| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50293271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540934 (CHEMBL1029884) |
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| Ki | >1000±n/a nM |
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| Citation |  Plonska-Ocypa, K; Sicinski, RR; Plum, LA; Grzywacz, P; Frelek, J; Clagett-Dame, M; DeLuca, HF 13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation. Bioorg Med Chem17:1747-63 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47811.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1505946 |
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| Residue: | 423 |
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| Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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| BDBM50293271 |
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| n/a |
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| Name | BDBM50293271 |
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| Synonyms: | (7Z)-(20S)-1alpha,25-Dihydroxy-2-methylene-8(12),14(17)-diseco-13(17)-dehydro-9,11,15,16,18,19-hexanorvitamin D3 | CHEMBL456834 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H36O3 |
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| Mol. Mass. | 348.5194 |
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| SMILES | [#6]-[#6@@H](-[#6]-[#6]-[#6]C([#6])([#6])[#8])\[#6]=[#6](/[#6])-[#6]\[#6]=[#6]/[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| |
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| Structure | 
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