Reaction Details |
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Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM375525 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1754736 (CHEMBL4189496) |
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IC50 | 16±n/a nM |
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Citation | Yang, H; Chennamaneni, LR; Ho, MWT; Ang, SH; Tan, ESW; Jeyaraj, DA; Yeap, YS; Liu, B; Ong, EH; Joy, JK; Wee, JLK; Kwek, P; Retna, P; Dinie, N; Nguyen, TTH; Tai, SJ; Manoharan, V; Pendharkar, V; Low, CB; Chew, YS; Vuddagiri, S; Sangthongpitag, K; Choong, ML; Lee, MA; Kannan, S; Verma, CS; Poulsen, A; Lim, S; Chuah, C; Ong, TS; Hill, J; Matter, A; Nacro, K Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. J Med Chem61:4348-4369 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-interacting serine/threonine-protein kinase 1 |
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Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 51342.85 |
Organism: | Homo sapiens (Human) |
Description: | Q9BUB5 |
Residue: | 465 |
Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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BDBM375525 |
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n/a |
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Name | BDBM375525 |
Synonyms: | 4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | US9908886, Example 65 |
Type | Small organic molecule |
Emp. Form. | C24H20N6O |
Mol. Mass. | 408.4552 |
SMILES | O=C(N1CCNCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 |
Structure |
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