BindingDB PrimarySearch

Found 38 hits with Last Name = 'fillingham' and Initial = 'ya'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50031873 (5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium falciparum (isolate K1 / Thailand))	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18498 (6-methyl-5-[(3S)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium falciparum (isolate K1 / Thailand))	BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine \|...) Show SMILES CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18492 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18492 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	169	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50082924 (6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Pneumocystis carinii DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18496 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18490 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-...) Show SMILES COc1cc(CC#Cc2c(C)nc(N)nc2N)cc(OC)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18498 (6-methyl-5-[(3S)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18491 (5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimid...) Show SMILES COc1cc(cc(OC)c1OC)C(C)C#Cc1cnc(N)nc1N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50188084 (5-(1-(3,4,5-trimethoxyphenyl)propyl)pyrimidine-2,4...) Show SMILES CCC(c1cc(OC)c(OC)c(OC)c1)c1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18496 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18491 (5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimid...) Show SMILES COc1cc(cc(OC)c1OC)C(C)C#Cc1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18494 (3-(2,4-diamino-6-methylpyrimidin-5-yl)-1-(3,4,5-tr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18495 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18490 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-...) Show SMILES COc1cc(CC#Cc2c(C)nc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Pneumocystis carinii DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18493 (3-(2,4-diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyp...) Show SMILES COc1cc(cc(OC)c1OC)C(O)C#Cc1cnc(N)nc1N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18489 (5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimi...) Show SMILES COc1cc(CC#Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18489 (5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimi...) Show SMILES COc1cc(CC#Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.61E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18488 (5-[2-(3,4,5-trimethoxyphenyl)ethyl]pyrimidine-2,4-...) Show SMILES COc1cc(CCc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.02E+4	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50188082 (5-(2-methyl-1-(3,4,5-trimethoxyphenyl)propyl)pyrim...) Show SMILES COc1cc(cc(OC)c1OC)C(C(C)C)c1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50082924 (6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.19E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18495 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18494 (3-(2,4-diamino-6-methylpyrimidin-5-yl)-1-(3,4,5-tr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.41E+5	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18493 (3-(2,4-diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyp...) Show SMILES COc1cc(cc(OC)c1OC)C(O)C#Cc1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.94E+5	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50188083 (5-(1-(3,4,5-trimethoxyphenyl)ethyl)pyrimidine-2,4-...) Show SMILES COc1cc(cc(OC)c1OC)C(C)c1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18486 (5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyrimidin...) Show SMILES COc1cc(\C=C\c2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18485 (5-[2-(3,4,5-trimethoxyphenyl)ethynyl]pyrimidine-2,...) Show SMILES COc1cc(cc(OC)c1OC)C#Cc1cnc(N)nc1N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18488 (5-[2-(3,4,5-trimethoxyphenyl)ethyl]pyrimidine-2,4-...) Show SMILES COc1cc(CCc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine \|...) Show SMILES CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Dartmouth College Curated by ChEMBL					Assay Description Inhibition of Cryptosporidium hominis DHFR				Bioorg Med Chem Lett 16: 4366-70 (2006) Article DOI: 10.1016/j.bmcl.2006.05.047 BindingDB Entry DOI: 10.7270/Q2CC1097
Dartmouth College Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18487 (5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyrimidin...) Show SMILES COc1cc(\C=C/c2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.0	25
Dartmouth College					Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...				J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ
Dartmouth College					More data for this Ligand-Target Pair