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Compile Data Set for Download or QSAR

Found 39 hits with Last Name = 'kher' and Initial = 'sm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056605
PNG
(7-Chloro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES Cc1c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6ClN3O4/c1-3-4(10)2-5-6(7(3)13(16)17)12-9(15)8(14)11-5/h2H,1H3,(H2,11,12,14,15)
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n/an/a 4.70n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50038161
PNG
(6,7-Dichloro-3-hydroxy-5-nitro-3,4-dihydro-1H-quin...)
Show SMILES [O-][N+](=O)c1c(Cl)c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c12
Show InChI InChI=1S/C8H3Cl2N3O4/c9-2-1-3-5(6(4(2)10)13(16)17)12-8(15)7(14)11-3/h1H,(H2,11,12,14,15)
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n/an/a 5.90n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056596
PNG
(7-Bromo-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Show SMILES Cc1c(Br)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6BrN3O4/c1-3-4(10)2-5-6(7(3)13(16)17)12-9(15)8(14)11-5/h2H,1H3,(H2,11,12,14,15)
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n/an/a 8.70n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056618
PNG
(6,7-Dibromo-5-nitro-1,4-dihydro-quinoxaline-2,3-di...)
Show SMILES [O-][N+](=O)c1c(Br)c(Br)cc2[n-]c(=[OH+])c(=O)[nH]c12
Show InChI InChI=1S/C8H3Br2N3O4/c9-2-1-3-5(6(4(2)10)13(16)17)12-8(15)7(14)11-3/h1H,(H2,11,12,14,15)
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n/an/a 20n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056620
PNG
(6-Chloro-7-ethyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Show SMILES CCc1cc2[n-]c(=[OH+])c(=O)[nH]c2c(c1Cl)[N+]([O-])=O
Show InChI InChI=1S/C10H8ClN3O4/c1-2-4-3-5-7(8(6(4)11)14(17)18)13-10(16)9(15)12-5/h3H,2H2,1H3,(H2,12,13,15,16)
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n/an/a 29n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056595
PNG
(6,7-Dimethyl-5-nitro-1,4-dihydro-quinoxaline-2,3-d...)
Show SMILES Cc1cc2[n-]c(=[OH+])c(=O)[nH]c2c(c1C)[N+]([O-])=O
Show InChI InChI=1S/C10H9N3O4/c1-4-3-6-7(8(5(4)2)13(16)17)12-10(15)9(14)11-6/h3H,1-2H3,(H2,11,12,14,15)
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n/an/a 29n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056600
PNG
(6-Chloro-7-methyl-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES Cc1cc2[n-]c(=[OH+])c(=O)[nH]c2c(c1Cl)[N+]([O-])=O
Show InChI InChI=1S/C9H6ClN3O4/c1-3-2-4-6(7(5(3)10)13(16)17)12-9(15)8(14)11-4/h2H,1H3,(H2,11,12,14,15)
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n/an/a 45n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056591
PNG
(7-Bromo-6-methoxy-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES COc1c(Br)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6BrN3O5/c1-18-7-3(10)2-4-5(6(7)13(16)17)12-9(15)8(14)11-4/h2H,1H3,(H2,11,12,14,15)
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n/an/a 64n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056598
PNG
(7-Methyl-8-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quin...)
Show SMILES Cc1c(cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O)C#N
Show InChI InChI=1S/C10H6N4O4/c1-4-5(3-11)2-6-7(8(4)14(17)18)13-10(16)9(15)12-6/h2H,1H3,(H2,12,13,15,16)
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n/an/a 73n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056611
PNG
(6-Bromo-7-ethyl-5-nitro-1,4-dihydro-quinoxaline-2,...)
Show SMILES CCc1cc2[n-]c(=[OH+])c(=O)[nH]c2c(c1Br)[N+]([O-])=O
Show InChI InChI=1S/C10H8BrN3O4/c1-2-4-3-5-7(8(6(4)11)14(17)18)13-10(16)9(15)12-5/h3H,2H2,1H3,(H2,12,13,15,16)
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n/an/a 82n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056597
PNG
(7-Fluoro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES Cc1c(F)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6FN3O4/c1-3-4(10)2-5-6(7(3)13(16)17)12-9(15)8(14)11-5/h2H,1H3,(H2,11,12,14,15)
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n/an/a 95n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056592
PNG
(7-Chloro-6-ethyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Show SMILES CCc1c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C10H8ClN3O4/c1-2-4-5(11)3-6-7(8(4)14(17)18)13-10(16)9(15)12-6/h3H,2H2,1H3,(H2,12,13,15,16)
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n/an/a 130n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM22778
PNG
(6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione | 6...)
Show SMILES Clc1cc2[nH]c(=O)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C8H4Cl2N2O2/c9-3-1-5-6(2-4(3)10)12-8(14)7(13)11-5/h1-2H,(H,11,13)(H,12,14)
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n/an/a 130n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056621
PNG
(7-Chloro-6-methoxy-5-nitro-1,4-dihydro-quinoxaline...)
Show SMILES COc1c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6ClN3O5/c1-18-7-3(10)2-4-5(6(7)13(16)17)12-9(15)8(14)11-4/h2H,1H3,(H2,11,12,14,15)
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n/an/a 150n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056615
PNG
(5-Amino-7-chloro-6-methyl-1,4-dihydro-quinoxaline-...)
Show SMILES Cc1c(Cl)cc2[nH]c(=O)c(=O)[nH]c2c1N
Show InChI InChI=1S/C9H8ClN3O2/c1-3-4(10)2-5-7(6(3)11)13-9(15)8(14)12-5/h2H,11H2,1H3,(H,12,14)(H,13,15)
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n/an/a 150n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056606
PNG
(6,7-Diethyl-5-nitro-1,4-dihydro-quinoxaline-2,3-di...)
Show SMILES CCc1cc2[n-]c(=[OH+])c(=O)[nH]c2c(c1CC)[N+]([O-])=O
Show InChI InChI=1S/C12H13N3O4/c1-3-6-5-8-9(14-12(17)11(16)13-8)10(15(18)19)7(6)4-2/h5H,3-4H2,1-2H3,(H2,13,14,16,17)
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n/an/a 160n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056593
PNG
(7-Chloro-6-ethylsulfanyl-5-nitro-1,4-dihydro-quino...)
Show SMILES CCSc1c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C10H8ClN3O4S/c1-2-19-8-4(11)3-5-6(7(8)14(17)18)13-10(16)9(15)12-5/h3H,2H2,1H3,(H2,12,13,15,16)
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n/an/a 640n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056622
PNG
(6-Chloro-7-methyl-1,4-dihydro-quinoxaline-2,3-dion...)
Show SMILES Cc1cc2[nH]c(=O)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C9H7ClN2O2/c1-4-2-6-7(3-5(4)10)12-9(14)8(13)11-6/h2-3H,1H3,(H,11,13)(H,12,14)
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n/an/a 780n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056614
PNG
(6-Bromo-7-methoxy-1,4-dihydro-quinoxaline-2,3-dion...)
Show SMILES COc1cc2[nH]c(=O)c(=O)[nH]c2cc1Br
Show InChI InChI=1S/C9H7BrN2O3/c1-15-7-3-6-5(2-4(7)10)11-8(13)9(14)12-6/h2-3H,1H3,(H,11,13)(H,12,14)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056613
PNG
(6-Chloro-7-ethyl-1,4-dihydro-quinoxaline-2,3-dione...)
Show SMILES CCc1cc2[nH]c(=O)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C10H9ClN2O2/c1-2-5-3-7-8(4-6(5)11)13-10(15)9(14)12-7/h3-4H,2H2,1H3,(H,12,14)(H,13,15)
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n/an/a 1.40E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056623
PNG
(6,7-Diethyl-1,4-dihydro-quinoxaline-2,3-dione | CH...)
Show SMILES CCc1cc2[nH]c(=O)c(=O)[nH]c2cc1CC
Show InChI InChI=1S/C12H14N2O2/c1-3-7-5-9-10(6-8(7)4-2)14-12(16)11(15)13-9/h5-6H,3-4H2,1-2H3,(H,13,15)(H,14,16)
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n/an/a 1.80E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056610
PNG
(7-Fluoro-6-methoxy-5-nitro-1,4-dihydro-quinoxaline...)
Show SMILES COc1c(F)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6FN3O5/c1-18-7-3(10)2-4-5(6(7)13(16)17)12-9(15)8(14)11-4/h2H,1H3,(H2,11,12,14,15)
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n/an/a 1.90E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056594
PNG
(8-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-6...)
Show SMILES [O-][N+](=O)c1cc(cc2[n-]c(=[OH+])c(=O)[nH]c12)C#N
Show InChI InChI=1S/C9H4N4O4/c10-3-4-1-5-7(6(2-4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H2,11,12,14,15)
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n/an/a 2.80E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056602
PNG
(5-Nitro-4,6,7,8-tetrahydro-1H-cyclopenta[g]quinoxa...)
Show SMILES [O-][N+](=O)c1c2CCCc2cc2[n-]c(=[OH+])c(=O)[nH]c12
Show InChI InChI=1S/C11H9N3O4/c15-10-11(16)13-8-7(12-10)4-5-2-1-3-6(5)9(8)14(17)18/h4H,1-3H2,(H2,12,13,15,16)
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n/an/a 3.10E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50008768
PNG
(6,7-Dimethyl-1,4-dihydro-quinoxaline-2,3-dione | C...)
Show SMILES Cc1cc2[nH]c(=O)c(=O)[nH]c2cc1C
Show InChI InChI=1S/C10H10N2O2/c1-5-3-7-8(4-6(5)2)12-10(14)9(13)11-7/h3-4H,1-2H3,(H,11,13)(H,12,14)
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n/an/a 3.30E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056616
PNG
(6-Ethoxy-7-fluoro-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES CCOc1c(F)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C10H8FN3O5/c1-2-19-8-4(11)3-5-6(7(8)14(17)18)13-10(16)9(15)12-5/h3H,2H2,1H3,(H2,12,13,15,16)
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n/an/a 3.60E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056617
PNG
(7-Fluoro-5-nitro-6-(3-phenyl-propoxy)-1,4-dihydro-...)
Show SMILES [O-][N+](=O)c1c(OCCCc2ccccc2)c(F)cc2[n-]c(=[OH+])c(=O)[nH]c12
Show InChI InChI=1S/C17H14FN3O5/c18-11-9-12-13(20-17(23)16(22)19-12)14(21(24)25)15(11)26-8-4-7-10-5-2-1-3-6-10/h1-3,5-6,9H,4,7-8H2,(H2,19,20,22,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056624
PNG
(6-Butoxy-7-fluoro-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES CCCCOc1c(F)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C12H12FN3O5/c1-2-3-4-21-10-6(13)5-7-8(9(10)16(19)20)15-12(18)11(17)14-7/h5H,2-4H2,1H3,(H2,14,15,17,18)
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n/an/a 4.30E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase


(Homo sapiens (Human))		BDBM81264
PNG
(5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide |...)
Show SMILES NCCc1cc(O)c(O)cc1O
Show InChI InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2
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n/an/a 8.00E+3n/an/an/an/an/an/a



New York University

Curated by ChEMBL


Assay Description
Inhibition of GAPDH

Nat Chem Biol 3: 55-9 (2007)


Article DOI: 10.1038/nchembio833
BindingDB Entry DOI: 10.7270/Q29W0FPQ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056601
PNG
(7-Methyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dione...)
Show SMILES Cc1cc([N+]([O-])=O)c2[nH]c(=O)c(=[OH+])[n-]c2c1
Show InChI InChI=1S/C9H7N3O4/c1-4-2-5-7(6(3-4)12(15)16)11-9(14)8(13)10-5/h2-3H,1H3,(H2,10,11,13,14)
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n/an/a 9.30E+3n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056612
PNG
(6-Amino-7-fluoro-5-nitro-1,4-dihydro-quinoxaline-2...)
Show SMILES Nc1c(F)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C8H5FN4O4/c9-2-1-3-5(6(4(2)10)13(16)17)12-8(15)7(14)11-3/h1H,(H4,10,11,12,14,15)
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n/an/a 1.10E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056619
PNG
(4,6,7,8-Tetrahydro-1H-cyclopenta[g]quinoxaline-2,3...)
Show SMILES O=c1[nH]c2cc3CCCc3cc2[nH]c1=O
Show InChI InChI=1S/C11H10N2O2/c14-10-11(15)13-9-5-7-3-1-2-6(7)4-8(9)12-10/h4-5H,1-3H2,(H,12,14)(H,13,15)
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n/an/a 1.50E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase


(Oryctolagus cuniculus)		BDBM50324683
PNG
(CHEMBL1222315 | N-(2-(2-(2-(4-(3,4-dihydroxyphenet...)
Show SMILES Oc1ccc(CCNc2nc(NCCOCCOCCNC(=O)c3ccccc3)nc(Nc3ccccc3)n2)cc1O
Show InChI InChI=1S/C30H35N7O5/c38-25-12-11-22(21-26(25)39)13-14-32-28-35-29(37-30(36-28)34-24-9-5-2-6-10-24)33-16-18-42-20-19-41-17-15-31-27(40)23-7-3-1-4-8-23/h1-12,21,38-39H,13-20H2,(H,31,40)(H3,32,33,34,35,36,37)
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n/an/a 1.50E+4n/an/an/an/an/an/a



New York University

Curated by ChEMBL


Assay Description
Inhibition of rabbit GAPDH glycolytic activity

Nat Chem Biol 3: 55-9 (2007)


Article DOI: 10.1038/nchembio833
BindingDB Entry DOI: 10.7270/Q29W0FPQ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056607
PNG
(1,4-Dihydro-benzo[g]quinoxaline-2,3-dione | CHEMBL...)
Show SMILES O=c1[nH]c2cc3ccccc3cc2[nH]c1=O
Show InChI InChI=1S/C12H8N2O2/c15-11-12(16)14-10-6-8-4-2-1-3-7(8)5-9(10)13-11/h1-6H,(H,13,15)(H,14,16)
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n/an/a 1.60E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056599
PNG
(6,7-Dimethoxy-1,4-dihydro-quinoxaline-2,3-dione | ...)
Show SMILES COc1cc2[nH]c(=O)c(=O)[nH]c2cc1OC
Show InChI InChI=1S/C10H10N2O4/c1-15-7-3-5-6(4-8(7)16-2)12-10(14)9(13)11-5/h3-4H,1-2H3,(H,11,13)(H,12,14)
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n/an/a 1.70E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056604
PNG
(5-Hydroxy-6,7-dimethoxy-1,4-dihydro-quinoxaline-2,...)
Show SMILES COc1cc2[nH]c(=O)c(=O)[nH]c2c(O)c1OC
Show InChI InChI=1S/C10H10N2O5/c1-16-5-3-4-6(7(13)8(5)17-2)12-10(15)9(14)11-4/h3,13H,1-2H3,(H,11,14)(H,12,15)
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n/an/a 1.70E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056603
PNG
(Acetic acid 6,7-dimethoxy-2,3-dioxo-1,2,3,4-tetrah...)
Show SMILES COc1cc2[nH]c(=O)c(=O)[nH]c2c(OC(C)=O)c1OC
Show InChI InChI=1S/C12H12N2O6/c1-5(15)20-10-8-6(13-11(16)12(17)14-8)4-7(18-2)9(10)19-3/h4H,1-3H3,(H,13,16)(H,14,17)
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n/an/a 5.30E+4n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056608
PNG
(6,7-Dihydroxy-1,4-dihydro-quinoxaline-2,3-dione | ...)
Show SMILES Oc1cc2[nH]c(=O)c(=O)[nH]c2cc1O
Show InChI InChI=1S/C8H6N2O4/c11-5-1-3-4(2-6(5)12)10-8(14)7(13)9-3/h1-2,11-12H,(H,9,13)(H,10,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50056609
PNG
(5,8-Dihydro-1,3-dioxa-5,8-diaza-cyclopenta[b]napht...)
Show SMILES O=c1[nH]c2cc3OCOc3cc2[nH]c1=O
Show InChI InChI=1S/C9H6N2O4/c12-8-9(13)11-5-2-7-6(14-3-15-7)1-4(5)10-8/h1-2H,3H2,(H,10,12)(H,11,13)
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n/an/a>1.00E+5n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...

J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair