Found 18 hits with Last Name = 'loe' and Initial = 'tk' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM50004764
(CHEMBL3233733)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(ccc12)-c1ccccc1 Show InChI InChI=1S/C27H22N2O2/c1-17-7-9-19(10-8-17)26-24(27(31)29-28-26)16-23-22-13-11-20(18-5-3-2-4-6-18)15-21(22)12-14-25(23)30/h2-15,30H,16H2,1H3,(H2,28,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50004887
(CHEMBL3233749)Show SMILES Cc1ccc(cc1)-c1[nH]oc(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H16BrNO3/c1-12-2-4-13(5-3-12)20-18(21(25)26-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)24/h2-10,23-24H,11H2,1H3 | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50004795
(CHEMBL3233748)Show SMILES CC(C)c1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2nc(Cl)ccc12 Show InChI InChI=1S/C22H20ClN3O2/c1-12(2)13-3-5-14(6-4-13)21-17(22(28)26-25-21)11-16-15-7-10-20(23)24-18(15)8-9-19(16)27/h3-10,12,27H,11H2,1-2H3,(H2,25,26,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50004777
(CHEMBL3233742)Show SMILES COc1cc2ccccc2c(Cc2c([nH][nH]c2=O)-c2ccc(C)cc2)c1O Show InChI InChI=1S/C22H20N2O3/c1-13-7-9-14(10-8-13)20-18(22(26)24-23-20)12-17-16-6-4-3-5-15(16)11-19(27-2)21(17)25/h3-11,25H,12H2,1-2H3,(H2,23,24,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50004764
(CHEMBL3233733)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(ccc12)-c1ccccc1 Show InChI InChI=1S/C27H22N2O2/c1-17-7-9-19(10-8-17)26-24(27(31)29-28-26)16-23-22-13-11-20(18-5-3-2-4-6-18)15-21(22)12-14-25(23)30/h2-15,30H,16H2,1H3,(H2,28,29,31) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50004765
(CHEMBL3233739)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H17BrN2O2/c1-12-2-4-13(5-3-12)20-18(21(26)24-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)25/h2-10,25H,11H2,1H3,(H2,23,24,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50004764
(CHEMBL3233733)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(ccc12)-c1ccccc1 Show InChI InChI=1S/C27H22N2O2/c1-17-7-9-19(10-8-17)26-24(27(31)29-28-26)16-23-22-13-11-20(18-5-3-2-4-6-18)15-21(22)12-14-25(23)30/h2-15,30H,16H2,1H3,(H2,28,29,31) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM29040
(cambinol)Show SMILES Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM29040
(cambinol)Show SMILES Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50004795
(CHEMBL3233748)Show SMILES CC(C)c1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2nc(Cl)ccc12 Show InChI InChI=1S/C22H20ClN3O2/c1-12(2)13-3-5-14(6-4-13)21-17(22(28)26-25-21)11-16-15-7-10-20(23)24-18(15)8-9-19(16)27/h3-10,12,27H,11H2,1-2H3,(H2,25,26,28) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM50004795
(CHEMBL3233748)Show SMILES CC(C)c1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2nc(Cl)ccc12 Show InChI InChI=1S/C22H20ClN3O2/c1-12(2)13-3-5-14(6-4-13)21-17(22(28)26-25-21)11-16-15-7-10-20(23)24-18(15)8-9-19(16)27/h3-10,12,27H,11H2,1-2H3,(H2,25,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50004765
(CHEMBL3233739)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H17BrN2O2/c1-12-2-4-13(5-3-12)20-18(21(26)24-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)25/h2-10,25H,11H2,1H3,(H2,23,24,26) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM29040
(cambinol)Show SMILES Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50004887
(CHEMBL3233749)Show SMILES Cc1ccc(cc1)-c1[nH]oc(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H16BrNO3/c1-12-2-4-13(5-3-12)20-18(21(25)26-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)24/h2-10,23-24H,11H2,1H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM50004765
(CHEMBL3233739)Show SMILES Cc1ccc(cc1)-c1[nH][nH]c(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H17BrN2O2/c1-12-2-4-13(5-3-12)20-18(21(26)24-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)25/h2-10,25H,11H2,1H3,(H2,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM50004777
(CHEMBL3233742)Show SMILES COc1cc2ccccc2c(Cc2c([nH][nH]c2=O)-c2ccc(C)cc2)c1O Show InChI InChI=1S/C22H20N2O3/c1-13-7-9-14(10-8-13)20-18(22(26)24-23-20)12-17-16-6-4-3-5-15(16)11-19(27-2)21(17)25/h3-11,25H,12H2,1-2H3,(H2,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM50004887
(CHEMBL3233749)Show SMILES Cc1ccc(cc1)-c1[nH]oc(=O)c1Cc1c(O)ccc2cc(Br)ccc12 Show InChI InChI=1S/C21H16BrNO3/c1-12-2-4-13(5-3-12)20-18(21(25)26-23-20)11-17-16-8-7-15(22)10-14(16)6-9-19(17)24/h2-10,23-24H,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT3 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50004777
(CHEMBL3233742)Show SMILES COc1cc2ccccc2c(Cc2c([nH][nH]c2=O)-c2ccc(C)cc2)c1O Show InChI InChI=1S/C22H20N2O3/c1-13-7-9-14(10-8-13)20-18(22(26)24-23-20)12-17-16-6-4-3-5-15(16)11-19(27-2)21(17)25/h3-11,25H,12H2,1-2H3,(H2,23,24,26) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
| Assay Description Inhibition of SIRT2 (unknown origin) by luminescence assay |
J Med Chem 57: 3283-94 (2014)
Article DOI: 10.1021/jm4018064 BindingDB Entry DOI: 10.7270/Q28G8N7Z |
More data for this Ligand-Target Pair | |