Compile Data Set for Download or QSAR

Found 373 hits with Last Name = 'chen' and Initial = 'lr'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375523 (4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H26N6O/c1-31(2)23-13-15-32(16-14-23)27(34)22-9-7-20(8-10-22)24-11-12-26-29-18-25(33(26)30-24)21-5-3-19(17-28)4-6-21/h3-12,18,23H,13-16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375523 (4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H26N6O/c1-31(2)23-13-15-32(16-14-23)27(34)22-9-7-20(8-10-22)24-11-12-26-29-18-25(33(26)30-24)21-5-3-19(17-28)4-6-21/h3-12,18,23H,13-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375525 (4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCNCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H20N6O/c25-15-17-1-3-19(4-2-17)22-16-27-23-10-9-21(28-30(22)23)18-5-7-20(8-6-18)24(31)29-13-11-26-12-14-29/h1-10,16,26H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375513 ((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c1-29-12-14-30(15-13-29)25(32)21-8-6-19(7-9-21)22-10-11-24-27-17-23(31(24)28-22)20-4-2-18(16-26)3-5-20/h2-11,17H,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375522 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375513 ((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c1-29-12-14-30(15-13-29)25(32)21-8-6-19(7-9-21)22-10-11-24-27-17-23(31(24)28-22)20-4-2-18(16-26)3-5-20/h2-11,17H,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375525 (4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCNCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H20N6O/c25-15-17-1-3-19(4-2-17)22-16-27-23-10-9-21(28-30(22)23)18-5-7-20(8-6-18)24(31)29-13-11-26-12-14-29/h1-10,16,26H,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50455538 (CHEMBL4214092) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(=O)NO Show InChI InChI=1S/C25H24N6O3/c1-29-10-12-30(13-11-29)25(33)20-8-2-17(3-9-20)21-16-31-22(14-27-23(31)15-26-21)18-4-6-19(7-5-18)24(32)28-34/h2-9,14-16,34H,10-13H2,1H3,(H,28,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375522 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50455538 (CHEMBL4214092) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(=O)NO Show InChI InChI=1S/C25H24N6O3/c1-29-10-12-30(13-11-29)25(33)20-8-2-17(3-9-20)21-16-31-22(14-27-23(31)15-26-21)18-4-6-19(7-5-18)24(32)28-34/h2-9,14-16,34H,10-13H2,1H3,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375544 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375543 (4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C26H23N5O/c1-29-12-14-30(15-13-29)26(32)22-8-6-20(7-9-22)23-10-11-25-28-17-24(31(25)18-23)21-4-2-19(16-27)3-5-21/h2-11,17-18H,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375543 (4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C26H23N5O/c1-29-12-14-30(15-13-29)26(32)22-8-6-20(7-9-22)23-10-11-25-28-17-24(31(25)18-23)21-4-2-19(16-27)3-5-21/h2-11,17-18H,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375544 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Agency for Science, Technology and Research (A*STAR) Curated by ChEMBL					Assay Description Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...				J Med Chem 61: 4348-4369 (2018) Article DOI: 10.1021/acs.jmedchem.7b01714 BindingDB Entry DOI: 10.7270/Q20004P7
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375620 (4-(5-(3-hydroxy-4-(morpholine-4-carbonyl)phenyl)py...) Show SMILES OCc1cc(ccc1C(=O)N1CCOCC1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1 Show InChI InChI=1S/C25H21N5O3/c26-14-17-1-3-18(4-2-17)22-15-27-30-8-7-23(28-24(22)30)19-5-6-21(20(13-19)16-31)25(32)29-9-11-33-12-10-29/h1-8,13,15,31H,9-12,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375621 (N-(5-(3-(4-cyanophenol)pyrazolo[1,5-a]pyrimidin-5-...) Show SMILES N=COCc1cc(ccc1C(=O)N1CCOCC1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1 Show InChI InChI=1S/C26H22N6O3/c27-14-18-1-3-19(4-2-18)23-15-29-32-8-7-24(30-25(23)32)20-5-6-22(21(13-20)16-35-17-28)26(33)31-9-11-34-12-10-31/h1-8,13,15,17,28H,9-12,16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375621 (N-(5-(3-(4-cyanophenol)pyrazolo[1,5-a]pyrimidin-5-...) Show SMILES N=COCc1cc(ccc1C(=O)N1CCOCC1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1 Show InChI InChI=1S/C26H22N6O3/c27-14-18-1-3-19(4-2-18)23-15-29-32-8-7-24(30-25(23)32)20-5-6-22(21(13-20)16-35-17-28)26(33)31-9-11-34-12-10-31/h1-8,13,15,17,28H,9-12,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375313 ((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(O)cc1 Show InChI InChI=1S/C24H23N5O2/c1-27-10-12-28(13-11-27)24(31)19-4-2-17(3-5-19)21-16-29-22(14-26-23(29)15-25-21)18-6-8-20(30)9-7-18/h2-9,14-16,30H,10-13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375313 ((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(O)cc1 Show InChI InChI=1S/C24H23N5O2/c1-27-10-12-28(13-11-27)24(31)19-4-2-17(3-5-19)21-16-29-22(14-26-23(29)15-25-21)18-6-8-20(30)9-7-18/h2-9,14-16,30H,10-13H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375321 (4-(6-(4-(4,4-dimethylpiperidine-1-carbonyl)phenyl)...) Show SMILES CC1(C)CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C27H27N5O2/c1-27(2)11-13-31(14-12-27)26(34)21-9-3-18(4-10-21)22-17-32-23(15-30-24(32)16-29-22)19-5-7-20(8-6-19)25(28)33/h3-10,15-17H,11-14H2,1-2H3,(H2,28,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375322 (4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...) Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C25H24N6O2/c26-20-9-11-30(12-10-20)25(33)19-7-1-16(2-8-19)21-15-31-22(13-29-23(31)14-28-21)17-3-5-18(6-4-17)24(27)32/h1-8,13-15,20H,9-12,26H2,(H2,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375322 (4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...) Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C25H24N6O2/c26-20-9-11-30(12-10-20)25(33)19-7-1-16(2-8-19)21-15-31-22(13-29-23(31)14-28-21)17-3-5-18(6-4-17)24(27)32/h1-8,13-15,20H,9-12,26H2,(H2,27,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375335 (4-(6-(4-(4-tert-butylpiperazine-1-carbonyl)phenyl)...) Show SMILES CC(C)(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C28H30N6O2/c1-28(2,3)33-14-12-32(13-15-33)27(36)22-10-4-19(5-11-22)23-18-34-24(16-31-25(34)17-30-23)20-6-8-21(9-7-20)26(29)35/h4-11,16-18H,12-15H2,1-3H3,(H2,29,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375335 (4-(6-(4-(4-tert-butylpiperazine-1-carbonyl)phenyl)...) Show SMILES CC(C)(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C28H30N6O2/c1-28(2,3)33-14-12-32(13-15-33)27(36)22-10-4-19(5-11-22)23-18-34-24(16-31-25(34)17-30-23)20-6-8-21(9-7-20)26(29)35/h4-11,16-18H,12-15H2,1-3H3,(H2,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375359 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)phe...) Show SMILES CC1(N)CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N6O/c1-26(28)10-12-31(13-11-26)25(33)21-8-6-19(7-9-21)22-17-32-23(15-30-24(32)16-29-22)20-4-2-18(14-27)3-5-20/h2-9,15-17H,10-13,28H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375385 (4-(6-(4-(4-aminopineridine-1-carbonyl)-3-methylphe...) Show SMILES Cc1cc(ccc1C(=O)N1CCC(N)CC1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N6O/c1-17-12-20(6-7-22(17)26(33)31-10-8-21(28)9-11-31)23-16-32-24(14-30-25(32)15-29-23)19-4-2-18(13-27)3-5-19/h2-7,12,14-16,21H,8-11,28H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375385 (4-(6-(4-(4-aminopineridine-1-carbonyl)-3-methylphe...) Show SMILES Cc1cc(ccc1C(=O)N1CCC(N)CC1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N6O/c1-17-12-20(6-7-22(17)26(33)31-10-8-21(28)9-11-31)23-16-32-24(14-30-25(32)15-29-23)19-4-2-18(13-27)3-5-19/h2-7,12,14-16,21H,8-11,28H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375389 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)-3-...) Show SMILES Cc1cc(ccc1C(=O)N1CCC(C)(N)CC1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C27H26N6O/c1-18-13-21(7-8-22(18)26(34)32-11-9-27(2,29)10-12-32)23-17-33-24(15-31-25(33)16-30-23)20-5-3-19(14-28)4-6-20/h3-8,13,15-17H,9-12,29H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375389 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)-3-...) Show SMILES Cc1cc(ccc1C(=O)N1CCC(C)(N)CC1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C27H26N6O/c1-18-13-21(7-8-22(18)26(34)32-11-9-27(2,29)10-12-32)23-17-33-24(15-31-25(33)16-30-23)20-5-3-19(14-28)4-6-20/h3-8,13,15-17H,9-12,29H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375438 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)-3-...) Show SMILES CC1(N)CCN(CC1)C(=O)c1ccc(cc1Cl)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C26H23ClN6O/c1-26(29)8-10-32(11-9-26)25(34)20-7-6-19(12-21(20)27)22-16-33-23(14-31-24(33)15-30-22)18-4-2-17(13-28)3-5-18/h2-7,12,14-16H,8-11,29H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375505 (4-aminopiperidin-1-yl)(4-(3-(4-chlorophenyl)imidaz...) Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H22N6O/c26-13-17-1-3-19(4-2-17)23-14-29-24-15-28-22(16-31(23)24)18-5-7-20(8-6-18)25(32)30-11-9-21(27)10-12-30/h1-8,14-16,21H,9-12,27H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375513 ((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c1-29-12-14-30(15-13-29)25(32)21-8-6-19(7-9-21)22-10-11-24-27-17-23(31(24)28-22)20-4-2-18(16-26)3-5-20/h2-11,17H,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375513 ((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c1-29-12-14-30(15-13-29)25(32)21-8-6-19(7-9-21)22-10-11-24-27-17-23(31(24)28-22)20-4-2-18(16-26)3-5-20/h2-11,17H,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375514 (4-(6-(4-(4-hydroxypiperidine-1-carbonyl)phenyl)imi...) Show SMILES OC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H21N5O2/c26-15-17-1-3-19(4-2-17)23-16-27-24-10-9-22(28-30(23)24)18-5-7-20(8-6-18)25(32)29-13-11-21(31)12-14-29/h1-10,16,21,31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375514 (4-(6-(4-(4-hydroxypiperidine-1-carbonyl)phenyl)imi...) Show SMILES OC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H21N5O2/c26-15-17-1-3-19(4-2-17)23-16-27-24-10-9-22(28-30(23)24)18-5-7-20(8-6-18)25(32)29-13-11-21(31)12-14-29/h1-10,16,21,31H,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375515 (4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...) Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c26-15-17-1-3-19(4-2-17)23-16-28-24-10-9-22(29-31(23)24)18-5-7-20(8-6-18)25(32)30-13-11-21(27)12-14-30/h1-10,16,21H,11-14,27H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375515 (4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...) Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C25H22N6O/c26-15-17-1-3-19(4-2-17)23-16-28-24-10-9-22(29-31(23)24)18-5-7-20(8-6-18)25(32)30-13-11-21(27)12-14-30/h1-10,16,21H,11-14,27H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375516 (N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-...) Show SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H24N6O2/c1-18(34)30-23-12-14-32(15-13-23)27(35)22-8-6-20(7-9-22)24-10-11-26-29-17-25(33(26)31-24)21-4-2-19(16-28)3-5-21/h2-11,17,23H,12-15H2,1H3,(H,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375516 (N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-...) Show SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H24N6O2/c1-18(34)30-23-12-14-32(15-13-23)27(35)22-8-6-20(7-9-22)24-10-11-26-29-17-25(33(26)31-24)21-4-2-19(16-28)3-5-21/h2-11,17,23H,12-15H2,1H3,(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375517 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)phe...) Show SMILES CC1(N)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-26(28)12-14-31(15-13-26)25(33)21-8-6-19(7-9-21)22-10-11-24-29-17-23(32(24)30-22)20-4-2-18(16-27)3-5-20/h2-11,17H,12-15,28H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375517 (4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)phe...) Show SMILES CC1(N)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-26(28)12-14-31(15-13-26)25(33)21-8-6-19(7-9-21)22-10-11-24-29-17-23(32(24)30-22)20-4-2-18(16-27)3-5-20/h2-11,17H,12-15,28H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375519 (4-(6-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)i...) Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H26N6O/c1-19(2)31-13-15-32(16-14-31)27(34)23-9-7-21(8-10-23)24-11-12-26-29-18-25(33(26)30-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,13-16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375519 (4-(6-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)i...) Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H26N6O/c1-19(2)31-13-15-32(16-14-31)27(34)23-9-7-21(8-10-23)24-11-12-26-29-18-25(33(26)30-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,13-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375520 (4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...) Show SMILES CNC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-28-22-12-14-31(15-13-22)26(33)21-8-6-19(7-9-21)23-10-11-25-29-17-24(32(25)30-23)20-4-2-18(16-27)3-5-20/h2-11,17,22,28H,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375520 (4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...) Show SMILES CNC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-28-22-12-14-31(15-13-22)26(33)21-8-6-19(7-9-21)23-10-11-25-29-17-24(32(25)30-23)20-4-2-18(16-27)3-5-20/h2-11,17,22,28H,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375521 (4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...) Show SMILES CCN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-2-30-13-15-31(16-14-30)26(33)22-9-7-20(8-10-22)23-11-12-25-28-18-24(32(25)29-23)21-5-3-19(17-27)4-6-21/h3-12,18H,2,13-16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375521 (4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...) Show SMILES CCN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C26H24N6O/c1-2-30-13-15-31(16-14-30)26(33)22-9-7-20(8-10-22)23-11-12-25-28-18-24(32(25)29-23)21-5-3-19(17-27)4-6-21/h3-12,18H,2,13-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375522 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375522 (4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...) Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375523 (4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 Show InChI InChI=1S/C27H26N6O/c1-31(2)23-13-15-32(16-14-23)27(34)22-9-7-20(8-10-22)24-11-12-26-29-18-25(33(26)30-24)21-5-3-19(17-28)4-6-21/h3-12,18,23H,13-16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair

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