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Compile Data Set for Download or QSAR

Found 210 hits with Last Name = 'boiziau' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 7n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 7n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 7n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 28n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453606
PNG
(CHEMBL168533)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)OCCCc2ccccc2)c1
Show InChI InChI=1S/C23H23NO5/c25-19-9-11-21(26)17(13-19)15-24-18-8-10-22(27)20(14-18)23(28)29-12-4-7-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,24-27H,4,7,12,15H2
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n/an/a 30n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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n/an/a 30n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 33n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 34n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340503
PNG
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)
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n/an/a 34n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 34n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 35n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340500
PNG
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24)
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n/an/a 43n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340501
PNG
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25)
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n/an/a 47n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453600
PNG
(CHEMBL355294)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)NOCc2ccccc2)c1
Show InChI InChI=1S/C21H20N2O5/c24-17-7-9-19(25)15(10-17)12-22-16-6-8-20(26)18(11-16)21(27)23-28-13-14-4-2-1-3-5-14/h1-11,22,24-26H,12-13H2,(H,23,27)
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n/an/a 50n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 55n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453594
PNG
(CHEMBL169970)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)Oc2ccccc2)c1
Show InChI InChI=1S/C20H17NO5/c22-15-7-9-18(23)13(10-15)12-21-14-6-8-19(24)17(11-14)20(25)26-16-4-2-1-3-5-16/h1-11,21-24H,12H2
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n/an/a 70n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453576
PNG
(CHEMBL352583)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)OCc2ccccc2)c1
Show InChI InChI=1S/C21H19NO5/c23-17-7-9-19(24)15(10-17)12-22-16-6-8-20(25)18(11-16)21(26)27-13-14-4-2-1-3-5-14/h1-11,22-25H,12-13H2
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n/an/a 80n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 87n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453586
PNG
(CHEMBL169514)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)Oc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H19NO5/c26-19-7-10-22(27)17(11-19)14-25-18-6-9-23(28)21(13-18)24(29)30-20-8-5-15-3-1-2-4-16(15)12-20/h1-13,25-28H,14H2
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n/an/a 90n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453601
PNG
(CHEMBL422335)
Show SMILES Oc1cccc(OC(=O)c2cc(NCc3cc(O)ccc3O)ccc2O)c1
Show InChI InChI=1S/C20H17NO6/c22-14-2-1-3-16(10-14)27-20(26)17-9-13(4-6-19(17)25)21-11-12-8-15(23)5-7-18(12)24/h1-10,21-25H,11H2
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n/an/a 90n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340503
PNG
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)
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n/an/a 92n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340503
PNG
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)
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n/an/a 92n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 98n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 98n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453584
PNG
(CHEMBL170996)
Show SMILES CC(C)(C)ONC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C18H22N2O5/c1-18(2,3)25-20-17(24)14-9-12(4-6-16(14)23)19-10-11-8-13(21)5-7-15(11)22/h4-9,19,21-23H,10H2,1-3H3,(H,20,24)
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n/an/a 100n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453597
PNG
(CHEMBL168915)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)Oc2cccc3ccccc23)c1
Show InChI InChI=1S/C24H19NO5/c26-18-9-11-21(27)16(12-18)14-25-17-8-10-22(28)20(13-17)24(29)30-23-7-3-5-15-4-1-2-6-19(15)23/h1-13,25-28H,14H2
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n/an/a 110n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340514
PNG
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3
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n/an/a 117n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453607
PNG
(CHEMBL168366)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)OCCc2ccccc2)c1
Show InChI InChI=1S/C22H21NO5/c24-18-7-9-20(25)16(12-18)14-23-17-6-8-21(26)19(13-17)22(27)28-11-10-15-4-2-1-3-5-15/h1-9,12-13,23-26H,10-11,14H2
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n/an/a 130n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 145n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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n/an/a 150n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibition of EGFR(epidermal growth factor receptor) autophosphorylation in ER22 cell membranes

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340501
PNG
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25)
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n/an/a 154n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340501
PNG
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25)
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n/an/a 154n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340502
PNG
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)
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n/an/a 175n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340513
PNG
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Show SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1
Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISA

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453607
PNG
(CHEMBL168366)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)OCCc2ccccc2)c1
Show InChI InChI=1S/C22H21NO5/c24-18-7-9-20(25)16(12-18)14-23-17-6-8-21(26)19(13-17)22(27)28-11-10-15-4-2-1-3-5-15/h1-9,12-13,23-26H,10-11,14H2
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n/an/a 200n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibition of EGFR(epidermal growth factor receptor) autophosphorylation in ER22 cell membranes

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340500
PNG
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24)
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n/an/a 202n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340500
PNG
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24)
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n/an/a 202n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340514
PNG
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3
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n/an/a 264n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340514
PNG
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3
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n/an/a 264n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453572
PNG
(CHEMBL169657)
Show SMILES CONC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H16N2O5/c1-22-17-15(21)12-7-10(2-4-14(12)20)16-8-9-6-11(18)3-5-13(9)19/h2-7,16,18-20H,8H2,1H3,(H,17,21)
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n/an/a 300n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))		BDBM50340484
PNG
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)
Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12
Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor kinase

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340484
PNG
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)
Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12
Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453571
PNG
(CHEMBL171054)
Show SMILES CC(COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O)Cc1ccccc1
Show InChI InChI=1S/C24H25NO5/c1-16(11-17-5-3-2-4-6-17)15-30-24(29)21-13-19(7-9-23(21)28)25-14-18-12-20(26)8-10-22(18)27/h2-10,12-13,16,25-28H,11,14-15H2,1H3
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n/an/a 360n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453605
PNG
(CHEMBL172449)
Show SMILES ONC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H14N2O5/c17-10-2-4-12(18)8(5-10)7-15-9-1-3-13(19)11(6-9)14(20)16-21/h1-6,15,17-19,21H,7H2,(H,16,20)
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n/an/a 400n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453569
PNG
(CHEMBL435902)
Show SMILES Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)OCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H25NO5/c26-20-10-12-22(27)18(14-20)16-25-19-9-11-23(28)21(15-19)24(29)30-13-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-12,14-15,25-28H,4-5,8,13,16H2
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n/an/a 400n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453577
PNG
(CHEMBL354128)
Show SMILES CC(CCOC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O)c1ccccc1
Show InChI InChI=1S/C24H25NO5/c1-16(17-5-3-2-4-6-17)11-12-30-24(29)21-14-19(7-9-23(21)28)25-15-18-13-20(26)8-10-22(18)27/h2-10,13-14,16,25-28H,11-12,15H2,1H3
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n/an/a 400n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50453603
PNG
(CHEMBL355857)
Show SMILES CCOC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C16H17NO5/c1-2-22-16(21)13-8-11(3-5-15(13)20)17-9-10-7-12(18)4-6-14(10)19/h3-8,17-20H,2,9H2,1H3
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n/an/a 400n/an/an/an/an/an/a



U266 INSERM-URA D1500 CNRS

Curated by ChEMBL


Assay Description
Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane

J Med Chem 37: 845-59 (1994)


BindingDB Entry DOI: 10.7270/Q2QV3KJ3
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340516
PNG
((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Show SMILES Cc1c(O)n(-c2ccc(SC(F)(F)F)cc2)c(=O)n1Cc1ccnc2ccccc12
Show InChI InChI=1S/C21H16F3N3O2S/c1-13-19(28)27(15-6-8-16(9-7-15)30-21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3
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n/an/a 410n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340499
PNG
(1-((2-(isopropylamino)pyridin-4-yl)methyl)-5,5-dim...)
Show SMILES CC(C)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H23F3N4O2S/c1-13(2)26-17-11-14(9-10-25-17)12-27-19(30)28(18(29)20(27,3)4)15-5-7-16(8-6-15)31-21(22,23)24/h5-11,13H,12H2,1-4H3,(H,25,26)
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n/an/a 453n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50340520
PNG
(5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Show SMILES CC1(C)N(Cc2ccnc3ccccc23)C(=O)N(C1=O)c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C22H18F3N3O4S/c1-21(2)19(29)28(15-7-9-16(10-8-15)33(31,32)22(23,24)25)20(30)27(21)13-14-11-12-26-18-6-4-3-5-17(14)18/h3-12H,13H2,1-2H3
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n/an/a 460n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay

Bioorg Med Chem Lett 21: 2224-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK
More data for this
Ligand-Target Pair
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