Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521421![]() (6-(2,4- dichlorophenyl)- 1-fluoro-5-[6- [(3S)-1-(3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521262![]() (6-(6-ethoxy-2- fluoro-3- pyridyl)-5-[4- [[(3S)-1-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521255![]() (3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521384![]() (4-(6-ethoxy-2- fluoro-3- pyridyl)-5-[6- [(3S)-1-(3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521413![]() (6-(2-fluoro-4- methyl-phenyl)- 5-[6-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521428![]() (6-(6-ethoxy-2- fluoro-3- pyridyl)-1- fluoro-5-[6- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521382![]() (4-(2-chloro-4- methyl-phenyl)- 5-[6-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263706![]() (6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521254![]() (3-(2-fluoro-4- methyl-phenyl)- 4-[6-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50447089![]() (CHEMBL3112849) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Curated by ChEMBL | Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT... | J Med Chem 57: 903-20 (2014) Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521221![]() (3-(2-fluoro-6- methoxy-3- pyridyl)-4-[4- [(3S)-1-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521417![]() (6-[4- (difluoromethoxy)- 3-fluoro- phenyl]-5-[6- [...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521418![]() (6-(2,2- dimethylindolin- 5-yl)-5-[6-[(3S)- 1-(3- f...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521425![]() (6-[4- (difluoromethoxy)- 3-fluoro- phenyl]-1- fluo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521369![]() (4-(2,2-difluoro- 1,3- benzodioxol-5- yl)-5-[4-[(3S...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521373![]() (5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521374![]() (4-(2,2- dimethylindolin- 5-yl)-5-[4-[(3S)- 1-(3- f...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521377![]() (4-(2,2-dimethyl- 3H-benzofuran- 5-yl)-5-[4-[(3S)- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521378![]() (5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521381![]() (4-(2,4- dichlorophenyl)- 5-[(6-[(3S)-1-(3- fluorop...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521394![]() (4-[4- (fluoromethoxy) phenyl]-5-[4- [(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521360![]() (4-(benzofuran- 5-yl)-5-[4-[(3S)- 1-(3- fluoropropy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521362![]() (4-(4-ethoxy-2- methyl-phenyl)- 5-[4-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521261![]() (6-(2,4- dichlorophenyl)- 5-[4-[[(3S)-1- (3- fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263847![]() (6-(2,2-dimethylindolin-5-yl)-5-[4-[(3S)-1-(3-fluor...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521334![]() (5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263764![]() (6-(2,2- dimethyl- 3H- benzo- furan-5-yl)-5- [4-[(3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263774![]() (US9714221, Example 108) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263775![]() (US9714221, Example 109) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263737![]() (6-(6- ethoxy-2- fluoro-3- pyridyl)-5- [4-[(3S)- 1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263743![]() (5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263748![]() (US9714221, Example 82) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263755![]() (6-(2- chloro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263707![]() (5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263709![]() (6-(4- ethoxy-2- methyl- phenyl)-1- fluoro-5-[4- [(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263712![]() (6-(2,3- dihydro- 1,4- benzodioxin-6-yl)-5- [4-[(3S...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263719![]() (6-(1,3- benzoxazol- 5-yl)-5-[4- [(3S)-1-(3- fluoro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263860![]() (5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263892![]() (5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263893![]() (5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263900![]() (6-[2,3- difluoro-4- (1-piperidyl)- phenyl]-5- [4-[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM263911![]() (US9714221, Example 207) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
SANOFI US Patent | Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b... | US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50447088![]() (CHEMBL3112850) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Curated by ChEMBL | Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT... | J Med Chem 57: 903-20 (2014) Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521363![]() (4-(6-ethoxy-2- fluoro-3- pyridyl)-5-[4- [(3S)-1-(3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521295![]() (4-(4-ethoxy-2- methyl-phenyl)- 5-[4-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50392456![]() (CHEMBL2151926) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Curated by ChEMBL | Assay Description Inhibition of PI3Kbeta | Bioorg Med Chem Lett 22: 6381-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.072 BindingDB Entry DOI: 10.7270/Q2FN179H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521297![]() (4-(2-fluoro-4- methoxy- phenyl)-5-[4- [(3S)-1-(3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521267![]() (5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521270![]() (4-(2-fluoro-4- hydroxy- phenyl)-5-[4- [(3S)-1-(3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521203![]() (3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[4- [(3S)-1-(3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair |
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