Ki Summary

Reaction Details

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Target

Eukaryotic translation initiation factor 4E

Ligand

BDBM50525090

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1895503 (CHEMBL4397538)

30±n/a nM

Citation

Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G. J Med Chem62:4967-4978 (2019) [PubMed] Article

More Info.:

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Eukaryotic translation initiation factor 4E

Name:

Eukaryotic translation initiation factor 4E

Synonyms:

Type:

Protein

Mol. Mass.:

25095.44

Organism:

Homo sapiens (Human)

Description:

P06730

Residue:

217

Sequence:

MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

BDBM50525090

n/a

Name

BDBM50525090

Synonyms:

CHEMBL4558213

Type

Small organic molecule

Emp. Form.

C97H146N24O19

Mol. Mass.

1952.3465

SMILES

CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@](C)(CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O |r,c:25|

Structure