| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM29040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338279 (CHEMBL3242722) |
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| IC50 | 51000±n/a nM |
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| Citation |  Mahajan, SS; Scian, M; Sripathy, S; Posakony, J; Lao, U; Loe, TK; Leko, V; Thalhofer, A; Schuler, AD; Bedalov, A; Simon, JA Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. J Med Chem57:3283-94 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM29040 |
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| n/a |
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| Name | BDBM29040 |
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| Synonyms: | cambinol |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16N2O2S |
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| Mol. Mass. | 360.429 |
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| SMILES | Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 |
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| Structure | 
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