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Compile Data Set for Download or QSAR

Found 106 hits with Last Name = 'kang' and Initial = 'sj'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476709
PNG
(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Show SMILES C[C@H]1CN(Cc2cc(cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)c2O)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-22-23(11-31-25(22)8-16)27-24(30)12-32-29(35-27)34-26-10-20(19-5-6-19)9-21(28(26)37)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-19,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM546731
PNG
((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3cn(c4cc(CO)ccc34)S(=O)(=O)c3ccc(C)cc3)cc(c2)C2CC2)C[C@@H](C)N1 |r|
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476709
PNG
(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Show SMILES C[C@H]1CN(Cc2cc(cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)c2O)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-22-23(11-31-25(22)8-16)27-24(30)12-32-29(35-27)34-26-10-20(19-5-6-19)9-21(28(26)37)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-19,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476704
PNG
( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(CO)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-13-36(14-18(2)33-17)15-20-7-22(21-4-5-21)10-23(8-20)34-29-32-12-26(30)28(35-29)25-11-31-27-9-19(16-37)3-6-24(25)27/h3,6-12,17-18,21,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM546731
PNG
((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3cn(c4cc(CO)ccc34)S(=O)(=O)c3ccc(C)cc3)cc(c2)C2CC2)C[C@@H](C)N1 |r|
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476704
PNG
( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(CO)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-13-36(14-18(2)33-17)15-20-7-22(21-4-5-21)10-23(8-20)34-29-32-12-26(30)28(35-29)25-11-31-27-9-19(16-37)3-6-24(25)27/h3,6-12,17-18,21,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476699
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)CCN1
Show InChI InChI=1S/C27H29ClN6/c1-17-15-34(9-8-29-17)16-18-10-20(19-6-7-19)12-21(11-18)32-27-31-14-24(28)26(33-27)23-13-30-25-5-3-2-4-22(23)25/h2-5,10-14,17,19,29-30H,6-9,15-16H2,1H3,(H,31,32,33)/t17-/m1/s1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476699
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)CCN1
Show InChI InChI=1S/C27H29ClN6/c1-17-15-34(9-8-29-17)16-18-10-20(19-6-7-19)12-21(11-18)32-27-31-14-24(28)26(33-27)23-13-30-25-5-3-2-4-22(23)25/h2-5,10-14,17,19,29-30H,6-9,15-16H2,1H3,(H,31,32,33)/t17-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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n/an/a 1.80n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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n/an/a 1.90n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476710
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)(C)N1
Show InChI InChI=1S/C30H35ClN6/c1-18-5-8-24-25(13-32-27(24)9-18)28-26(31)14-33-29(35-28)34-23-11-20(10-22(12-23)21-6-7-21)16-37-15-19(2)36-30(3,4)17-37/h5,8-14,19,21,32,36H,6-7,15-17H2,1-4H3,(H,33,34,35)/t19-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476710
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)(C)N1
Show InChI InChI=1S/C30H35ClN6/c1-18-5-8-24-25(13-32-27(24)9-18)28-26(31)14-33-29(35-28)34-23-11-20(10-22(12-23)21-6-7-21)16-37-15-19(2)36-30(3,4)17-37/h5,8-14,19,21,32,36H,6-7,15-17H2,1-4H3,(H,33,34,35)/t19-/m1/s1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476708
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4c(O)c(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-23-24(11-31-27(23)28(16)37)26-25(30)12-32-29(35-26)34-22-9-19(8-21(10-22)20-5-6-20)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-18,20,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476708
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4c(O)c(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-23-24(11-31-27(23)28(16)37)26-25(30)12-32-29(35-26)34-22-9-19(8-21(10-22)20-5-6-20)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-18,20,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50384888
PNG
(CHEMBL2035810)
Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccn3)c(Cl)c2)c1-c1nc(CNC(=O)C=C)co1
Show InChI InChI=1S/C23H20ClN7O3/c1-2-19(32)27-10-16-12-34-23(31-16)20-21(25)28-13-29-22(20)30-14-6-7-18(17(24)9-14)33-11-15-5-3-4-8-26-15/h2-9,12-13H,1,10-11H2,(H,27,32)(H3,25,28,29,30)
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n/an/a 3.30n/an/an/an/an/an/a



Hanmi Research Center

Curated by ChEMBL


Assay Description
Inhibition of wild-type EGFR preincubated for 10 mins followed by incubation for 30 mins by fluorescence polarization assay

J Med Chem 55: 2846-57 (2012)


Article DOI: 10.1021/jm201758g
BindingDB Entry DOI: 10.7270/Q23T9J8F
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476697
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H35ClN6O/c1-19-16-36(17-20(2)37(19)9-10-38)18-21-11-23(22-7-8-22)13-24(12-21)34-30-33-15-27(31)29(35-30)26-14-32-28-6-4-3-5-25(26)28/h3-6,11-15,19-20,22,32,38H,7-10,16-18H2,1-2H3,(H,33,34,35)/t19-,20+
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n/an/a 3.60n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476701
PNG
(US10870639, Example 10 | US11292786, Example 10 | ...)
Show SMILES CC1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)N1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476701
PNG
(US10870639, Example 10 | US11292786, Example 10 | ...)
Show SMILES CC1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)N1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476697
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H35ClN6O/c1-19-16-36(17-20(2)37(19)9-10-38)18-21-11-23(22-7-8-22)13-24(12-21)34-30-33-15-27(31)29(35-30)26-14-32-28-6-4-3-5-25(26)28/h3-6,11-15,19-20,22,32,38H,7-10,16-18H2,1-2H3,(H,33,34,35)/t19-,20+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476706
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)c(O)cc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-6-26-23(10-27(16)37)24(11-31-26)28-25(30)12-32-29(35-28)34-22-8-19(7-21(9-22)20-4-5-20)15-36-13-17(2)33-18(3)14-36/h6-12,17-18,20,31,33,37H,4-5,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476706
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)c(O)cc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-6-26-23(10-27(16)37)24(11-31-26)28-25(30)12-32-29(35-28)34-22-8-19(7-21(9-22)20-4-5-20)15-36-13-17(2)33-18(3)14-36/h6-12,17-18,20,31,33,37H,4-5,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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n/an/a 3.70n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4


(Homo sapiens (Human))		BDBM50384888
PNG
(CHEMBL2035810)
Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccn3)c(Cl)c2)c1-c1nc(CNC(=O)C=C)co1
Show InChI InChI=1S/C23H20ClN7O3/c1-2-19(32)27-10-16-12-34-23(31-16)20-21(25)28-13-29-22(20)30-14-6-7-18(17(24)9-14)33-11-15-5-3-4-8-26-15/h2-9,12-13H,1,10-11H2,(H,27,32)(H3,25,28,29,30)
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n/an/a 4n/an/an/an/an/an/a



Hanmi Research Center

Curated by ChEMBL


Assay Description
Inhibition of HER4 preincubated for 10 mins followed by incubation for 30 mins by fluorescence polarization assay

J Med Chem 55: 2846-57 (2012)


Article DOI: 10.1021/jm201758g
BindingDB Entry DOI: 10.7270/Q23T9J8F
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476712
PNG
((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1O
Show InChI InChI=1S/C29H33ClN6O/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(34-28)33-23-10-20(9-22(11-23)21-5-6-21)16-35-14-18(2)36(37)19(3)15-35/h4,7-13,18-19,21,31,37H,5-6,14-16H2,1-3H3,(H,32,33,34)/t18-,19+
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n/an/a 6.90n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476712
PNG
((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1O
Show InChI InChI=1S/C29H33ClN6O/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(34-28)33-23-10-20(9-22(11-23)21-5-6-21)16-35-14-18(2)36(37)19(3)15-35/h4,7-13,18-19,21,31,37H,5-6,14-16H2,1-3H3,(H,32,33,34)/t18-,19+
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n/an/a 6.90n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476698
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C31H37ClN6O/c1-19-4-7-26-27(14-33-29(26)10-19)30-28(32)15-34-31(36-30)35-25-12-22(11-24(13-25)23-5-6-23)18-37-16-20(2)38(8-9-39)21(3)17-37/h4,7,10-15,20-21,23,33,39H,5-6,8-9,16-18H2,1-3H3,(H,34,35,36)/t20-,21+
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n/an/a 7.20n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476698
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C31H37ClN6O/c1-19-4-7-26-27(14-33-29(26)10-19)30-28(32)15-34-31(36-30)35-25-12-22(11-24(13-25)23-5-6-23)18-37-16-20(2)38(8-9-39)21(3)17-37/h4,7,10-15,20-21,23,33,39H,5-6,8-9,16-18H2,1-3H3,(H,34,35,36)/t20-,21+
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n/an/a 7.20n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1


(Homo sapiens (Human))		BDBM50187114
PNG
(CHEMBL3823303)
Show SMILES CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1
Show InChI InChI=1S/C25H28FN7O2/c1-2-17-12-18(14-20(13-17)35-11-10-32-8-5-19(34)6-9-32)30-25-28-15-21(26)24(31-25)22-16-27-23-4-3-7-29-33(22)23/h3-4,7,12-16,19,34H,2,5-6,8-11H2,1H3,(H,28,30,31)
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n/an/a 8n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1


(Homo sapiens (Human))		BDBM50187114
PNG
(CHEMBL3823303)
Show SMILES CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1
Show InChI InChI=1S/C25H28FN7O2/c1-2-17-12-18(14-20(13-17)35-11-10-32-8-5-19(34)6-9-32)30-25-28-15-21(26)24(31-25)22-16-27-23-4-3-7-29-33(22)23/h3-4,7,12-16,19,34H,2,5-6,8-11H2,1H3,(H,28,30,31)
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n/an/a 8n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7


(Homo sapiens (Human))		BDBM50187114
PNG
(CHEMBL3823303)
Show SMILES CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1
Show InChI InChI=1S/C25H28FN7O2/c1-2-17-12-18(14-20(13-17)35-11-10-32-8-5-19(34)6-9-32)30-25-28-15-21(26)24(31-25)22-16-27-23-4-3-7-29-33(22)23/h3-4,7,12-16,19,34H,2,5-6,8-11H2,1H3,(H,28,30,31)
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n/an/a 8n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLAG-tagged TAK1 (unknown origin) co-expressed with TAB (unknown origin) in baculovirus using BT-MKK as substrate after 1 h...

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7


(Homo sapiens (Human))		BDBM50187114
PNG
(CHEMBL3823303)
Show SMILES CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1
Show InChI InChI=1S/C25H28FN7O2/c1-2-17-12-18(14-20(13-17)35-11-10-32-8-5-19(34)6-9-32)30-25-28-15-21(26)24(31-25)22-16-27-23-4-3-7-29-33(22)23/h3-4,7,12-16,19,34H,2,5-6,8-11H2,1H3,(H,28,30,31)
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n/an/a 8n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLAG-tagged TAK1 (unknown origin) co-expressed with TAB (unknown origin) in baculovirus using BT-MKK as substrate after 1 h...

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476696
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(6-fluoro-1H-indole-3...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(F)ccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H34ClFN6O/c1-18-15-37(16-19(2)38(18)7-8-39)17-20-9-22(21-3-4-21)11-24(10-20)35-30-34-14-27(31)29(36-30)26-13-33-28-12-23(32)5-6-25(26)28/h5-6,9-14,18-19,21,33,39H,3-4,7-8,15-17H2,1-2H3,(H,34,35,36)/t18-,19+
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n/an/a 8.10n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476696
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(6-fluoro-1H-indole-3...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(F)ccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H34ClFN6O/c1-18-15-37(16-19(2)38(18)7-8-39)17-20-9-22(21-3-4-21)11-24(10-20)35-30-34-14-27(31)29(36-30)26-13-33-28-12-23(32)5-6-25(26)28/h5-6,9-14,18-19,21,33,39H,3-4,7-8,15-17H2,1-2H3,(H,34,35,36)/t18-,19+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476703
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(C)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H34N6/c1-18-13-31-29(34-28(18)26-14-30-27-7-5-4-6-25(26)27)33-24-11-21(10-23(12-24)22-8-9-22)17-35-15-19(2)32-20(3)16-35/h4-7,10-14,19-20,22,30,32H,8-9,15-17H2,1-3H3,(H,31,33,34)/t19-,20+
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n/an/a 8.70n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476703
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(C)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H34N6/c1-18-13-31-29(34-28(18)26-14-30-27-7-5-4-6-25(26)27)33-24-11-21(10-23(12-24)22-8-9-22)17-35-15-19(2)32-20(3)16-35/h4-7,10-14,19-20,22,30,32H,8-9,15-17H2,1-3H3,(H,31,33,34)/t19-,20+
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n/an/a 8.70n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1


(Homo sapiens (Human))		BDBM50042034
PNG
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
Show SMILES COc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O |r,c:19,t:10|
Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assay

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1


(Homo sapiens (Human))		BDBM50042034
PNG
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
Show SMILES COc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O |r,c:19,t:10|
Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assay

Eur J Med Chem 163: 660-670 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.025
BindingDB Entry DOI: 10.7270/Q2280C2F
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
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