Found 8 hits with Last Name = 'falsitta' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ATP-dependent RNA helicase DDX1
(Homo sapiens (Human)) | BDBM50537055
(CHEMBL4591917)Show SMILES CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1cccc2cnccc12 Show InChI InChI=1S/C21H21N5O2S/c1-2-3-7-17-15-26(25-23-17)18-8-5-9-19(13-18)29(27,28)24-21-10-4-6-16-14-22-12-11-20(16)21/h4-6,8-15,24H,2-3,7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX1 helicase activity |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX1
(Homo sapiens (Human)) | BDBM50537056
(CHEMBL4571759)Show SMILES CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C19H19F3N4O2S/c1-2-3-7-14-13-26(25-23-14)15-8-6-9-16(12-15)29(27,28)24-18-11-5-4-10-17(18)19(20,21)22/h4-6,8-13,24H,2-3,7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX1 helicase activity |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50537055
(CHEMBL4591917)Show SMILES CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1cccc2cnccc12 Show InChI InChI=1S/C21H21N5O2S/c1-2-3-7-17-15-26(25-23-17)18-8-5-9-19(13-18)29(27,28)24-21-10-4-6-16-14-22-12-11-20(16)21/h4-6,8-15,24H,2-3,7H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50537058
(CHEMBL4531719)Show InChI InChI=1S/C20H23N5O/c1-3-4-8-17-14-25(24-23-17)18-12-10-16(11-13-18)21-20(26)22-19-9-6-5-7-15(19)2/h5-7,9-14H,3-4,8H2,1-2H3,(H2,21,22,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50537057
(CHEMBL4551611)Show InChI InChI=1S/C12H10N2O5S/c15-12-7-2-1-6-11(12)13-20(18,19)10-5-3-4-9(8-10)14(16)17/h1-8,13,15H | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX1
(Homo sapiens (Human)) | BDBM50537058
(CHEMBL4531719)Show InChI InChI=1S/C20H23N5O/c1-3-4-8-17-14-25(24-23-17)18-12-10-16(11-13-18)21-20(26)22-19-9-6-5-7-15(19)2/h5-7,9-14H,3-4,8H2,1-2H3,(H2,21,22,26) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX1 helicase activity |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX1
(Homo sapiens (Human)) | BDBM50537057
(CHEMBL4551611)Show InChI InChI=1S/C12H10N2O5S/c15-12-7-2-1-6-11(12)13-20(18,19)10-5-3-4-9(8-10)14(16)17/h1-8,13,15H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX1 helicase activity |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50537056
(CHEMBL4571759)Show SMILES CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C19H19F3N4O2S/c1-2-3-7-14-13-26(25-23-14)15-8-6-9-16(12-15)29(27,28)24-18-11-5-4-10-17(18)19(20,21)22/h4-6,8-13,24H,2-3,7H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description
Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay |
J Med Chem 62: 2333-2347 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01403
BindingDB Entry DOI: 10.7270/Q2X06BJK |
More data for this
Ligand-Target Pair | |
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