Found 191 hits with Last Name = 'basnet' and Initial = 'skc' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM370121
(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)Show SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(C(F)F)c1=O |r| Show InChI InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1 | MMDB
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| | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611455
(CHEMBL5286090)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Cl | MMDB
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50139171
(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)Show SMILES CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO |r| Show InChI InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 | MMDB
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Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM168281
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20) | PDB
MMDB
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Reactome pathway
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| PC cid
PC sid
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| Article
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611459
(CHEMBL5277565)Show SMILES Cc1nn(C)cc1-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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| | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50139171
(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)Show SMILES CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO |r| Show InChI InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 | MMDB
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Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50263263
(CHEMBL4073443)Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21) | PDB
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| PDB
Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM168281
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20) | PDB
MMDB
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| PC cid
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| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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| | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50431360
(CHEMBL2347597)Show SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F Show InChI InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) | MMDB
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50593923
(CHEMBL5195030)Show SMILES CC[C@@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@H](C)O |r| | MMDB
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611455
(CHEMBL5286090)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Cl | MMDB
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| | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277622
(CHEMBL4162390)Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(nc2C)N(C)C)c(OC)c1 Show InChI InChI=1S/C18H21N5O2S/c1-11-16(26-18(20-11)23(2)3)14-8-9-19-17(22-14)21-13-7-6-12(24-4)10-15(13)25-5/h6-10H,1-5H3,(H,19,21,22) | PDB
NCI pathway
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KEGG
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| PC cid
PC sid
UniChem
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| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50263263
(CHEMBL4073443)Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21) | PDB
MMDB
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| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611454
(CHEMBL5277074)Show SMILES Cn1cc(cn1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1Cl | MMDB
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| | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611451
(CHEMBL5286978)Show SMILES Cn1cc(cn1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F | MMDB
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| | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611456
(CHEMBL5281179)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1Cl | MMDB
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| | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611452
(CHEMBL5286271)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1F | MMDB
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| | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277601
(CHEMBL4167646)Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCN(C)C)nc2C)c(OC)c1 Show InChI InChI=1S/C20H25N5O2S2/c1-13-18(29-20(22-13)28-11-10-25(2)3)16-8-9-21-19(24-16)23-15-7-6-14(26-4)12-17(15)27-5/h6-9,12H,10-11H2,1-5H3,(H,21,23,24) | PDB
NCI pathway
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611456
(CHEMBL5281179)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1Cl | MMDB
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| | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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| |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611457
(CHEMBL5285230)Show SMILES Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
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| | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611457
(CHEMBL5285230)Show SMILES Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
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| | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611459
(CHEMBL5277565)Show SMILES Cc1nn(C)cc1-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
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| | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611459
(CHEMBL5277565)Show SMILES Cc1nn(C)cc1-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
KEGG
UniProtKB/SwissProt
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| PC cid
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UniChem
| | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611455
(CHEMBL5286090)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Cl | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
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| PC cid
PC sid
UniChem
| | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611458
(CHEMBL5286293)Show SMILES Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
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| PC cid
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UniChem
| | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611452
(CHEMBL5286271)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
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| PC cid
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UniChem
| | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611452
(CHEMBL5286271)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611451
(CHEMBL5286978)Show SMILES Cn1cc(cn1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
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| PC cid
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UniChem
| | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
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Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611457
(CHEMBL5285230)Show SMILES Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1Cl | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611451
(CHEMBL5286978)Show SMILES Cn1cc(cn1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277603
(CHEMBL4167329)Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCCN(C)C)nc2C)c(OC)c1 Show InChI InChI=1S/C21H27N5O2S2/c1-14-19(30-21(23-14)29-12-6-11-26(2)3)17-9-10-22-20(25-17)24-16-8-7-15(27-4)13-18(16)28-5/h7-10,13H,6,11-12H2,1-5H3,(H,22,24,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50512740
(CHEMBL4449736)Show InChI InChI=1S/C17H17ClN4O2/c18-12-10-13(20-11-4-8-19-9-5-11)16(24)22-14(12)15(23)21-17(22)6-2-1-3-7-17/h4-5,8-10H,1-3,6-7H2,(H,19,20)(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277602
(CHEMBL4164283)Show InChI InChI=1S/C17H19N5O2S/c1-10-15(25-17(18-2)20-10)13-7-8-19-16(22-13)21-12-6-5-11(23-3)9-14(12)24-4/h5-9H,1-4H3,(H,18,20)(H,19,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611455
(CHEMBL5286090)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Cl | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
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| PC cid
PC sid
UniChem
| | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611456
(CHEMBL5281179)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1Cl | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
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| PC cid
PC sid
UniChem
| | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611458
(CHEMBL5286293)Show SMILES Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611453
(CHEMBL5270069)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
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| PC cid
PC sid
UniChem
| | 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50512741
(CHEMBL4466664)Show InChI InChI=1S/C15H15ClN4O3/c16-9-8-10(17-11-4-7-23-19-11)14(22)20-12(9)13(21)18-15(20)5-2-1-3-6-15/h4,7-8H,1-3,5-6H2,(H,17,19)(H,18,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50113281
(AT-7519)Show SMILES Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 Show InChI InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) | MMDB
KEGG
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| Purchase
DrugBank
MCE
PC cid
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PDB
UniChem
Patents
Similars
| | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277648
(CHEMBL4159419)Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCc3cccnc3)nc2C)c(OC)c1 Show InChI InChI=1S/C22H21N5O2S2/c1-14-20(31-22(25-14)30-13-15-5-4-9-23-12-15)18-8-10-24-21(27-18)26-17-7-6-16(28-2)11-19(17)29-3/h4-12H,13H2,1-3H3,(H,24,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membrane |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277618
(CHEMBL4165526)Show InChI InChI=1S/C18H14N4O/c23-17-8-4-3-7-16(17)22-18-19-10-9-15(21-18)13-11-20-14-6-2-1-5-12(13)14/h1-11,20,23H,(H,19,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50277604
(CHEMBL4159742)Show SMILES COCCSc1nc(C)c(s1)-c1ccnc(Nc2ccc(OC)cc2OC)n1 Show InChI InChI=1S/C19H22N4O3S2/c1-12-17(28-19(21-12)27-10-9-24-2)15-7-8-20-18(23-15)22-14-6-5-13(25-3)11-16(14)26-4/h5-8,11H,9-10H2,1-4H3,(H,20,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay |
Eur J Med Chem 139: 762-772 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.006
BindingDB Entry DOI: 10.7270/Q24B33VW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611460
(CHEMBL5277367)Show SMILES Cn1cc(cn1)-c1nc(Nc2ccc(cc2)S(=O)(=O)C(F)(F)F)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50512739
(CHEMBL4535537)Show InChI InChI=1S/C17H16ClFN4O2/c18-10-8-13(21-12-4-7-20-9-11(12)19)16(25)23-14(10)15(24)22-17(23)5-2-1-3-6-17/h4,7-9H,1-3,5-6H2,(H,20,21)(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo... |
Bioorg Med Chem Lett 29: 2650-2654 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.043
BindingDB Entry DOI: 10.7270/Q2B56P2W |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50611451
(CHEMBL5286978)Show SMILES Cn1cc(cn1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
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