Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50304738 (2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503760 (CHEMBL4442450) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50398716 (CHEMBL2179618 | US10227295, Compound 5g | US940985...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC6 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followe... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC6 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followe... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503756 (CHEMBL4473741) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503754 (CHEMBL4458733) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503757 (CHEMBL4541841) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50180950 (CHEMBL3818203) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant GCP2 expressed in Schneider 2 cells preincubated for 15 mins using [3H]-NAAG/NAAG as substrate measured after 20 mins... | J Med Chem 59: 4539-50 (2016) Article DOI: 10.1021/acs.jmedchem.5b01806 BindingDB Entry DOI: 10.7270/Q2154JZB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50180951 (CHEMBL3818465) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant GCP2 expressed in Schneider 2 cells preincubated for 15 mins using [3H]-NAAG/NAAG as substrate measured after 20 mins... | J Med Chem 59: 4539-50 (2016) Article DOI: 10.1021/acs.jmedchem.5b01806 BindingDB Entry DOI: 10.7270/Q2154JZB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50180949 (CHEMBL3818599) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant GCP2 expressed in Schneider 2 cells preincubated for 15 mins using [3H]-NAAG/NAAG as substrate measured after 20 mins... | J Med Chem 59: 4539-50 (2016) Article DOI: 10.1021/acs.jmedchem.5b01806 BindingDB Entry DOI: 10.7270/Q2154JZB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC8 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by s... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC4 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by s... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 9 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC9 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by s... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 7 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC7 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by s... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 5 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC5 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by s... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC1 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followe... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50503977 (CHEMBL4465902) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal tagged human HDAC11 expressed in HEK293T/17 using Boc-[TFA-Lys]-AMC as substrate preincubated for 10 mins followed by ... | J Med Chem 62: 7042-7057 (2019) Article DOI: 10.1021/acs.jmedchem.9b00516 BindingDB Entry DOI: 10.7270/Q2MP56H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503758 (CHEMBL4587808) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 531 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503755 (CHEMBL4462654) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50129195 (2-(2-Hydroxycarbamoyl-ethyl)-pentanedioic acid | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of recombinant human GCP2 using [3H]-NAAG as substrate | J Med Chem 59: 4539-50 (2016) Article DOI: 10.1021/acs.jmedchem.5b01806 BindingDB Entry DOI: 10.7270/Q2154JZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase 2 (Homo sapiens (Human)) | BDBM50503759 (CHEMBL4513258) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biotechnology of the Czech Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei... | Bioorg Med Chem 27: 255-264 (2019) Article DOI: 10.1016/j.bmc.2018.11.022 BindingDB Entry DOI: 10.7270/Q2F47SC4 | |||||||||||
More data for this Ligand-Target Pair |