BindingDB PrimarySearch

Found 12 hits with Last Name = 'frelek' and Initial = 'j'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vitamin D3 receptor (Rattus norvegicus)	BDBM50200182 ((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293269 ((1R,3R)-5-[(E)-(5'S,7'S)-11'-hydroxy-5',7',11'-tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293270 ((1R,3R)-5-[(E)-(5'R,7'S)-11'-Hydroxy-5',7',11'-tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293268 ((1R,3R)-5-((R)-11-hydroxy-7,11-dimethyldodec-2-eny...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293272 ((20S)-1alpha,25-Dihydroxy-2-methylene-8(12),14(17)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293271 ((7Z)-(20S)-1alpha,25-Dihydroxy-2-methylene-8(12),1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293268 ((1R,3R)-5-((R)-11-hydroxy-7,11-dimethyldodec-2-eny...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293271 ((7Z)-(20S)-1alpha,25-Dihydroxy-2-methylene-8(12),1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293270 ((1R,3R)-5-[(E)-(5'R,7'S)-11'-Hydroxy-5',7',11'-tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293269 ((1R,3R)-5-[(E)-(5'S,7'S)-11'-hydroxy-5',7',11'-tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Rattus norvegicus)	BDBM50200182 ((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Vitamin D3 receptor (Rattus norvegicus)	BDBM50293272 ((20S)-1alpha,25-Dihydroxy-2-methylene-8(12),14(17)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...				Bioorg Med Chem 17: 1747-63 (2009) Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair