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Compile Data Set for Download or QSAR

Found 60 hits with Last Name = 'ferro' and Initial = 'mp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086479
PNG
(4-Chloro-benzoic acid N'-p-tolyl-hydrazide | CHEMB...)
Show SMILES Cc1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C14H13ClN2O/c1-10-2-8-13(9-3-10)16-17-14(18)11-4-6-12(15)7-5-11/h2-9,16H,1H3,(H,17,18)
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n/an/a 10n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086492
PNG
(1,3-Diphenyl-1,4,5,6,7,8-hexahydro-cycloheptapyraz...)
Show SMILES C1CCc2c(CC1)n(nc2-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-4-10-16(11-5-1)20-18-14-8-3-9-15-19(18)22(21-20)17-12-6-2-7-13-17/h1-2,4-7,10-13H,3,8-9,14-15H2
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n/an/a 120n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086500
PNG
(4-Chloro-benzoic acid N'-(4-methoxy-phenyl)-hydraz...)
Show SMILES COc1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C14H13ClN2O2/c1-19-13-8-6-12(7-9-13)16-17-14(18)10-2-4-11(15)5-3-10/h2-9,16H,1H3,(H,17,18)
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n/an/a 130n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086498
PNG
(3-(4-Chloro-phenyl)-1-phenyl-1,4,5,6,7,8-hexahydro...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccccc1
Show InChI InChI=1S/C20H19ClN2/c21-16-13-11-15(12-14-16)20-18-9-5-2-6-10-19(18)23(22-20)17-7-3-1-4-8-17/h1,3-4,7-8,11-14H,2,5-6,9-10H2
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n/an/a 140n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086492
PNG
(1,3-Diphenyl-1,4,5,6,7,8-hexahydro-cycloheptapyraz...)
Show SMILES C1CCc2c(CC1)n(nc2-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-4-10-16(11-5-1)20-18-14-8-3-9-15-19(18)22(21-20)17-12-6-2-7-13-17/h1-2,4-7,10-13H,3,8-9,14-15H2
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n/an/a 170n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086487
PNG
(Benzoic acid N'-(4-methoxy-phenyl)-hydrazide | CHE...)
Show SMILES COc1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O2/c1-18-13-9-7-12(8-10-13)15-16-14(17)11-5-3-2-4-6-11/h2-10,15H,1H3,(H,16,17)
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n/an/a 180n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086476
PNG
(4-Chloro-benzoic acid N'-phenyl-hydrazide | CHEMBL...)
Show SMILES Clc1ccc(cc1)C(=O)NNc1ccccc1
Show InChI InChI=1S/C13H11ClN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h1-9,15H,(H,16,17)
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n/an/a 330n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086481
PNG
(Benzoic acid N'-p-tolyl-hydrazide | CHEMBL157950)
Show SMILES Cc1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O/c1-11-7-9-13(10-8-11)15-16-14(17)12-5-3-2-4-6-12/h2-10,15H,1H3,(H,16,17)
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n/an/a 330n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086488
PNG
(4-Chloro-benzoic acid N'-(4-chloro-phenyl)-hydrazi...)
Show SMILES Clc1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C13H10Cl2N2O/c14-10-3-1-9(2-4-10)13(18)17-16-12-7-5-11(15)6-8-12/h1-8,16H,(H,17,18)
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n/an/a 340n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086478
PNG
(3-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-4,5,6,7-t...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(O)CCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19ClN2O2/c1-25-17-9-6-15(7-10-17)23-19-11-8-16(24)12-18(19)20(22-23)13-2-4-14(21)5-3-13/h2-7,9-10,16,24H,8,11-12H2,1H3
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n/an/a 460n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086496
PNG
(4-Methoxy-benzoic acid N'-(4-chloro-phenyl)-hydraz...)
Show SMILES COc1ccc(cc1)C(=O)NNc1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN2O2/c1-19-13-8-2-10(3-9-13)14(18)17-16-12-6-4-11(15)5-7-12/h2-9,16H,1H3,(H,17,18)
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n/an/a 470n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086484
PNG
(1,3-Diphenyl-4,5,6,7-tetrahydro-1H-indazole | CHEM...)
Show SMILES C1CCc2c(C1)c(nn2-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21(20-19)16-11-5-2-6-12-16/h1-6,9-12H,7-8,13-14H2
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n/an/a 490n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086489
PNG
(Benzoic acid N'-(4-chloro-phenyl)-hydrazide | CHEM...)
Show SMILES Clc1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C13H11ClN2O/c14-11-6-8-12(9-7-11)15-16-13(17)10-4-2-1-3-5-10/h1-9,15H,(H,16,17)
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n/an/a 530n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086484
PNG
(1,3-Diphenyl-4,5,6,7-tetrahydro-1H-indazole | CHEM...)
Show SMILES C1CCc2c(C1)c(nn2-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21(20-19)16-11-5-2-6-12-16/h1-6,9-12H,7-8,13-14H2
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n/an/a 570n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086485
PNG
(3-(4-Chloro-phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCCc12)-c1ccccc1
Show InChI InChI=1S/C19H17ClN2/c20-15-12-10-14(11-13-15)19-17-8-4-5-9-18(17)22(21-19)16-6-2-1-3-7-16/h1-3,6-7,10-13H,4-5,8-9H2
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n/an/a 620n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086480
PNG
(3-(4-Chloro-phenyl)-1-p-tolyl-1,4,5,6,7,8-hexahydr...)
Show SMILES Cc1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2/c1-15-7-13-18(14-8-15)24-20-6-4-2-3-5-19(20)21(23-24)16-9-11-17(22)12-10-16/h7-14H,2-6H2,1H3
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n/an/a 640n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086498
PNG
(3-(4-Chloro-phenyl)-1-phenyl-1,4,5,6,7,8-hexahydro...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccccc1
Show InChI InChI=1S/C20H19ClN2/c21-16-13-11-15(12-14-16)20-18-9-5-2-6-10-19(18)23(22-20)17-7-3-1-4-8-17/h1,3-4,7-8,11-14H,2,5-6,9-10H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086494
PNG
(3-(4-Methoxy-phenyl)-1-phenyl-1,4,5,6,7,8-hexahydr...)
Show SMILES COc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccccc1
Show InChI InChI=1S/C21H22N2O/c1-24-18-14-12-16(13-15-18)21-19-10-6-3-7-11-20(19)23(22-21)17-8-4-2-5-9-17/h2,4-5,8-9,12-15H,3,6-7,10-11H2,1H3
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n/an/a 1.24E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086495
PNG
(3-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1,4,5,6,7...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O/c1-25-18-13-11-17(12-14-18)24-20-6-4-2-3-5-19(20)21(23-24)15-7-9-16(22)10-8-15/h7-14H,2-6H2,1H3
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n/an/a 1.56E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086497
PNG
(3-(4-Chloro-phenyl)-5-fluoro-1-(4-methoxy-phenyl)-...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(F)CCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClFN2O/c1-25-17-9-7-16(8-10-17)24-19-11-6-15(22)12-18(19)20(23-24)13-2-4-14(21)5-3-13/h2-5,7-10,15H,6,11-12H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086490
PNG
(CHEMBL346697 | N-[3-(4-Chloro-phenyl)-1-(4-methoxy...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(CCc12)N(O)C(C)=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3O3/c1-14(27)26(28)18-9-12-21-20(13-18)22(15-3-5-16(23)6-4-15)24-25(21)17-7-10-19(29-2)11-8-17/h3-8,10-11,18,28H,9,12-13H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086472
PNG
(3-(4-Chloro-phenyl)-1-phenyl-1,4,5,6-tetrahydro-cy...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCc12)-c1ccccc1
Show InChI InChI=1S/C18H15ClN2/c19-14-11-9-13(10-12-14)18-16-7-4-8-17(16)21(20-18)15-5-2-1-3-6-15/h1-3,5-6,9-12H,4,7-8H2
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n/an/a 2.59E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086486
PNG
(1,3-Diphenyl-1,4,5,6-tetrahydro-cyclopentapyrazole...)
Show SMILES C1Cc2c(C1)n(nc2-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H16N2/c1-3-8-14(9-4-1)18-16-12-7-13-17(16)20(19-18)15-10-5-2-6-11-15/h1-6,8-11H,7,12-13H2
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n/an/a 6.20E+3n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086494
PNG
(3-(4-Methoxy-phenyl)-1-phenyl-1,4,5,6,7,8-hexahydr...)
Show SMILES COc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccccc1
Show InChI InChI=1S/C21H22N2O/c1-24-18-14-12-16(13-15-18)21-19-10-6-3-7-11-20(19)23(22-21)17-8-4-2-5-9-17/h2,4-5,8-9,12-15H,3,6-7,10-11H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086493
PNG
(3-(4-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-1...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O2S/c1-27(25,26)18-13-11-17(12-14-18)24-20-6-4-2-3-5-19(20)21(23-24)15-7-9-16(22)10-8-15/h7-14H,2-6H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086497
PNG
(3-(4-Chloro-phenyl)-5-fluoro-1-(4-methoxy-phenyl)-...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(F)CCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClFN2O/c1-25-17-9-7-16(8-10-17)24-19-11-6-15(22)12-18(19)20(23-24)13-2-4-14(21)5-3-13/h2-5,7-10,15H,6,11-12H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086474
PNG
(4-Chloro-benzoic acid N'-(4-methanesulfonyl-phenyl...)
Show SMILES CS(=O)(=O)c1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C14H13ClN2O3S/c1-21(19,20)13-8-6-12(7-9-13)16-17-14(18)10-2-4-11(15)5-3-10/h2-9,16H,1H3,(H,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086475
PNG
(Benzoic acid N'-(4-methanesulfonyl-phenyl)-hydrazi...)
Show SMILES CS(=O)(=O)c1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c1-20(18,19)13-9-7-12(8-10-13)15-16-14(17)11-5-3-2-4-6-11/h2-10,15H,1H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086473
PNG
(1,3-Bis-(4-chloro-phenyl)-1,4,5,6,7,8-hexahydro-cy...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2/c21-15-8-6-14(7-9-15)20-18-4-2-1-3-5-19(18)24(23-20)17-12-10-16(22)11-13-17/h6-13H,1-5H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086477
PNG
(1,3-Bis-(4-chloro-phenyl)-1,4,5,6-tetrahydro-cyclo...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N2/c19-13-6-4-12(5-7-13)18-16-2-1-3-17(16)22(21-18)15-10-8-14(20)9-11-15/h4-11H,1-3H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086491
PNG
(4-Methoxy-benzoic acid N'-phenyl-hydrazide | CHEMB...)
Show SMILES COc1ccc(cc1)C(=O)NNc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c1-18-13-9-7-11(8-10-13)14(17)16-15-12-5-3-2-4-6-12/h2-10,15H,1H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086483
PNG
(3-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(c2CCCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O2S/c1-26(24,25)17-12-10-16(11-13-17)23-19-5-3-2-4-18(19)20(22-23)14-6-8-15(21)9-7-14/h6-13H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086482
PNG
(5-[(acetyloxy)amino]-3-(4-chlorophenyl)-1-(4-metho...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(CCc12)NOC(C)=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3O3/c1-14(27)29-25-17-7-12-21-20(13-17)22(15-3-5-16(23)6-4-15)24-26(21)18-8-10-19(28-2)11-9-18/h3-6,8-11,17,25H,7,12-13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086499
PNG
(3-(4-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(c2CCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19ClN2O2S/c1-26(24,25)17-12-10-16(11-13-17)23-19-5-3-2-4-18(19)20(22-23)14-6-8-15(21)9-7-14/h6-13H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086501
PNG
(Benzoic acid N'-phenyl-hydrazide | CHEMBL444539)
Show SMILES O=C(NNc1ccccc1)c1ccccc1
Show InChI InChI=1S/C13H12N2O/c16-13(11-7-3-1-4-8-11)15-14-12-9-5-2-6-10-12/h1-10,14H,(H,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))
BDBM50086493
PNG
(3-(4-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-1...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O2S/c1-27(25,26)18-13-11-17(12-14-18)24-20-6-4-2-3-5-19(20)21(23-24)15-7-9-16(22)10-8-15/h7-14H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086476
PNG
(4-Chloro-benzoic acid N'-phenyl-hydrazide | CHEMBL...)
Show SMILES Clc1ccc(cc1)C(=O)NNc1ccccc1
Show InChI InChI=1S/C13H11ClN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h1-9,15H,(H,16,17)
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086474
PNG
(4-Chloro-benzoic acid N'-(4-methanesulfonyl-phenyl...)
Show SMILES CS(=O)(=O)c1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C14H13ClN2O3S/c1-21(19,20)13-8-6-12(7-9-13)16-17-14(18)10-2-4-11(15)5-3-10/h2-9,16H,1H3,(H,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086496
PNG
(4-Methoxy-benzoic acid N'-(4-chloro-phenyl)-hydraz...)
Show SMILES COc1ccc(cc1)C(=O)NNc1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN2O2/c1-19-13-8-2-10(3-9-13)14(18)17-16-12-6-4-11(15)5-7-12/h2-9,16H,1H3,(H,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086491
PNG
(4-Methoxy-benzoic acid N'-phenyl-hydrazide | CHEMB...)
Show SMILES COc1ccc(cc1)C(=O)NNc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c1-18-13-9-7-11(8-10-13)14(17)16-15-12-5-3-2-4-6-12/h2-10,15H,1H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086473
PNG
(1,3-Bis-(4-chloro-phenyl)-1,4,5,6,7,8-hexahydro-cy...)
Show SMILES Clc1ccc(cc1)-c1nn(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2/c21-15-8-6-14(7-9-15)20-18-4-2-1-3-5-19(18)24(23-20)17-12-10-16(22)11-13-17/h6-13H,1-5H2
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086482
PNG
(5-[(acetyloxy)amino]-3-(4-chlorophenyl)-1-(4-metho...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(CCc12)NOC(C)=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3O3/c1-14(27)29-25-17-7-12-21-20(13-17)22(15-3-5-16(23)6-4-15)24-26(21)18-8-10-19(28-2)11-9-18/h3-6,8-11,17,25H,7,12-13H2,1-2H3
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086475
PNG
(Benzoic acid N'-(4-methanesulfonyl-phenyl)-hydrazi...)
Show SMILES CS(=O)(=O)c1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c1-20(18,19)13-9-7-12(8-10-13)15-16-14(17)11-5-3-2-4-6-11/h2-10,15H,1H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086490
PNG
(CHEMBL346697 | N-[3-(4-Chloro-phenyl)-1-(4-methoxy...)
Show SMILES COc1ccc(cc1)-n1nc(c2CC(CCc12)N(O)C(C)=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3O3/c1-14(27)26(28)18-9-12-21-20(13-18)22(15-3-5-16(23)6-4-15)24-25(21)17-7-10-19(29-2)11-8-17/h3-8,10-11,18,28H,9,12-13H2,1-2H3
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086481
PNG
(Benzoic acid N'-p-tolyl-hydrazide | CHEMBL157950)
Show SMILES Cc1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O/c1-11-7-9-13(10-8-11)15-16-14(17)12-5-3-2-4-6-12/h2-10,15H,1H3,(H,16,17)
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086488
PNG
(4-Chloro-benzoic acid N'-(4-chloro-phenyl)-hydrazi...)
Show SMILES Clc1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C13H10Cl2N2O/c14-10-3-1-9(2-4-10)13(18)17-16-12-7-5-11(15)6-8-12/h1-8,16H,(H,17,18)
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086495
PNG
(3-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1,4,5,6,7...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O/c1-25-18-13-11-17(12-14-18)24-20-6-4-2-3-5-19(20)21(23-24)15-7-9-16(22)10-8-15/h7-14H,2-6H2,1H3
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086500
PNG
(4-Chloro-benzoic acid N'-(4-methoxy-phenyl)-hydraz...)
Show SMILES COc1ccc(NNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C14H13ClN2O2/c1-19-13-8-6-12(7-9-13)16-17-14(18)10-2-4-11(15)5-3-10/h2-9,16H,1H3,(H,17,18)
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086480
PNG
(3-(4-Chloro-phenyl)-1-p-tolyl-1,4,5,6,7,8-hexahydr...)
Show SMILES Cc1ccc(cc1)-n1nc(c2CCCCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2/c1-15-7-13-18(14-8-15)24-20-6-4-2-3-5-19(20)21(23-24)16-9-11-17(22)12-10-16/h7-14H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))
BDBM50086487
PNG
(Benzoic acid N'-(4-methoxy-phenyl)-hydrazide | CHE...)
Show SMILES COc1ccc(NNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O2/c1-18-13-9-7-12(8-10-13)15-16-14(17)11-5-3-2-4-6-11/h2-10,15H,1H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2


Bioorg Med Chem Lett 10: 601-4 (2000)


BindingDB Entry DOI: 10.7270/Q2TH8KWZ
More data for this
Ligand-Target Pair
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