Compile Data Set for Download or QSAR

Found 589 hits with Last Name = 'brenning' and Initial = 'b'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242374 (US10047093, 8-31 | US10392392, Example 8-31 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:7.10,wD:4.3,(-8.7,2.48,;-7.36,3.25,;-7.36,4.79,;-8.7,4.02,;-6.03,2.48,;-6.03,.94,;-4.7,.17,;-3.36,.94,;-3.36,2.48,;-4.7,3.25,;-2.03,.17,;-.69,.94,;-.69,2.48,;.64,3.25,;1.97,2.48,;3.44,2.96,;4.34,1.71,;3.44,.47,;3.84,-1.02,;2.75,-2.11,;3.15,-3.6,;4.63,-4,;5.82,-2.9,;5.32,-1.42,;7.31,-3.28,;8.8,-3.66,;6.93,-4.77,;7.69,-1.79,;1.97,.94,;.64,.17,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242374 (US10047093, 8-31 | US10392392, Example 8-31 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:7.10,wD:4.3,(-8.7,2.48,;-7.36,3.25,;-7.36,4.79,;-8.7,4.02,;-6.03,2.48,;-6.03,.94,;-4.7,.17,;-3.36,.94,;-3.36,2.48,;-4.7,3.25,;-2.03,.17,;-.69,.94,;-.69,2.48,;.64,3.25,;1.97,2.48,;3.44,2.96,;4.34,1.71,;3.44,.47,;3.84,-1.02,;2.75,-2.11,;3.15,-3.6,;4.63,-4,;5.82,-2.9,;5.32,-1.42,;7.31,-3.28,;8.8,-3.66,;6.93,-4.77,;7.69,-1.79,;1.97,.94,;.64,.17,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242374 (US10047093, 8-31 | US10392392, Example 8-31 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:7.10,wD:4.3,(-8.7,2.48,;-7.36,3.25,;-7.36,4.79,;-8.7,4.02,;-6.03,2.48,;-6.03,.94,;-4.7,.17,;-3.36,.94,;-3.36,2.48,;-4.7,3.25,;-2.03,.17,;-.69,.94,;-.69,2.48,;.64,3.25,;1.97,2.48,;3.44,2.96,;4.34,1.71,;3.44,.47,;3.84,-1.02,;2.75,-2.11,;3.15,-3.6,;4.63,-4,;5.82,-2.9,;5.32,-1.42,;7.31,-3.28,;8.8,-3.66,;6.93,-4.77,;7.69,-1.79,;1.97,.94,;.64,.17,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242374 (US10047093, 8-31 | US10392392, Example 8-31 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:7.10,wD:4.3,(-8.7,2.48,;-7.36,3.25,;-7.36,4.79,;-8.7,4.02,;-6.03,2.48,;-6.03,.94,;-4.7,.17,;-3.36,.94,;-3.36,2.48,;-4.7,3.25,;-2.03,.17,;-.69,.94,;-.69,2.48,;.64,3.25,;1.97,2.48,;3.44,2.96,;4.34,1.71,;3.44,.47,;3.84,-1.02,;2.75,-2.11,;3.15,-3.6,;4.63,-4,;5.82,-2.9,;5.32,-1.42,;7.31,-3.28,;8.8,-3.66,;6.93,-4.77,;7.69,-1.79,;1.97,.94,;.64,.17,)| Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242397 (US10047093, 8-79 | US10392392, Example 8-79 | US10...) Show SMILES CC(C)(N)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:7.10,wD:4.3,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-5.29,.54,;-3.95,-.23,;-2.62,.54,;-2.62,2.08,;-3.95,2.85,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H26ClN5/c1-21(2,23)15-6-8-17(9-7-15)25-19-10-11-20-24-13-18(27(20)26-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17H,6-9,23H2,1-2H3,(H,25,26)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242397 (US10047093, 8-79 | US10392392, Example 8-79 | US10...) Show SMILES CC(C)(N)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:7.10,wD:4.3,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-5.29,.54,;-3.95,-.23,;-2.62,.54,;-2.62,2.08,;-3.95,2.85,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H26ClN5/c1-21(2,23)15-6-8-17(9-7-15)25-19-10-11-20-24-13-18(27(20)26-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17H,6-9,23H2,1-2H3,(H,25,26)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242397 (US10047093, 8-79 | US10392392, Example 8-79 | US10...) Show SMILES CC(C)(N)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:7.10,wD:4.3,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-5.29,.54,;-3.95,-.23,;-2.62,.54,;-2.62,2.08,;-3.95,2.85,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H26ClN5/c1-21(2,23)15-6-8-17(9-7-15)25-19-10-11-20-24-13-18(27(20)26-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17H,6-9,23H2,1-2H3,(H,25,26)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242397 (US10047093, 8-79 | US10392392, Example 8-79 | US10...) Show SMILES CC(C)(N)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:7.10,wD:4.3,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-5.29,.54,;-3.95,-.23,;-2.62,.54,;-2.62,2.08,;-3.95,2.85,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H26ClN5/c1-21(2,23)15-6-8-17(9-7-15)25-19-10-11-20-24-13-18(27(20)26-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17H,6-9,23H2,1-2H3,(H,25,26)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242352 (US10047093, 8-8 | US10392392, Example 8-8 | US1087...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-18-9-8-17(26-27(16)18)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242380 (US10047093, 8-37 | US10392392, Example 8-37 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.3,wD:7.10,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-3.95,2.85,;-2.62,2.08,;-2.62,.54,;-3.95,-.23,;-5.29,.54,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242388 (US10047093, 8-68 | US10392392, Example 8-68 | US10...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.7,wD:1.0,(-7.29,3.62,;-5.95,2.85,;-5.95,1.31,;-4.62,.54,;-3.29,1.31,;-3.29,2.85,;-4.62,3.62,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-18-9-8-17(23-24(16)18)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242352 (US10047093, 8-8 | US10392392, Example 8-8 | US1087...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-18-9-8-17(26-27(16)18)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242380 (US10047093, 8-37 | US10392392, Example 8-37 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.3,wD:7.10,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-3.95,2.85,;-2.62,2.08,;-2.62,.54,;-3.95,-.23,;-5.29,.54,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242388 (US10047093, 8-68 | US10392392, Example 8-68 | US10...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.7,wD:1.0,(-7.29,3.62,;-5.95,2.85,;-5.95,1.31,;-4.62,.54,;-3.29,1.31,;-3.29,2.85,;-4.62,3.62,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-18-9-8-17(23-24(16)18)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242352 (US10047093, 8-8 | US10392392, Example 8-8 | US1087...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-18-9-8-17(26-27(16)18)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242380 (US10047093, 8-37 | US10392392, Example 8-37 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.3,wD:7.10,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-3.95,2.85,;-2.62,2.08,;-2.62,.54,;-3.95,-.23,;-5.29,.54,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242388 (US10047093, 8-68 | US10392392, Example 8-68 | US10...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.7,wD:1.0,(-7.29,3.62,;-5.95,2.85,;-5.95,1.31,;-4.62,.54,;-3.29,1.31,;-3.29,2.85,;-4.62,3.62,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-18-9-8-17(23-24(16)18)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242380 (US10047093, 8-37 | US10392392, Example 8-37 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.3,wD:7.10,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-3.95,2.85,;-2.62,2.08,;-2.62,.54,;-3.95,-.23,;-5.29,.54,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)| Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242352 (US10047093, 8-8 | US10392392, Example 8-8 | US1087...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-18-9-8-17(26-27(16)18)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242388 (US10047093, 8-68 | US10392392, Example 8-68 | US10...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.7,wD:1.0,(-7.29,3.62,;-5.95,2.85,;-5.95,1.31,;-4.62,.54,;-3.29,1.31,;-3.29,2.85,;-4.62,3.62,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-18-9-8-17(23-24(16)18)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242372 (US10047093, 8-29 | US10392392, Example 8-29 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:4.7,wD:1.0,(-8.03,4.02,;-6.7,3.25,;-6.7,1.71,;-5.36,.94,;-4.03,1.71,;-4.03,3.25,;-5.36,4.02,;-2.7,.94,;-1.36,1.71,;-1.36,3.25,;-.03,4.02,;1.31,3.25,;2.77,3.73,;3.68,2.48,;2.77,1.24,;3.17,-.25,;2.08,-1.34,;2.48,-2.83,;3.97,-3.23,;5.15,-2.13,;4.66,-.65,;6.64,-2.51,;8.14,-2.89,;6.26,-4,;7.03,-1.02,;1.31,1.71,;-.03,.94,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242372 (US10047093, 8-29 | US10392392, Example 8-29 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:4.7,wD:1.0,(-8.03,4.02,;-6.7,3.25,;-6.7,1.71,;-5.36,.94,;-4.03,1.71,;-4.03,3.25,;-5.36,4.02,;-2.7,.94,;-1.36,1.71,;-1.36,3.25,;-.03,4.02,;1.31,3.25,;2.77,3.73,;3.68,2.48,;2.77,1.24,;3.17,-.25,;2.08,-1.34,;2.48,-2.83,;3.97,-3.23,;5.15,-2.13,;4.66,-.65,;6.64,-2.51,;8.14,-2.89,;6.26,-4,;7.03,-1.02,;1.31,1.71,;-.03,.94,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242372 (US10047093, 8-29 | US10392392, Example 8-29 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:4.7,wD:1.0,(-8.03,4.02,;-6.7,3.25,;-6.7,1.71,;-5.36,.94,;-4.03,1.71,;-4.03,3.25,;-5.36,4.02,;-2.7,.94,;-1.36,1.71,;-1.36,3.25,;-.03,4.02,;1.31,3.25,;2.77,3.73,;3.68,2.48,;2.77,1.24,;3.17,-.25,;2.08,-1.34,;2.48,-2.83,;3.97,-3.23,;5.15,-2.13,;4.66,-.65,;6.64,-2.51,;8.14,-2.89,;6.26,-4,;7.03,-1.02,;1.31,1.71,;-.03,.94,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242372 (US10047093, 8-29 | US10392392, Example 8-29 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:4.7,wD:1.0,(-8.03,4.02,;-6.7,3.25,;-6.7,1.71,;-5.36,.94,;-4.03,1.71,;-4.03,3.25,;-5.36,4.02,;-2.7,.94,;-1.36,1.71,;-1.36,3.25,;-.03,4.02,;1.31,3.25,;2.77,3.73,;3.68,2.48,;2.77,1.24,;3.17,-.25,;2.08,-1.34,;2.48,-2.83,;3.97,-3.23,;5.15,-2.13,;4.66,-.65,;6.64,-2.51,;8.14,-2.89,;6.26,-4,;7.03,-1.02,;1.31,1.71,;-.03,.94,)| Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50043692 (CHEMBL3355542 | US10047093, 8-52 | US10392392, Exa...) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)| Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242348 (US10047093, 8-4 | US10392392, Example 8-4 | US1087...) Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-17-8-9-18(24-25(16)17)27-14-6-4-13(26)5-7-14/h1-3,8-11,13-14,26H,4-7H2/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242378 (US10047093, 8-35 | US10392392, Example 8-35 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:1.0,wD:4.7,(-7.29,3.62,;-5.95,2.85,;-4.62,3.62,;-3.29,2.85,;-3.29,1.31,;-4.62,.54,;-5.95,1.31,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242348 (US10047093, 8-4 | US10392392, Example 8-4 | US1087...) Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-17-8-9-18(24-25(16)17)27-14-6-4-13(26)5-7-14/h1-3,8-11,13-14,26H,4-7H2/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242378 (US10047093, 8-35 | US10392392, Example 8-35 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:1.0,wD:4.7,(-7.29,3.62,;-5.95,2.85,;-4.62,3.62,;-3.29,2.85,;-3.29,1.31,;-4.62,.54,;-5.95,1.31,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242348 (US10047093, 8-4 | US10392392, Example 8-4 | US1087...) Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-17-8-9-18(24-25(16)17)27-14-6-4-13(26)5-7-14/h1-3,8-11,13-14,26H,4-7H2/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242348 (US10047093, 8-4 | US10392392, Example 8-4 | US1087...) Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)| Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-17-8-9-18(24-25(16)17)27-14-6-4-13(26)5-7-14/h1-3,8-11,13-14,26H,4-7H2/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242378 (US10047093, 8-35 | US10392392, Example 8-35 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:1.0,wD:4.7,(-7.29,3.62,;-5.95,2.85,;-4.62,3.62,;-3.29,2.85,;-3.29,1.31,;-4.62,.54,;-5.95,1.31,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242378 (US10047093, 8-35 | US10392392, Example 8-35 | US10...) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:1.0,wD:4.7,(-7.29,3.62,;-5.95,2.85,;-4.62,3.62,;-3.29,2.85,;-3.29,1.31,;-4.62,.54,;-5.95,1.31,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)| Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50364776 (CHEMBL1952141 | CHEMBL1952329) Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay				ACS Med Chem Lett 6: 63-7 (2015) Article DOI: 10.1021/ml500300c BindingDB Entry DOI: 10.7270/Q2J67JHN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM228294 (US10047093, 8-11 | US10392392, Example 8-11 | US10...) Show SMILES OC[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-7.96,5.19,;-7.96,3.65,;-6.62,2.88,;-5.24,3.62,;-3.91,2.85,;-3.91,1.31,;-5.24,.54,;-6.57,1.31,;-2.57,.54,;-1.24,1.31,;-1.24,2.85,;.09,3.62,;1.43,2.85,;2.89,3.33,;3.8,2.08,;2.89,.84,;3.29,-.65,;2.2,-1.74,;2.6,-3.23,;4.09,-3.62,;5.23,-2.55,;6.72,-2.95,;7.81,-1.86,;8.9,-.77,;8.9,-2.95,;6.72,-.77,;4.78,-1.05,;1.43,1.31,;.09,.54,)| Show InChI InChI=1S/C20H21F3N4O2/c21-20(22,23)29-16-3-1-2-14(10-16)17-11-24-19-9-8-18(26-27(17)19)25-15-6-4-13(12-28)5-7-15/h1-3,8-11,13,15,28H,4-7,12H2,(H,25,26)/t13-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM476631 (US10875864, EX. 8-70) Show SMILES N[C@@H]1CCCC(C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r| Show InChI InChI=1S/C18H20ClN5/c19-13-4-1-3-12(9-13)16-11-21-18-8-7-17(23-24(16)18)22-15-6-2-5-14(20)10-15/h1,3-4,7-9,11,14-15H,2,5-6,10,20H2,(H,22,23)/t14-,15?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM228294 (US10047093, 8-11 | US10392392, Example 8-11 | US10...) Show SMILES OC[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-7.96,5.19,;-7.96,3.65,;-6.62,2.88,;-5.24,3.62,;-3.91,2.85,;-3.91,1.31,;-5.24,.54,;-6.57,1.31,;-2.57,.54,;-1.24,1.31,;-1.24,2.85,;.09,3.62,;1.43,2.85,;2.89,3.33,;3.8,2.08,;2.89,.84,;3.29,-.65,;2.2,-1.74,;2.6,-3.23,;4.09,-3.62,;5.23,-2.55,;6.72,-2.95,;7.81,-1.86,;8.9,-.77,;8.9,-2.95,;6.72,-.77,;4.78,-1.05,;1.43,1.31,;.09,.54,)| Show InChI InChI=1S/C20H21F3N4O2/c21-20(22,23)29-16-3-1-2-14(10-16)17-11-24-19-9-8-18(26-27(17)19)25-15-6-4-13(12-28)5-7-15/h1-3,8-11,13,15,28H,4-7,12H2,(H,25,26)/t13-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242389 (US9416132, 8-70) Show SMILES NC1CCCC(C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 Show InChI InChI=1S/C18H20ClN5/c19-13-4-1-3-12(9-13)16-11-21-18-8-7-17(23-24(16)18)22-15-6-2-5-14(20)10-15/h1,3-4,7-9,11,14-15H,2,5-6,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM228294 (US10047093, 8-11 | US10392392, Example 8-11 | US10...) Show SMILES OC[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-7.96,5.19,;-7.96,3.65,;-6.62,2.88,;-5.24,3.62,;-3.91,2.85,;-3.91,1.31,;-5.24,.54,;-6.57,1.31,;-2.57,.54,;-1.24,1.31,;-1.24,2.85,;.09,3.62,;1.43,2.85,;2.89,3.33,;3.8,2.08,;2.89,.84,;3.29,-.65,;2.2,-1.74,;2.6,-3.23,;4.09,-3.62,;5.23,-2.55,;6.72,-2.95,;7.81,-1.86,;8.9,-.77,;8.9,-2.95,;6.72,-.77,;4.78,-1.05,;1.43,1.31,;.09,.54,)| Show InChI InChI=1S/C20H21F3N4O2/c21-20(22,23)29-16-3-1-2-14(10-16)17-11-24-19-9-8-18(26-27(17)19)25-15-6-4-13(12-28)5-7-15/h1-3,8-11,13,15,28H,4-7,12H2,(H,25,26)/t13-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM228361 (US10047093, 8-70 | US10392392, Example 8-70) Show SMILES N[C@@H]1CCC[C@H](C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r| Show InChI InChI=1S/C18H20ClN5/c19-13-4-1-3-12(9-13)16-11-21-18-8-7-17(23-24(16)18)22-15-6-2-5-14(20)10-15/h1,3-4,7-9,11,14-15H,2,5-6,10,20H2,(H,22,23)/t14-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242355 (US9416132, 8-11) Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-9.3,2.86,;-7.96,3.63,;-6.63,2.86,;-5.25,3.6,;-3.91,2.83,;-3.91,1.29,;-5.25,.52,;-6.58,1.29,;-2.58,.52,;-1.25,1.29,;-1.25,2.83,;.09,3.6,;1.42,2.83,;2.89,3.31,;3.79,2.06,;2.89,.82,;3.28,-.67,;2.2,-1.76,;2.59,-3.25,;4.08,-3.65,;5.22,-2.57,;6.71,-2.97,;7.11,-4.46,;7.51,-5.94,;8.6,-4.06,;5.62,-4.86,;4.77,-1.07,;1.42,1.29,;.09,.52,)| Show InChI InChI=1S/C20H21F3N4O2/c1-28-15-7-5-14(6-8-15)25-18-9-10-19-24-12-17(27(19)26-18)13-3-2-4-16(11-13)29-20(21,22)23/h2-4,9-12,14-15H,5-8H2,1H3,(H,25,26)/t14-,15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM228361 (US10047093, 8-70 | US10392392, Example 8-70) Show SMILES N[C@@H]1CCC[C@H](C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r| Show InChI InChI=1S/C18H20ClN5/c19-13-4-1-3-12(9-13)16-11-21-18-8-7-17(23-24(16)18)22-15-6-2-5-14(20)10-15/h1,3-4,7-9,11,14-15H,2,5-6,10,20H2,(H,22,23)/t14-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242354 (US10047093, 8-10 | US10392392, Example 8-10 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)| Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242354 (US10047093, 8-10 | US10392392, Example 8-10 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)| Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242354 (US10047093, 8-10 | US10392392, Example 8-10 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)| Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM242354 (US10047093, 8-10 | US10392392, Example 8-10 | US10...) Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)| Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 589 total )  |  Next  |  Last  >>

Jump to: