BindingDB PrimarySearch

Found 16 hits with Last Name = 'farias' and Initial = 'jj'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50387569 (CHEMBL2057714) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human nAChR alpha4beta2 expressed in human SH-EP1 cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50257941 (7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane \| CHEMB...) Show SMILES C1CNC2(C1)CCN(C2)c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human nAChR alpha4beta2 expressed in human SH-EP1 cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50387567 (CHEMBL2057712) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human nAChR alpha4beta2 expressed in human SH-EP1 cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50387568 (CHEMBL2057713) Show SMILES C1CC2(CN1c1cccnc1)CC1CCN2CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human nAChR alpha4beta2 expressed in human SH-EP1 cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387569 (CHEMBL2057714) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387568 (CHEMBL2057713) Show SMILES C1CC2(CN1c1cccnc1)CC1CCN2CC1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50257941 (7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane \| CHEMB...) Show SMILES C1CNC2(C1)CCN(C2)c1cccnc1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387567 (CHEMBL2057712) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50257941 (7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane \| CHEMB...) Show SMILES C1CNC2(C1)CCN(C2)c1cccnc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50387569 (CHEMBL2057714) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50387567 (CHEMBL2057712) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50387568 (CHEMBL2057713) Show SMILES C1CC2(CN1c1cccnc1)CC1CCN2CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50257941 (7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane \| CHEMB...) Show SMILES C1CNC2(C1)CCN(C2)c1cccnc1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387567 (CHEMBL2057712) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387568 (CHEMBL2057713) Show SMILES C1CC2(CN1c1cccnc1)CC1CCN2CC1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50387569 (CHEMBL2057714) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
Targacept, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis				Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1
Targacept, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair