Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neprilysin (Homo sapiens (Human)) | BDBM50024101 ((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50024102 (((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023103 (CHEMBL3298934) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023104 (CHEMBL3298935) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023097 (CHEMBL3298860) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023069 (CHEMBL3298859) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023131 (CHEMBL3298940) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023131 (CHEMBL3298940) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50024102 (((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023128 (CHEMBL3298937) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023134 (CHEMBL3298943) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023133 (CHEMBL3298942) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023134 (CHEMBL3298943) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023133 (CHEMBL3298942) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023135 (CHEMBL3298944) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023132 (CHEMBL3298941) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023127 (CHEMBL3298936) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023136 (CHEMBL3298945) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023129 (CHEMBL3298938) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023137 (CHEMBL3298946) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023152 (CHEMBL3298947) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023130 (CHEMBL3298939) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL | Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry | J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50023131 (CHEMBL3298940) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50024102 (((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50023134 (CHEMBL3298943) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads Curated by ChEMBL | Assay Description Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af... | Eur J Med Chem 102: 58-67 (2015) Article DOI: 10.1016/j.ejmech.2015.07.027 BindingDB Entry DOI: 10.7270/Q2V989WW | |||||||||||
More data for this Ligand-Target Pair |