Compile Data Set for Download or QSAR

Found 962 hits with Last Name = 'burke' and Initial = 'mj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587457 (US11534441, Compound 167) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)nc2C11CC1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587477 (US11534441, Compound 187) Show SMILES CC[C@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)O[C@@H](C)C5(CC5)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587461 (US11534441, Compound 171) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)nc2C1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587460 (US11534441, Compound 170) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CCC3)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587372 (US11534441, Compound 80) Show SMILES CC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587444 (US11534441, Compound 154) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587478 (US11534441, Compound 188) Show SMILES COC[C@@](C)(N)c1cnc(OC)c2cnc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587367 (US11534441, Compound 75) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587446 (US11534441, Compound 156) Show SMILES CC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587348 (US11534441, Compound 56) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587486 (US11534441, Compound 196) Show SMILES CC[C@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)C5(CC5)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Pantetheinase (Homo sapiens (Human))	BDBM408834 (US10364255, Ex. 25) Show SMILES O=C(N1CC[C@@H](C1)N1CCCC1=O)c1cnc2NC3(CC3)CCOc2c1 |r| Show InChI InChI=1S/C19H24N4O3/c24-16-2-1-7-23(16)14-3-8-22(12-14)18(25)13-10-15-17(20-11-13)21-19(4-5-19)6-9-26-15/h10-11,14H,1-9,12H2,(H,20,21)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingleheim International GmbH US Patent					Assay Description Method 1:Vanin-1 Enzymatic Assay:The test compounds are dissolved in 100% DMSO at a concentration of 10 mM and in a first step diluted in DMSO to a c...				US Patent US10364255 (2019) BindingDB Entry DOI: 10.7270/Q28S4S8N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587483 (US11534441, Compound 193) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(O[C@H]5C[C@H](O)C5)c4cn3)[C@@](C)(N)C3CC3)nc2[C@H]1C |r,wU:26.29,18.17,34.40,wD:26.30,20.20,1.0,(8.16,8.71,;6.82,7.94,;6.82,6.4,;5.49,5.63,;5.49,4.09,;4.15,6.4,;2.82,5.63,;1.49,6.4,;1.49,7.94,;.15,8.71,;-1.18,7.94,;-2.51,8.71,;-3.85,7.94,;-5.18,8.71,;-6.51,7.94,;-6.51,6.4,;-5.18,5.63,;-5.18,4.09,;-3.85,3.32,;-2.36,3.72,;-1.96,2.23,;-.63,1.46,;-3.45,1.83,;-3.85,6.4,;-2.51,5.63,;-1.18,6.4,;-5.18,10.25,;-4.41,11.58,;-3.64,10.25,;-6.67,10.65,;-7.76,11.73,;-8.16,10.25,;2.82,8.71,;4.15,7.94,;5.49,8.71,;5.49,10.25,)| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587382 (US11534441, Compound 91) Show SMILES C[C@@H]1c2nc(Nc3cc4c(cnc(OC5(C)CC5)c4cn3)[C@](C)(N)C3CC3)ccc2C(=O)OC1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587392 (US11534441, Compound 101) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)ncc12)[C@](C)(N)C1CC1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587394 (US11534441, Compound 103) Show SMILES COc1ccc(c2cc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)ncc12)C(C)(C)N Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587363 (US11534441, Compound 71) Show SMILES C[C@@H]1c2nc(Nc3cc4c(cnc(OC5CC5)c4cn3)C(C)(C)N)ccc2C(=O)OC1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587438 (US11534441, Compound 148) Show SMILES C[C@@](N)(C1CC1)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)NC(C)(C)Cc4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587314 (US11534441, Compound 22 | US11534441, Compound 23) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC[C@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587419 (US11534441, Compound 129) Show SMILES CC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)O[C@@](C)(CC)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587410 (US11534441, Compound 119) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)C(C)(C)N)nc2C11CC1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587368 (US11534441, Compound 76) Show SMILES C[C@@H]1c2nc(Nc3cc4c(ncc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)ccc2C(=O)OC1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587366 (US11534441, Compound 74) Show SMILES C[C@@](N)(C1CC1)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587359 (US11534441, Compound 67) Show SMILES CCOc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587390 (US11534441, Compound 99) Show SMILES COc1ncc(c2cc(Nc3ccc4CO[C@@H](C)[C@H](C)c4n3)ncc12)[C@@](C)(N)C1CC1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587325 (US11534441, Compound 33) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC5(CC5)Cc4n3)ncc12)C(C)(C)N Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587395 (US11534441, Compound 104) Show SMILES CC(C)(N)c1ccc(Cl)c2cnc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)cc12 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587385 (US11534441, Compound 94) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5(C)CC5)c4cn3)[C@](C)(N)C3CC3)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587387 (US11534441, Compound 96) Show SMILES CC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)O[C@H](C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587482 (US11534441, Compound 192 | US11534441, Compound 20...) Show SMILES COC[C@@](C)(N)c1cnc(OC)c2cnc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587329 (US11534441, Compound 37) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587447 (US11534441, Compound 157) Show SMILES CC[C@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)O[C@H](C)C(C)(C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587458 (US11534441, Compound 168) Show SMILES C[C@@](N)(C1CCC1)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587353 (US11534441, Compound 61) Show SMILES CC[C@@](C)(N)c1cnc(OC)c2cnc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587332 (US11534441, Compound 40) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)O[C@@H](C)[C@@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587413 (US11534441, Compound 122) Show SMILES CC[C@](C)(N)c1cnc(NC2CC2)c2cnc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587349 (US11534441, Compound 57) Show SMILES CCOc1ncc(c2cc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587479 (US11534441, Compound 189) Show SMILES COC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587379 (US11534441, Compound 88) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5(C)CC5)c4cn3)[C@@](C)(N)C3CC3)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587373 (US11534441, Compound 82) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5(C)CC5)c4cn3)C(C)(C)N)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587327 (US11534441, Compound 35 | US11534441, Compound 36) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)ncc12)C(C)(C)N Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587417 (US11534441, Compound 127) Show SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)C(C)(C)N)nc2C1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587422 (US11534441, Compound 132) Show SMILES CC[C@@](C)(N)c1cnc(OC2CC2)c2cnc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587471 (US11534441, Compound 181 | US11534441, Compound 18...) Show SMILES CC[C@@](C)(N)c1cnc(OCC(F)(F)F)c2cnc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587358 (US11534441, Compound 66) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)C(C)(C)N)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587352 (US11534441, Compound 60) Show SMILES CCOc1ncc(c2cc(Nc3ccc4C(=O)O[C@@H](C)[C@@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587347 (US11534441, Compound 55) Show SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)[C@@H](C)c4n3)ncc12)C(C)(C)N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587370 (US11534441, Compound 78) Show SMILES C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OCC(F)(F)F)c4cn3)C(C)(C)N)nc2[C@H]1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587374 (US11534441, Compound 83) Show SMILES C[C@@H]1c2nc(Nc3cc4c(cnc(OC5(C)CC5)c4cn3)C(C)(C)N)ccc2C(=O)OC1(C)C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM587496 (US11534441, Compound 206) Show SMILES COC[C@@](C)(N)c1cnc(C)c2cnc(Nc3ccc4C(=O)OC(C)(C)[C@H](C)c4n3)cc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7SMZ
					More data for this Ligand-Target Pair

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