Found 17 hits with Last Name = 'chmiel' and Initial = 'af' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565476
(CHEMBL4780117)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565475
(CHEMBL4777401)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525088
(CHEMBL4461497)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525090
(CHEMBL4558213)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@](C)(CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O |r,c:25| Show InChI InChI=1S/C97H146N24O19/c1-58(2)51-72-85(132)115-73(52-59(3)4)91(138)121-97(7,93(140)118-75(54-62-31-17-13-18-32-62)87(134)112-70(43-44-78(100)124)84(131)113-71(80(101)127)53-61-29-15-12-16-30-61)46-24-11-9-8-10-23-45-96(6,92(139)119-76(88(135)114-72)55-63-33-19-14-20-34-63)120-90(137)69(38-28-50-107-95(104)105)111-89(136)77(57-79(125)126)117-86(133)74(56-64-39-41-65(123)42-40-64)116-83(130)68(37-27-49-106-94(102)103)110-82(129)67(36-22-26-48-99)109-81(128)66(108-60(5)122)35-21-25-47-98/h8-9,12-20,29-34,39-42,58-59,66-77,123H,10-11,21-28,35-38,43-57,98-99H2,1-7H3,(H2,100,124)(H2,101,127)(H,108,122)(H,109,128)(H,110,129)(H,111,136)(H,112,134)(H,113,131)(H,114,135)(H,115,132)(H,116,130)(H,117,133)(H,118,140)(H,119,139)(H,120,137)(H,121,138)(H,125,126)(H4,102,103,106)(H4,104,105,107)/b9-8-/t66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,96-,97-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525091
(CHEMBL4447089)Show SMILES CC(C)C[C@H](NC(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1)C(N)=O |r,c:13| Show InChI InChI=1S/C75H130N22O16/c1-43(2)38-54(60(79)102)95-71(113)75(9)33-17-13-11-10-12-16-32-74(8,70(112)94-53(30-31-59(78)101)64(106)90-55(39-44(3)4)65(107)91-56(40-45(5)6)69(111)97-75)96-68(110)52(25-21-37-85-73(82)83)89-67(109)58(42-98)93-66(108)57(41-47-26-28-48(100)29-27-47)92-63(105)51(24-20-36-84-72(80)81)88-62(104)50(23-15-19-35-77)87-61(103)49(86-46(7)99)22-14-18-34-76/h10-11,26-29,43-45,49-58,98,100H,12-25,30-42,76-77H2,1-9H3,(H2,78,101)(H2,79,102)(H,86,99)(H,87,103)(H,88,104)(H,89,109)(H,90,106)(H,91,107)(H,92,105)(H,93,108)(H,94,112)(H,95,113)(H,96,110)(H,97,111)(H4,80,81,84)(H4,82,83,85)/b11-10-/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,74-,75-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525089
(CHEMBL4464315)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C90H134N24O21/c1-51(2)43-66(77(124)101-50-73(118)103-68(46-55-23-11-7-12-24-55)85(132)108-63(35-37-72(93)117)82(129)109-65(76(94)123)45-54-21-9-6-10-22-54)110-84(131)67(44-52(3)4)111-86(133)69(47-56-25-13-8-14-26-56)113-83(130)64(36-38-74(119)120)107-80(127)61(29-19-41-99-89(95)96)106-88(135)71(49-75(121)122)114-87(134)70(48-57-31-33-58(116)34-32-57)112-81(128)62(30-20-42-100-90(97)98)105-79(126)60(28-16-18-40-92)104-78(125)59(102-53(5)115)27-15-17-39-91/h6-14,21-26,31-34,51-52,59-71,116H,15-20,27-30,35-50,91-92H2,1-5H3,(H2,93,117)(H2,94,123)(H,101,124)(H,102,115)(H,103,118)(H,104,125)(H,105,126)(H,106,135)(H,107,127)(H,108,132)(H,109,129)(H,110,131)(H,111,133)(H,112,128)(H,113,130)(H,114,134)(H,119,120)(H,121,122)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525092
(CHEMBL4444144)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(N)=O |r| Show InChI InChI=1S/C68H118N22O18/c1-36(2)30-48(56(72)98)81-54(95)34-79-57(99)49(31-37(3)4)87-64(106)50(32-38(5)6)88-63(105)46(22-24-53(71)94)85-62(104)47(23-25-55(96)97)86-60(102)44(16-12-28-77-67(73)74)84-66(108)52(35-91)90-65(107)51(33-40-18-20-41(93)21-19-40)89-61(103)45(17-13-29-78-68(75)76)83-59(101)43(15-9-11-27-70)82-58(100)42(80-39(7)92)14-8-10-26-69/h18-21,36-38,42-52,91,93H,8-17,22-35,69-70H2,1-7H3,(H2,71,94)(H2,72,98)(H,79,99)(H,80,92)(H,81,95)(H,82,100)(H,83,101)(H,84,108)(H,85,104)(H,86,102)(H,87,106)(H,88,105)(H,89,103)(H,90,107)(H,96,97)(H4,73,74,77)(H4,75,76,78)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525088
(CHEMBL4461497)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525088
(CHEMBL4461497)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | n/a | 0.0110 | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565475
(CHEMBL4777401)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | n/a | 0.00420 | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565476
(CHEMBL4780117)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | n/a | 0.00690 | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525088
(CHEMBL4461497)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565475
(CHEMBL4777401)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525089
(CHEMBL4464315)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C90H134N24O21/c1-51(2)43-66(77(124)101-50-73(118)103-68(46-55-23-11-7-12-24-55)85(132)108-63(35-37-72(93)117)82(129)109-65(76(94)123)45-54-21-9-6-10-22-54)110-84(131)67(44-52(3)4)111-86(133)69(47-56-25-13-8-14-26-56)113-83(130)64(36-38-74(119)120)107-80(127)61(29-19-41-99-89(95)96)106-88(135)71(49-75(121)122)114-87(134)70(48-57-31-33-58(116)34-32-57)112-81(128)62(30-20-42-100-90(97)98)105-79(126)60(28-16-18-40-92)104-78(125)59(102-53(5)115)27-15-17-39-91/h6-14,21-26,31-34,51-52,59-71,116H,15-20,27-30,35-50,91-92H2,1-5H3,(H2,93,117)(H2,94,123)(H,101,124)(H,102,115)(H,103,118)(H,104,125)(H,105,126)(H,106,135)(H,107,127)(H,108,132)(H,109,129)(H,110,131)(H,111,133)(H,112,128)(H,113,130)(H,114,134)(H,119,120)(H,121,122)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50565476
(CHEMBL4780117)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112655
BindingDB Entry DOI: 10.7270/Q2KS6W8F |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525087
(CHEMBL4577429)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,c:79| Show InChI InChI=1S/C92H149N27O22S2/c1-12-50(5)70(117-84(138)71(51(6)13-2)116-75(129)58(29-24-39-102-89(97)98)108-85(139)72(52(7)120)115-68(124)47-104-53(8)121)83(137)112-63(44-55-31-33-56(122)34-32-55)77(131)111-65(46-69(125)126)79(133)106-59(30-25-40-103-90(99)100)81(135)118-91(9)36-21-16-14-15-17-22-37-92(10,87(141)114-66(48-142)80(134)105-57(28-23-38-101-88(95)96)74(128)109-61(73(94)127)45-67(93)123)119-82(136)60(35-41-143-11)107-76(130)62(42-49(3)4)110-78(132)64(113-86(91)140)43-54-26-19-18-20-27-54/h14-15,18-20,26-27,31-34,49-52,57-66,70-72,120,122,142H,12-13,16-17,21-25,28-30,35-48H2,1-11H3,(H2,93,123)(H2,94,127)(H,104,121)(H,105,134)(H,106,133)(H,107,130)(H,108,139)(H,109,128)(H,110,132)(H,111,131)(H,112,137)(H,113,140)(H,114,141)(H,115,124)(H,116,129)(H,117,138)(H,118,135)(H,119,136)(H,125,126)(H4,95,96,101)(H4,97,98,102)(H4,99,100,103)/b15-14-/t50-,51-,52+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,70-,71-,72-,91-,92-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
Eukaryotic translation initiation factor 4E
(Homo sapiens (Human)) | BDBM50525088
(CHEMBL4461497)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... |
J Med Chem 62: 4967-4978 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00068
BindingDB Entry DOI: 10.7270/Q2JQ14FP |
More data for this
Ligand-Target Pair | |
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