Found 114 hits Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50000541' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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Similars
| DrugBank Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Czech Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 synthesis using arachidonic acid substrate by ELISA |
J Nat Prod 82: 1839-1848 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00081 BindingDB Entry DOI: 10.7270/Q2V40ZJH |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of 5-Lipoxygenase of rat basophilic leukemia cells |
Bioorg Med Chem Lett 2: 1079-1084 (1992)
Article DOI: 10.1016/S0960-894X(00)80622-8 BindingDB Entry DOI: 10.7270/Q2S75G70 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Consejo Superior de Investigaciones Cient�ficas (IQM-CSIC)
Curated by ChEMBL
| Assay Description Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured aft... |
Eur J Med Chem 156: 534-553 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.026 BindingDB Entry DOI: 10.7270/Q2N300PH |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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Similars
| DrugBank Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112090 BindingDB Entry DOI: 10.7270/Q2P272WN |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Korea Research Institute of Chemical Technology
| Assay Description 5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation... |
Chem Biol Drug Des 80: 89-98 (2012)
Article DOI: 10.1111/j.1747-0285.2012.01371.x BindingDB Entry DOI: 10.7270/Q21G0JW1 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Mus musculus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Sookmyung Women's University
Curated by ChEMBL
| Assay Description Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay |
Bioorg Med Chem 23: 7069-78 (2015)
Article DOI: 10.1016/j.bmc.2015.09.025 BindingDB Entry DOI: 10.7270/Q23N256M |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| Article
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested for its inhibitory activity against 5-lipoxygenase in rat. |
Bioorg Med Chem Lett 2: 1699-1702 (1992)
Article DOI: 10.1016/S0960-894X(00)80459-X BindingDB Entry DOI: 10.7270/Q29C6XB4 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Guru Nanak Dev University
Curated by ChEMBL
| Assay Description Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate after 5 mins by EIA |
Bioorg Med Chem 22: 1642-8 (2014)
Article DOI: 10.1016/j.bmc.2014.01.027 BindingDB Entry DOI: 10.7270/Q2KH0PT3 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
| Assay Description The compound was tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase |
J Med Chem 35: 1299-318 (1992)
BindingDB Entry DOI: 10.7270/Q25X27WS |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay |
J Med Chem 43: 690-705 (2000)
BindingDB Entry DOI: 10.7270/Q2HD7WCR |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
The Czech Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition a... |
J Nat Prod 80: 999-1006 (2017)
Article DOI: 10.1021/acs.jnatprod.6b01011 BindingDB Entry DOI: 10.7270/Q2668GW1 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assay |
J Med Chem 37: 3663-7 (1994)
BindingDB Entry DOI: 10.7270/Q27943Q2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assay |
J Med Chem 51: 8068-76 (2008)
Article DOI: 10.1021/jm801085s BindingDB Entry DOI: 10.7270/Q2639QN4 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at San Diego
Curated by ChEMBL
| Assay Description Inhibition of 5-LOX (unknown origin)-mediated leukotriene (LT)B4 biosynthesis |
J Med Chem 56: 7997-8007 (2013)
Article DOI: 10.1021/jm401053m BindingDB Entry DOI: 10.7270/Q2N29ZC4 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production |
J Med Chem 40: 1955-68 (1997)
Article DOI: 10.1021/jm9700474 BindingDB Entry DOI: 10.7270/Q2NV9JWT |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/OSF Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation ... |
Bioorg Med Chem 20: 3575-83 (2012)
Article DOI: 10.1016/j.bmc.2012.04.003 BindingDB Entry DOI: 10.7270/Q2HD7WPS |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of 5-LOX in stimulated leukocytes |
J Med Chem 55: 2597-605 (2012)
Article DOI: 10.1021/jm201497k BindingDB Entry DOI: 10.7270/Q20P115J |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Groningen Research Institute of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of 5-LOX |
Bioorg Med Chem 20: 5027-32 (2012)
Article DOI: 10.1016/j.bmc.2012.06.019 BindingDB Entry DOI: 10.7270/Q20R9QJG |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/OSF Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 ... |
Bioorg Med Chem 20: 3575-83 (2012)
Article DOI: 10.1016/j.bmc.2012.04.003 BindingDB Entry DOI: 10.7270/Q2HD7WPS |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1 |
J Med Chem 35: 2501-24 (1992)
BindingDB Entry DOI: 10.7270/Q23B60R4 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/OSF Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase |
Bioorg Med Chem Lett 22: 1969-75 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.038 BindingDB Entry DOI: 10.7270/Q2P84CCK |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate |
J Med Chem 40: 819-24 (1997)
Article DOI: 10.1021/jm9606150 BindingDB Entry DOI: 10.7270/Q2DF6Q9T |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
OXIS International, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cells |
J Med Chem 41: 420-7 (1998)
Article DOI: 10.1021/jm970034q BindingDB Entry DOI: 10.7270/Q2JD4VW7 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Natural Product Research and Infection Biology e.V.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10... |
J Nat Prod 82: 2544-2549 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00403 BindingDB Entry DOI: 10.7270/Q2QN6B77 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Natural Product Research and Infection Biology e.V.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10... |
J Nat Prod 82: 2544-2549 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00403 BindingDB Entry DOI: 10.7270/Q2QN6B77 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 518 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against human 5-lipoxygenase |
Bioorg Med Chem Lett 15: 1083-5 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.023 BindingDB Entry DOI: 10.7270/Q2PN954N |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 521 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of 5-LO in human PMNL cells assessed as reduction in LTB4, 5-H(P)ETE, 12-HETE and 15-HETE products formation using arachidonic acid as sub... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112518 BindingDB Entry DOI: 10.7270/Q21J9FF2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ferrara
Curated by ChEMBL
| Assay Description Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon... |
Eur J Med Chem 101: 573-83 (2015)
Article DOI: 10.1016/j.ejmech.2015.07.011 BindingDB Entry DOI: 10.7270/Q2V69MDP |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Inhibition of 5-LO (unknown origin) |
Eur J Med Chem 67: 269-79 (2013)
Article DOI: 10.1016/j.ejmech.2013.06.039 BindingDB Entry DOI: 10.7270/Q2XW4M9Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate after 10 mins |
Eur J Med Chem 67: 269-79 (2013)
Article DOI: 10.1016/j.ejmech.2013.06.039 BindingDB Entry DOI: 10.7270/Q2XW4M9Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Vellore Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISA |
Bioorg Med Chem 27: 604-619 (2019)
Article DOI: 10.1016/j.bmc.2018.12.043 BindingDB Entry DOI: 10.7270/Q2VH5S90 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Vellore Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISA |
Bioorg Med Chem 27: 604-619 (2019)
Article DOI: 10.1016/j.bmc.2018.12.043 BindingDB Entry DOI: 10.7270/Q2VH5S90 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-... |
Eur J Med Chem 94: 132-9 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.042 BindingDB Entry DOI: 10.7270/Q2T72K5H |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins by HPLC ana... |
Eur J Med Chem 81: 492-8 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.033 BindingDB Entry DOI: 10.7270/Q2TX3GXD |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to control |
J Med Chem 57: 3715-23 (2014)
Article DOI: 10.1021/jm401740w BindingDB Entry DOI: 10.7270/Q2NS0WGG |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate incubated 5 to 10 mins prior to... |
J Med Chem 56: 9031-44 (2013)
Article DOI: 10.1021/jm401557w BindingDB Entry DOI: 10.7270/Q24B32R4 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells |
J Med Chem 34: 2158-65 (1991)
BindingDB Entry DOI: 10.7270/Q2NS0SWM |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of 5-Lipoxygenase (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01541 BindingDB Entry DOI: 10.7270/Q2M61PTP |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human 5LOX expressed in baculovirus infected Sf insect cells using linoleic acid as substrate preincubated for 5 mins follo... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.111863 BindingDB Entry DOI: 10.7270/Q27S7SFQ |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| DrugBank Article PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant 5-LOX assessed as reduction in LTB4 level using 800 uM arachidonic acid as substrate preincubated with enzyme for 10 ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112620 BindingDB Entry DOI: 10.7270/Q2736VK2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Lille-Nord de France
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase in human whole blood |
Bioorg Med Chem 18: 3910-24 (2010)
Article DOI: 10.1016/j.bmc.2010.04.034 BindingDB Entry DOI: 10.7270/Q28K7B16 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Lille-Nord de France
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 production by HPLC method |
Bioorg Med Chem 18: 3910-24 (2010)
Article DOI: 10.1016/j.bmc.2010.04.034 BindingDB Entry DOI: 10.7270/Q28K7B16 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples
Curated by ChEMBL
| Assay Description Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production from arachidonic acid preincubated for 15 mins by ... |
Eur J Med Chem 81: 492-8 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.033 BindingDB Entry DOI: 10.7270/Q2TX3GXD |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187). |
J Med Chem 40: 1955-68 (1997)
Article DOI: 10.1021/jm9700474 BindingDB Entry DOI: 10.7270/Q2NV9JWT |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description 5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le... |
J Med Chem 38: 4768-75 (1996)
BindingDB Entry DOI: 10.7270/Q2V40VV9 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoa... |
J Med Chem 40: 819-24 (1997)
Article DOI: 10.1021/jm9606150 BindingDB Entry DOI: 10.7270/Q2DF6Q9T |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Gazi University
Curated by ChEMBL
| Assay Description Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187 |
Eur J Med Chem 46: 5021-33 (2011)
Article DOI: 10.1016/j.ejmech.2011.08.009 BindingDB Entry DOI: 10.7270/Q2445MVS |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Athens
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su... |
J Nat Prod 80: 699-706 (2017)
Article DOI: 10.1021/acs.jnatprod.6b01008 BindingDB Entry DOI: 10.7270/Q2J38W29 |
More data for this Ligand-Target Pair | |