Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of ram seminal vesicle COX1 assessed as PGE2 level by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM50029593 (CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of sheep placental cotyledens COX2 assessed as PGE2 level by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50315285 (CHEMBL1089840 | aR-6,7-dihydro-6-(10-hydroxyethyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in stimulated human neutrophile granulocytes after 10 mins by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50315286 (CHEMBL1088887 | aR-6-(10-iodoethyl)-1,2,3,9,10,11-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in stimulated human neutrophile granulocytes after 10 mins by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50000541 ((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in stimulated human neutrophile granulocytes after 10 mins by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM50315284 (CHEMBL1089510 | aR-6,7-Dihydro-6-(10-hydroxyethyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Graz Curated by ChEMBL | Assay Description Inhibition of sheep placental cotyledens COX2 assessed as PGE2 level by EIA | Bioorg Med Chem 18: 2809-15 (2010) Article DOI: 10.1016/j.bmc.2009.10.031 BindingDB Entry DOI: 10.7270/Q2MG7PNG | |||||||||||
More data for this Ligand-Target Pair |