| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50512741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1849833 (CHEMBL4350374) |
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| Ki | 43±n/a nM |
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| Citation |  Abdelaziz, AM; Basnet, SKC; Islam, S; Li, M; Tadesse, S; Albrecht, H; Gerber, C; Yu, M; Wang, S Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors. Bioorg Med Chem Lett29:2650-2654 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
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| Type: | Protein |
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| Mol. Mass.: | 51870.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HBH9 |
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| Residue: | 465 |
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| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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| BDBM50512741 |
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| n/a |
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| Name | BDBM50512741 |
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| Synonyms: | CHEMBL4466664 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN4O3 |
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| Mol. Mass. | 334.758 |
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| SMILES | Clc1cc(Nc2ccon2)c(=O)n2c1C(=O)NC21CCCCC1 |
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| Structure | 
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