| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX1 |
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| Ligand | BDBM50537056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1935574 (CHEMBL4481333) |
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| IC50 | >200000±n/a nM |
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| Citation |  Brai, A; Martelli, F; Riva, V; Garbelli, A; Fazi, R; Zamperini, C; Pollutri, A; Falsitta, L; Ronzini, S; Maccari, L; Maga, G; Giannecchini, S; Botta, M DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. J Med Chem62:2333-2347 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DDX1 |
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| Name: | ATP-dependent RNA helicase DDX1 |
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| Synonyms: | DBP-RB | DDX1 | DDX1_HUMAN | DEAD box protein 1 | DEAD box protein retinoblastoma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82440.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811952 |
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| Residue: | 740 |
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| Sequence: | MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPV
IQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWH
GCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFD
NYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKF
NFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAE
QTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLN
LSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSE
KIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGAN
SPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQF
SCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV
HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLS
EIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEK
EAQTSFLHLGYLPNQLFRTF
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| BDBM50537056 |
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| n/a |
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| Name | BDBM50537056 |
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| Synonyms: | CHEMBL4571759 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19F3N4O2S |
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| Mol. Mass. | 424.44 |
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| SMILES | CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1C(F)(F)F |
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| Structure | 
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