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Compile Data Set for Download or QSAR

Found 916 hits with Last Name = 'cheung' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459080
PNG
(CHEMBL4211423)
Show SMILES NC(=N)NC(=O)c1nc(-c2cnc(N)nc2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H22N10O/c17-12-11(14(27)25-15(18)19)23-10(9-7-21-16(20)22-8-9)13(24-12)26-5-3-1-2-4-6-26/h7-8H,1-6H2,(H2,17,24)(H2,20,21,22)(H4,18,19,25,27)
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21n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459060
PNG
(CHEMBL4208530)
Show SMILES NC(=N)NC(=O)c1nc(-c2cnc(NCCO)nc2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C18H26N10O2/c19-14-13(16(30)27-17(20)21)25-12(11-9-23-18(24-10-11)22-5-8-29)15(26-14)28-6-3-1-2-4-7-28/h9-10,29H,1-8H2,(H2,19,26)(H,22,23,24)(H4,20,21,27,30)
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41n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459079
PNG
(CHEMBL4206764)
Show SMILES COc1ncc(c(OC)n1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C18H25N9O3/c1-29-16-10(9-22-18(26-16)30-2)11-14(27-7-5-3-4-6-8-27)24-13(19)12(23-11)15(28)25-17(20)21/h9H,3-8H2,1-2H3,(H2,19,24)(H4,20,21,25,28)
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42n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459072
PNG
(CHEMBL4215861)
Show SMILES CC(C)Nc1ncc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C19H28N10O/c1-11(2)25-19-23-9-12(10-24-19)13-16(29-7-5-3-4-6-8-29)27-15(20)14(26-13)17(30)28-18(21)22/h9-11H,3-8H2,1-2H3,(H2,20,27)(H,23,24,25)(H4,21,22,28,30)
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42n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459071
PNG
(CHEMBL4204195)
Show SMILES CNc1ncc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C17H24N10O/c1-21-17-22-8-10(9-23-17)11-14(27-6-4-2-3-5-7-27)25-13(18)12(24-11)15(28)26-16(19)20/h8-9H,2-7H2,1H3,(H2,18,25)(H,21,22,23)(H4,19,20,26,28)
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43n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459059
PNG
(CHEMBL4217043)
Show SMILES COc1ncc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C17H23N9O2/c1-28-17-21-8-10(9-22-17)11-14(26-6-4-2-3-5-7-26)24-13(18)12(23-11)15(27)25-16(19)20/h8-9H,2-7H2,1H3,(H2,18,24)(H4,19,20,25,27)
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53n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459055
PNG
(CHEMBL4207715)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3c(F)cccc3o2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C20H22FN7O2/c21-12-6-5-7-13-11(12)10-14(30-13)15-18(28-8-3-1-2-4-9-28)26-17(22)16(25-15)19(29)27-20(23)24/h5-7,10H,1-4,8-9H2,(H2,22,26)(H4,23,24,27,29)
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88n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459068
PNG
(CHEMBL4212068)
Show SMILES NC(=N)NC(=O)c1nc(-c2cncnc2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H21N9O/c17-13-12(15(26)24-16(18)19)22-11(10-7-20-9-21-8-10)14(23-13)25-5-3-1-2-4-6-25/h7-9H,1-6H2,(H2,17,23)(H4,18,19,24,26)
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108n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459053
PNG
(CHEMBL4208241)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccco2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H21N7O2/c17-13-12(15(24)22-16(18)19)20-11(10-6-5-9-25-10)14(21-13)23-7-3-1-2-4-8-23/h5-6,9H,1-4,7-8H2,(H2,17,21)(H4,18,19,22,24)
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156n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459078
PNG
(CHEMBL4216516)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccoc2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H21N7O2/c17-13-12(15(24)22-16(18)19)20-11(10-5-8-25-9-10)14(21-13)23-6-3-1-2-4-7-23/h5,8-9H,1-4,6-7H2,(H2,17,21)(H4,18,19,22,24)
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166n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459054
PNG
(CHEMBL4213248)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3o2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C20H23N7O2/c21-17-16(19(28)26-20(22)23)24-15(14-11-12-7-3-4-8-13(12)29-14)18(25-17)27-9-5-1-2-6-10-27/h3-4,7-8,11H,1-2,5-6,9-10H2,(H2,21,25)(H4,22,23,26,28)
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183n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529264
PNG
(CHEMBL4513418)
Show SMILES COc1ncc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C11H13N9O2/c1-22-11-16-2-4(3-17-11)5-7(12)19-8(13)6(18-5)9(21)20-10(14)15/h2-3H,1H3,(H4,12,13,19)(H4,14,15,20,21)
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204n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459073
PNG
(CHEMBL4203654)
Show SMILES NC(=N)NC(=O)c1nc(Nc2ncccn2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H22N10O/c17-11-10(14(27)25-15(18)19)22-12(24-16-20-6-5-7-21-16)13(23-11)26-8-3-1-2-4-9-26/h5-7H,1-4,8-9H2,(H2,17,23)(H4,18,19,25,27)(H,20,21,22,24)
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228n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529261
PNG
(CHEMBL4445592)
Show SMILES COc1ccc2oc(cc2c1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C15H15N7O3/c1-24-7-2-3-8-6(4-7)5-9(25-8)10-12(16)21-13(17)11(20-10)14(23)22-15(18)19/h2-5H,1H3,(H4,16,17,21)(H4,18,19,22,23)
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287n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529246
PNG
(CHEMBL4473654)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3o2)c(N)nc1N
Show InChI InChI=1S/C14H13N7O2/c15-11-9(8-5-6-3-1-2-4-7(6)23-8)19-10(12(16)20-11)13(22)21-14(17)18/h1-5H,(H4,15,16,20)(H4,17,18,21,22)
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302n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459070
PNG
(CHEMBL4216389)
Show SMILES COc1cc(c(OC)nn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C18H25N9O3/c1-29-11-9-10(17(30-2)26-25-11)12-15(27-7-5-3-4-6-8-27)23-14(19)13(22-12)16(28)24-18(20)21/h9H,3-8H2,1-2H3,(H2,19,23)(H4,20,21,24,28)
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315n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529247
PNG
(CHEMBL4550786)
Show SMILES NC(=N)NC(=O)c1nc(c(N)nc1N)-c1ccc2occc2c1
Show InChI InChI=1S/C14H13N7O2/c15-11-9(7-1-2-8-6(5-7)3-4-23-8)19-10(12(16)20-11)13(22)21-14(17)18/h1-5H,(H4,15,16,20)(H4,17,18,21,22)
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350n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459074
PNG
(Upamostat | Wx-671)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(\N)=N\O)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C32H47N5O6S/c1-8-43-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34-40)35-44(41,42)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35,40H,8,12-15,17H2,1-7H3,(H2,33,34)/t28-/m0/s1
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410n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of uPA (unknown origin)


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529248
PNG
(CHEMBL4547122)
Show SMILES COc1ccc2cc(oc2c1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C15H15N7O3/c1-24-7-3-2-6-4-9(25-8(6)5-7)10-12(16)21-13(17)11(20-10)14(23)22-15(18)19/h2-5H,1H3,(H4,16,17,21)(H4,18,19,22,23)
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439n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529252
PNG
(CHEMBL4565975)
Show SMILES Cn1cc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C10H13N9O/c1-19-3-4(2-15-19)5-7(11)17-8(12)6(16-5)9(20)18-10(13)14/h2-3H,1H3,(H4,11,12,17)(H4,13,14,18,20)
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482n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529263
PNG
(CHEMBL4438665)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccoc2)c(N)nc1N
Show InChI InChI=1S/C10H11N7O2/c11-7-5(4-1-2-19-3-4)15-6(8(12)16-7)9(18)17-10(13)14/h1-3H,(H4,11,12,16)(H4,13,14,17,18)
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499n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459064
PNG
(CHEMBL4203547)
Show SMILES Cn1cc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C16H23N9O/c1-24-9-10(8-20-24)11-14(25-6-4-2-3-5-7-25)22-13(17)12(21-11)15(26)23-16(18)19/h8-9H,2-7H2,1H3,(H2,17,22)(H4,18,19,23,26)
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508n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529251
PNG
(CHEMBL4554541)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3cc(Cl)ccc3o2)c(N)nc1N
Show InChI InChI=1S/C14H12ClN7O2/c15-6-1-2-7-5(3-6)4-8(24-7)9-11(16)21-12(17)10(20-9)13(23)22-14(18)19/h1-4H,(H4,16,17,21)(H4,18,19,22,23)
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578n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529244
PNG
(CHEMBL4447661)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3cc(F)ccc3o2)c(N)nc1N
Show InChI InChI=1S/C14H12FN7O2/c15-6-1-2-7-5(3-6)4-8(24-7)9-11(16)21-12(17)10(20-9)13(23)22-14(18)19/h1-4H,(H4,16,17,21)(H4,18,19,22,23)
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587n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529262
PNG
(CHEMBL4575138)
Show SMILES Cc1ccc2oc(cc2c1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C15H15N7O2/c1-6-2-3-8-7(4-6)5-9(24-8)10-12(16)21-13(17)11(20-10)14(23)22-15(18)19/h2-5H,1H3,(H4,16,17,21)(H4,18,19,22,23)
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642n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459077
PNG
(CHEMBL4210813)
Show SMILES NC(=N)NC(=O)c1nc(-c2cnn(CCN3CCOCC3)c2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C21H32N10O2/c22-18-17(20(32)28-21(23)24)26-16(19(27-18)30-5-3-1-2-4-6-30)15-13-25-31(14-15)8-7-29-9-11-33-12-10-29/h13-14H,1-12H2,(H2,22,27)(H4,23,24,28,32)
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658n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529258
PNG
(CHEMBL4451872)
Show SMILES NC(=N)NC(=O)c1nc(c(N)nc1N)-c1cncnc1
Show InChI InChI=1S/C10H11N9O/c11-7-5(4-1-15-3-16-2-4)17-6(8(12)18-7)9(20)19-10(13)14/h1-3H,(H4,11,12,18)(H4,13,14,19,20)
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771n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529253
PNG
(CHEMBL4450051)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccco2)c(N)nc1N
Show InChI InChI=1S/C10H11N7O2/c11-7-5(4-2-1-3-19-4)15-6(8(12)16-7)9(18)17-10(13)14/h1-3H,(H4,11,12,16)(H4,13,14,17,18)
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776n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459052
PNG
(CHEMBL4211642)
Show SMILES COc1ccc(c(OC)n1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C19H26N8O3/c1-29-12-8-7-11(18(23-12)30-2)13-16(27-9-5-3-4-6-10-27)25-15(20)14(24-13)17(28)26-19(21)22/h7-8H,3-6,9-10H2,1-2H3,(H2,20,25)(H4,21,22,26,28)
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884n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529249
PNG
(CHEMBL4527266)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3cc(ccc3o2)C#N)c(N)nc1N
Show InChI InChI=1S/C15H12N8O2/c16-5-6-1-2-8-7(3-6)4-9(25-8)10-12(17)22-13(18)11(21-10)14(24)23-15(19)20/h1-4H,(H4,17,18,22)(H4,19,20,23,24)
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904n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459063
PNG
(CHEMBL4218928)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccc3OCOc3c2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C19H23N7O3/c20-16-15(18(27)25-19(21)22)23-14(11-5-6-12-13(9-11)29-10-28-12)17(24-16)26-7-3-1-2-4-8-26/h5-6,9H,1-4,7-8,10H2,(H2,20,24)(H4,21,22,25,27)
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934n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459057
PNG
(CHEMBL4203367)
Show SMILES NC(=N)NC(=O)c1nc(-c2ccsc2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H21N7OS/c17-13-12(15(24)22-16(18)19)20-11(10-5-8-25-9-10)14(21-13)23-6-3-1-2-4-7-23/h5,8-9H,1-4,6-7H2,(H2,17,21)(H4,18,19,22,24)
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1.03E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529255
PNG
(CHEMBL4476829)
Show SMILES COc1ccc(c(OC)n1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C13H16N8O3/c1-23-6-4-3-5(12(18-6)24-2)7-9(14)20-10(15)8(19-7)11(22)21-13(16)17/h3-4H,1-2H3,(H4,14,15,20)(H4,16,17,21,22)
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1.21E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529254
PNG
(CHEMBL4576924)
Show SMILES NC(=N)NC(=O)c1nc(-c2cccs2)c(N)nc1N
Show InChI InChI=1S/C10H11N7OS/c11-7-5(4-2-1-3-19-4)15-6(8(12)16-7)9(18)17-10(13)14/h1-3H,(H4,11,12,16)(H4,13,14,17,18)
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1.26E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459058
PNG
(CHEMBL4207061)
Show SMILES COc1cc(OC)cc(c1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C20H27N7O3/c1-29-13-9-12(10-14(11-13)30-2)15-18(27-7-5-3-4-6-8-27)25-17(21)16(24-15)19(28)26-20(22)23/h9-11H,3-8H2,1-2H3,(H2,21,25)(H4,22,23,26,28)
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1.32E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81818
PNG
(CAS_1794 | CHEMBL1909810 | HMA | NSC_1794)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
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PubMed
1.36E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529259
PNG
(CHEMBL4546029)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3s2)c(N)nc1N
Show InChI InChI=1S/C14H13N7OS/c15-11-9(8-5-6-3-1-2-4-7(6)23-8)19-10(12(16)20-11)13(22)21-14(17)18/h1-5H,(H4,15,16,20)(H4,17,18,21,22)
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1.41E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529260
PNG
(CHEMBL4551391)
Show SMILES NC(=N)NC(=O)c1nc(c(N)nc1N)-c1ccc2OCCc2c1
Show InChI InChI=1S/C14H15N7O2/c15-11-9(7-1-2-8-6(5-7)3-4-23-8)19-10(12(16)20-11)13(22)21-14(17)18/h1-2,5H,3-4H2,(H4,15,16,20)(H4,17,18,21,22)
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1.48E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Mus musculus (Mouse))
BDBM50459059
PNG
(CHEMBL4217043)
Show SMILES COc1ncc(cn1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C17H23N9O2/c1-28-17-21-8-10(9-22-17)11-14(26-6-4-2-3-5-7-26)24-13(18)12(23-11)15(27)25-16(19)20/h8-9H,2-7H2,1H3,(H2,18,24)(H4,19,20,25,27)
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1.61E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529245
PNG
(CHEMBL4456193)
Show SMILES COc1ncc(c(OC)n1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C12H15N9O3/c1-23-10-4(3-17-12(21-10)24-2)5-7(13)19-8(14)6(18-5)9(22)20-11(15)16/h3H,1-2H3,(H4,13,14,19)(H4,15,16,20,22)
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1.63E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459067
PNG
(CHEMBL4204836)
Show SMILES NC(=N)NC(=O)c1nc(c(nc1N)N1CCCCCC1)-c1cccnc1F
Show InChI InChI=1S/C17H21FN8O/c18-13-10(6-5-7-22-13)11-15(26-8-3-1-2-4-9-26)24-14(19)12(23-11)16(27)25-17(20)21/h5-7H,1-4,8-9H2,(H2,19,24)(H4,20,21,25,27)
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1.78E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Mus musculus (Mouse))
BDBM50459054
PNG
(CHEMBL4213248)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3o2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C20H23N7O2/c21-17-16(19(28)26-20(22)23)24-15(14-11-12-7-3-4-8-13(12)29-14)18(25-17)27-9-5-1-2-6-10-27/h3-4,7-8,11H,1-2,5-6,9-10H2,(H2,21,25)(H4,22,23,26,28)
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1.80E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459069
PNG
(CHEMBL4211937)
Show SMILES COc1ccc(c(OC)c1)-c1nc(C(=O)NC(N)=N)c(N)nc1N1CCCCCC1
Show InChI InChI=1S/C20H27N7O3/c1-29-12-7-8-13(14(11-12)30-2)15-18(27-9-5-3-4-6-10-27)25-17(21)16(24-15)19(28)26-20(22)23/h7-8,11H,3-6,9-10H2,1-2H3,(H2,21,25)(H4,22,23,26,28)
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2.20E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Mus musculus (Mouse))
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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2.31E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529257
PNG
(CHEMBL4589488)
Show SMILES CSc1ccc(cc1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Show InChI InChI=1S/C13H15N7OS/c1-22-7-4-2-6(3-5-7)8-10(14)19-11(15)9(18-8)12(21)20-13(16)17/h2-5H,1H3,(H4,14,15,19)(H4,16,17,20,21)
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2.41E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459066
PNG
(CHEMBL4212621)
Show SMILES NC(=N)NC(=O)c1nc(-c2cccs2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C16H21N7OS/c17-13-12(15(24)22-16(18)19)20-11(10-6-5-9-25-10)14(21-13)23-7-3-1-2-4-8-23/h5-6,9H,1-4,7-8H2,(H2,17,21)(H4,18,19,22,24)
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2.42E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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2.43E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50356156
PNG
(CHEMBL1909815)
Show SMILES NC(=N)NC(=O)c1nc(c(N)nc1N)-c1ccccc1
Show InChI InChI=1S/C12H13N7O/c13-9-7(6-4-2-1-3-5-6)17-8(10(14)18-9)11(20)19-12(15)16/h1-5H,(H4,13,14,18)(H4,15,16,19,20)
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2.50E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50529256
PNG
(CHEMBL4450426)
Show SMILES NC(=N)NC(=O)c1nc(c(N)nc1N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H12F3N7O/c14-13(15,16)6-3-1-5(2-4-6)7-9(17)22-10(18)8(21-7)11(24)23-12(19)20/h1-4H,(H4,17,18,22)(H4,19,20,23,24)
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3.14E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126753
BindingDB Entry DOI: 10.7270/Q2BV7M3S
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50459075
PNG
(CHEMBL4208316)
Show SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3s2)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C20H23N7OS/c21-17-16(19(28)26-20(22)23)24-15(14-11-12-7-3-4-8-13(12)29-14)18(25-17)27-9-5-1-2-6-10-27/h3-4,7-8,11H,1-2,5-6,9-10H2,(H2,21,25)(H4,22,23,26,28)
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3.31E+3n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay


J Med Chem 61: 8299-8320 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00838
BindingDB Entry DOI: 10.7270/Q2QF8WH4
More data for this
Ligand-Target Pair
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