Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25127 ((2E)-3-{3-chloro-4-[3-(3,3-dimethylbut-1-yn-1-yl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein tyrosine phosphatase receptor type C-associated protein (Homo sapiens (Human)) | BDBM50212333 (5-[3'-(1-adamantyl)-2-chloro-4'-hydroxy-4-biphenyl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Institute for Medical Research Curated by ChEMBL | Assay Description Inhibition of CD45 PTP by fluorescence spectrometry | J Med Chem 50: 2622-39 (2007) Article DOI: 10.1021/jm0613323 BindingDB Entry DOI: 10.7270/Q2XS5V3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50212333 (5-[3'-(1-adamantyl)-2-chloro-4'-hydroxy-4-biphenyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Institute for Medical Research Curated by ChEMBL | Assay Description Inhibition of SHP2 PTP by fluorescence spectroscopy | J Med Chem 50: 2622-39 (2007) Article DOI: 10.1021/jm0613323 BindingDB Entry DOI: 10.7270/Q2XS5V3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25124 ((2E)-3-{4-[3-(adamantan-1-yl)-4-aminophenyl]-3-chl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25122 ((2E)-3-{4-[3-(adamantan-1-yl)-4-hydroxyphenyl]-3-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25125 ((2E)-3-{4-[3-(adamantan-1-yl)-4-fluorophenyl]-3-ch...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.11E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50212331 (5-[1-(3'-adamantan-1-yl-2-chloro-4'-hydroxy-biphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Institute for Medical Research Curated by ChEMBL | Assay Description Inhibition of SHP2 PTP by fluorescence spectroscopy | J Med Chem 50: 2622-39 (2007) Article DOI: 10.1021/jm0613323 BindingDB Entry DOI: 10.7270/Q2XS5V3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25131 ((2E)-3-{3-chloro-4-[3-(3,5-dimethyladamantan-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.27E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein tyrosine phosphatase receptor type C-associated protein (Homo sapiens (Human)) | BDBM50212331 (5-[1-(3'-adamantan-1-yl-2-chloro-4'-hydroxy-biphen...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Institute for Medical Research Curated by ChEMBL | Assay Description Inhibition of CD45 PTP by fluorescence spectrometry | J Med Chem 50: 2622-39 (2007) Article DOI: 10.1021/jm0613323 BindingDB Entry DOI: 10.7270/Q2XS5V3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25129 ((2E)-3-[3-chloro-4-(4-hydroxy-3-{tricyclo[3.3.1.0^...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.91E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25123 ((2E)-3-{4-[3-(adamantan-1-yl)-4-acetamidophenyl]-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.55E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25133 ((2E)-3-{3-chloro-4-[3-(3-ethylpentan-3-yl)-4-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.37E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25130 ((2E)-3-{3-chloro-4-[4-hydroxy-3-(1-methylcyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25132 ((2E)-3-{3-chloro-4-[4-hydroxy-3-(2-methyl-1,3-dith...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25128 ((2E)-3-{3-chloro-4-[3-(2,6-dimethylphenyl)-4-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.99E+4 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 [205-593] (Homo sapiens (Human)) | BDBM25126 ((2E)-3-[3-chloro-4-(4-fluorophenyl)phenyl]prop-2-e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | 6.0 | 30 |
Burnham Institute for Medical Research | Assay Description The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen... | J Med Chem 51: 5650-62 (2008) Article DOI: 10.1021/jm800456k BindingDB Entry DOI: 10.7270/Q24T6GNQ | |||||||||||
More data for this Ligand-Target Pair |