Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+ | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 1/2 (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50470046 (CHEMBL126869) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Tested for affinity of compound against cannabinoid receptor in rat forebrain membranes | J Med Chem 37: 3867-70 (1994) Article DOI: 10.1021/jm00049a002 BindingDB Entry DOI: 10.7270/Q20R9S4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179201 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADPH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 1/2 (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50470045 (CHEMBL420512) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Tested for affinity of compound against cannabinoid receptor in rat forebrain membranes | J Med Chem 37: 3867-70 (1994) Article DOI: 10.1021/jm00049a002 BindingDB Entry DOI: 10.7270/Q20R9S4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179201 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179198 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179200 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179194 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179195 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179197 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
17-beta-hydroxysteroid dehydrogenase type 1 (Homo sapiens (Human)) | BDBM50179202 (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CHUQ - Pavillon CHUL and Université Laval Curated by ChEMBL | Assay Description Inhibition of (unknown origin) 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH | Eur J Med Chem 43: 2298-306 (2008) Article DOI: 10.1016/j.ejmech.2008.01.044 BindingDB Entry DOI: 10.7270/Q2P84BP6 | |||||||||||
More data for this Ligand-Target Pair |