 mins by HTRF assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112241
BindingDB Entry DOI: 10.7270/Q21R6V5C
More data for this
Ligand-Target Pair
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