Compile Data Set for Download or QSAR

Found 375 hits with Last Name = 'durden' and Initial = 'dl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM259884 (US10308662, Compound 125 | US9505780, 125) Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1 Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.87	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50403068 (CHEMBL2216870 | IDELALISIB | US9745321, CAL-101) Show SMILES CC[C@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427456 (CHEMBL2326953 | US10308662, Compound 44 | US950578...) Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427456 (CHEMBL2326953 | US10308662, Compound 44 | US950578...) Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427456 (CHEMBL2326953 | US10308662, Compound 44 | US950578...) Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427485 (CHEMBL2326959 | US10308662, Compound 120 | US95057...) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427455 (CHEMBL2326951) Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C20H23N5O3S/c1-23-2-4-25(5-3-23)20-21-11-14(12-22-20)15-13-29-19-16(26)10-17(28-18(15)19)24-6-8-27-9-7-24/h10-13H,2-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427489 (CHEMBL2326955) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-12-20(26-8-10-29-11-9-26)30-21-18(14-31-22(19)21)15-3-5-17(6-4-15)25-23(28)16-2-1-7-24-13-16/h1-7,12-14H,8-11H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427485 (CHEMBL2326959 | US10308662, Compound 120 | US95057...) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427485 (CHEMBL2326959 | US10308662, Compound 120 | US95057...) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427459 (CHEMBL2326954) Show SMILES CNc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H18N2O3S/c1-19-13-4-2-12(3-5-13)14-11-24-18-15(21)10-16(23-17(14)18)20-6-8-22-9-7-20/h2-5,10-11,19H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM259897 (US9505780, JQ-1) Show SMILES Cc1nnc2[C@@H](N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1)C(=O)OC(C)(C)C |c:6| Show InChI InChI=1S/C22H23ClN4O2S/c1-11-12(2)30-20-16(11)17(14-7-9-15(23)10-8-14)24-18(21(28)29-22(4,5)6)19-26-25-13(3)27(19)20/h7-10,18H,1-6H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.1	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427453 (CHEMBL2322228 | US10308662, Compound 28 | US950578...) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427453 (CHEMBL2322228 | US10308662, Compound 28 | US950578...) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50427453 (CHEMBL2322228 | US10308662, Compound 28 | US950578...) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM259897 (US9505780, JQ-1) Show SMILES Cc1nnc2[C@@H](N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1)C(=O)OC(C)(C)C |c:6| Show InChI InChI=1S/C22H23ClN4O2S/c1-11-12(2)30-20-16(11)17(14-7-9-15(23)10-8-14)24-18(21(28)29-22(4,5)6)19-26-25-13(3)27(19)20/h7-10,18H,1-6H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.1	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [349-460] (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50427453 (CHEMBL2322228 | US10308662, Compound 28 | US950578...) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427489 (CHEMBL2326955) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-12-20(26-8-10-29-11-9-26)30-21-18(14-31-22(19)21)15-3-5-17(6-4-15)25-23(28)16-2-1-7-24-13-16/h1-7,12-14H,8-11H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM259879 (US10308662, Compound 118 | US9505780, 118) Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM259879 (US10308662, Compound 118 | US9505780, 118) Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50427488 (CHEMBL2326956 | US10308662, Compound 100 | US95057...) Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427488 (CHEMBL2326956 | US10308662, Compound 100 | US95057...) Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55.2	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427459 (CHEMBL2326954) Show SMILES CNc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H18N2O3S/c1-19-13-4-2-12(3-5-13)14-11-24-18-15(21)10-16(23-17(14)18)20-6-8-22-9-7-20/h2-5,10-11,19H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427492 (CHEMBL2322244) Show SMILES COc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H17NO4S/c1-21-13-4-2-12(3-5-13)14-11-24-18-15(20)10-16(23-17(14)18)19-6-8-22-9-7-19/h2-5,10-11H,6-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427480 (CHEMBL2326964) Show SMILES O=C(Nc1ccccn1)c1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C23H19N3O4S/c27-18-13-20(26-8-10-29-11-9-26)30-21-17(14-31-22(18)21)15-4-3-5-16(12-15)23(28)25-19-6-1-2-7-24-19/h1-7,12-14H,8-11H2,(H,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427481 (CHEMBL2326963) Show SMILES O=C(Nc1ccncc1)c1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-8-10-29-11-9-26)30-21-18(14-31-22(19)21)15-2-1-3-16(12-15)23(28)25-17-4-6-24-7-5-17/h1-7,12-14H,8-11H2,(H,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427467 (CHEMBL2322229) Show SMILES COc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H17NO4S/c1-21-13-4-2-3-12(9-13)14-11-24-18-15(20)10-16(23-17(14)18)19-5-7-22-8-6-19/h2-4,9-11H,5-8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427493 (CHEMBL2322243) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCOc2c1)N1CCOCC1 Show InChI InChI=1S/C18H15NO5S/c20-13-8-16(19-3-5-21-6-4-19)24-17-12(9-25-18(13)17)11-1-2-14-15(7-11)23-10-22-14/h1-2,7-9H,3-6,10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427475 (CHEMBL2326967) Show SMILES O=c1cc(oc2c(csc12)-c1cc2ccccc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C19H16N2O3S/c22-16-10-17(21-5-7-23-8-6-21)24-18-13(11-25-19(16)18)15-9-12-3-1-2-4-14(12)20-15/h1-4,9-11,20H,5-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427488 (CHEMBL2326956 | US10308662, Compound 100 | US95057...) Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427460 (CHEMBL2322236) Show SMILES CC(=O)Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H18N2O4S/c1-12(22)20-14-4-2-13(3-5-14)15-11-26-19-16(23)10-17(25-18(15)19)21-6-8-24-9-7-21/h2-5,10-11H,6-9H2,1H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427482 (CHEMBL2326962) Show SMILES O=C(Nc1ccccn1)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C23H19N3O4S/c27-18-13-20(26-9-11-29-12-10-26)30-21-17(14-31-22(18)21)15-4-6-16(7-5-15)23(28)25-19-3-1-2-8-24-19/h1-8,13-14H,9-12H2,(H,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50403068 (CHEMBL2216870 | IDELALISIB | US9745321, CAL-101) Show SMILES CC[C@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110gamma (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM259879 (US10308662, Compound 118 | US9505780, 118) Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM259879 (US10308662, Compound 118 | US9505780, 118) Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50427485 (CHEMBL2326959 | US10308662, Compound 120 | US95057...) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427491 (CHEMBL2322245) Show SMILES CN(C)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H20N2O3S/c1-20(2)14-5-3-13(4-6-14)15-12-25-19-16(22)11-17(24-18(15)19)21-7-9-23-10-8-21/h3-6,11-12H,7-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427485 (CHEMBL2326959 | US10308662, Compound 120 | US95057...) Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1 Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
SignalRx Pharmaceuticals, Inc. US Patent					Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...				US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427463 (CHEMBL2322233) Show SMILES Clc1ccc(cc1Cl)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C17H13Cl2NO3S/c18-12-2-1-10(7-13(12)19)11-9-24-17-14(21)8-15(23-16(11)17)20-3-5-22-6-4-20/h1-2,7-9H,3-6H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427484 (CHEMBL2326960) Show SMILES O=C(Nc1cccnc1)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C23H19N3O4S/c27-19-12-20(26-8-10-29-11-9-26)30-21-18(14-31-22(19)21)15-3-5-16(6-4-15)23(28)25-17-2-1-7-24-13-17/h1-7,12-14H,8-11H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427469 (CHEMBL2322226) Show SMILES O=c1cc(oc2c(csc12)-c1ccsc1)N1CCOCC1 Show InChI InChI=1S/C15H13NO3S2/c17-12-7-13(16-2-4-18-5-3-16)19-14-11(9-21-15(12)14)10-1-6-20-8-10/h1,6-9H,2-5H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427464 (CHEMBL2322232) Show SMILES Clc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C17H14ClNO3S/c18-12-3-1-11(2-4-12)13-10-23-17-14(20)9-15(22-16(13)17)19-5-7-21-8-6-19/h1-4,9-10H,5-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50427471 (CHEMBL2326971) Show SMILES Cc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H17NO3S/c1-12-3-2-4-13(9-12)14-11-23-18-15(20)10-16(22-17(14)18)19-5-7-21-8-6-19/h2-4,9-11H,5-8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110alpha (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50427460 (CHEMBL2322236) Show SMILES CC(=O)Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C19H18N2O4S/c1-12(22)20-14-4-2-13(3-5-14)15-11-26-19-16(23)10-17(25-18(15)19)21-6-8-24-9-7-21/h2-5,10-11H,6-9H2,1H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110delta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50427477 (CHEMBL2322242) Show SMILES O=c1cc(oc2c(csc12)-c1ccco1)N1CCOCC1 Show InChI InChI=1S/C15H13NO4S/c17-11-8-13(16-3-6-18-7-4-16)20-14-10(9-21-15(11)14)12-2-1-5-19-12/h1-2,5,8-9H,3-4,6-7H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of PI3K p110beta (unknown origin)				J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9
					More data for this Ligand-Target Pair

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