| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50180950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1585175 (CHEMBL3820983) |
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| IC50 | 44±n/a nM |
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| Citation |  Novakova, Z; Wozniak, K; Jancarik, A; Rais, R; Wu, Y; Pavlicek, J; Ferraris, D; Havlinova, B; Ptacek, J; Vavra, J; Hin, N; Rojas, C; Majer, P; Slusher, BS; Tsukamoto, T; Barinka, C Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J Med Chem59:4539-50 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84333.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497035 |
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| Residue: | 750 |
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| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM50180950 |
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| n/a |
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| Name | BDBM50180950 |
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| Synonyms: | CHEMBL3818203 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NO6 |
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| Mol. Mass. | 281.2613 |
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| SMILES | ONC(=O)CC[C@H](Cc1ccc(cc1)C(O)=O)C(O)=O |r| |
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| Structure | 
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